The contributions of positive outgroup and negative ingroup evaluation to implicit bias favoring outgroups.

People sometimes prefer groups to which they do not belong (outgroups) over their own groups (ingroups). Many long-standing theoretical perspectives assume that this outgroup favorability bias primarily reflects negative ingroup evaluations rather than positive outgroup evaluations. To examine the contributions of negative ingroup versus positive outgroup evaluations to outgroup bias, we examined participants' data (total n > 879,000) from Implicit Association Tests [A. G. Greenwald, D. E. McGhee, J. L. K. Schwartz, J. Pers. Soc. Psychol. 74, 1464-1480 (1998)] measuring intergroup attitudes across four social domains in exploratory and preregistered confirmatory analyses. Process modeling [F. R. Conrey, J. W. Sherman, B. Gawronski, K. Hugenberg, C. J. Groom, J. Pers. Soc. Psychol. 89, 469-487 (2005)] was applied to the responses of participants who demonstrated implicit outgroup bias to separately estimate the contributions of negative ingroup and positive outgroup evaluations. The outgroup biases of lower-status group members (i.e., Asian, Black, gay and lesbian, and older people) consistently reflected greater contributions of positive outgroup evaluations than negative ingroup evaluations. In contrast, the outgroup biases of higher-status group members (i.e., White, straight, and younger people) reflected a more varied pattern of evaluations. We replicated this pattern of results using explicitly measured intergroup evaluations. Taking these data together, the present research demonstrates a positive-negative asymmetry effect of outgroup bias, primarily among members of lower-status groups.

Teprotumumab for the Treatment of Active Thyroid Eye Disease.

BACKGROUND: Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular condition for which no Food and Drug Administration-approved medical therapy is available. Strong evidence has implicated the insulin-like growth factor I receptor (IGF-IR) in the pathogenesis of this disease. METHODS: In a randomized, double-masked, placebo-controlled, phase 3 multicenter trial, we assigned patients with active thyroid eye disease in a 1:1 ratio to receive intravenous infusions of the IGF-IR inhibitor teprotumumab (10 mg per kilogram of body weight for the first infusion and 20 mg per kilogram for subsequent infusions) or placebo once every 3 weeks for 21 weeks; the last trial visit for this analysis was at week 24. The primary outcome was a proptosis response (a reduction in proptosis of ≥2 mm) at week 24. Prespecified secondary outcomes at week 24 were an overall response (a reduction of ≥2 points in the Clinical Activity Score plus a reduction in proptosis of ≥2 mm), a Clinical Activity Score of 0 or 1 (indicating no or minimal inflammation), the mean change in proptosis across trial visits (from baseline through week 24), a diplopia response (a reduction in diplopia of ≥1 grade), and the mean change in overall score on the Graves' ophthalmopathy-specific quality-of-life (GO-QOL) questionnaire across trial visits (from baseline through week 24; a mean change of ≥6 points is considered clinically meaningful). RESULTS: A total of 41 patients were assigned to the teprotumumab group and 42 to the placebo group. At week 24, the percentage of patients with a proptosis response was higher with teprotumumab than with placebo (83% [34 patients] vs. 10% [4 patients], P<0.001), with a number needed to treat of 1.36. All secondary outcomes were significantly better with teprotumumab than with placebo, including overall response (78% of patients [32] vs. 7% [3]), Clinical Activity Score of 0 or 1 (59% [24] vs. 21% [9]), the mean change in proptosis (-2.82 mm vs. -0.54 mm), diplopia response (68% [19 of 28] vs. 29% [8 of 28]), and the mean change in GO-QOL overall score (13.79 points vs. 4.43 points) (P≤0.001 for all). Reductions in extraocular muscle, orbital fat volume, or both were observed in 6 patients in the teprotumumab group who underwent orbital imaging. Most adverse events were mild or moderate in severity; two serious events occurred in the teprotumumab group, of which one (an infusion reaction) led to treatment discontinuation. CONCLUSIONS: Among patients with active thyroid eye disease, teprotumumab resulted in better outcomes with respect to proptosis, Clinical Activity Score, diplopia, and quality of life than placebo; serious adverse events were uncommon. (Funded by Horizon Therapeutics; OPTIC ClinicalTrials.gov number, NCT03298867, and EudraCT number, 2017-002763-18.).

