Is justice grounded? How expertise shapes conceptual representation of institutional concepts.

Using abstract concepts is a hallmark of human cognition. While multiple kinds of abstract concepts exist, they so far have been conceived as a unitary kind in opposition to concrete ones. Here, we focus on Institutional concepts, like justice or norm, investigating their fine-grained differences with respect to other kinds of abstract and concrete concepts, and exploring whether their representation varies according to individual proficiency. Specifically, we asked experts and non-experts in the legal field to evaluate four kinds of concepts (i.e., institutional, theoretical, food, artefact) on 16 dimensions: abstractness-concreteness; imageability; contextual availability; familiarity; age of acquisition; modality of acquisition; social valence; social metacognition; arousal; valence; interoception; metacognition; perceptual modality strength; body-object interaction; mouth and hand involvement. Results showed that Institutional concepts rely more than other categories on linguistic/social and inner experiences and are primarily characterized by positive valence. In addition, a more subtle characterization of the institutional domain emerged: Pure-institutional concepts (e.g., parliament) were perceived as more similar to technical tools, while Meta-institutional concepts (e.g., validity) were characterized mainly by abstract components. Importantly, for what concerns individual proficiency, we found that the level of expertise affects conceptual representation. Only law-experts associated Institutional concepts with exteroceptive and emotional experiences, showing also a more grounded and situated representation of the two types of institutional concepts. Overall, our finding highlights the richness and flexibility of abstract concepts and suggests that they differ in the degree of embodiment and grounding. Implications of the results for current theories of conceptual representation and social institutions are discussed.

Consensus Paper: Current Perspectives on Abstract Concepts and Future Research Directions.

concepts are relevant to a wide range of disciplines, including cognitive science, linguistics, psychology, cognitive, social, and affective neuroscience, and philosophy. This consensus paper synthesizes the work and views of researchers in the field, discussing current perspectives on theoretical and methodological issues, and recommendations for future research. In this paper, we urge researchers to go beyond the traditional abstract-concrete dichotomy and consider the multiple dimensions that characterize concepts (e.g., sensorimotor experience, social interaction, conceptual metaphor), as well as the mediating influence of linguistic and cultural context on conceptual representations. We also promote the use of interactive methods to investigate both the comprehension and production of abstract concepts, while also focusing on individual differences in conceptual representations. Overall, we argue that abstract concepts should be studied in a more nuanced way that takes into account their complexity and diversity, which should permit us a fuller, more holistic understanding of abstract cognition.

Assessing Interpersonal Proximity Evaluation in the COVID-19 Era: Evidence From the Affective Priming Task.

Social proximity has since ever been evaluated as positive. However, the outbreak of the COVID-19 pandemic has dramatically reduced our social relations to avoid spreading the contagion. The present study aims to investigate people's current assessment of social proximity by using an affective priming paradigm (APP). We hypothesized that if our evaluation of social proximity is positive, then words with positive valence (e.g., relaxed) should be processed faster when preceded by images of social proximity than social distancing. On the contrary, if our evaluation of social proximity is turning negative, then words with a negative valence (e.g., sad) should be processed faster when preceded by images of social proximity than social distancing. To this end, we presented participants with prime images showing line drawings representing humans in situations of proximity or distancing and asked them to evaluate the valence (i.e., positive or negative) of a subsequent target word. In a follow-up session, the same participants evaluated the prime images as being positively or negatively valenced. Results showed that a large subset of participants who rated the prime images of social proximity as positive also processed positive words faster when these were preceded by images of social proximity than social distancing. Conversely, a smaller subset of participants who rated the prime images of social proximity as less positive processed negative words faster when these were preceded by images of social proximity than social distancing. These results suggest individual differences in the assessment of social proximity likely driven by the pandemic.

Abstract and concrete concepts in conversation.

