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1.

Getting a Grip on Microtubules.

Schaletzky, Julia; Rape, Michael.

Cell ; 164(5): 836-7, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26919420

2.

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

Kelsen, Anne; Kent, Robyn S; Snyder, Anne K; Wehri, Eddie; Bishop, Stephen J; Stadler, Rachel V; Powell, Cameron; Martorelli di Genova, Bruno; Rompikuntal, Pramod K; Boulanger, Martin J; Warshaw, David M; Westwood, Nicholas J; Schaletzky, Julia; Ward, Gary E.

PLoS Biol ; 21(5): e3002110, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-37155705

3.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Jack, Amanda; Ferro, Luke S; Trnka, Michael J; Wehri, Eddie; Nadgir, Amrut; Nguyenla, Xammy; Fox, Douglas; Costa, Katelyn; Stanley, Sarah; Schaletzky, Julia; Yildiz, Ahmet.

PLoS Biol ; 19(10): e3001425, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34634033

4.

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design.

Baker, Jordan J; Mathy, Christopher J P; Schaletzky, Julia.

PLoS Comput Biol ; 17(12): e1009624, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34914686

5.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.

Moussaoui, Dihia; Robblee, James P; Robert-Paganin, Julien; Auguin, Daniel; Fisher, Fabio; Fagnant, Patricia M; Macfarlane, Jill E; Schaletzky, Julia; Wehri, Eddie; Mueller-Dieckmann, Christoph; Baum, Jake; Trybus, Kathleen M; Houdusse, Anne.

Nat Commun ; 14(1): 3463, 2023 06 12.

Artículo en Inglés | MEDLINE | ID: mdl-37308472

6.

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.

Hendricks, Joseph M; Doubravsky, Cody E; Wehri, Eddie; Li, Zhipeng; Roberts, Melissa A; Deol, Kirandeep K; Lange, Mike; Lasheras-Otero, Irene; Momper, Jeremiah D; Dixon, Scott J; Bersuker, Kirill; Schaletzky, Julia; Olzmann, James A.

Cell Chem Biol ; 30(9): 1090-1103.e7, 2023 09 21.

Artículo en Inglés | MEDLINE | ID: mdl-37178691

7.

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.

Bajaj, Teena; Wehri, Eddie; Suryawanshi, Rahul K; King, Elizabeth; Pardeshi, Kundan Singh; Behrouzi, Kamyar; Khodabakhshi, Zahra; Schulze-Gahmen, Ursula; Kumar, G Renuka; Mofrad, Mohammad R K; Nomura, Daniel K; Ott, Melanie; Schaletzky, Julia; Murthy, Niren.

RSC Adv ; 13(26): 17667-17677, 2023 Jun 09.

Artículo en Inglés | MEDLINE | ID: mdl-37312993

8.

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

Nguyenla, Xammy; Wehri, Eddie; Van Dis, Erik; Biering, Scott B; Yamashiro, Livia H; Zhu, Chi; Stroumza, Julien; Dugast-Darzacq, Claire; Graham, Thomas G W; Wang, Xuanting; Jockusch, Steffen; Tao, Chuanjuan; Chien, Minchen; Xie, Wei; Patel, Dinshaw J; Meyer, Cindy; Garzia, Aitor; Tuschl, Thomas; Russo, James J; Ju, Jingyue; Näär, Anders M; Stanley, Sarah; Schaletzky, Julia.

Sci Rep ; 12(1): 18506, 2022 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-36323770

9.

An intranasal ASO therapeutic targeting SARS-CoV-2.

Zhu, Chi; Lee, Justin Y; Woo, Jia Z; Xu, Lei; Nguyenla, Xammy; Yamashiro, Livia H; Ji, Fei; Biering, Scott B; Van Dis, Erik; Gonzalez, Federico; Fox, Douglas; Wehri, Eddie; Rustagi, Arjun; Pinsky, Benjamin A; Schaletzky, Julia; Blish, Catherine A; Chiu, Charles; Harris, Eva; Sadreyev, Ruslan I; Stanley, Sarah; Kauppinen, Sakari; Rouskin, Silvi; Näär, Anders M.

Nat Commun ; 13(1): 4503, 2022 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-35922434

10.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

Biering, Scott B; Sarnik, Sylvia A; Wang, Eleanor; Zengel, James R; Leist, Sarah R; Schäfer, Alexandra; Sathyan, Varun; Hawkins, Padraig; Okuda, Kenichi; Tau, Cyrus; Jangid, Aditya R; Duffy, Connor V; Wei, Jin; Gilmore, Rodney C; Alfajaro, Mia Madel; Strine, Madison S; Nguyenla, Xammy; Van Dis, Erik; Catamura, Carmelle; Yamashiro, Livia H; Belk, Julia A; Begeman, Adam; Stark, Jessica C; Shon, D Judy; Fox, Douglas M; Ezzatpour, Shahrzad; Huang, Emily; Olegario, Nico; Rustagi, Arjun; Volmer, Allison S; Livraghi-Butrico, Alessandra; Wehri, Eddie; Behringer, Richard R; Cheon, Dong-Joo; Schaletzky, Julia; Aguilar, Hector C; Puschnik, Andreas S; Button, Brian; Pinsky, Benjamin A; Blish, Catherine A; Baric, Ralph S; O'Neal, Wanda K; Bertozzi, Carolyn R; Wilen, Craig B; Boucher, Richard C; Carette, Jan E; Stanley, Sarah A; Harris, Eva; Konermann, Silvana; Hsu, Patrick D.