The dual-system approach is a useful heuristic but does not accurately describe behavior.

We argue that the dual-system approach and, particularly, the default-interventionist framework favored by De Neys unnecessarily constrains process models, limiting their range of application. In turn, the accommodations De Neys makes for these constraints raise questions of parsimony and falsifiability. We conclude that the extent to which processes possess features of system 1 versus system 2 must be tested empirically.

Retrieval cues fail to influence contextualized evaluations.

Initial evaluations generalise to new contexts, whereas counter-attitudinal evaluations are context-specific. Counter-attitudinal information may not change evaluations in new contexts because perceivers fail to retrieve counter-attitudinal cue-evaluation associations from memory outside the counter-attitudinal learning context. The current work examines whether an additional, counter-attitudinal retrieval cue can enhance the generalizability of counter-attitudinal evaluations. In four experiments, participants learned positive information about a target person, Bob, in one context, and then learned negative information about Bob in a different context. While learning the negative information, participants wore a wristband as a retrieval cue for counter-attitudinal Bob-negative associations. Participants then made speeded as well as deliberate evaluations of Bob while wearing or not wearing the wristband. Internal meta-analysis failed to find a reliable effect of the counter-attitudinal retrieval cue on speeded or deliberate evaluations, whereas the context cues influenced speeded and deliberate evaluations. Counter to predictions, counter-attitudinal retrieval cues did not disrupt the generalisation of first-learned evaluations or the context-specificity of second-learned evaluations (Experiments 2-4), but the counter-attitudinal retrieval cue did influence evaluations in the absence of context cues (Experiment 1). The current work provides initial evidence that additional counter-attitudinal retrieval cues fail to disrupt the renewal and generalizability of first-learned evaluations.

Measures of Implicit Gender Attitudes May Exaggerate Differences in Underlying Associations among Chinese Urban and Rural Women.

The oppression of women in rural China is more severe than in urban China, not only because the two areas differ in terms of social hierarchy, but also because urban women are more likely to fight against their subordination, which is endorsed by conventional social views on gender. To independently assess these relationships, we applied the Quadruple Process model to measure the processes underlying implicit gender attitudes in a sample of urban and rural females. The results indicated that the urban women had higher in-group favoritism than did the rural women. Application of the Quad model, however, showed that pro-women associations were similarly activated among urban and rural women, but that women in rural settings more effectively inhibited activated associations. Differences in inhibition, rather than in activated associations, appear to account for the less favorable attitudes among rural women. Thus, the differences in attitudinal responses among urban and rural women exaggerate the differences in underlying evaluative associations with respect to gender and conceal differences in self-regulating the expression of those associations.

Changing implicit attitudes toward smoking: results from a web-based approach-avoidance practice intervention.

Implicit attitudes have been shown to predict smoking behaviors. Therefore, an important goal is the development of interventions to change these attitudes. This study assessed the effects of a web-based intervention on implicit attitudes toward smoking and receptivity to smoking-related information. Smokers (N = 284) were recruited to a two-session web-based study. In the first session, baseline data were collected. Session two contained the intervention, which consisted of assignment to the experimental or control version of an approach-avoidance task and assignment to an anti-smoking or control public service announcement (PSA), and post-intervention measures. Among smokers with less education and with plans to quit, implicit attitudes were more negative for those who completed the approach-avoidance task. Smokers with more education who viewed the anti-smoking PSA and completed the approach-avoidance task spent more time reading smoking-related information. An approach-avoidance task is a potentially feasible strategy for changing implicit attitudes toward smoking and increasing receptivity to smoking-related information.

Intoxicated prejudice: The impact of alcohol consumption on implicitly and explicitly measured racial attitudes.

