RESUMEN
Twins of identical appearance were both affected by Alzheimer's senile dementia. In one, dementia began in her late 60s. She died at age 74. In the other, onset was at age 83. She died of ovarian carcinoma at age 85. The histopathologic findings of Alzheimer's disease were confirmed in both twin sisters.
Asunto(s)
Enfermedad de Alzheimer/genética , Demencia/genética , Enfermedades en Gemelos , Anciano , Enfermedad de Alzheimer/patología , Atrofia , Femenino , Lóbulo Frontal/patología , HumanosRESUMEN
In an effort to improve the clinical signs of Parkinson's disease, we have implanted mesencephalic dopamine cells from a 7-week human embryo into the caudate and putamen of a 52-year-old man with Parkinson's disease. Fetal tissue was obtained from elective abortion. The woman and the patient with Parkinson's disease were unknown to each other. The woman gave specific consent and was not paid. The patient had a 20-year history of parkinsonism treated with multiple drug therapies including levodopa/carbidopa (Sinemet) every 2 1/2 hours. His symptoms were worse on the left side. For 5 months prior to transplantation, the patient underwent clinical evaluations by both a neurologist and a computer system installed in his home for daily measurement of walking and hand movements. Preoperative positron emission tomographic scanning with 6-L[18F]fluorodopa (fluorodopa) demonstrated severe dopamine depletion bilaterally. Fetal tissue was matched to the patient for ABO blood antigens, and maternal serum was screened for hepatitis B and human immunodeficiency virus type 1 prior to surgery. Fetal tissue was implanted stereotactically throughout the caudate and putamen on the right side of the brain via 10 needle tracks. The patient was not immunosuppressed. Results 12 months after surgery showed 42% improvement in left-hand speed before the first morning dose of drug and 40% greater response to drug therapy. Right-hand speed increased 15% before drug therapy and 23% after drug therapy. Reaction time was unaffected. Walking speed increased 33% after drug administration, although walking speed before the first morning dose of drugs declined 40%. Walking speed on an all-day basis improved 17%.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Dopamina/metabolismo , Mesencéfalo/trasplante , Enfermedad de Parkinson/terapia , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Feto , Estudios de Seguimiento , Humanos , Imagen por Resonancia Magnética , Masculino , Mesencéfalo/embriología , Mesencéfalo/metabolismo , Persona de Mediana Edad , Movimiento , Examen Neurológico , Enfermedad de Parkinson/diagnóstico , Enfermedad de Parkinson/fisiopatología , Tomografía Computarizada de Emisión , Tomografía Computarizada por Rayos XRESUMEN
A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal.
Asunto(s)
Meningitis/microbiología , Mielitis/microbiología , Sífilis , Adulto , Seropositividad para VIH , Humanos , Imagen por Resonancia Magnética , Masculino , Mielitis/diagnóstico , Paraparesia Espástica Tropical/etiología , Penicilinas/uso terapéutico , Piel/patología , Médula Espinal/patología , Sífilis/complicaciones , Sífilis/tratamiento farmacológico , Sífilis/patologíaRESUMEN
Thirty cases of diffuse Lewy body disease (DLBD) have been reported, primarily by neuropathologists, but an associated clinical syndrome has not been clearly defined. Four recent cases have led us to examine the clinicopathologic correlations. Patients are usually elderly, with symptoms lasting from 1 to 20 years. Progressive dementia or psychosis is typically the first and most prominent feature. Parkinsonian signs, initially mild or absent, become common eventually, and rigidity is usually severe. Involuntary movements, myoclonus, quadriparesis in flexion, orthostatic hypotension, and dysphagia have also been noted. Classic, concentric Lewy bodies are found profusely in the brainstem, basal forebrain, and hypothalamic nuclei, while less well defined "Lewy-like" bodies occur in limbic structures and in deep neocortical layers. In addition, focal spongiform changes in the mesial temporal lobe were found in two of our cases. We suggest that DLBD may be another specific cause of progressive dementia.
