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1.
Occup Med (Lond) ; 69(5): 342-351, 2019 Aug 22.
Artículo en Inglés | MEDLINE | ID: mdl-31375830

RESUMEN

BACKGROUND: Long-term health outcomes in cohorts of workers from the electricity supply industry have been studied. AIMS: The aim of the study was to examine updated cancer incidence findings among a cohort of UK electricity generation and transmission workers. METHODS: Cancer morbidity experienced by 81 616 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-2015. All employees had worked for at least 6 months with some employment between 1973 and 1982. Standardized registration ratios (SRRs) were calculated based on national rates. RESULTS: Overall cancer morbidity was slightly below expectation in males. Significant excesses were found in male workers for mesothelioma (observed [Obs] 763, SRR 326), skin cancer (non-melanoma) (Obs 5616, SRR 106), and prostate cancer (Obs 4298, SRR 106), and in female workers for cancer of the small intestine (Obs 13, SRR 220), nasal cancer (Obs 11, SRR 407), and breast cancer (Obs 758, SRR 110). More detailed analyses showed important contrasts, particularly for mesothelioma, lung cancer, skin cancer, prostate cancer and breast cancer. CONCLUSIONS: A clear occupational excess of mesothelioma was not matched by a corresponding excess of asbestos-induced lung cancer. Confident interpretation of the excesses of cancers of the nasal cavities and small intestine is not possible, although occupational exposures received in this industry may well not be involved. An excess of skin cancer in transmission workers may be associated with outdoor working.


Asunto(s)
Neoplasias/epidemiología , Enfermedades Profesionales/epidemiología , Centrales Eléctricas , Amianto/efectos adversos , Femenino , Humanos , Incidencia , Masculino , Mesotelioma/epidemiología , Mesotelioma/etiología , Neoplasias/etiología , Exposición Profesional/efectos adversos , Exposición Profesional/estadística & datos numéricos , Reino Unido/epidemiología
2.
Br J Cancer ; 119(6): 756-762, 2018 09.
Artículo en Inglés | MEDLINE | ID: mdl-30131555

RESUMEN

BACKGROUND: Significant research on the epidemiology and natural history of childhood cancer took place in the Universities of Oxford and Birmingham over sixty years. This is the first of three papers recording this work and describes the Oxford Survey of Childhood Cancers (OSCC), the largest case-control survey of childhood cancer ever undertaken. METHODS: The OSCC studied deaths in Britain from 1953 to 1981. Parents were interviewed and medical records from ante-natal clinics and treatment centres were followed up and abstracted. The survey left Oxford in 1975 and was run subsequently from Birmingham. The data are now being documented and archived to make them available for future study. RESULTS: Many papers have resulted from this survey, most notably those relating to the association first reported therein between childhood cancer and ante-natal X-raying. This paper is a historical review of the OSCC. CONCLUSIONS: In spite of many analyses of the study, this historic data set has continuing value because of the large number of examples of some very rare tumours and the detailed clinical and family history data that are available; and also because of the possibility of carrying out new analyses to investigate emerging research issues.


Asunto(s)
Investigación Biomédica/estadística & datos numéricos , Neoplasias/epidemiología , Estudios de Casos y Controles , Niño , Femenino , Humanos , Neoplasias/mortalidad , Neoplasias Inducidas por Radiación/epidemiología , Neoplasias Inducidas por Radiación/mortalidad , Embarazo , Efectos Tardíos de la Exposición Prenatal/epidemiología , Efectos Tardíos de la Exposición Prenatal/mortalidad , Sistema de Registros , Factores de Riesgo , Reino Unido/epidemiología
3.
Occup Environ Med ; 74(6): 417-421, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-28062833