Concepts allow us to make sense of the world. Most evidence on their acquisition and representation comes from studies of single decontextualized words and focuses on the opposition between concrete and abstract concepts (e.g., "bottle" vs. "truth"). A significant step forward in research on concepts consists in investigating them in online interaction during their use. Our study examines linguistic exchanges analyzing the differences between sub-kinds of concepts. Participants were submitted to an online task in which they had to simulate a conversational exchange by responding to sentences involving sub-kinds of concrete (tools, animals, food) and abstract concepts (PS, philosophical-spiritual; EMSS, emotional-social, PSTQ, physical-spatio-temporal-quantitative). We found differences in content: foods evoked interoception; tools and animals elicited materials, spatial, auditive features, confirming their sensorimotor grounding. PS and EMSS yielded inner experiences (e.g., emotions, cognitive states, introspections) and opposed PSTQ, tied to visual properties and concrete agency. More crucially, the various concepts elicited different interactional dynamics: more abstract concepts generated higher uncertainty and more interactive exchanges than concrete ones. Investigating concepts in situated interactions opens new possibilities for studying conceptual knowledge and its pragmatic and social aspects.

Does social distancing affect the processing of brand logos?

Social distancing and isolation have been imposed to contrast the spread of COVID-19. The present study investigates whether social distancing affects our cognitive system, in particular the processing of different types of brand logos in different moments of the pandemic spread in Italy. In a size discrimination task, six different logos belonging to three categories (letters, symbols, and social images) were presented in their original format and spaced. Two samples of participants were tested: one just after the pandemic spread in Italy, the other one after 6 months. Results showed an overall distancing effect (i.e., spaced stimuli are processed slower than original ones) that interacted with the sample, revealing a significant effect only for participants belonging to the second sample. However, both groups showed a distancing effect modulated by the type of logo as it only emerged for social images. Results suggest that social distancing behaviors have been integrated in our cognitive system as they appear to affect our perception of distance when social images are involved.

Wearing the face mask affects our social attention over space.

Recent studies suggest that covering the face inhibits the recognition of identity and emotional expressions. However, it might also make the eyes more salient, since they are a reliable index to orient our social and spatial attention. This study investigates (1) whether the pervasive interaction with people with face masks fostered by the COVID-19 pandemic modulates the processing of spatial information essential to shift attention according to other's eye-gaze direction (i.e., gaze-cueing effect: GCE), and (2) whether this potential modulation interacts with motor responses (i.e., Simon effect). Participants were presented with face cues orienting their gaze to a congruent or incongruent target letter location (gaze-cueing paradigm) while wearing a surgical mask (Mask), a patch (Control), or nothing (No-Mask). The task required to discriminate the identity of the lateralized target letters by pressing one of two lateralized response keys, in a corresponding or a non-corresponding position with respect to the target. Results showed that GCE was not modulated by the presence of the Mask, but it occurred in the No-Mask condition, confirming previous studies. Crucially, the GCE interacted with Simon effect in the Mask and Control conditions, though in different ways. While in the Mask condition the GCE emerged only when target and response positions corresponded (i.e., Simon-corresponding trials), in the Control condition it emerged only when they did not correspond (i.e., Simon-non-corresponding trials). These results indicate that people with face masks induce us to jointly orient our visual attention in the direction of the seen gaze (GCE) in those conditions resembling (or associated with) a general approaching behavior (Simon-corresponding trials). This is likely promoted by the fact that we tend to perceive wearing the mask as a personal safety measure and, thus, someone wearing the face mask is perceived as a trustworthy person. In contrast, people with a patch on their face can be perceived as more threatening, therefore inducing a GCE in those conditions associated with a general avoidance behavior (Simon-non-corresponding trials).

Sensorimotor and interoceptive dimensions in concrete and abstract concepts.

Recent theories propose that abstract concepts, compared to concrete ones, might activate to a larger extent interoceptive, social and linguistic experiences. At the same time, recent research has underlined the importance of investigating how different sub-kinds of abstract concepts are represented. We report a pre-registered experiment, preceded by a pilot study, in which we asked participants to evaluate the difficulty of 3 kinds of concrete concepts (natural objects, tools, and food concepts) and abstract concepts (Philosophical and Spiritual concepts, PS, Physical Space Time and Quantity concepts, PSTQ, and Emotional, Mental State and Social concepts, EMSS). While rating the words, participants were assigned to different conditions designed to interfere with conceptual processing: they were required to squeeze a ball (hand motor system activation), to chew gum (mouth motor system activation), to self-estimate their heartbeats (interoception), and to perform a motor articulatory task (inner speech involvement). In a control condition they simply rated the difficulty of words. A possible interference should result in the increase of the difficulty ratings. Bayesian analyses reveal that, compared to concrete ones, abstract concepts are more grounded in interoceptive experience and concrete concepts less in linguistic experience (mouth motor system involvement), and that the experience on which different kinds of abstract and concrete concepts differs widely. For example, within abstract concepts interoception plays a major role for EMSS and PS concepts, while the ball squeezing condition interferes more for PSTQ concepts, confirming that PSTQ are the most concrete among abstract concepts, and tap into sensorimotor manual experience. Implications of the results for current theories of conceptual representation are discussed.