Asunto(s)
Encéfalo/ultraestructura , Demencia/patología , Cuerpos de Inclusión , Anciano , Humanos , Masculino , Enfermedad de Parkinson/patologíaAsunto(s)
Neoplasias Encefálicas/etiología , Trasplante de Riñón , Linfoma/etiología , Adolescente , Adulto , Autopsia , Biopsia , Encéfalo/patología , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patología , Neoplasias Encefálicas/radioterapia , Cerebelo/patología , Femenino , Humanos , Linfoma/diagnóstico , Linfoma/patología , Linfoma/radioterapia , Masculino , Manifestaciones Neurológicas , Trasplante HomólogoAsunto(s)
Esclerosis Cerebral Difusa de Schilder , Encefalitis , Vacuna Antisarampión , Ganglios Basales/patología , Enfermedades del Sistema Nervioso Central , Cerebelo/patología , Corteza Cerebral/patología , Niño , Esclerosis Cerebral Difusa de Schilder/diagnóstico , Esclerosis Cerebral Difusa de Schilder/patología , Electroencefalografía , Femenino , Lóbulo Frontal/patología , Humanos , Cuerpos de Inclusión Viral , Masculino , Neuroglía , Factores de TiempoAsunto(s)
Neoplasias Encefálicas , Meningioma , Fosa Craneal Posterior , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Enfermedades del Sistema Nervioso Central/diagnóstico , Enfermedades del Sistema Nervioso Central/patología , Corteza Cerebral/patología , Enfermedades Desmielinizantes , Diagnóstico Diferencial , Esclerosis Cerebral Difusa de Schilder/diagnóstico , Fatiga/complicaciones , Femenino , Humanos , Hiperventilación/complicaciones , Hipotálamo/patología , Lactante , Lipidosis , Bulbo Raquídeo/patología , Enfermedades Musculares/complicaciones , Necrosis , Degeneración Nerviosa , Nistagmo Patológico , Atrofia Óptica/complicaciones , Nervio Óptico/patología , Trastornos por Fotosensibilidad , Puente/patología , Reflejo Anormal/complicaciones , Médula Espinal/patología , Sustancia Negra/patología , Pliegues Vocales , Vómitos/complicaciones , Encefalopatía de Wernicke/diagnósticoAsunto(s)
Terapia de Inmunosupresión/efectos adversos , Trasplante de Riñón , Micosis/etiología , Adolescente , Adulto , Humanos , Incidencia , Masculino , Micosis/complicaciones , Micosis/epidemiología , Neumonía/complicaciones , Radiografía Torácica , Factores de Riesgo , Sepsis/complicaciones , Esputo/microbiologíaAsunto(s)
Tronco Encefálico/trasplante , Trasplante de Tejido Encefálico , Trasplante de Tejido Fetal , Enfermedad de Parkinson/cirugía , Antiparkinsonianos/uso terapéutico , Tronco Encefálico/embriología , Núcleo Caudado/cirugía , Terapia Combinada , Estudios de Evaluación como Asunto , Humanos , Masculino , Persona de Mediana Edad , Destreza Motora , Enfermedad de Parkinson/tratamiento farmacológico , Putamen/cirugía , Técnicas Estereotáxicas , CaminataAsunto(s)
Antiparkinsonianos/uso terapéutico , Trasplante de Tejido Fetal , Enfermedad de Parkinson/tratamiento farmacológico , Enfermedad de Parkinson/cirugía , Antiparkinsonianos/administración & dosificación , Relación Dosis-Respuesta a Droga , Humanos , Masculino , Persona de Mediana Edad , Movimiento , Enfermedad de Parkinson/fisiopatología , Instrumentos Quirúrgicos , Resultado del TratamientoAsunto(s)
Trasplante de Tejido Encefálico/fisiología , Dopamina/fisiología , Trasplante de Tejido Fetal/fisiología , Regeneración Nerviosa/fisiología , Enfermedad de Parkinson/cirugía , Receptores Dopaminérgicos/fisiología , Antiparkinsonianos/administración & dosificación , Núcleo Caudado/fisiopatología , Núcleo Caudado/cirugía , Terapia Combinada , Dominancia Cerebral/fisiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Examen Neurológico , Enfermedad de Parkinson/fisiopatología , Putamen/fisiopatología , Putamen/cirugíaAsunto(s)
Trasplante de Tejido Encefálico/inmunología , Trasplante de Tejido Fetal/inmunología , Mesencéfalo/trasplante , Enfermedad de Parkinson/terapia , Linfocitos T Citotóxicos/inmunología , Animales , Formación de Anticuerpos , Citotoxicidad Celular Dependiente de Anticuerpos , Línea Celular , Ciclosporina/sangre , Ciclosporina/uso terapéutico , Citotoxicidad Inmunológica , Estudios de Seguimiento , Humanos , Inmunidad Celular , Levodopa/uso terapéutico , Ganglios Linfáticos/inmunología , Enfermedad de Parkinson/fisiopatología , Prednisona/uso terapéutico , Primates , Bazo/inmunología , Factores de Tiempo , Trasplante HomólogoAsunto(s)
Examen Neurológico/métodos , Relaciones Médico-Paciente , Femenino , Humanos , Masculino , Espacio PersonalRESUMEN
Being selected to provide medical care to other physicians or their family members represents not only a gratifying professional recognition of competence by one's peers but also a challenge. Many personal and psychological factors may influence the medical care of physicians. III physicians may have difficulty with role reversal and "the VIP syndrome," while treating physicians may have to deal with their own anxiety and issues such as confidentiality, privacy, empathy, and intrusion by a physician-relative into the care of medical family members. Based on experience with more than 200 physician-patients and many adult family members of physicians, suggestions are offered for care of these patient groups.