RESUMEN

OBJECTIVES: Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK. METHODS: Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence ratios (SIRs), based on country-specific and period-specific incidence rates, were analysed for all cancers combined (except non-melanoma skin), bladder, lung, stomach cancer, leukaemia, non-Hodgkin's lymphoma and multiple myeloma. Exploratory analyses were conducted for other cancers with a minimum of 10 cases in both genders combined. RESULTS: 16 026 individuals (12 441 men; 3585 women) contributed to 397 975 person-years of observation, with 846 cancers observed overall (437 in the UK, 409 in Sweden). No statistically significant increased risk was observed for any site of cancer. A reduced risk was evident for all cancers combined (SIR=0.83, 95% CI (0.74 to 0.92)), lung cancer (SIR=0.74, 95% CI (0.59 to 0.93)), non-Hodgkin's lymphoma (SIR=0.67, 95% CI (0.45 to 1.00)) and prostate cancer (SIR=0.77, 95% CI (0.64 to 0.92)). For stomach cancer and multiple myeloma, SIRs were 0.93 (95% CI (0.61 to 1.43)) and 0.92 (95% CI 0.44 to 1.91), respectively. No increased risk of bladder cancer was observed (SIR=0.88, 95% CI (0.61 to 1.28)). CONCLUSIONS: No significantly increased risk of cancer incidence was observed in the combined cohort of rubber workers first employed since 1975. Continued surveillance of the present cohorts is required to confirm absence of long-term risk and confirmatory findings from other cohorts would be important.


Asunto(s)
Neoplasias/inducido químicamente , Neoplasias/epidemiología , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/epidemiología , Exposición Profesional/efectos adversos , Goma/efectos adversos , Adulto , Estudios de Cohortes , Femenino , Humanos , Incidencia , Masculino , Industria Manufacturera , Persona de Mediana Edad , Distribución de Poisson , Distribución por Sexo , Suecia/epidemiología , Reino Unido/epidemiología , Neoplasias de la Vejiga Urinaria/epidemiología , Adulto Joven
4.
Ann Oncol ; 27(5): 933-41, 2016 05.
Artículo en Inglés | MEDLINE | ID: mdl-26884594

RESUMEN

BACKGROUND: Increased cancer risk has been reported among workers in the rubber manufacturing industry employed before the 1960s. It is unclear whether risk remains increased among workers hired subsequently. The present study focused on risk of cancer mortality for rubber workers first employed since 1975 in 64 factories. PATIENTS AND METHODS: Anonymized data from cohorts of rubber workers employed for at least 1 year from Germany, Italy, Poland, Sweden, and the UK were pooled. Standardized mortality ratios (SMRs), based on country-specific death rates, were reported for bladder and lung cancer (primary outcomes of interest), for other selected cancer sites, and for cancer sites with a minimum of 10 deaths in men or women. Analyses stratified by type of industry, period, and duration of employment were carried out. RESULTS: A total of 38 457 individuals (29 768 men; 8689 women) contributed to 949 370 person-years. No increased risk of bladder cancer was observed [SMR = 0.80, 95% confidence interval (CI) 0.46; 1.38]. The risk of lung cancer death was reduced (SMR = 0.81, 95% CI 0.70; 0.94). No statistically significant increased risk was observed for any other cause of death. A reduced risk was evident for total cancer mortality (SMR = 0.81, 95% CI 0.76; 0.87). Risks were lower for workers in the tyre industry compared with workers in the general rubber goods sector. Analysis by employment duration showed a negative trend with SMRs decreasing with increasing duration of employment. In an analysis of secondary end points, when stratified by type of industry and period of first employment, excess risks of myeloma and gastric cancer were observed each due, essentially, to results from one centre. CONCLUSION: No consistent increased risk of cancer death was observed among rubber workers first employed since 1975, no overall analysis of the pooled cohort produced significantly increased risk. Continued surveillance of the present cohorts is required to confirm the absence of long-term risk.


Asunto(s)
Neoplasias Pulmonares/mortalidad , Neoplasias/mortalidad , Exposición Profesional/efectos adversos , Neoplasias de la Vejiga Urinaria/mortalidad , Adulto , Anciano , Estudios de Cohortes , Femenino , Humanos , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/patología , Masculino , Industria Manufacturera , Persona de Mediana Edad , Neoplasias/inducido químicamente , Neoplasias/patología , Goma/toxicidad , Neoplasias de la Vejiga Urinaria/inducido químicamente , Neoplasias de la Vejiga Urinaria/patología
5.
Occup Med (Lond) ; 64(3): 150-6, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24562301

