Systematic review of functional outcomes and quality of life after transanal endoscopic microsurgery and transanal minimally invasive surgery: a word of caution.

PURPOSE: The introduction of transanal endoscopic or minimally invasive surgery has allowed organ preservation for rectal tumors with good oncological results. Data on functional and quality-of-life (QoL) outcomes are scarce and controversial. This systematic review sought to synthesize fecal continence, QoL, and manometric outcomes after transanal endoscopic microsurgery (TEM) or transanal minimally invasive surgery (TAMIS). METHODS: A systematic review of the literature including Medline, Embase, and the Cochrane Library databases was conducted searching for articles reporting on functional outcomes after TEM or TAMIS between January 1995 and June 2018. The evaluated outcome parameters were pre- and postoperative fecal continence (primary endpoint), QoL, and manometric results. Data were extracted using the same scales and measurement units as from the original study. RESULTS: A total of 29 studies comprising 1297 patients were included. Fecal continence outcomes were evaluated in 23 (79%) studies with a wide variety of assessment tools and divergent results. Ten studies (34%) analyzed QoL changes, and manometric variables were assessed in 15 studies (51%). Most studies reported some deterioration in manometric scores without major QoL impairment. Due to the heterogeneity of the data, it was not possible to perform any pooled analysis or meta-analysis. CONCLUSIONS: These techniques do not seem to affect continence by themselves except in minor cases. The possibility of worsened function after TEM and TAMIS should not be underestimated. There is a need to homogenize or standardize functional and manometric outcomes assessment after TEM or TAMIS.

Pathologic response grade after long-course neoadjuvant chemoradiation does not influence morbidity in locally advanced mid-low rectal cancer resected by laparoscopy.

PURPOSE: Patients with locally advanced rectal cancer and pathologic complete response to neoadjuvant chemoradiation therapy have lower rates of recurrence compared to those who do not. However, the influences of the pathologic response on surgical complications and survival remain unclear. This study aimed to investigate the influence of neoadjuvant therapy for rectal cancer on postoperative morbidity and long-term survival. METHODS: This was a comparative study of consecutive patients who underwent laparoscopic total mesorectal excision for rectal cancer in two European tertiary hospitals between 2004 and 2014. Patients with and without pathologic complete responses were compared in terms of postoperative morbidity, mortality, and survival. RESULTS: Fifty patients with complete response (ypT0N0) were compared with 141 patients who exhibited non-complete response. No group differences were observed in the postoperative mortality or morbidity rates. The median follow-up time was 57 months (range 1-121). Over this period, 11 (5.8 %) patients, all of whom were in the non-complete response group, exhibited local recurrence. The 5-year overall survival and disease-free survival were significantly better in the complete response group, 92.5 vs. 75.3 % (p = 0.004) and 89 vs. 73.4 % (p = 0.002), respectively. CONCLUSIONS: Postoperative complication rate after laparoscopic total mesorectal excision is not associated with the pathologic response grade to neoadjuvant chemoradiation therapy.

Multicentre propensity score-matched analysis of laparoscopic versus open surgery for T4 rectal cancer.

BACKGROUND: The use of laparoscopy for advanced-stage rectal cancer remains controversial. This study aimed to compare the operative and oncologic outcomes of laparoscopic (LAR) versus open anterior rectal resection (OAR) for patients with pT4 rectal cancer. METHODS: This is a multicenter propensity score matching (PSM) study of patients undergoing elective curative-intent LAR or OAR for pT4 rectal cancer (TNM stage II/III/IV) between 2005 and 2015. RESULTS: In total, 137 patients were included in the analysis. After PSM, demographic, clinical and tumor characteristics were similar between the 52 LAR and the 52 OAR patients. Overall, 52 tumors were located in the high rectum, 25 in the mid-rectum and 27 in the low rectum. Multivisceral resection was performed in 26.9% of LAR and 30.8% of OAR patients (p = 0.829). Conversion was required in 11 LAR patients (21.2%). The LAR group showed significantly shorter time to flatus (3.13 vs. 4.97 days, p = 0.001), time to regular diet (3.59 vs. 6.36 days, p < 0.0001) and hospital stay (15.49 vs. 17.96 days, p = 0.002) compared to the OAR group. The 90-day morbidity and mortality were not different between groups. In the majority of patients (85.6%), R0 resection was achieved. A complete mesorectal excision was obtained in 82.7% of LAR and 78.8% of OAR patients (p = 0.855). The 1-, 2- and 3-year overall survival rates were, respectively, 95.6, 73.8 and 66.7% for the LAR group and 86.7, 66.9 and 64.1% for the OAR group (p = 0.219). The presence of synchronous metastases (hazard ratio 2.26), R1 resection (HR 2.71) and lymph node involvement (HR 2.24) were significant predictors of overall survival. CONCLUSION: The present study suggests that LAR for pT4 rectal cancer can achieve good pathologic and oncologic outcomes similar to open surgery despite the risk of conversion. Moreover, laparoscopy offers the benefits of a faster recovery and a shorter hospital stay.