Asunto(s)
Familia , Rol del Médico , Relaciones Médico-Paciente , HumanosRESUMEN
Two cases of interhemispheric subdural haematoma are reported. The first patient presented with a falx syndrome of contralateral hemiparesis, most marked in the lower extremity. The second patient had vertex headaches and was diagnosed with computerised tomography. Serial studies suggested that the interhemispheric haematoma may have migrated to a lateral position over the cerebral convexity.
Asunto(s)
Dominancia Cerebral , Hematoma Subdural/diagnóstico por imagen , Hemiplejía/diagnóstico por imagen , Adulto , Anciano , Lesiones Encefálicas/diagnóstico por imagen , Angiografía Cerebral , Femenino , Hematoma Subdural/cirugía , Humanos , Masculino , Tomografía Computarizada por Rayos XRESUMEN
Two otherwise healthy immunocompetent men, ages 62 and 66 years, experienced years of radicular pain without zoster rash. An extensive search for systemic disease and malignancy was negative. Varicella-zoster virus DNA, but not herpes simplex virus DNA, was found in the cerebrospinal fluid of the first patient 5 months after the onset of pain, and in the second patient 8 months after the onset of pain. Prolonged radicular pain without zoster rash combined with the presence of varicella-zoster virus in the cerebrospinal fluid indicates that both men had zoster sine herpete, and strongly supports this syndrome as a clinical variant.
Asunto(s)
Herpes Zóster/microbiología , Aciclovir/uso terapéutico , Anciano , Líquido Cefalorraquídeo/microbiología , ADN Viral/análisis , Herpesvirus Humano 3/inmunología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
By most measures, academic neurology is thriving as never before, yet convening forces are changing the face of academic neurology. This report focuses on changes that academic neurology and the American Neurological Association could undertake to seize new opportunities and resist damaging potential changes. These proposals can be categorized in the following four major goals: (1) enhance the quality of a smaller neurology workforce and augment the recruitment of gifted young neuroscientists into neurology; (2) foster new diversity in neurological investigation, including clinical research in neurology; (3) document the benefits and relative costs of neurological care, in general, and of academic neurology, in particular; and (4) foster the role of neurologists as teachers to medical caregivers at all levels, including medical students, nonneurological house staff, and primary practitioners.
Asunto(s)
Planificación en Salud , Neurología/educación , Neurología/organización & administración , Sociedades Médicas , Educación de Postgrado en Medicina/organización & administración , Educación de Postgrado en Medicina/normas , Personal de Salud , Servicios de Salud/estadística & datos numéricos , Humanos , Asistentes Médicos , Estados Unidos , Recursos HumanosRESUMEN
Nine of 48 adult patients who underwent orthotopic liver transplantation developed significant clinical neurological abnormalities recognized shortly after operation. Decrease in consciousness occurred with resultant coma, focal and generalized seizures and the occasional appearance of a state of akinetic mutism. Neuropathological abnormalities consisted of multifocal areas of infarction in cerebral cortex and basal ganglia in five patients, central pontine myelinolysis in five (often more extensive than usually reported), Wernicke's encephalopathy in three, glial nodules in two, and fungal abscesses in one. Alzheimer II astrocytosis was found in all brains available for retrospective study. There was direct evidence in two of the patients that air embolization from the homografts had occurred. Correlation of this with the brain infarcts in these and other cases seems reasonable. The ease with which air passed to the systemic circulation is explicable by the right to left venous--arterial shunts that are common in chronic liver disease. With the delination of this cause for the neurologic complications, measures to prevent it in future cases have been described.