RESUMEN

AIMS: To investigate whether leukaemia risks are related to occupational exposure to low-frequency magnetic fields. METHODS: Leukaemia risks experienced by 73 051 employees of the former Central Electricity Generating Board of England and Wales were investigated for the period 1973-2010. All employees were hired in the period 1952-82 and were employed for at least 6 months with some employment in the period 1973-82. Detailed calculations had been performed by others to enable an assessment to be made of exposures to magnetic fields. Poisson regression was used to calculate relative risks (rate ratios) of developing leukaemia or leukaemia subtypes for categories of lifetime, distant (lagged) and recent (lugged) exposure. RESULTS: Findings for all leukaemias combined were unexceptional; risks were close to unity for all exposure categories and there was no suggestion of risks increasing with cumulative (or recent or distant) magnetic field exposures. There were no statistically significant dose-response effects shown for acute myeloid leukaemia, chronic myeloid leukaemia or chronic lymphocytic leukaemia. There was a significant positive trend for acute lymphocytic leukaemia (ALL), but this was based, in the main, on unusually low risks in the lowest exposure category. CONCLUSIONS: This study found no convincing evidence to support the hypothesis that exposure to magnetic fields is a risk factor for leukaemia, and the findings are consistent with the hypotheses that both distant and recent magnetic field exposures are not causally related to the generality of leukaemia. The limited positive findings for ALL may well be chance findings.


Asunto(s)
Electricidad , Leucemia/etiología , Campos Magnéticos , Enfermedades Profesionales , Exposición Profesional , Centrales Eléctricas , Anciano , Estudios de Cohortes , Inglaterra , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Exposición Profesional/efectos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiología , Factores de Riesgo , Gales
6.
Occup Med (Lond) ; 64(3): 157-65, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24562302

RESUMEN

AIMS: To investigate whether brain tumour risks are related to occupational exposure to low-frequency magnetic fields. METHODS: Brain tumour risks experienced by 73 051 employees of the former Central Electricity Generating Board of England and Wales were investigated for the period 1973-2010. All employees were hired in the period 1952-82 and were employed for at least 6 months with some employment in the period 1973-82. Detailed calculations had been performed by others to enable an assessment to be made of exposures to magnetic fields. Poisson regression was used to calculate relative risks (rate ratios) of developing a brain tumour (or glioma or meningioma) for categories of lifetime, distant (lagged) and recent (lugged) exposure. RESULTS: Findings for glioma and for the generality of all brain tumours were unexceptional; risks were close to (or below) unity for all exposure categories and there was no suggestion of risks increasing with cumulative (or recent or distant) magnetic field exposures. There were no statistically significant dose-response effects shown for meningioma, but there was some evidence of elevated risks in the three highest exposure categories for exposures received >10 years ago. CONCLUSIONS: This study found no evidence to support the hypothesis that exposure to magnetic fields is a risk factor for gliomas, and the findings are consistent with the hypotheses that both distant and recent magnetic field exposures are not causally related to gliomas. The limited positive findings for meningioma may be chance findings; national comparisons argue against a causal interpretation.


Asunto(s)
Neoplasias Encefálicas , Electricidad , Campos Magnéticos , Enfermedades Profesionales , Exposición Profesional , Centrales Eléctricas , Anciano , Neoplasias Encefálicas/etiología , Inglaterra , Femenino , Glioma/etiología , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Exposición Profesional/efectos adversos , Reino Unido , Gales
7.
Occup Med (Lond) ; 64(6): 454-60, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25104278

RESUMEN

BACKGROUND: Previous research has suggested a possible link between neurodegenerative disease and exposure to extremely low-frequency electric and magnetic fields. AIMS: To investigate whether risks of Alzheimer's, motor neurone or Parkinson's disease are related to occupational exposure to magnetic fields. METHODS: The mortality experienced by a cohort of 73051 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-2010. All employees were hired in the period 1952-82, were employed for at least 6 months and had some employment after 1 January 1973. Detailed calculations had been performed by others to enable an assessment to be made of exposures to magnetic fields. Poisson regression was used to calculate relative risks (rate ratios) of developing any of the three diseases under investigation for categories of lifetime, distant (lagged) and recent (lugged) exposure. RESULTS: No statistically significant trends were shown for risks of any of these diseases to increase with estimates of lifetime, recent or distant exposure to magnetic fields. CONCLUSIONS: There is no convincing evidence that UK electricity generation and transmission workers have suffered elevated risks from neurodegenerative diseases as a consequence of exposure to magnetic fields.


