RESUMEN
INTRODUCTION AND OBJECTIVES: As of January 2021, over 88 million people have been infected with COVID-19. Almost two million people have died of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high SOFA score and a D-Dimer >1 µg/mL identifies patients with high risk of mortality. High lactate dehydrogenase (LDH) levels on admission are associated with severity and mortality. Different degrees of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. The aim of this study was to explore the correlation between LDH and in-hospital mortality in Mexican patients admitted with COVID-19. MATERIALS & METHODS: We performed a retrospective multi-centre cohort study with 377 hospitalized patients with confirmed SARS-CoV-2 in three centres in Mexico City, Mexico, who were ≥18 years old and died or were discharged between April 1 and May 31, 2020. RESULTS: A total of 377 patients were evaluated, 298 (79.1%) patients were discharged, and 79 (20.9%) patients died during hospitalization. Non-survivors were older, with a median age of 46.7 ± 25.7 years old, most patients were male. An ALT > 61 U/l (OR 3.45, 95% CI 1.27-9.37; p = 0.015), C-reactive protein (CRP) > 231 mg/l (OR 4.71, 95% CI 2.35-9.46; p = 0.000), LDH > 561 U/l (OR 3.03, 95% CI 1.40-6.55; p = 0.005) were associated with higher odds for in-hospital death. CONCLUSIONS: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.
Asunto(s)
COVID-19/sangre , COVID-19/mortalidad , Pruebas Enzimáticas Clínicas , Mortalidad Hospitalaria , Hospitalización , L-Lactato Deshidrogenasa/sangre , Adulto , Anciano , Alanina Transaminasa/sangre , Biomarcadores/sangre , Proteína C-Reactiva/análisis , COVID-19/diagnóstico , Femenino , Humanos , Masculino , México , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Factores de Tiempo , Regulación hacia Arriba , Adulto JovenAsunto(s)
COVID-19 , Humanos , L-Lactato Deshidrogenasa , Lactatos , México/epidemiología , SARS-CoV-2RESUMEN
Con el objeto de conocer si los conceptos acerca de la religión, expresados por un grupo de jóvenes mujeres, concuerdan con sus opiniones de aceptación o rechazo al aborto, se elaboraron dos cuestionario de acuerdo a los criterios de Liskert: uno sobre la religión y el otro sobre el aborto. Estos fueron aplicados a 479 estudiantes, entre 18 y 20 años de edad, que cursaban estudios de licenciatura en áreas de las ciencias biológicas y humanísticas. Los resultados mostraron que las jóvenes con firmes convicciones religiosas, expresaban opiniones de franco rechazo al aborto; en sentido opuesto, las que referían tener actualidades liberales para su religión, externaban opiniones a favor de la interrupción del embarazo. Los coeficientes de concordancia (kapa) fueron altamante significativos. Se comentan los informes del aborto es independiente de la religiosidad de las mujeres, por lo que habría que probar si las jóvenes encuestadas adoptarían una conducta congruente con su modo de pensar, ante un embarazo no deseado