Preventing Parastomal Hernia Using a Modified Sugarbaker Technique With Composite Mesh During Laparoscopic Abdominoperineal Resection: A Randomized Controlled Trial.

OBJECTIVE: The aim of this study was to assess the reduction in the incidence of parastomal hernia (PH) after placement of prophylactic synthetic mesh using a modified Sugarbaker technique when a permanent end-colostomy is needed. SUMMARY OF BACKGROUND DATA: Prevention of PH formation is crucial given the high prevalence of PH and difficulties in the surgical repair of PH. METHODS: A randomized, prospective, double-blind, and controlled trial. Rectal cancer patients undergoing laparoscopic abdominoperineal resection with permanent colostomy were randomized (1 : 1) to the mesh and nonmesh arms. In the mesh group, a large-pore lightweight composite mesh was placed in the intraperitoneal/onlay fashion using a modified Sugarbaker technique. PH was detected by computed tomography (CT) after a minimum follow-up of 12 months. Analysis was per-protocol. RESULTS: The mesh group included 24 patients and the control group 28. Preoperative data, surgical time, and postoperative morbidity were similar. The median follow-up was 26 months. After CT examination, 6 of 24 PHs (25%) were observed in the mesh group compared with 18 of 28 (64.3%) in the nonmesh group (odds ratio 0.39, 95% confidence interval 0.18-0.82; P = 0.005). The Kaplan-Meier curves showed significant differences in favor of the mesh group (long-rank = 4.21, P = 0.04). The number needed to treat was 2.5, which confirmed the effectiveness of the intervention. CONCLUSIONS: Placement of a prosthetic mesh by the laparoscopic approach following the modified Sugarbaker technique is safe and effective in the prevention of PH, reducing significantly the incidence of PH.

Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicenter randomized clinical trial (DIVER Trial).

OBJECTIVE: We compare the results of 2 different strategies for the management of patients with uncomplicated left colonic diverticulitis and to analyze differences in quality of life and economic costs. BACKGROUND: The most frequent standard management of acute uncomplicated diverticulitis still is hospital admission both in Europe and United States. METHODS: This multicenter, randomized controlled trial included patients older than 18 years with acute uncomplicated diverticulitis. All the patients underwent abdominal computed tomography. There were 2 strategies of management: hospitalization (group 1) and outpatient (group 2). The first dose of antibiotic was given intravenously to all patients in the emergency department and then group 1 patients were hospitalized whereas patients in group 2 were discharged. The primary end point was the treatment failure rate of the outpatient protocol and need for hospital admission. The secondary end points included quality-of-life assessment and evaluation of costs. RESULTS: A total of 132 patients were randomized: 4 patients in group 1 and 3 patients in group 2 presented treatment failure without differences between the groups (P=0.619). The overall health care cost per episode was 3 times lower in group 2, with savings of €1124.70 per patient. No differences were observed between the groups in terms of quality of life. CONCLUSIONS: Outpatient treatment is safe and effective in selected patients with uncomplicated acute diverticulitis. Outpatient treatment allows important costs saving to the health systems without negative influence on the quality of life of patients with uncomplicated diverticulitis. Trial registration ID: EudraCT number 2008-008452-17.

