[Long-term effect of trabeculotomy on primary congenital glaucoma].

OBJECTIVE: To evaluate the long-term effect of trabeculotomy on primary congenital glaucoma. METHODS: This retrospective study included primary congenital glaucoma patients who underwent trabeculotomy as an initial surgery between 1988 and 1999 with follow-up at least one year. Definitions of successful operation were determined as (1) intraocular pressure (IOP) /= 0.4, 29.1% between 0.1 and 0.3, and 29.2% 0.8 (P = 0.013) was risk factor responsible for poor vision. Among 18 eyes that were examined for visual field, glaucomatous visual field loss was found in 14 eyes (77.7%). Early-stage defect was seen in 42.8%, intermediate-stage in 28.6%, and late-stage in 28.6% of eyes. Hyphema was found in 14 eyes (42.4%). However, hyphema in 10 out of 14 eyes (71.4%) was absorbed in just one day. Therefore, hyphema should not be considered as a high risk for surgical failure (P = 0.795). CONCLUSIONS: Trabeculotomy had a high success rate in treatment of primary congenital glaucoma with fewer complications during the follow-up time. Observation from repeated operations also showed satisfactory results. Therefore, the optimal goal in preserving useful visual acuity and visual field is to obtain better control of glaucoma with trabeculotomy and treatment of amblyopia.

Single nucleotide polymorphisms in promoter of angiotensin II type 1 receptor gene associated with essential hypertension and coronary heart disease in Chinese population.

AIM: To discover single nucleotide polymorphisms (SNPs) in the promoter region of angiotensin II type 1 receptor (AT1) gene and evaluate their associations with the occurrence of essential hypertension (EH) and coronary heart disease (CHD) in Chinese Han population. METHODS: SNPs detection was performed by PCR-sequencing. The genotype was determined by the same method in a total number of 473 unrelated patients including 160 EH cases, 128 CHD cases, and 185 EH combined with CHD cases as well as 160 healthy controls. RESULTS: Six SNPs were discovered in the promoter region of AT1 gene. -810A/T was almost in completely linkage disequilibrium with -713G/T, -214A/C, -213G/C, and -153A/G polymorphisms. No statistically association was found in our population between -810A/T polymorphism and EH, the association of -810A allele and CHD was of borderline significant (chi2=3.649, P=0.056). However, significant differences of genotype distributions were observed in the EH combined with CHD group (TT=126, TA=51, AA=8) compared with the EH patients (TT=127,TA=26, AA=7, chi2=6.410, P=0.041) and the healthy controls (TT=130, TA=24, AA=6, chi2=7.742, P=0.021). The EH combined with CHD patients had a significantly increased A allele frequency than the normal references (0.181 vs 0.106, chi2=7.690, P=0.006) and the EH subjects (0.181 vs 0.125, chi2=4.119, P=0.042). Hypertensive patients carrying TA genotype (OR=1.977, 95 % CI 1.160-3.354, P=0.011) or A allele (OR=1.548, 95 % CI 1.015-2.361, P=0.043) had an increased risk for CHD morbidity. CONCLUSION: we firstly report that -810A/T polymorphism in the promoter region of AT1 gene might be a genetic risk factor for the pathogenesis of CHD complicated with EH in Chinese Han population.