Asunto(s)
Campos Electromagnéticos/efectos adversos , Enfermedades Neurodegenerativas/epidemiología , Enfermedades Profesionales/epidemiología , Exposición Profesional/efectos adversos , Electricidad , Inglaterra/epidemiología , Femenino , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Masculino , Enfermedades Neurodegenerativas/etiología , Enfermedades Profesionales/etiología , Centrales Eléctricas , Factores de Riesgo
8.
Occup Med (Lond) ; 62(7): 496-505, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22949586

RESUMEN

BACKGROUND: The effects of magnetic field exposure on cancer risks remains unclear. AIMS: To examine cancer incidence among a cohort of UK electricity generation and transmission workers. METHODS: Cancer morbidity experienced by a cohort of 81 842 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-2008. All employees had worked for at least 6 months with some employment between 1973 and 1982. Standardized registration ratios (SRRs) were calculated on the basis of national rates. RESULTS: Overall cancer morbidity was slightly below expectation in males and females. Significant excesses were found in male workers for mesothelioma (Observed [Obs] 504, SRR 331), skin cancer (non-melanoma) (Obs 3187, SRR 107) and prostate cancer (Obs 2684, SRR 107) and in female workers for cancer of the small intestine (Obs 10, SRR 306) and nasal cancer (Obs 9, SRR 474). Brain cancers were close to expectation in males and below expectation in females. Leukaemia incidence (all types) was slightly below expectation in males and females. More detailed analyses showed import ant contrasts for mesothelioma and leukaemia. CONCLUSIONS: The clear occupational excess of mesothelioma was not matched by a corresponding excess of lung cancer, and the level of asbestos-induced lung cancer in this industry must be low. Leukaemia risks declined with period from hire; confident interpretation of this finding is not possible. The excesses of cancers of the nasal cavities and small intestine are probably not occupational, though the excess of skin cancer may be due to outdoor work.


Asunto(s)
Electricidad/efectos adversos , Melanoma/epidemiología , Mesotelioma/epidemiología , Neoplasias/epidemiología , Enfermedades Profesionales/epidemiología , Exposición Profesional/estadística & datos numéricos , Centrales Eléctricas , Femenino , Humanos , Incidencia , Masculino , Neoplasias/etiología , Enfermedades Profesionales/etiología , Exposición Profesional/prevención & control , Sistema de Registros , Encuestas y Cuestionarios , Reino Unido/epidemiología
9.
Occup Environ Med ; 66(4): 269-73, 2009 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19158128

RESUMEN

OBJECTIVES: To investigate cancer risks in chemical production workers exposed to 2-mercaptobenzothiazole (MBT). METHODS: The mortality (1955-2005) and cancer morbidity experience (1971-2005) of a cohort of 363 male production workers exposed to MBT while employed at a chemical factory in north Wales were investigated. Two analytical approaches were used, indirect standardisation and Poisson regression. RESULTS: Based on national mortality rates, significant excess mortality was found for cancers of the large intestine (observed; Obs 8, standardised mortality ratio (SMR) 232, 95% CI 100 to 457) and bladder (Obs 8, SMR 374, 95% CI 162 to 737). Non-significant excesses were shown for lung cancer (Obs 27, SMR 138, 95% CI 91 to 201) and multiple myeloma (Obs 3, SMR 440, 95% CI 91 to 1287). Based on national cancer incidence rates, significant excess morbidity was found for cancer of the bladder (Obs 12, standardised registration ratio (SRR) 253, 95% CI 131 to 441) and multiple myeloma (Obs 4, SRR 465, 95% CI 127 to 1191). Non-significant excesses were shown for cancers of the large intestine (Obs 9, SRR 181, 95% CI 83 to 344) and lung (Obs 26, SRR 152, 95% CI 99 to 223). In analyses that included follow-up information on an additional 1797 plant employees not exposed to MBT, Poisson regression showed significant positive trends both for risks of cancer of the large intestine and for risks of multiple myeloma in relation to estimated cumulative exposure to MBT. CONCLUSIONS: MBT may be a human carcinogen; confident evaluation awaits findings from other studies.


