RESUMEN
OBJECTIVE: To analyze safety and efficiency of a subcutaneous figure of eight suture for hemostasis after large caliber venous sheath access in children. BACKGROUND: Vascular complications remain a significant cause of morbidity after pediatric cardiac catheterization. In an attempt to reduce such complications and yet improve lab efficiency and decrease length of stay, various techniques have been applied to improve time to hemostasis. METHODS: Prospectively recorded were vascular complications and hemostasis times in children where hemostasis was attempted using a figure of eight subcutaneous suture following large caliber venous cannulation. These were compared to a matched group achieving hemostasis using standard manual pressure techniques. Vascular ultrasound assessments were performed within 24 hr of hemostasis in both groups. RESULTS: Thirty-two subcutaneous sutures were placed in 26 children, mean weights 31.9 kg [median (range): 29.4 (8.4 to 96) kg], with a mean sheath French size of 9.2 [8; (6 to 22)], 11 >10 French, compared to 33 sheaths in 30 cases using manual compression, mean sheath French size 9.1 (9; (6 to 13), with 10 cases ≥10 French. The mean and median times to hemostasis were shorter in the suture group: 13.6 min (P < 0.05) and 10 min (P < 0.05), respectively. Vascular complication rate was also lower in the suture group (n = 0) compared with the control group (n = 2) but did not achieve statistical significance. CONCLUSIONS: A subcutaneous figure of eight suture hemostasis strategy can provide a safe and efficient method for large caliber venous hemostasis in a pediatric practice with improved hemostasis times and no additional morbidity.
Asunto(s)
Cateterismo Cardíaco/efectos adversos , Vena Femoral , Hemorragia/prevención & control , Técnicas Hemostáticas , Técnicas de Sutura , Adolescente , Factores de Edad , Cateterismo Cardíaco/instrumentación , Catéteres , Niño , Preescolar , Diseño de Equipo , Hemorragia/etiología , Técnicas Hemostáticas/efectos adversos , Humanos , Lactante , Ontario , Presión , Punciones , Estudios Retrospectivos , Técnicas de Sutura/efectos adversos , Resultado del TratamientoRESUMEN
Congenital heart defects (CHD) are very common in patients with trisomy 18 (T18) and trisomy 13 (T13). The surgical indication of CHD remains controversial since the natural history of these trisomies is documented to be poor. To investigate the outcome of CHD in patients with T18 and T13, we collected and evaluated clinical data from 134 patients with T18 and 27 patients with T13 through nationwide network of Japanese Society of Pediatric Cardiology and Cardiac Surgery. In patients with T18, 23 (17%) of 134 were alive at this survey. One hundred twenty-six (94%) of 134 patients had CHDs. The most common CHD was ventricular septal defect (VSD, 59%). Sixty-five (52%) of 126 patients with CHD developed pulmonary hypertension (PH). Thirty-two (25%) of 126 patients with CHD underwent cardiac surgery and 18 patients (56%) have survived beyond postoperative period. While palliative surgery was performed in most patients, six cases (19%) underwent intracardiac repair for VSD. Operated patients survived longer than those who did not have surgery (P < 0.01). In patients with T13, 5 (19%) of 27 patients were alive during study period. Twenty-three (85%) of 27 patients had CHD and 13 (57%) of 27 patients had PH. Atrial septal defect was the most common form of CHD (22%). Cardiac surgery was done in 6 (26%) of 23 patients. In this study, approximately a quarter of patients underwent surgery for CHD in both trisomies. Cardiac surgery may improve survival in selected patients with T18.
Asunto(s)
Trastornos de los Cromosomas/genética , Cromosomas Humanos Par 18/genética , Cardiopatías Congénitas/genética , Trisomía/genética , Adolescente , Niño , Preescolar , Trastornos de los Cromosomas/epidemiología , Trastornos de los Cromosomas/mortalidad , Trastornos de los Cromosomas/terapia , Cromosomas Humanos Par 13/genética , Femenino , Edad Gestacional , Cardiopatías Congénitas/epidemiología , Cardiopatías Congénitas/mortalidad , Cardiopatías Congénitas/cirugía , Defectos del Tabique Interventricular/epidemiología , Defectos del Tabique Interventricular/genética , Defectos del Tabique Interventricular/mortalidad , Defectos del Tabique Interventricular/cirugía , Humanos , Lactante , Japón/epidemiología , Estimación de Kaplan-Meier , Masculino , Edad Materna , Edad Paterna , Encuestas y Cuestionarios , Procedimientos Quirúrgicos Torácicos/métodos , Procedimientos Quirúrgicos Torácicos/estadística & datos numéricos , Resultado del Tratamiento , Síndrome de la Trisomía 13 , Adulto JovenRESUMEN
BACKGROUND: Femoral venous and arterial approaches are the commonly used to obtain vascular access for pediatric cardiac catheterization. Hemostasis after catheter removal is usually obtained by manual compression. However, this technique is time consuming and at times painful. Although several closure devices are available for adults, they are not widely applicable in children. OBJECTIVES: To evaluate the safety and efficacy of a microporous polysaccharide hemospheres hemostasis (MPH) bandage compared to manual compression. METHODS: Prospective randomized study, involving 112 children after cardiac catheterization. One group received the MPH bandage, another manual compression. Compression time was predetermined by the size of sheath plus one minute. Success was defined as no bleeding or hematoma formation. If bleeding continued, compression was continued as needed and time to hemostasis recorded. Informed consent was obtained prior to randomization. Group comparisons were performed with a Student's t, Pearson's Chi Square, and Fisher's exact test as appropriate. RESULTS: Fewer children required a compression time of >15 min (P = 0.006) and more had a shorter time to hemostasis (P = 0.003) in the MPH group for venous access control. Time to hemostasis was also shorter in the MPH (P = 0.048) in arterial access cases, but the number of children requiring a compression time >15 min was the same. Complications including hematoma formation in each group were similar. CONCLUSIONS: The MPH bandage allows a shorter time to achieve hemostasis compared to manual compression. This improves turnaround time and laboratory efficiency.