Ultralow anterior resection with mechanical anastomosis in the treatment of distal third rectal cancer.

Tumors of the lower third of the rectum are a challenge for the surgeon. Among the various techniques of surgical treatment of these lesions, radical surgery and ultra low anterior anastomosis is one of the therapeutic options. This technique is a defy both in the evaluation of the potential patient as in the surgical technique. Such evaluation and treatment processes must be audited in order to keep proper quality indices both in the oncological as in their functional results. This is only possible when both the multidisciplinary and surgical teams have an adequate and ongoing specialized training and a satisfactory volume of patients treated. Details of this technique, its indications and results are reported in this paper.

Abdominal wall closure after a stomal reversal procedure.

The closure of a temporary stoma involves 2 different surgical procedures: the stoma reversal procedure and the abdominal wall reconstruction of the stoma site. The management of the abdominal wall has different areas that should be analyzed such us how to avoid surgical site infection (SSI), the technique to be used in case of a concomitant hernia at the stoma site or to prevent an incisional hernia in the future, how to deal with the incision when the stoma reversal procedure is performed by laparoscopy and how to close the skin at the stoma site. The aim of this paper is to analyze these aspects in relation to abdominal wall reconstruction during a stoma reversal procedure.

[Post-surgical complications and mortality after two-stage coloanal anastomosis using the Turnbull-Cutait procedure]. / Complicaciones y mortalidad postoperatorias tras anastomosis coloanal en dos tiempos según técnica de Turnbull-Cutait.

INTRODUCTION: As colo-anal anastomoses continue to have a high risk of post-surgical dehiscence it is recommended to combine this with a protective stoma. The main purpose of this study was to determine the post-operative morbidity and mortality rate in patients operated on using the Turnbull-Cutait (T-C) technique with delayed colo-anal anastomosis without a protective ileostomy. MATERIAL AND METHODS: An observational study was conducted on 17 patients. The surgical indication was classified as "primary" (group I), and "secondary" (group II) when rescue was performed due to complications in the short to long-term after rectal resection. The surgical technique consisted of two stages: 1) low anterior resection, circumferential mucosectomy from the pectinate line, pulling the colon through the anal canal; 2) resection of the pull-through segment and colo-anal anastomosis between the fifth and tenth day. Demographic data, associated comorbidities, and ASA score were recorded, as well as post-surgical complications, post-surgical mortality, and technical failure (defined as performing a definitive stoma). RESULTS: The review consisted of 13 patients in group I and 4 in group II. Twelve patients were operated on due to rectal cancer, one patient due to a recto-vesico-vaginal fistula, two due to rescue of early complications (from the Emergency Department), and two were operated due to chronic complications after rectal resection. Six patients (35.3%) had one or more complications, three of them required new surgery. There were no postoperative deaths. CONCLUSIONS: The T-C could be a first option in cancer of the rectum, with no need for a protective ileostomy. It could be an alternative in urgent re-interventions of patients who have rectal surgery complications.

Outcomes of Intra- versus Extra-Corporeal Ileocolic Anastomosis after Minimally Invasive Right Colectomy for Cancer: An Observational Study.

Intracorporeal anastomoses (IA) are increasingly being used in colorectal surgery. Some data suggest that these might confer benefits compared with extracorporeal anastomoses (EA). The aim of this study is to compare the short-term complications associated with IA versus EA for minimally invasive right colectomy. This is a single-centre, retrospective study on a prospective database. Patients who underwent minimally invasive right colectomy for cancer between January 2017 and December 2019 were assessed for inclusion. The primary outcome was global 30-day morbidity. Overall, 189 patients were included, of whom 102 had IA. Global morbidity and medical complications were higher in patients with EA (23.5% vs. 40.2%, p = 0.014; 5.9% vs. 14.9%, p = 0.039, respectively). None of the patients with IA had non-infectious surgical wound complications, compared to 4.6% in the EA group (p = 0.029). No differences were found in anastomotic leakage (9.8% vs. 10.3%, p = 0.55). At multivariable analysis, EA was an independent risk factor for both surgical (OR = 3.71 95% CI: 1.06-12.91, p = 0.04) and overall complications (OR = 3.58 95% CI: 1.06-12.12, p = 0.04). IA lowers the risk for global, medical, and surgical complications with minimum risk for wound complications, without increasing the risk of AL.