Asunto(s)
Benzotiazoles/toxicidad , Neoplasias Intestinales/epidemiología , Neoplasias Pulmonares/epidemiología , Mieloma Múltiple/epidemiología , Enfermedades Profesionales/epidemiología , Neoplasias de la Vejiga Urinaria/epidemiología , Adulto , Anciano , Anciano de 80 o más Años , Industria Química , Estudios de Cohortes , Humanos , Neoplasias Intestinales/mortalidad , Neoplasias Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Morbilidad , Mieloma Múltiple/mortalidad , Enfermedades Profesionales/mortalidad , Exposición Profesional/efectos adversos , Riesgo , Neoplasias de la Vejiga Urinaria/mortalidad , Gales/epidemiología
10.
Occup Environ Med ; 64(12): 820-6, 2007 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-17626136

RESUMEN

BACKGROUND: There are a number of reports linking magnetic field exposure to increased risks of Alzheimer's disease and motor neuron disease. METHODS: The mortality experienced by a cohort of 83 997 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-2004. All employees were employed for at least six months with some employment in the period 1973-82. Computerised work histories were available for 79 972 study subjects for the period 1971-93. Information on job and facility (location) were used to estimate exposures to magnetic fields. Two analytical approaches were used to evaluate risks, indirect standardisation (n = 83 997) and Poisson regression (n = 79 972). RESULTS: Based on serial mortality rates for England and Wales, deaths from Alzheimer's disease and motor neuron disease were unexceptional. There was an excess of deaths from Parkinson's disease of borderline significance. No statistically significant trends were shown for risks of any of these diseases to increase with lifetime cumulative exposure to magnetic fields (RR per 10 µT-y: Alzheimer's disease 1.10 (95% CI 0.90 to 1.33); motor neuron disease 1.06 (95% CI 0.86 to 1.32); Parkinson's disease 0.88 (95% CI 0.74 to 1.05)) CONCLUSIONS: There is no convincing evidence that UK electricity generation and transmission workers have suffered increased risks from neurodegenerative diseases as a consequence of exposure to magnetic fields.


Asunto(s)
Enfermedad de Alzheimer/mortalidad , Campos Magnéticos/efectos adversos , Neuronas Motoras/patología , Enfermedades Neurodegenerativas/mortalidad , Enfermedades Profesionales/mortalidad , Exposición Profesional/efectos adversos , Enfermedad de Parkinson/mortalidad , Estudios de Cohortes , Electricidad , Inglaterra/epidemiología , Femenino , Humanos , Masculino , Centrales Eléctricas , Factores de Riesgo , Reino Unido/epidemiología , Gales/epidemiología
11.
J Natl Cancer Inst ; 78(6): 1095-100, 1987 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-3473250

RESUMEN

For investigation of the hypothesis that elevated birth weight characterizes children dying from cancer, birth weights of over 3,000 children who died of cancer were compared with those of matched controls alive at the time of the case's death. Analysis revealed no consistent pattern of association between birth weight and subsequent cancer death. Girls who died of solid tumors between ages 1 and 10 had a significantly higher mean birth weight and an excess of high birth weights separate from the influence of maternal age, birth order, and socioeconomic status. Boys who died of solid tumors between birth and 2 years had a significantly lower mean birth weight and exhibited a significant, progressive linear decrease in representation across the birth-weight distribution in the controlled analysis. However, this study, the largest to date, did not support previous claims that birth weight may be an important predictor of childhood cancer risk.


Asunto(s)
Peso al Nacer , Neoplasias/mortalidad , Adolescente , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Factores Sexuales
12.
Occup Environ Med ; 62(2): 80-5, 2005 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15657188

