RESUMEN
A child developed hydrocephalus. Sixteen months later, it was discovered to be a complication of coccidioidal meningitis. The infection's source was uncertain until genomic analysis of the fungal isolate identified its origin to be a visit to Beeville, Texas. Improved national reporting of cases of coccidioidomycosis might reduce diagnostic delays.
Asunto(s)
Coccidioides/genética , Coccidioidomicosis/diagnóstico , Coccidioidomicosis/microbiología , Genoma Fúngico , Genómica , Meningitis Fúngica/diagnóstico , Meningitis Fúngica/microbiología , Biomarcadores , Coccidioidomicosis/epidemiología , Trazado de Contacto , Genómica/métodos , Humanos , Lactante , Masculino , Meningitis Fúngica/epidemiología , New York/epidemiología , Evaluación de Síntomas , Texas/epidemiologíaRESUMEN
Infection with varicella-zoster virus (VZV) in oncology patients can result in severe disease with an increased risk of morbidity and mortality [1, 2]. Among patients on cancer chemotherapy, only nonimmune persons are considered to be susceptible to varicella [1]. We present a case of varicella in a child with leukemia that occurred despite immunity as defined by 2 doses of varicella vaccine and documentation of positive VZV immunoglobulin G titer before initiation of chemotherapy.