Treatment of Fistula-in-ano With OTSC® Proctology Clip Device: Short-term Results. / Tratamiento de la fístula anal mediante clip con el dispositivo OTSC®: resultados a corto plazo.

INTRODUCTION: The treatment of anal fistula with the OTSC® (over-the-scope-clip) proctology device involves the placement of an elastic alloy clip called Nitinol on the internal fistula opening to achieve fistula healing. The aim of this study was to analyze preliminary results of this technique in a case series. METHODS: This was a retrospective analysis of patients who underwent OTSC® clip placement for fistula-in-ano treatment between June 2015 and March 2017 at a specialized colorectal unit. Patients with simple and complex fistulae, either previously treated or not, were included in the study. Both cryptoglandular and stable Crohn's disease fistulae were considered for this approach. Technique failure was determined by the re-appearance of anorectal suppuration or in clip-related complications. RESULTS: Ten patients were treated surgically for anal fistula with a median age of 54 years (range: 41-70years). The etiology of the fistulae was mainly cryptoglandular. Three patients had simple fistulae, whereas seven had complex disease. 80% of the patients had already undergone previous fistula surgery. No events occurred during the procedure. The success rate for healing was 60%, with a median follow-up of 15months (range: 6-26months). Three patients developed suppuration relapse and one patient required clip extraction due to invalidating anal pain. No fecal incontinence was recorded after the procedure. CONCLUSIONS: The treatment of anal fistulae with the OTSC® device is a safe sphincter-saving technique in the short term.

Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia.

BACKGROUND: Optimal elective surgical treatment for splenic flexure neoplasm (SFN) is unclear. Subtotal colectomy (STC) and left hemicolectomy (LHC) are the two more common strategies used. METHODS: Observational multicentric study comparing postoperative morbidity, mortality and long-term survival on patients with SFN electively operated by STC versus LHC between 2003 and 2014. RESULTS: After revision of the databases, 144 patients were included (STC group, n = 68; LHC group, n = 76). No differences were found on epidemiological and surgical data. A higher global morbidity (58%vs37%, p = 0.014), surgical morbidity (50%vs33%, p = 0.037), postoperative ileus (37%vs20%, p = 0.023) and harvested lymph nodes (26vs18, p = 0.0001) were found on the STC group. No significant differences in complications according to severity, reoperation rate, hospital stay, mortality, recurrence or long-term survival were found between groups. CONCLUSIONS: A higher surgical morbidity was found on the STC group, mainly due to mild postoperative ileus. No differences on long-term oncological results were found.

Tratamiento de la fístula anal mediante clip con el dispositivo OTSC(R): resultados a corto plazo / Treatment of Fistula-in-ano With OTSC(R) Proctology Clip Device: Short-term Results

INTRODUCCIÓN: El tratamiento de la fístula anal con el dispositivo OTSC(R)(over-the-scope-clip) consiste en la inserción de un clip de una aleación elástica denominado Nitinol que ejerce una presión constante sobre el orificio fistuloso interno y facilita el cierre de la fístula. El objetivo de este estudio es analizar los resultados a corto plazo de esta técnica en una serie de casos. MÉTODOS: Análisis retrospectivo de una serie de casos intervenidos de cierre de fístula anal entre junio de 2015 y marzo de 2017 tratados en una unidad especializada con el dispositivo OTSC®. Se incluyeron pacientes con fístulas anales simples y complejas, tratadas previamente o sin tratamientos previos, de origen criptoglandular o por enfermedad de Crohn estable. Se consideró fracaso de la técnica a la supuración anal o complicaciones relacionadas con la inserción del clip. RESULTADOS: Se intervino a 10 pacientes con fístula anal con una mediana de edad de 54 años (rango: 41-70 años). Nueve fístulas fueron de origen criptoglandular y una por enfermedad de Crohn controlada. Tres pacientes presentaron fístulas simples y siete, complejas. El 80% de los pacientes habían presentado cirugías anales previas. La tasa de curación de la fístula fue del 60% con un seguimiento mediano de 15 meses (rango: 6-26 meses). Tres pacientes presentaron recidiva clínica y un paciente requirió extracción del clip por dolor invalidante. No hubo aparición de incontinencia fecal. CONCLUSIONES: El tratamiento de la fístula anal con el dispositivo OTSC(R) es una técnica conservadora de esfínteres segura con resultados satisfactorios a corto plazo