Recent research has shown that alcohol consumption can exacerbate expressions of racial bias by increasing reliance on stereotypes. However, little work has investigated how alcohol affects intergroup evaluations. The current work sought to address the issue in the context of the correspondence between implicit and explicit measures of anti-black attitudes. Participants were randomly assigned to consume an alcoholic (target BAC of 0.08%), placebo, or control beverage prior to completing implicit and explicit measures of racial attitudes. Although beverage condition did not affect prejudice levels on either measure, it did change the correlation between them. Implicitly measured attitudes significantly predicted explicit reports of prejudice and discrimination only for participants who consumed alcohol. We discuss the implications of our findings for debates regarding dissociations between implicit and explicit measures and the cultural phenomenon of intoxicated individuals attributing prejudiced statements to alcohol consumption rather than personal attitudes.

A recognition advantage for members of higher-status racial groups.

The other-race effect (ORE) is a recognition memory advantage afforded to one's racial ingroup versus outgroup. The motivational relevance of the ingroup-because of relationships, belonging and self-esteem-is central to many theoretical explanations for the ORE. However, to date, the motivational relevance of outgroups has received considerably less attention in the ORE literature. Across six experiments, Black, White, Asian and Latinx American participants consistently demonstrated better recognition memory for the faces of relatively higher-status racial/ethnic group members than those of lower-status groups. This higher-status recognition advantage even appeared to override the ORE, such that participants better recognized members of higher-status outgroups-but not an outgroup of equivalent status-compared to members of their own ingroup. However, across a variety of self-reported perceived status measures, status differences between the high- and low-status groups generally did not moderate the documented recognition advantage. These findings provide initial evidence for the potential role of group status in the ORE and in recognition memory more broadly, but future work is needed to rule out alternative explanations.

Intergroup Context Moderates the Impact of White Americans' Identification on Racial Categorization of Ambiguous Faces.

We examined how the number of groups in a categorization task influences how White Americans categorize ambiguous faces. We investigated the strength of identity-driven ingroup overexclusion-wherein highly identified perceivers overexclude ambiguous members from the ingroup-proposing that, compared with dichotomous tasks (with only the ingroup and one outgroup), tasks with more outgroups attenuate identity-driven ingroup overexclusion (a dilution effect). Fourteen studies (n = 4,001) measured White Americans' racial identification and their categorizations of ambiguous faces and manipulated the categorization task to have two groups, three groups, or an unspecified number of groups (open-ended). In all three conditions, participants overexcluded faces from the White category on average. There was limited support for the dilution effect: identity-driven ingroup overexclusion was absent in the three-group task and only weakly supported in the open-ended task. The presence of multiple outgroups may dampen the impact of racial identity on race perceptions among White Americans.

Why Barack Obama is black: a cognitive account of hypodescent.

We propose that hypodescent-the assignment of mixed-race individuals to a minority group-is an emergent feature of basic cognitive processes of learning and categorization. According to attention theory, minority groups are learned by attending to the features that distinguish them from previously learned majority groups. Selective attention creates a strong association between minority groups and their distinctive features, producing a tendency to see individuals who possess a mixture of majority- and minority-group traits as minority-group members. Two experiments on face categorization, using both naturally occurring and manipulated minority groups, support this view, suggesting that hypodescent need not be the product of racist or political motivations, but can be sufficiently explained by an individual's learning history.

Perspective taking reduces intergroup bias in visual representations of faces.

Intergroup biases shape most aspects of person construal, including lower-level visual representations of group members' faces. Specifically, ingroup members' faces tend to be represented more positively than outgroup members' faces. Here, we used a reverse-correlation paradigm to test whether engaging in perspective taking (i.e., actively imagining another person's mental states) can reduce these biased visual representations. In an initial image-generation experiment, participants were randomly assigned to a minimal group and then composed a narrative essay about an ingroup or an outgroup target person, either while adopting the person's perspective or while following control instructions. Afterward, they generated an image of the person's face in a reverse-correlation image-classification task. Subsequent image-assessment experiments using an explicit rating task, a sequential priming task, and an economic trust game with separate samples of participants revealed that ingroup faces elicited more likability and trustworthiness than did outgroup faces. Importantly, this pattern of intergroup bias was consistently weaker in faces created by perspective takers. Additional image-assessment experiments identified the mouth (i.e., smiling cues) as a critical facial region wherein the interactive effects of group membership and perspective taking emerged. These findings provide initial evidence that perspective taking may be an effective strategy for attenuating, though not for eliminating, intergroup biases in visual representations of what group members look like.

