Gene mapping as a method for verifying sequence localization based on interspecific chromosome painting (ZOO-FISH).

The results obtained in the present study made it possible to place selected markers on the physical map of the arctic fox genome. With the use of fluorescence in situ hybridization (FISH) the GHR (3q24) and 1110 (1q21.1-21.2) genes and the FH2537 (5q11.3) microsatellite were localized on arctic fox chromosomes. The results confirmed previously proposed homologies using the ZOO-FISH technique, except for the 1110 gene. This suggests that the gene underwent a rearrangement (an inversion) that changed its localization compared to the dog.