INTRODUCTION: The treatment of anal fistula with the OTSC(R) (over-the-scope-clip) proctology device involves the placement of an elastic alloy clip called Nitinol on the internal fistula opening to achieve fistula healing. The aim of this study was to analyze preliminary results of this technique in a case series. METHODS: This was a retrospective analysis of patients who underwent OTSC(R) clip placement for fistula-in-ano treatment between June 2015 and March 2017 at a specialized colorectal unit. Patients with simple and complex fistulae, either previously treated or not, were included in the study. Both cryptoglandular and stable Crohn's disease fistulae were considered for this approach. Technique failure was determined by the re-appearance of anorectal suppuration or in clip-related complications. RESULTS: Ten patients were treated surgically for anal fistula with a median age of 54 years (range: 41-70 years). The etiology of the fistulae was mainly cryptoglandular. Three patients had simple fistulae, whereas seven had complex disease. 80% of the patients had already undergone previous fistula surgery. No events occurred during the procedure. The success rate for healing was 60%, with a median follow-up of 15months (range: 6-26 months). Three patients developed suppuration relapse and one patient required clip extraction due to invalidating anal pain. No fecal incontinence was recorded after the procedure. CONCLUSIONS: The treatment of anal fistulae with the OTSC(R) device is a safe sphincter-saving technique in the short term

Resección anterior ultrabaja con anastomosis mecánica en el tratamiento del cáncer de recto del tercio inferior / Ultralow anterior resection with mechanical anastomosis in the treatment of distal third rectal cancer

Los tumores del tercio inferior de recto son un reto para el cirujano. Entre las diferentes técnicas de tratamiento quirúrgico de estas lesiones se encuentra la cirugía radical y la anastomosis anterior ultrabaja, en la que solamente se conservan los últimos 2 cm hasta la unión anorrectal. Esta técnica constituye un desafío, tanto en la valoración del paciente candidato a esta como en el mismo gesto quirúrgico. Dichos procesos de evaluación y de ejecución deben mantener en las auditorías unos índices de calidad correctos en los resultados oncológicos y funcionales. Esto solo es posible cuando tanto el equipo multidisciplinar como el quirúrgico tienen una formación especializada adecuada y continua y un adecuado volumen de pacientes tratados. En este artículo se exponen los detalles de esta técnica, sus indicaciones y resultados

Tumors of the lower third of the rectum are a challenge for the surgeon. Among the various techniques of surgical treatment of these lesions, radical surgery and ultra low anterior anastomosis is one of the therapeutic options. This technique is a defy both in the evaluation of the potential patient as in the surgical technique. Such evaluation and treatment processes must be audited in order to keep proper quality indices both in the oncological as in their functional results. This is only possible when both the multidisciplinary and surgical teams have an adequate and ongoing specialized training and a satisfactory volume of patients treated. Details of this technique, its indications and results are reported in this paper

Cierre de la pared abdominal después del cierre de un estoma temporal / Abdominal wall closure after a stomal reversal procedure

Revertir un estoma temporal implica 2 procedimientos quirúrgicos diferentes: la reconstrucción del tránsito intestinal y el cierre de la pared abdominal en el sitio del estoma. Este último presenta diferentes aspectos que deben ser analizados: a) la infección del sitio quirúrgico (ISQ), b) el manejo de una hernia coincidente en el sitio del estoma en el momento de su cierre, c) la prevención del desarrollo de una hernia incisional posterior, d) el cierre del estoma en el caso de que se realice la reconstrucción del tránsito por vía laparoscópica, o e) el cierre de la piel del sitio del estoma. El objetivo de este trabajo es analizar estos aspectos en relación con la reconstrucción de la pared abdominal por la que emerge un estoma temporal cuando se procede al cierre de este

