[The rationale for the application of magnetophoresis for the treatment of intra-articular pathology]. / Obosnovanie vozmozhnosti primeneniia magnitoforeza pri patologii sustavov.

The present study was designed to elucidate the influence of the magnetic field on the spectroscopic characteristics of nimesulide and glucosamine sulfate preparations. The secondary objective of the study was to evaluate the clinical effectiveness of the combined application of magnetotherapy and transdermal forms containing a non-steroidal anti-inflammatory preparation and a chondroprotector with the use of magnetophoresis. For this purpose, we analyzed the samples exposed to the running magnetic field in an infrared spectrometer to elucidate the changes in the optical characteristics of the preparations of interest. The clinical effectiveness of the combined application of magnetophoresis was estimated in 83 patients presenting with knee osteoarthritis. The use of the infrared spectroscopic technique in the combination with the Fourier analysis made it possible to visualize the absence of coarse optical defects and structural changes in the test samples under the influence of the physical factors which provides the basis for their physiophoretic administration. The clinical studies conducted with the application of the combined physio-pharmacological treatment have demonstrated the feasibility and high effectiveness of this approach for the management of the patients presenting with articular pathology. The rehabilitative measures accelerated the earlier appearance of the pronounced analgesic effect and promoted the restoration of the joint function. Moreover, they reduced the drug load and improved the quality of life of the patients.

Promising Methods of Antibacterial Finishing of Textile Materials.

A review article, containing information on the options, possibilities, and prospects for the development of antibacterial finishing of textile materials, is presented. A wide range of products designed to impart antibacterial, antimicrobial, and antiviral properties to textile materials is considered. The main factors determining the appropriate decision on the technological and functional choice of the protective composition are presented, including the nature of the fiber-forming polymer, the tasks that the resulting material is designed to solve, and its application options. Compositions providing the required effect of destruction of the pathogenic flora and their application technologies are described. Special attention is paid to antimicrobial agents based on silver nanoparticles. Nanoparticles of this metal have a detrimental effect on antibiotic-resistant strains of bacteria; their effectiveness is higher as compared to a number of well-known antibiotics, for example, penicillin and its analogues. Silver nanoparticles are harmless to the human body. Acting as an inhibitor, they limit the activity of the enzyme responsible for oxygen consumption by single-cell bacteria, viruses, and fungi. In this case, silver ions bind to the outer and inner proteins of the bacterial cell membranes, blocking cellular respiration and reproduction. Various options to apply microencapsulation methods for the implementation of antibacterial finishing are considered, including: phase separation, suspension crosslinking, simple and complex coacervation, spray drying, crystallization from the melt, evaporation of the solvent, co-extrusion, layering, fluidized bed spraying, deposition, emulsion and interphase polymerization, layer-by-layer electrostatic self-assembly etc. All presented technologies are at various development stages-from the laboratory stage to production tests, they all have certain advantages and disadvantages. The accelerated development and implementation of the described methods in production of textile materials is relevant and is related to the existing complex epidemiological situation in the world.