The Four Deadly Sins of Implicit Attitude Research.

In this article, we describe four theoretical and methodological problems that have impeded implicit attitude research and the popular understanding of its findings. The problems all revolve around assumptions made about the relationships among measures (indirect vs. versus direct), constructs (implicit vs. explicit attitudes), cognitive processes (e.g., associative vs. propositional), and features of processing (automatic vs. controlled). These assumptions have confused our understandings of exactly what we are measuring, the processes that produce implicit evaluations, the meaning of differences in implicit evaluations across people and contexts, the meaning of changes in implicit evaluations in response to intervention, and how implicit evaluations predict behavior. We describe formal modeling as one means to address these problems, and provide illustrative examples. Clarifying these issues has important implications for our understanding of who has particular implicit evaluations and why, when those evaluations are likely to be particularly problematic, how we might best try to change them, and what interventions are best suited to minimize the effects of implicit evaluations on behavior.

Further Validation of Measures of Target Detection and Stereotype Activation in the Stereotype Misperception Task.

Previous research presented a multinomial model to estimate four latent processes (target detection, stereotype activation, stereotype application, guessing) that contribute to responses in the Stereotype Misperception Task, an indirect measure of stereotyping (Krieglmeyer and Sherman, 2012). The present research further investigates the validity of the target detection (D) and stereotype activation (SAC) parameters. To this end, the data from Experiment 2 and Experiment 4 in Krieglmeyer and Sherman (2012) were re-analyzed using a bootstrap method to investigate the robustness of the results. Furthermore, two conceptual replication studies were conducted and analyzed with the same bootstrap method. A manipulation of target distinctness influenced the D parameter as predicted. A manipulation of prime prototypicality influenced the SAC parameter as predicted. Taken together, the results support the validity of the D and SAC model parameters.

Examining the Relationships Among Categorization, Stereotype Activation, and Stereotype Application.

Increased category salience is associated with increased stereotyping. Prior research has not examined the processes that may account for this relationship. That is, it is unclear whether category salience leads to increased stereotyping by increasing stereotype activation (i.e., increased accessibility of stereotypic information), application (i.e., increasing the tendency to apply activated stereotypes), or both processes simultaneously. We examined this question across three studies by manipulating category salience in an implicit stereotyping measure and by applying a process model that provides independent estimates of stereotype activation and application. Our results replicated past findings that category salience increases stereotyping. Modeling results showed that category salience consistently increased the extent of stereotype application but increased stereotype activation in more limited contexts. Implications for models of social categorization and stereotyping are discussed.

On the Roles of Stereotype Activation and Application in Diminishing Implicit Bias.

Stereotypes can influence social perception in undesirable ways. However, activated stereotypes are not always applied in judgments. The present research investigated how stereotype activation and application processes impact social judgments as a function of available resources for control over stereotypes. Specifically, we varied the time available to intervene in the stereotyping process and used multinomial modeling to independently estimate stereotype activation and application. As expected, social judgments were less stereotypic when participants had more time to intervene. In terms of mechanisms, stereotype application, and not stereotype activation, corresponded with reductions in stereotypic biases. With increasing time, stereotype application was reduced, reflecting the fact that controlling application is time-dependent. In contrast, stereotype activation increased with increasing time, apparently due to increased engagement with stereotypic material. Stereotype activation was highest when judgments were least stereotypical, and thus, reduced stereotyping may coincide with increased stereotype activation if stereotype application is simultaneously decreased.

The practice of psychological science: searching for Cronbach's two streams in social-personality psychology.