RESUMEN

BACKGROUND: Excess risks of respiratory cancer have been shown in some groups of nickel exposed workers. It is clear, however, that not all forms of nickel exposure are implicated in these excess risks. AIM: To determine whether occupational exposures received in a modern nickel carbonyl refinery lead to increased risks of cancer, in particular nasal cancer and lung cancer. METHODS: The mortality experienced by a cohort of 812 workers employed at a nickel refinery was investigated. Study subjects were all male workforce employees first employed in the period 1953-92 who had at least five years' employment with the company. Observed numbers of cause specific deaths were compared with expectations based on national mortality rates; SMRs were also calculated by period from commencing employment, year of commencing employment, and type of work. RESULTS: Overall, standardised mortality ratios (SMRs) were close to 100 for all causes (Obs 191, SMR 96, 95% CI 83 to 111), all neoplasms (Obs 63, SMR 104, 95% CI 80 to 133), non-malignant diseases of the respiratory system (Obs 18, SMR 97, 95% CI 57 to 153), and diseases of the circulatory system (Obs 85, SMR 94, 95% CI 75 to 116). There were no significantly increased SMRs for any site of cancer. There was a non-significant excess for lung cancer (Obs 28, Exp 20.17, SMR 139, 95% CI 92 to 201), and in subgroup analyses a significantly increased SMR of 231 (Obs 9) was found for those 142 workers with at least five years' employment in the feed handling and nickel extraction departments. In the total cohort there was a single death from nasal cancer (Exp 0.10). CONCLUSIONS: The non-significant excess of lung cancer deaths may well be a chance finding, but in light of previous studies some role for nickel exposures cannot be excluded.


Asunto(s)
Metalurgia , Neoplasias/mortalidad , Enfermedades Profesionales/mortalidad , Compuestos Organometálicos/toxicidad , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Causas de Muerte , Estudios de Cohortes , Polvo/análisis , Humanos , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Neoplasias/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Exposición Profesional/efectos adversos , Exposición Profesional/análisis , Compuestos Organometálicos/análisis , Fumar/efectos adversos , Gales/epidemiología
13.
Occup Environ Med ; 62(4): 231-6, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15778255

RESUMEN

AIMS: To examine mortality from different causes and cancer incidence among a cohort of benzene workers in England and Wales. METHODS: A cohort of 5514 workers who had been occupationally exposed to benzene in 1966/67 or earlier was assembled by the former Factory Inspectorate and the Medical Research Council from details provided by 233 employers in England and Wales. The cohort was followed up for mortality (1968-2002) and cancer registrations (1971-2001). National mortality rates and cancer registration (incidence) rates were used to calculate standardised mortality ratios and standardised registration ratios. RESULTS: Mortality was close to expectation for all causes and significantly increased for cancer of the lip, cancer of the lung and bronchus, secondary and unspecified cancers, acute non-lymphocytic leukaemia (ANLL), and all neoplasms. Significant deficits were shown for three non-malignant categories (mental disorders, diseases of the digestive system, accidents). SMRs for other leukaemia, lymphomas, and multiple myeloma were close to or below expectation. There was some evidence of under-ascertainment of cancer registrations, although significantly increased SRRs were shown for lung cancer and cancer of the pleura (mesothelioma). CONCLUSIONS: Many study subjects would have been exposed to carcinogens other than benzene (for example, asbestos, rubber industry fumes, foundry fumes, polycyclic aromatic hydrocarbons), and the excesses of lung cancer and mesothelioma are likely to reflect exposures to these other carcinogens. The carcinogenic effects of benzene exposure on the lymphohaematopoietic system were limited to ANLL.


Asunto(s)
Benceno/toxicidad , Carcinógenos Ambientales/toxicidad , Neoplasias/mortalidad , Enfermedades Profesionales/mortalidad , Causas de Muerte , Estudios de Cohortes , Inglaterra/epidemiología , Femenino , Humanos , Incidencia , Leucemia/mortalidad , Leucemia Mieloide Aguda/mortalidad , Neoplasias de los Labios/mortalidad , Neoplasias Pulmonares/mortalidad , Masculino , Neoplasias/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Exposición Profesional/efectos adversos , Factores de Riesgo , Gales/epidemiología
14.
Ann Epidemiol ; 5(5): 354-9, 1995 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-8653207

RESUMEN

Reported consumptions of alcohol and tobacco for the parents of 1641 children who died with cancer in England and Wales during the period 1977 to 1981 were compared with similar information for the parents of 1641 control subjects. Consumption of alcohol by fathers was not associated with an increased risk of childhood cancer (relative risk (RR)) = 1.05; 95% confidence interval (CI): 0.86 to 1.28), but for daily consumption of cigarettes was not shown to be associated with an increased risk and consumption of alcohol was associated with a relatively low cancer risk (RR = 0.82; 95% CI: 0.70 to 0.96). Relations between maternal consumption of cigarettes and birth weights suggested that the smoking data were equally reliable for case patients and control subjects.


