RESUMEN
Humans are living longer, but this is accompanied by an increased incidence of age-related chronic diseases. Many of these diseases are influenced by age-associated metabolic dysregulation, but how metabolism changes in multiple organs during aging in males and females is not known. Answering this could reveal new mechanisms of aging and age-targeted therapeutics. In this study, we describe how metabolism changes in 12 organs in male and female mice at 5 different ages. Organs show distinct patterns of metabolic aging that are affected by sex differently. Hydroxyproline shows the most consistent change across the dataset, decreasing with age in 11 out of 12 organs investigated. We also developed a metabolic aging clock that predicts biological age and identified alpha-ketoglutarate, previously shown to extend lifespan in mice, as a key predictor of age. Our results reveal fundamental insights into the aging process and identify new therapeutic targets to maintain organ health.
RESUMEN
The speed of recovery from supply chain disruption has been identified as the predominant factor in building a resilient supply chain. However, COVID-19 as an example of an evolving crisis may challenge this assumption. Infection risk concerns may influence production resumption decision-making because any incidents of infection may lead to further shutdowns of production lines and undermine firms' long-term cash flows. Sampling 244 production resumption announcements by Chinese manufacturers in the early COVID-19 crisis (February-March 2020), our analysis shows that, generally, investors react positively to production resumptions. However, investors perceived the earlier production resumptions were higher risk (indicated by declined stock price). Such concerns were exacerbated by more locally confirmed cases of COVID-19 but were less salient for manufacturers with high debts (liquidity pressure). This study calls for a reassessment of the current disruption management mindset in response to new evolving crises (e.g., COVID-19) and provides theoretical, practical, and policy implications for building resilient supply chains.
RESUMEN
Resilience amidst a crisis is vital to survival in the turbulent contemporary business environment. Diversifying the supply chain has been proposed as an important means to build this capability. However, there is insufficient empirical evidence demonstrating the merits of supply chain diversification during a crisis. Sampling 1434 Chinese manufacturing firms amidst the COVID-19 crisis, our two-stage least squares (2SLS) regression analyses show that firms with a diversified supply base are associated with a larger supply stream (increased abnormal inventory) and increased profitability during the COVID-19 crisis, including both the disruption and recovery periods. In addition, firms with a diversified customer base are associated with a larger demand stream (reduced abnormal inventory) during the COVID-19 crisis (both disruption and recovery periods) but show increased profitability only during the recovery period. Our study contributes to the literature on supply chain risk, disruption, diversification, and inventory management. We also discuss the practical implications of supply chain structure design in building resilience.