The present research surveyed a group of editors and editorial board members of personality and social psychology journals to examine the practice of psychological science in their field. Findings demonstrate that (a) although personality and social researchers tend to use many of the same approaches, methods, and procedures, they nonetheless show average differences in each of these domains, as well as in their overarching theoretical aims and perspectives; (b) these average differences largely conform to social and personality researchers' stereotypes about each subgroup; (c) despite their methodological and philosophical differences, the 2 subgroups study many of the same research topics; and (d) the structure of social-personality research practices can be characterized as having 2 independent factors, which closely correspond to L. J. Cronbach's (1957) correlational and experimental "streams of research."

Attentional processes in stereotype formation: a common model for category accentuation and illusory correlation.

Stereotype formation may be based on the exaggeration of real group differences (category accentuation) or the misperception of group differences that do not exist (illusory correlation). This research sought to account for both phenomena with J. K. Kruschke's (1996, 2001, 2003) attention theory of category learning. According to the model, the features of majority groups are learned earlier than the features of minority groups. In turn, the features that become associated with a minority are those that most distinguish it from the majority. This second process is driven by an attention-shifting mechanism that directs attention toward group-attribute pairings that facilitate differentiation of the two groups and may lead to the formation of stronger minority stereotypes. Five experiments supported this model as a common account for category accentuation and distinctiveness-based illusory correlation. Implications for the natures of stereotype formation, illusory correlation, and impression formation are discussed.

Pharmacokinetic/pharmacodynamic modeling and simulation of neutropenia during phase I development of liposome-entrapped paclitaxel.

PURPOSE: To evaluate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of liposome-entrapped paclitaxel easy-to-use (LEP-ETU) and to characterize the relationship between LEP-ETU concentrations and the time course of neutropenia in cancer patients. EXPERIMENTAL DESIGN: LEP-ETU was administered to 88 patients and 63 were evaluable for pharmacokinetic/pharmacodynamic (PK/PD) analysis following 1.5- and 3-h infusions every 3 weeks (q3w; dose range, 135-375 mg/m(2)). MTD was identified using a 3 + 3, up-and-down dose-finding algorithm. PK/PD modeling was done to describe the temporal relationship between paclitaxel concentrations and neutrophil count. Simulations assessed the influence of dose and schedule on neutropenia severity to help guide dose selection. RESULTS: The MTD of LEP-ETU was identified as 325 mg/m(2). DLTs occurring at 375 mg/m(2) consisted of febrile neutropenia and neuropathy. The C(max) and area under the plasma concentration-time curve of LEP-ETU were less than proportional with increasing dose. The PK/PD model showed that LEP-ETU inhibition of neutrophil proliferation was 9.1% per 10 mug/mL of total paclitaxel concentration. The incidence of grade 4 neutropenia increased from 33% to 42% across the dose range of 275 to 325 mg/m(2) q3w. For a dose of 110 mg/m(2) given weekly, grade 4 neutropenia was estimated to be 16% compared with 42% for the same total dose administered q3w. CONCLUSIONS: LEP-ETU can be administered safely at higher doses than Taxol. Modeling and simulation studies predict that 325 mg/m(2) LEP-ETU q3w provides acceptable neutropenic events relative to those observed at 175 mg/m(2) Taxol q3w. A 275 mg/m(2) dose may offer an improved therapeutic index.

Implementation Intentions Reduce Implicit Stereotype Activation and Application.

Research has found that implementation intentions, if-then action plans (e.g., "if I see a Black face, I will think safe"), reduce stereotyping on implicit measures. However, it is unknown by what process(es) implementation intentions reduce implicit stereotyping. The present research examines the effects of implementation intentions on stereotype activation (e.g., extent to which stereotypic information is accessible) and stereotype application (e.g., extent to which accessible stereotypes are applied in judgment). In addition, we assessed the efficiency of implementation intentions by manipulating cognitive resources (e.g., digit-span, restricted response window) while participants made judgments on an implicit stereotyping measure. Across four studies, implementation intentions reduced implicit stereotyping. This decrease in stereotyping was associated with reductions in both stereotype activation and application. In addition, these effects of implementation intentions were highly efficient and associated with reduced stereotyping even for groups for which people may have little practice inhibiting stereotypes (e.g., gender).