Asunto(s)
Consumo de Bebidas Alcohólicas/epidemiología , Neoplasias/epidemiología , Padres , Fumar/epidemiología , Peso al Nacer , Estudios de Casos y Controles , Niño , Intervalos de Confianza , Inglaterra/epidemiología , Padre , Femenino , Humanos , Masculino , Madres , Neoplasias/mortalidad , Oportunidad Relativa , Embarazo , Efectos Tardíos de la Exposición Prenatal , Factores de Riesgo , Tasa de Supervivencia , Gales/epidemiología
15.
Arch Dermatol ; 128(9): 1201-6, 1992 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-1519934

RESUMEN

BACKGROUND AND METHODS: Prevalence of benign melanocytic nevi (moles) has been shown to be a major predictor of malignant melanoma. In this study the prevalence of moles in a group of 2140 children, aged 4 to 11 years, was determined. A standard questionnaire was completed by the parents of each child and included information on environmental and life-style factors. Examination data for each child were linked to the data obtained from the questionnaire. RESULTS: Prevalence increases rapidly throughout childhood and studies of children may indicate which factors contribute to mole development. Boys had more moles than girls, as did white children when compared with other ethnic groups. Prevalence of moles increased with age in children of both sexes. Among whites, skin color had little influence on mole prevalence. The following characteristics, however, were associated with an increased prevalence of moles: a propensity to burn rather than tan, a history of sunburn, a tendency to freckle, and a life-style involving increased sun exposure. A striking positive association between prevalence of moles and number of foreign holidays in a hot climate was observed. This association was independent of a history of sunburn. CONCLUSIONS: The study supports the hypothesis that environmental factors influence the prevalence of moles in childhood.


Asunto(s)
Nevo Pigmentado/epidemiología , Neoplasias Cutáneas/epidemiología , Niño , Preescolar , Femenino , Humanos , Masculino , Nevo Pigmentado/etnología , Nevo Pigmentado/etiología , Nevo Pigmentado/patología , Prevalencia , Neoplasias Cutáneas/etnología , Neoplasias Cutáneas/etiología , Neoplasias Cutáneas/patología , Quemadura Solar/complicaciones , Reino Unido/epidemiología
16.
Arch Dis Child Fetal Neonatal Ed ; 72(2): F111-4, 1995 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-7536110

RESUMEN

Percentage fetal haemoglobins (% HbF) were measured in 7081 newborns at the University Hospital, Nottingham, between 1990 and 1992 to assess the effects of a range of factors, and to determine if there was an association between % HbF at birth and risk of SIDS (sudden infant death syndrome). Data from the obstetric clinical records were analysed by multiple linear regression to establish the major determinants of % HbF. New findings were the identification of maternal smoking, twin pregnancy, ethnic origin, and season of birth as significant determinants. Alcohol use, drug and vitamin intake, and duration of labour were not found to be important. The previously reported correlations between % HbF and sex, gestational age, and birthweight were confirmed, and the relative effects quantified. Overall, the major determinants of an increase in % HbF in neonates are similar to the known antenatal risk factors for sudden infant death syndrome (SIDS).


Asunto(s)
Hemoglobina Fetal/análisis , Recién Nacido/sangre , Muerte Súbita del Lactante/sangre , Peso al Nacer , Femenino , Edad Gestacional , Humanos , Modelos Lineales , Masculino , Embarazo , Embarazo Múltiple , Valores de Referencia , Factores de Riesgo , Factores Sexuales , Fumar/efectos adversos , Gemelos
17.
Occup Environ Med ; 61(2): 108-16, 2004 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-14739376