The Association between Ground Floor Features and Public Open Space Face-To-Face Interactions: Evidence from Nantou Village, Shenzhen.

With face-to-face interaction proving beneficial for mental health, there is still a paucity of research on the correlation between ground floor features (GFFs), defined here as the features of the ground floor of buildings overlooking a street, and public open space face-to-face interaction density (POSFTFID), defined as the density of human face-to-face interactions in the public open space (POS) adjacent to each building. Is there a correlation between GFFs and POSFTFID? This study aims to answer this question gaining empirical evidence from a Chinese village in the city (ViC). Behavioural mapping and statistical analysis were employed and the following GFFs were tested: Ground floor area, indoor visible space, presence of stairs, POS adjacent area, and land use. Results show an association between POSFTFID and: (1) The area of the POS adjacent to each building, (2) the degree of visibility (ratio of indoor visible space to total internal space) of the ground floor, (3) the presence of stairs. Moreover, food appears to be an important attribute fostering social interaction. Results can provide insights on future implications in urban design strategies and planning policies aiming at enhancing mental health conditions in contemporary cities.

Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome.

Mean platelet volume (MPV) has been proposed as a marker of platelet reactivity and cardiovascular risk. Its prognostic significance has not been thoroughly investigated in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). We included 1,041 consecutive patients with NSTE-ACS. Patients were divided in quartiles according to the MPV value on admission (fl) i.e. Q1<7.5; Q2=7.5-8.0; Q3=8.1-8.8; Q4≥8.9. The primary study endpoint was the composite of cardiovascular death and re-myocardial infarction (MI) at one year. Secondary study endpoints were individual cardiovascular death and re-MI. Patients in Q4 were older, had a higher prevalence of previous MI, peripheral artery disease and advanced Killip class compared to patients in Q1-Q3. Elevated MPV levels (Q4) was independently associated with gender, smoking status, platelet count and creatinine level. Overall, 210 patients (20.2%) reached the primary endpoint, 124 (12.1%) died from cardiovascular causes and 125 (12.0%) suffered from re-MI. On multivariable analysis patients in Q4 were at higher risk of primary endpoint (HR=1.41; 95%CI 1.06-1.89; p=0.02) whilst the association with cardiovascular death and re-MI was attenuated. MPV as continuous variable was independently associated with both primary endpoint (HR=1.19; 95%CI 1.06-1.33; p=0.003) and cardiovascular death (HR=1.23; 95%CI 1.06-1.42, p=0.006). The incorporation of MPV into a comprehensive model of risk significantly increased the likelihood ratio chi-square for prediction of both the composite endpoint (p=0.004) and cardiovascular death (p=0.009). Therefore, MPV may be useful to improve risk stratification in NSTE-ACS patients and should be included in future prospective studies evaluating the role of platelet function in promoting cardiovascular events.

Role of (99m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis.

OBJECTIVES: In a cohort of patients with hereditary transthyretin-related amyloidosis (ATTR), we aimed to assess the role of (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) in detecting myocardial amyloid infiltration across a wide spectrum of cardiac involvement and in predicting major adverse cardiac events (MACE). BACKGROUND: Hereditary transthyretin-related amyloidosis is a challenging and underdiagnosed condition where both early diagnosis and prognosis remain problematic. METHODS: We evaluated 63 patients with ATTR: 40 with and 23 without echocardiographically diagnosed amyloidotic cardiomyopathy (AC). Myocardial uptake of (99m)Tc-DPD scintigraphy was semiquantitatively and visually assessed at 5 min and 3 h. RESULTS: All patients with AC showed moderate-to-severe myocardial tracer uptake (i.e., visual score ≥2). Within the subgroup without AC, only 4 patients (with Ala36Pro, Gly47Ala, Thr49Ala, and Glu89Gln transthyretin mutations) showed myocardial tracer uptake and abnormal heart/whole body retention (H/WB) values: in all these cases endomyocardial biopsies showed amyloidotic infiltration. The H/WB was positively correlated with left ventricular (LV) mean wall thickness (Pearson's r=0.695, p<0.001) and negatively with LV ejection fraction (r=-0.368, p=0.004). The H/WB was an unfavorable predictor of MACE-free survival at Cox univariate analysis and contributed to the multivariate model. Notably, LV wall thickness >12 mm in combination with H/WB >7.5 was associated with the highest event rate. CONCLUSIONS: In ATTR, (99m)Tc-DPD scintigraphy can identify myocardial infiltration across a wide spectrum of morphologic/functional cardiac involvement, allowing an early diagnosis of the disease (even before the appearance of echocardiographic abnormalities). The (99m)Tc-DPD myocardial uptake is a prognostic determinant of "cardiac" outcome in ATTR, either alone or in combination with LV wall thickness.

