RESUMEN
Ovarian squamous cell carcinoma is a rare malignancy and its occurrence is commonly attributed to malignant transformation of a pre-existing mature cystic teratoma. The de novo occurrence of primary squamous cell carcinoma is extremely rare. Malignant transformation in a mature cystic teratoma is almost always unilateral; however, there have been isolated reports of an uncomplicated mature cystic teratoma in the contralateral ovary. We report here a case of a 40-year-old woman presenting with squamous cell carcinoma of both ovaries with antecedent dermoid cyst in the left ovary, along with involvement of the fallopian tubes, cervix and omentum.
Asunto(s)
Carcinoma de Células Escamosas/patología , Quiste Dermoide/patología , Neoplasias Primarias Secundarias , Neoplasias Ováricas/patología , Adulto , Carcinoma de Células Escamosas/secundario , Neoplasias de las Trompas Uterinas/patología , Neoplasias de las Trompas Uterinas/secundario , Femenino , Humanos , Neoplasias Primarias Secundarias/secundario , Epiplón/patología , Neoplasias Peritoneales/secundario , Teratoma/patología , Neoplasias del Cuello Uterino/secundarioRESUMEN
Myoepithelial lesions of the breast are extremely rare and can present with a diverse morphology. We report a case of malignant myoepithelioma characterized by proliferation of atypical oval to polygonal cells expressing typical myoepithelial markers. A 45-year-old lady presented with a mass in the left breast. Fine needle aspiration yielded a cellular smear with large papillae-like clusters of monomorphic cells with naked nuclei in the background. A diagnosis of sub-areolar sclerosing duct hyperplasia was made on cytology and the patient underwent excision. The surgical specimen showed a grey-white 5x3 cm mass on cut surface. Histopathology revealed mitotically active (5-6 per 10hpf) oval to polygonal cells tumor cells with clear to eosinophilic cytoplasm arranged in the form of nodules separated by dense sclerotic stroma mimicking clear cell or adenoid-cystic carcinoma. A diagnosis of malignant myoepithelioma was made as the cells were CK14 and SMA positive, and negative for ER and PR on immunohistochemistry. We discuss the unusual morphological features of malignant myoepithelioma, cytological findings and the important differential diagnoses of malignant myoepthelial lesions. A high degree of suspicion with a keen eye for morphological details coupled with relevant immunohistochemistry will aid in arriving at the diagnosis.
Asunto(s)
Neoplasias de la Mama/patología , Carcinoma/patología , Mioepitelioma/patología , Biomarcadores de Tumor/análisis , Neoplasias de la Mama/metabolismo , Carcinoma/metabolismo , Femenino , Humanos , Inmunohistoquímica , Persona de Mediana Edad , Mioepitelioma/metabolismoRESUMEN
Tubular adenoma a 'pure adenoma' is a benign neoplasm of breast presenting clinically like fibroadenoma. We report cytological and histological features of tubular adenoma in a 24 year old female with brief review of literature.
Asunto(s)
Adenoma/patología , Neoplasias de la Mama/patología , Adulto , Biopsia con Aguja Fina , Diagnóstico Diferencial , Femenino , Fibroadenoma/patología , Enfermedad Fibroquística de la Mama/patología , HumanosRESUMEN
Squamous epithelium in thyroid is an unusual finding. It is seen in a variety of inflammatory and neoplastic conditions. It's presence has been attributed to metaplastic change of follicular epithelium by some authors and to the persistence of ultimobranchial body by others. We encountered a case of multinodular goiter with groups of squamous cells lining a cystic cavity. We report it because of it's rarity with a brief review of literature.