FATIGUE IN PATIENTS WITH LONG COVID.

Purpose of the study - to characterize the metabolomic profile in patients with fatigue developing within the Long COVID, during dynamic observation. 24 patients diagnosed with U09.9 "Condition after COVID-19 unspecified" were included in a prospective study. Patients were recommended to engage in physical activity, which included moderate aerobic activity such as walking for 45 minutes a day, three days a week. Clinical assessment by scales (Modified Medical Research Council dyspnea scale; 6-minute walk test; Multidimensional fatigue inventory scale; Barthel index), and determination of metabolomic parameters were performed on days 1 and 14-18 of the study. During the observation period, lactate, fumaric acid, symmetrical dimethylarginine, asymmetric dimethylarginine remained above the reference values. The level of adipic acid returns to normal values. As a result of performing physical activity, such as walking, results on the Modified Medical Research Council scale dyspnea scale, Multidimensional fatigue inventory scale, 6 Minutes Walking Test and Barthel Index improve (p<0,001). Metabolic profile of patients with Long COVID demonstrates the complex of abnormalities at 60 days after the onset of the disease. These metabolic changes are point to possible therapeutic targets for specific pathogenetic pharmacotherapy.

[Complex rehabilitation of a patient with marked motor and cognitive impairments after a brain injury]. / Kompleksnaya reabilitatsiya patsienta posle tyazheloi zakrytoi cherepno-mozgovoi travmy s vyrazhennymi dvigatel'nymi i kognitivnymi narusheniyami.

In the presented case report, the complex approach of rehabilitation in the remote period of traumatic brain injury (TBI) allowed the achievement of the significant clinical effect. The authors analyzed the experience of reflex therapy in the treatment of TBI. The effectiveness and potential of acupuncture, objectification of the results are topical issues that require further research.

Cytogenic abnormalities in buccal cells during spinal deformities in children.

Evaluation of the incidence of nucleus abnormalities in buccal epithelium allows detecting the presence and intensity of the effect of various ecological conditions and pathologies of the musculoskeletal system. Two coefficients were used: mean number of NA per cell and ratio of cells with karyolysis to the total number of cells with NA. Coefficient of karyolysis decreases with increasing anthropogenic load In pupils of a special school in Moscow these coefficients were similar. Analysis of coefficients showed that karyolysis coefficient was reduced in mothers of children with spinal deformities.

Complex sorption therapy of locomotor system traumatic suppurative complications.

Complex sorption therapy efficacy in treating 271 patients with suppurative complications of extremity traumas is analyzed. All patients underwent 1-3 enterosorption courses, the wounds were treated with application of sorbents against the background of traditional therapy. In the event of aggravating intoxication, developing first symptoms of sepsic condition, or the desease chronic course 1-5 hemosorption sessions were performed. Clinical and laboratory-instrumental examination demonstrated positive effect of the complex of sorption methods on the patient' general state, temperature curve dynamics, blood indices, microcirculation, function of liver, kidneys, and immune system status. Pathogenic flora stability decreased, wound cleaning and healing was 1.5 times faster. The total therapeutic period was 28% shorter compared to the control group of patients, treated without sorption methods.