Nat Genet ; 54(8): 1078-1089, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35879412

11.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Jack, Amanda; Ferro, Luke S; Trnka, Michael J; Wehri, Eddie; Nadgir, Amrut; Nguyenla, Xammy; Costa, Katelyn; Stanley, Sarah; Schaletzky, Julia; Yildiz, Ahmet.

bioRxiv ; 2021 Mar 29.

Artículo en Inglés | MEDLINE | ID: mdl-32995779

12.

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Chuang, Chihyuan; Collibee, Scott; Ashcraft, Luke; Wang, Wenyue; Vander Wal, Mark; Wang, Xiaolin; Hwee, Darren T; Wu, Yangsong; Wang, Jingying; Chin, Eva R; Cremin, Peadar; Zamora, Jeanelle; Hartman, James; Schaletzky, Julia; Wehri, Eddie; Robertson, Laura A; Malik, Fady I; Morgan, Bradley P.

J Med Chem ; 64(19): 14142-14152, 2021 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-34606259

13.

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.

Collibee, Scott E; Bergnes, Gustave; Chuang, Chihyuan; Ashcraft, Luke; Gardina, Jeffrey; Garard, Marc; Jamison, Chris R; Lu, Kevin; Lu, Pu-Ping; Muci, Alexander; Romero, Antonio; Valkevich, Ellen; Wang, Wenyue; Warrington, Jeffrey; Yao, Bing; Durham, Nickie; Hartman, James; Marquez, Anna; Hinken, Aaron; Schaletzky, Julia; Xu, Donghong; Hwee, Darren T; Morgans, David; Malik, Fady I; Morgan, Bradley P.

J Med Chem ; 64(20): 14930-14941, 2021 10 28.

Artículo en Inglés | MEDLINE | ID: mdl-34636234

14.

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

Biering, Scott B; Van Dis, Erik; Wehri, Eddie; Yamashiro, Livia H; Nguyenla, Xammy; Dugast-Darzacq, Claire; Graham, Thomas G W; Stroumza, Julien R; Golovkine, Guillaume R; Roberts, Allison W; Fines, Daniel M; Spradlin, Jessica N; Ward, Carl C; Bajaj, Teena; Dovala, Dustin; Schulze-Gamen, Ursula; Bajaj, Ruchika; Fox, Douglas M; Ott, Melanie; Murthy, Niren; Nomura, Daniel K; Schaletzky, Julia; Stanley, Sarah A.

ACS Infect Dis ; 7(8): 2337-2351, 2021 08 13.

Artículo en Inglés | MEDLINE | ID: mdl-34129317

15.

Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane.

Schaletzky, Julia; Rapoport, Tom A.

Mol Biol Cell ; 17(9): 3860-9, 2006 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-16822833

16.

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Collibee, Scott E; Bergnes, Gustave; Muci, Alexander; Browne, William F; Garard, Marc; Hinken, Aaron C; Russell, Alan J; Suehiro, Ion; Hartman, James; Kawas, Raja; Lu, Pu-Ping; Lee, Kenneth H; Marquez, David; Tomlinson, Matthew; Xu, Donghong; Kennedy, Adam; Hwee, Darren; Schaletzky, Julia; Leung, Kwan; Malik, Fady I; Morgans, David J; Morgan, Bradley P.

ACS Med Chem Lett ; 9(4): 354-358, 2018 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-29670700

17.

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.

Short, Benjamin; Preisinger, Christian; Schaletzky, Julia; Kopajtich, Robert; Barr, Francis A.

Curr Biol ; 12(20): 1792-5, 2002 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-12401177

18.

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

Schaletzky, Julia; Dove, Stephen K; Short, Benjamin; Lorenzo, Oscar; Clague, Michael J; Barr, Francis A.

Curr Biol ; 13(6): 504-9, 2003 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-12646134

19.

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.

Russell, Alan J; Hartman, James J; Hinken, Aaron C; Muci, Alexander R; Kawas, Raja; Driscoll, Lena; Godinez, Guillermo; Lee, Kenneth H; Marquez, David; Browne, William F; Chen, Michael M; Clarke, David; Collibee, Scott E; Garard, Marc; Hansen, Richard; Jia, Zhiheng; Lu, Pu-Ping; Rodriguez, Hector; Saikali, Khalil G; Schaletzky, Julia; Vijayakumar, Vipin; Albertus, Daniel L; Claflin, Dennis R; Morgans, David J; Morgan, Bradley P; Malik, Fady I.

Nat Med ; 18(3): 452-5, 2012 Feb 19.

Artículo en Inglés | MEDLINE | ID: mdl-22344294

20.

Determining the conductance of the SecY protein translocation channel for small molecules.

Saparov, Sapar M; Erlandson, Karl; Cannon, Kurt; Schaletzky, Julia; Schulman, Sol; Rapoport, Tom A; Pohl, Peter.

Mol Cell ; 26(4): 501-9, 2007 May 25.

Artículo en Inglés | MEDLINE | ID: mdl-17531809

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Getting a Grip on Microtubules.

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

An intranasal ASO therapeutic targeting SARS-CoV-2.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane.

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.

Determining the conductance of the SecY protein translocation channel for small molecules.