RESUMEN

AIMS: To investigate mortality from lung cancer in nickel-cadmium battery workers in relation to cumulative exposure to cadmium hydroxide. METHODS: The mortality of a cohort of 926 male workers from a factory engaged in the manufacture of nickel-cadmium batteries in the West Midlands of England was investigated for the period 1947-2000. All subjects were first employed at the plant in the period 1947-75 and employed for a minimum period of 12 months. Work histories were available for the period 1947-86; the factory closed down in 1992. Two analytical approaches were used, indirect standardisation and Poisson regression. RESULTS: Based on serial mortality rates for the general population of England and Wales, significantly increased mortality was shown for cancers of the pharynx (observed (Obs) 4, expected (Exp) 0.7, standardised mortality ratio (SMR) 559, p<0.05), non-malignant diseases of the respiratory system (Obs 61, Exp 43.0, SMR 142, p<0.05), and non-malignant diseases of the genitourinary system (Obs 10, Exp 4.1, SMR 243, p<0.05). Non-significantly increased SMRs were shown for lung cancer (Obs 45, Exp 40.7, SMR 111) and cancer of the prostate (Obs 9, Exp 7.5, SMR 116). Estimated cumulative cadmium exposures were not related to risks of lung cancer or risks of chronic obstructive pulmonary diseases, even when exposure histories were lagged first by 10, then by 20 years. CONCLUSIONS: The study findings do not support the hypotheses that cadmium compounds are human lung carcinogens.


Asunto(s)
Compuestos de Cadmio/toxicidad , Neoplasias Pulmonares/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Suministros de Energía Eléctrica , Inglaterra/epidemiología , Monitoreo del Ambiente/métodos , Monitoreo Epidemiológico , Estudios de Seguimiento , Humanos , Neoplasias Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Níquel , Enfermedades Profesionales/mortalidad , Exposición Profesional/análisis , Enfermedad Pulmonar Obstructiva Crónica/inducido químicamente , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Estudios Retrospectivos
18.
BMJ ; 315(7117): 1181-8, 1997 Nov 08.
Artículo en Inglés | MEDLINE | ID: mdl-9393219

RESUMEN

OBJECTIVES: To test the "Gardner hypothesis" that childhood leukaemia and non-Hodgkin lymphoma can be caused by fathers' exposure to ionising radiation before the conception of the child, and, more generally, to investigate whether such radiation exposure of either parent is a cause of childhood cancer. DESIGN: Case-control study. SETTING: Great Britain. SUBJECTS: 35,949 children diagnosed as having cancer, together with matched controls. MAIN OUTCOME MEASURES: Parental employment as radiation worker as defined by inclusion in the National Registry for Radiation Workers and being monitored for external radiation before conception of child; cumulative dose of external ionising radiation for various periods of employment before conception; dose during pregnancy. RESULTS: After cases studied by Gardner and colleagues were excluded, fathers of children with leukaemia or non-Hodgkin lymphoma were significantly more likely than fathers of controls to have been radiation workers (relative risk 1.77, 95% confidence interval 1.05 to 3.03) but there was no dose-response relation for any of the exposure periods studied; indeed, the association was greatest for those with doses below the level of detection. No increased risk was found for fathers with a lifetime preconception dose of 100 mSv or more, or with a dose in the 6 months before conception of 10 mSv or more. There was no increased risk for the group of other childhood cancers. Mothers' radiation work was associated with a significant increase of childhood cancer (relative risk 5.00, 1.42 to 26.94; based on 15 cases and 3 controls). Only four of the case mothers and no controls were radiation workers during pregnancy. CONCLUSIONS: These results do not support the hypothesis that paternal preconception irradiation is a cause of childhood leukaemia and non-Hodgkin lymphoma; the observed associations may be chance findings or results from exposure to infective or other agents. If there is any increased risk for the children of fathers who are radiation workers, it is small in absolute terms: in Britain the average risk by age 15 years is 6.5 per 10,000; our best estimate, using all available data, is that the increase is 5.4 per 10,000. For mothers, the numbers are too small for reliable estimates of the risk, if any, to be made.


Asunto(s)
Personal de Salud , Leucemia Inducida por Radiación/etiología , Linfoma no Hodgkin/etiología , Exposición Materna , Neoplasias Inducidas por Radiación/etiología , Reactores Nucleares , Exposición Profesional , Exposición Paterna , Adolescente , Estudios de Casos y Controles , Niño , Preescolar , Relación Dosis-Respuesta en la Radiación , Femenino , Humanos , Lactante , Recién Nacido , Leucemia Inducida por Radiación/epidemiología , Linfoma no Hodgkin/epidemiología , Masculino , Neoplasias Inducidas por Radiación/epidemiología , Embarazo , Factores de Riesgo , Reino Unido/epidemiología
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