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1.
Am J Infect Control ; 48(4): 423-432, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-31676155

RESUMEN

BACKGROUND: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2012 to December 2017 in 523 intensive care units (ICUs) in 45 countries from Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. METHODS: During the 6-year study period, prospective data from 532,483 ICU patients hospitalized in 242 hospitals, for an aggregate of 2,197,304 patient days, were collected through the INICC Surveillance Online System (ISOS). The Centers for Disease Control and Prevention-National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI) were applied. RESULTS: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the medical-surgical ICUs, the pooled central line-associated bloodstream infection rate was higher (5.05 vs 0.8 per 1,000 central line-days); the ventilator-associated pneumonia rate was also higher (14.1 vs 0.9 per 1,000 ventilator-days,), as well as the rate of catheter-associated urinary tract infection (5.1 vs 1.7 per 1,000 catheter-days). From blood cultures samples, frequencies of resistance, such as of Pseudomonas aeruginosa to piperacillin-tazobactam (33.0% vs 18.3%), were also higher. CONCLUSIONS: Despite a significant trend toward the reduction in INICC ICUs, DA-HAI rates are still much higher compared with CDC-NHSN's ICUs representing the developed world. It is INICC's main goal to provide basic and cost-effective resources, through the INICC Surveillance Online System to tackle the burden of DA-HAIs effectively.


Asunto(s)
Infecciones Bacterianas/epidemiología , Infecciones Relacionadas con Catéteres/epidemiología , Infecciones Relacionadas con Catéteres/microbiología , Cateterismo Venoso Central/efectos adversos , Salud Global , Control de Infecciones , Antibacterianos/farmacología , Infecciones Bacterianas/microbiología , Infecciones Bacterianas/prevención & control , Catéteres de Permanencia/efectos adversos , Catéteres de Permanencia/microbiología , Farmacorresistencia Bacteriana , Humanos , Unidades de Cuidados Intensivos , Estudios Retrospectivos
2.
Trop Doct ; 39(4): 248-9, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19762586

RESUMEN

Hydatidosis is endemic in many Mediterranean countries, the Middle East, South America, Australia, New Zealand and Africa. It is caused by an infection from the Echinococcus granulosus larvae which can lead to the development of cysts. The most frequently affected organ is the liver. Splenic involvement alone is very rare. In this article, a case of an isolated giant splenic hydatid cyst is reported. The patient underwent splenectomy. The diagnosis of a hydatid cyst was confirmed by histopathology. This case suggests that hydatid disease should be considered as a differential diagnosis in every patient with a cystic mass of the spleen in endemic areas.


Asunto(s)
Equinococosis/diagnóstico , Enfermedades del Bazo/parasitología , Adulto , Albendazol/uso terapéutico , Antiprotozoarios/uso terapéutico , Diagnóstico por Imagen , Equinococosis/terapia , Femenino , Humanos , Enfermedades del Bazo/diagnóstico , Enfermedades del Bazo/terapia
3.
Mikrobiyol Bul ; 43(2): 203-9, 2009 Apr.
Artículo en Turco | MEDLINE | ID: mdl-19621604

RESUMEN

The detection of the methicillin-resistant Staphylococcus aureus (MRSA) carriers and the establishment of isolation precautions are of crucial importance to prevent the development of nosocomial infections due to MRSA. Previous studies have demonstrated that the use of enrichment broths increased the rate of MRSA isolation both in clinical samples and surveillance cultures. The aim of this study was to evaluate the MRSA isolation results obtained by inoculation of surveillance cultures in enrichment broth, for the patients staying in intensive care unit of our hospital during September 2006-January 2007 period. A total of 1536 samples (deep tracheal aspirate, nose, throat, pus, inguinal and axial swabs) from 250 patients were inoculated on routine primary media including sheep blood agar, EMB agar and 6 microg/ml oxacillin containing Mueller-Hinton agar (Ox-MH Agar) and also in an enrichment broth (EB) containing 6.5% NaCl in brain-heart infusion. After incubation for 24 and 48 hours, primary plates were examined for MRSA growth and enrichment broths were examined for turbidity. Turbid tubes were subcultured on Ox-MH agar. Tubes with no turbidity after 48 hours were discarded as negative; MRSA growth in both primary plates and in EBs were evaluated as "parallel growth". Parallel MRSA growth was detected in 15.2% (234/1536), MRSA growth only in EB was detected in 5.9% (91/1536) and MRSA growth only on primary plates was detected in 0.26% (4/1536) of the samples. Among the 71 patients in whom the first MRSA isolation was detected, 19 (27%) yielded MRSA only in EB, 44 (62%) exhibited parallel growth and 8 (11%) yielded MRSA either in EB or as parallel growth of different samples of the same patient. The use of the EB increased MRSA isolation 5.9% (91/1536) on specimen basis and 7.6% (19/250) on patient basis. It can be concluded that, inoculation of surveillance culture samples into an enrichment broth in addition to primary plate media aids to the early isolation of MRSA from colonized patients.


