Detalles de la búsqueda
1.
Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
Lancet
; 403(10428): 741-755, 2024 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38342126
2.
Antimicrobial Activity of Gepotidacin Tested against Escherichia coli and Staphylococcus saprophyticus Isolates Causing Urinary Tract Infections in Medical Centers Worldwide (2019 to 2020).
Antimicrob Agents Chemother
; 67(4): e0152522, 2023 04 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36877017
3.
Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea.
Sex Transm Infect
; 99(1): 64-69, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36411033
4.
In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes.
Antimicrob Agents Chemother
; 66(2): e0216521, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34930028
5.
Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections.
Antimicrob Agents Chemother
; 66(3): e0149221, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34978887
6.
Antimicrobial Resistance Trends in Urine Escherichia coli Isolates From Adult and Adolescent Females in the United States From 2011 to 2019: Rising ESBL Strains and Impact on Patient Management.
Clin Infect Dis
; 73(11): 1992-1999, 2021 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34143881
7.
Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems.
Antimicrob Agents Chemother
; 65(12): e0012221, 2021 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34543096
8.
Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944).
BMC Microbiol
; 21(1): 181, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34130619
9.
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32284384
10.
Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model.
Antimicrob Agents Chemother
; 64(10)2020 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32661002
11.
In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31818823
12.
Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.
Euro Surveill
; 25(43)2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33124551
13.
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation.
Clin Infect Dis
; 67(4): 504-512, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29617982
14.
Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30249694
15.
In vitro activity of the novel triazaacenaphthylene gepotidacin (GSK2140944) against MDR Neisseria gonorrhoeae.
J Antimicrob Chemother
; 73(8): 2072-2077, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29796611
16.
Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28373199
17.
Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226.
Antimicrob Agents Chemother
; 60(7): 4404-6, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27161642
18.
Correction to: Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944).
BMC Microbiol
; 21(1): 293, 2021 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34702186
19.
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
Antimicrob Agents Chemother
; 59(1): 289-98, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25348524
20.
Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent.
J Clin Microbiol
; 52(7): 2629-32, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24759716