[Chemoprevention of colorectal cancer]. / Chemoprewencja raka jelita grubego.

Gastrointestinal cancer poses a major clinical challenge in the developed world where the disease is common. Cancer chemoprevention is defined as the use of natural, synthetic or chemical agents to reverse, suppress or prevent carcinogenic progression to invasive cancer. The success of several clinical trials in preventing cancer in high-risk populations suggests that chemoprevention can be rational strategy. Besides, in population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, folate. Cyclooxygenase-2 inhibitors and NSAIDs reduce the incidence of colonic adenomas. However, these agents are associated with important cardiovascular events and gastrointestinal harms. Contemporary, the balance of benefits to risk does not favor chemoprevention in average-risk individualse.

[Perspectives in inflammatory bowel diseases treatment]. / Perspektywy leczenia nieswoistych chorób zapalnych jelit.

Development in immunology and better understanding of prolonged inflammatory process is basic in inflammatory bowel diseases treatment development. The new generation of drugs could be included infliximab and adalimumab. To the same group we include tumour necrosis factor inhibitors (infliximab, adalimumab, etanercept, certolizumab, onercept), selective adhesive molecules inhibitors (natalizumab, alicaforsen), Th1 dependent reaction inhibitors (anti-il-12, tacrolismus, il-10), lymphocytes migration inhibitors (natalizumab). Those drug are under development or in various clinical trials phases and are the future of inflammatory bowel diseases treatment.

[Dehydroepiandrosterone (DHEA)--slows down the aging process?]. / Dehydroepiandrosteron (DHEA)--opóznia procesy starzenia sie organizmu?

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are secondary adrenal androgens, mainly produced in the reticular layer as well as in the gonads and in the central nervous system. These prohormones influence many functions in human organism, but their most important effect seems to slow down the ageing process. It is well known that the concentrations of both substances are decreasing substantially with age, beginning at 50. According to that fact, they could become the markers of the aging process in human organism. Moreover low concentrations of DHEA and DHEAS are related to the evolution of many usual diseases contracted by older people, above all the diseases of cardiological, neurological, oncological, immunological system and osteoporosis. The influence of the hormones on the aspects above mentioned is present in this article and particularly the influence of DHEAS in the process of evolution the coronary artery disease.