Asunto(s)
Técnicas Bacteriológicas/normas , Medios de Cultivo/normas , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Infecciones Estafilocócicas/microbiología , Infección Hospitalaria/prevención & control , Humanos , Unidades de Cuidados Intensivos , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/prevención & control
4.
Surg Infect (Larchmt) ; 16(2): 151-4, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24897383

RESUMEN

BACKGROUND: We report an outbreak of surgical site infections due to genetically related strains of Streptococcus pyogenes in a cardiovascular surgery department. METHODS: The practices that were possibly related to the outbreak were investigated through direct observation and interviews with staff by an infection control team. Surveillance sampling from patients, health-care workers, and environment were done for the investigation of the source. Pulsed-field gel electrophoresis was used to investigate a clonal relationship among the S. pyogenes isolates. RESULTS: Four patients operated on in the cardiovascular surgery department developed surgical site infection due to S. pyogenes. Molecular characterization of S. pyogenes done by pulsed-field gel electrophoresis revealed the same strain. CONCLUSIONS: Although a definite source for the outbreak could not be identified, probably lack of adherence to hand hygiene practices during surgical dressings, contamination, and cross contamination led to this outbreak.


Asunto(s)
Procedimientos Quirúrgicos Cardiovasculares/efectos adversos , Infección Hospitalaria/epidemiología , Brotes de Enfermedades/estadística & datos numéricos , Infecciones Estreptocócicas/epidemiología , Streptococcus pyogenes , Infección de la Herida Quirúrgica/epidemiología , Adulto , Anciano , Infección Hospitalaria/microbiología , Femenino , Unidades Hospitalarias , Humanos , Masculino , Persona de Mediana Edad , Infecciones Estreptocócicas/microbiología , Infección de la Herida Quirúrgica/microbiología , Turquía/epidemiología
5.
J Chemother ; 24(3): 150-4, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22759759

RESUMEN

Trimethoprim-sulfamethoxazole (TMP-SMZ) is recommended as the treatment of choice for Stenotrophomonas maltophilia infections. However, when the administration of TMP-SMZ is not possible, alternative treatment options for S. maltophilia infections has not been clearly established. We compare the efficacy of tigecycline treatment with TMP-SMZ in nosocomial S. maltophilia infections during a 3-year period. For the treatment of S. maltophilia infection, 26 (57.8%) patients received TMP-SMZ and 19 (42.2%) patients received tigecycline. Culture positivity rate was 95.7% in TMP-SMZ group and 70.6% in tigecycline group at the seventh day (P = 0.028), whereas 26.3% versus 18.8% at the fourteenth day (P = 0.700). Clinical improvement was observed 69.2% in TMP-SMZ group and 68.4% in tigecycline group at the fourteenth day (P = 0.954). Mortality rates at the thirtieth day were respectively, 30.8 and 21.1% in TMP-SMZ and tigecycline groups (P = 0.517). There were no significant differences in mortality and clinical response rates between TMP-SMZ and tigecycline treatment. Tigecycline can be considered as an alternative option beyond TMP-SMZ in treatment of S. maltophilia infections.


Asunto(s)
Antiinfecciosos/uso terapéutico , Infecciones por Bacterias Gramnegativas/tratamiento farmacológico , Minociclina/análogos & derivados , Stenotrophomonas maltophilia/efectos de los fármacos , Adulto , Anciano , Anciano de 80 o más Años , Quimioterapia Combinada , Femenino , Infecciones por Bacterias Gramnegativas/microbiología , Infecciones por Bacterias Gramnegativas/mortalidad , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Minociclina/uso terapéutico , Pronóstico , Estudios Retrospectivos , Stenotrophomonas maltophilia/aislamiento & purificación , Tasa de Supervivencia , Tigeciclina , Combinación Trimetoprim y Sulfametoxazol
6.
Infect Dis Rep ; 4(1): e4, 2012 Jan 02.
Artículo en Inglés | MEDLINE | ID: mdl-24470934

RESUMEN

Splenic abscess is a very rare complication of non-typhoidal Salmonella infections. We report a case of splenic abscess caused by Salmonella enteritidis. The patient is a 63-year-old woman with diabetes mellitus and underwent splenectomy. This case suggests that the patients with comorbities are at increased risk for invasive infections in non-typhoidal Salmonella infections.