The closure of a temporary stoma involves 2 different surgical procedures: the stoma reversal procedure and the abdominal wall reconstruction of the stoma site The management of the abdominal wall has different areas that should be analyzed such us how to avoid surgical site infection (SSI), the technique to be used in case of a concomitant hernia at the stoma site or to prevent an incisional hernia in the future, how to deal with the incision when the stoma reversal procedure is performed by laparoscopy and how to close the skin at the stoma site. The aim of this paper is to analyze these aspects in relation to abdominal wall reconstruction during a stoma reversal procedure

Complicaciones y mortalidad postoperatorias tras anastomosis coloanal en dos tiempos según técnica de Turnbull-Cutait / Post-surgical complications and mortality after two-stage coloanal anastomosis using the Turnbull-Cutait procedure

Introducción Las anastomosis coloanales siguen presentando un alto riesgo de dehiscencia postoperatoria razón por la que se recomienda la asociación de un estoma de protección. El principal objetivo de este estudio fue determinar la tasa de morbimortalidad postoperatoria en pacientes intervenidos según técnica de Turnbull-Cutait (T-C) con anastomosis coloanal diferida sin ileostomía de protección. Material y Método Estudio observacional sobre 17 pacientes. La indicación quirúrgica fue clasificada como «primaria» (grupo I) y «secundaria» (grupo II) cuando se realizó de rescate por complicaciones a corto o largo plazo de resección de recto. La técnica quirúrgica consta de dos tiempos: 1) resección anterior baja, mucosectomía circunferencial desde la línea pectínea, exteriorización del colon por canal anal; 2) sección del segmento exteriorizado y anastomosis coloanal entre el quinto y el décimo día. Se registraron datos demográficos, comorbilidades asociadas, ASA score, complicaciones postoperatorias, mortalidad postoperatoria y fracaso de la técnica, definido como la realización de un estoma definitivo. Resultados Se revisó a 13 pacientes en el grupo I y a 4 en el grupo II. Doce pacientes intervenidos por neoplasia de recto, una paciente por fístula recto-vesico-vaginal, 2 por rescate de complicaciones precoces (de urgencias) y 2 fueron operados por complicaciones crónicas tras resección de recto. Seis pacientes (35,3%) presentaron una o más complicaciones postoperatorias, tres de ellos requirieron reintervención. No hubo mortalidad postoperatoria. Conclusiones La técnica de T-C puede constituir una opción primaria en cáncer de recto sin necesidad de ileostomía de protección. Puede también ser una alternativa en re-intervenciones urgentes de pacientes que presenten complicaciones de cirugía de recto (AU)

Introduction As colo-anal anastomoses continue to have a high risk of post-surgical dehiscence it is recommended to combine this with a protective stoma. The main purpose of this study was to determine the post-operative morbidity and mortality rate in patients operated on using the Turnbull-Cutait (T-C) technique with delayed colo-anal anastomosis without a protective ileostomy. Material and methods An observational study was conducted on 17 patients. The surgical indication was classified as "primary" (group I), and "secondary" (group II) when rescue was performed due to complications in the short to long-term after rectal resection. The surgical technique consisted of two stages: 1) low anterior resection, circumferential mucosectomy from the pectinate line, pulling the colon through the anal canal; 2) resection of the pull-through segment and colo-anal anastomosis between the fifth and tenth day. Demographic data, associated comorbidities, and ASA score were recorded, as well as post-surgical complications, post-surgical mortality, and technical failure (defined as performing a definitive stoma). Results The review consisted of 13 patients in group I and 4 in group II. Twelve patients were operated on due to rectal cancer, one patient due to a recto-vesico-vaginal fistula, two due to rescue of early complications (from the Emergency Department), and two were operated due to chronic complications after rectal resection. Six patients (35.3%) had one or more complications, three of them required new surgery. There were no postoperative deaths. Conclusions The T-C could be a first option in cancer of the rectum, with no need for a protective ileostomy. It could be an alternative in urgent re-interventions of patients who have rectal surgery complications (AU)