Short- and long-term prognostic significance of ST-segment elevation in lead aVR in patients with non-ST-segment elevation acute coronary syndrome.

We sought to evaluate the prognostic significance of ST-segment elevation (STE) in lead aVR in unselected patients with non-STE acute coronary syndrome (NSTE-ACS). We enrolled 1,042 consecutive patients with NSTE-ACS. Patients were divided into 5 groups according to the following electrocardiographic (ECG) patterns on admission: (1) normal electrocardiogram or no significant ST-T changes, (2) inverted T waves, (3) isolated ST deviation (ST depression [STD] without STE in lead aVR or transient STE), (4) STD plus STE in lead aVR, and (5) ECG confounders (pacing, right or left bundle branch block). The main angiographic end point was left main coronary artery (LM) disease as the culprit artery. Clinical end points were in-hospital and 1-year cardiovascular death defined as the composite of cardiac death, fatal stroke, and fatal bleeding. Prevalence of STD plus STE in lead aVR was 13.4%. Rates of culprit LM disease and in-hospital cardiovascular death were 8.1% and 3.8%, respectively. On multivariable analysis, patients with STD plus STE in lead aVR (group 4) showed an increased risk of culprit LM disease (odds ratio 4.72, 95% confidence interval [CI] 2.31 to 9.64, p <0.001) and in-hospital cardiovascular mortality (odds ratio 5.58, 95% CI 2.35 to 13.24, p <0.001) compared to patients without any ST deviation (pooled groups 1, 2, and 5), whereas patients with isolated ST deviation (group 3) did not. At 1-year follow-up 127 patients (12.2%) died from cardiovascular causes. On multivariable analysis, STD plus STE in lead aVR was a stronger independent predictor of cardiovascular death (hazard ratio 2.29, 95% CI 1.44 to 3.64, p <0.001) than isolated ST deviation (hazard ratio 1.52, 95% CI 0.98 to 2.36, p = 0.06). In conclusion, STD plus STE in lead aVR is associated with high-risk coronary lesions and predicts in-hospital and 1-year cardiovascular deaths in patients with NSTE-ACS. Therefore, this promptly available ECG pattern could be useful to improve risk stratification and management of patients with NSTE-ACS.

[Electrocardiographic diagnosis of acute myocardial infarction in the aera of primary percutaneous coronary intervention and hub and spoke networks]. / La diagnosi elettrocardiografica di infarto miocardico acuto nell'era dell'angioplastica primaria e delle reti hub and spoke.

More than a century after it was invented, standard ECG is enjoying a renaissance of sorts. With regard to acute ischemic heart disease, this phenomenon is due mainly to the availability of large databases that in an ordered and predefined manner collect patient ECG patterns along side their clinical and coronary angiography details as well as outcome data. The present review critically analyses the diagnostic role of standard ECG in acute coronary syndromes with or without ST-segment elevation (STEMI and NSTEMI, respectively) and focuses on interpretation pitfalls and patterns that can contribute to therapeutic decision-making. In front of a patient with a clinical presentation suggestive of acute myocardial infarction the ECG can help answer many questions. In case a STEMI is suspected: are we sure we can exclude an infarction? (the problem of false negatives); are we sure it is a real infarction and not a false positive? Which is the obstructed coronary artery and at what level? Has there been reperfusion? In case an NSTEMI is suspected: are we sure it is a real myocardial infarction, rather than a pulmonary embolism or an aortic dissection? Are we sure it is NSTEMI rather than a "masked" dorsal STEMI? Which coronary substrate and what ischemia extension can we hypothesize in this patient? In particular, is the substrate of such high risk suggesting an emergency invasive approach?