7.
Surg Infect (Larchmt) ; 12(2): 141-3, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21348768

RESUMEN

BACKGROUND: Mediastinitis due to Acinetobacter baumannii is rare. METHODS: We report a case of mediastinitis caused by pan-resistant A. baumannii in a patient with multiple comorbidities who underwent cardiopulmonary bypass and we also present a literature review. RESULTS: Successful treatment consisted of surgical debridement plus drainage, and tigecycline administration for three weeks. CONCLUSION: Surgical source control along with effective antibiotics is essential in the treatment of mediastinitis. Tigecycline has the potential to be an option for pan-resistant A. baumannii mediastinitis.


Asunto(s)
Infecciones por Acinetobacter/diagnóstico , Acinetobacter baumannii/aislamiento & purificación , Antibacterianos/administración & dosificación , Farmacorresistencia Bacteriana Múltiple , Mediastinitis/diagnóstico , Minociclina/análogos & derivados , Infecciones por Acinetobacter/tratamiento farmacológico , Infecciones por Acinetobacter/microbiología , Infecciones por Acinetobacter/cirugía , Acinetobacter baumannii/efectos de los fármacos , Puente Cardiopulmonar/efectos adversos , Desbridamiento , Drenaje , Femenino , Humanos , Mediastinitis/tratamiento farmacológico , Mediastinitis/microbiología , Mediastinitis/cirugía , Persona de Mediana Edad , Minociclina/administración & dosificación , Infección de la Herida Quirúrgica/diagnóstico , Infección de la Herida Quirúrgica/tratamiento farmacológico , Infección de la Herida Quirúrgica/microbiología , Infección de la Herida Quirúrgica/cirugía , Tigeciclina , Resultado del Tratamiento
8.
Turk J Gastroenterol ; 18(1): 33-40, 2007 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-17450493

RESUMEN

BACKGROUND/AIM: Biliary stents have been used for benign or malignant biliary strictures, preoperative biliary drainage, resolution of biliary or pancreatic leaks, and dissolution treatment of non-extractable bile duct stones since 1979, and should be replaced at 3-6 month intervals. The aim of this cross-sectional pioneer study was to identify the microorganisms in occluded bile duct stents and to determine incidence and diagnosis of multidrug resistance of the isolated microorganisms in stents and in blood cultures. METHODS: Fifty-one patients (14F, 37M, mean age: 58.2+/-11.6 yr) with cholangitis due to occluded stents were studied consecutively and prospectively after stent replacement was done. Independent variables were age, gender, underlying disease, duration of disease, size, length and period of stents, and blood biochemistry. Dependent variables were microorganisms isolated from the stent content and blood of the patients and the results of antibiogram tests. RESULTS: Primary disease was malignant in 25 (49.0%), stent size was 7F in 30 (58.8%), and stent length was 11 cm in 11 (21.6%) and 15 cm in 12 (23.5%) of the patients. The mean period after the 1st stent application was 207.0+/-111.3 days and the last stent duration was 111.0+/-64.0 days. Isolated microorganisms from stents and blood, respectively, were Escherichia coli (E. coli) (43.4%, 20.8%), Klebsiella spp. (17.1%, 17.0%), Pseudomonas aeruginosa (P. aeruginosa) (13.2%, 18.9%) and Enterococcus spp. (10.5%, 17.0%). Isolated microorganisms showed multidrug resistance at high percentages (81.6% for stent, 81.1% for blood). ALT, AST, ALP, and direct bilirubin levels showed statistically significant differences between the benign and malignant groups. CONCLUSION: All bile duct stents are contaminated by microorganisms, of which a high majority has multidrug resistance, and they frequently cause biliary sepsis. Biliary sepsis can be prevented by changing the stents periodically and by using proper antibiotic prophylaxis.


Asunto(s)
Colestasis/cirugía , Farmacorresistencia Bacteriana Múltiple , Stents/microbiología , Adulto , Anciano , Antibacterianos/uso terapéutico , Bacterias/aislamiento & purificación , Colangitis/microbiología , Colangitis/cirugía , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos
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