Detalles de la búsqueda
1.
Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine.
Pharm Res
; 35(11): 222, 2018 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30280329
2.
In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability.
Proc Natl Acad Sci U S A
; 111(52): 18601-6, 2014 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-25512516
3.
Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.
J Biol Chem
; 290(50): 29732-41, 2015 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26491012
4.
Specific catalysis of asparaginyl deamidation by carboxylic acids: kinetic, thermodynamic, and quantitative structure-property relationship analyses.
Mol Pharm
; 11(4): 1345-58, 2014 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24620787
5.
Investigation into temperature-induced aggregation of an antibody drug conjugate.
Bioconjug Chem
; 24(10): 1674-83, 2013 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-24070051
6.
Culture temperature modulates aggregation of recombinant antibody in cho cells.
Biotechnol Bioeng
; 109(1): 125-36, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21965146
7.
Opposite effects of polyols on antibody aggregation: thermal versus mechanical stresses.
Pharm Res
; 29(3): 683-94, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21948456
8.
Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes.
Bioconjug Chem
; 21(9): 1588-95, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20698491
9.
Triple light chain antibodies: factors that influence its formation in cell culture.
Biotechnol Bioeng
; 105(4): 748-60, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19845001
10.
In situ precipitation and vacuum drying of interferon alpha-2a: development of a single-step process for obtaining dry, stable protein formulation.
Int J Pharm
; 366(1-2): 88-98, 2009 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-18824225
11.
Effect of polyols on polyethylene glycol (PEG)-induced precipitation of proteins: Impact on solubility, stability and conformation.
Int J Pharm
; 366(1-2): 38-43, 2009 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-18809481
12.
Second derivative tryptophan fluorescence spectroscopy as a tool to characterize partially unfolded intermediates of proteins.
Int J Pharm
; 294(1-2): 193-9, 2005 Apr 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15814244
13.
Steady-state tryptophan fluorescence spectroscopy study to probe tertiary structure of proteins in solid powders.
J Pharm Sci
; 92(4): 890-9, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12661074
14.
Polyethylene glycol-induced precipitation of interferon alpha-2a followed by vacuum drying: development of a novel process for obtaining a dry, stable powder.
AAPS PharmSci
; 6(1): E4, 2004 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-15198505
15.
Effect of vacuum drying on protein-mannitol interactions: the physical state of mannitol and protein structure in the dried state.
AAPS PharmSciTech
; 5(1): E10, 2004 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15198531
16.
Application of second-derivative fluorescence spectroscopy to monitor subtle changes in a monoclonal antibody structure.
J Pharm Sci
; 102(1): 52-61, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23132555
17.
Characterization of antibody-polyol interactions by static light scattering: implications for physical stability of protein formulations.
Int J Pharm
; 448(2): 382-9, 2013 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23583711
18.
Isomerization of Asp-Asp motif in model peptides and a monoclonal antibody Fab fragment.
J Pharm Sci
; 102(3): 947-59, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23280575
19.
Modulation of the thermodynamic stability of proteins by polyols: significance of polyol hydrophobicity and impact on the chemical potential of water.
Int J Pharm
; 413(1-2): 19-28, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21515346
20.
Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: importance of the hydrophobicity of polyols.
J Pharm Sci
; 100(8): 3096-3104, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21541939