Asunto(s)
Vendajes , Cateterismo Cardíaco/efectos adversos , Arteria Femoral , Vena Femoral , Hemorragia/prevención & control , Técnicas Hemostáticas/instrumentación , Hemostáticos/uso terapéutico , Almidón/uso terapéutico , Adolescente , Distribución de Chi-Cuadrado , Niño , Preescolar , Diseño de Equipo , Femenino , Hematoma/etiología , Hematoma/prevención & control , Hemorragia/etiología , Técnicas Hemostáticas/efectos adversos , Hemostáticos/efectos adversos , Humanos , Lactante , Masculino , Ontario , Presión , Estudios Prospectivos , Punciones , Almidón/efectos adversos , Factores de Tiempo , Resultado del TratamientoRESUMEN
BACKGROUND: The effect of carvedilol on heart failure (HF) in patients with a functionally univentricular heart (UVH) remains unclear. METHODS AND RESULTS: Carvedilol was used to treat HF in 51 patients with a UVH, classified into 3 groups: after the Fontan operation (F), after the bidirectional Glenn operation (G), and patients who had not undergone Fontan or Glenn operation (NF). Carvedilol therapy was started at a mean age of 10 ± 12 years (range: 1 month to 34 years). The initial and maximum doses of carvedilol were 0.04 ± 0.03 and 0.42 ± 0.29 mg · kg(-1) · day(-1), respectively. After a mean follow-up of 11 months, the cardiothoracic ratio improved from 60 ± 8 to 58 ± 8% (P<0.01), and the dosage of furosemide was reduced from 1.4 ± 0.9 to 0.7 ± 0.7 mg · kg(-1) · day(-1) (P < 0.01). The ejection fraction also improved from 35 ± 12 to 40 ± 11% (P < 0.05), and this improvement was prominent in the F group (from 35 ± 15 to 45 ± 9%; P < 0.05). Clinical signs, symptoms, and New York Heart Association functional class also improved. CONCLUSIONS: Carvedilol may play an important role in treating HF associated with a UVH.
Asunto(s)
Antagonistas de Receptores Adrenérgicos alfa 1/uso terapéutico , Carbazoles/uso terapéutico , Cardiopatías Congénitas/tratamiento farmacológico , Insuficiencia Cardíaca/tratamiento farmacológico , Propanolaminas/uso terapéutico , Función Ventricular Izquierda/efectos de los fármacos , Función Ventricular Derecha/efectos de los fármacos , Adolescente , Adulto , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antiarrítmicos/uso terapéutico , Carvedilol , Niño , Preescolar , Quimioterapia Combinada , Femenino , Procedimiento de Fontan/efectos adversos , Cardiopatías Congénitas/complicaciones , Cardiopatías Congénitas/fisiopatología , Cardiopatías Congénitas/cirugía , Insuficiencia Cardíaca/etiología , Insuficiencia Cardíaca/fisiopatología , Humanos , Lactante , Japón , Masculino , Recuperación de la Función , Estudios Retrospectivos , Volumen Sistólico/efectos de los fármacos , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: The Windkessel model, proposed in 1895 by O. Frank, successfully explained systemic and abnormal pulmonary hemodynamics of congenital cardiac defects. The model is essentially a functional one and describes only hemodynamics, not anatomical or geographic structures. Because pulmonary arterial banding (PAB) adds a substantial resistance proximal to arterioles, it provides an ideal anatomical structure of the Windkessel model, namely, an elastic reservoir of much dilated main pulmonary artery (mPA) followed by a substantial artificial resistance of banding. METHODS: The pulmonary artery (PA) Windkessel size (WS) of 10 patients, several months to years after PAB, were estimated both in peak systole (WSs) and minimum diastole (WSd), as the product of Windkessel compliance and proximal to distal pulmonary arterial pressure difference at each cardiac phase. They were compared to cineangiogram-determined corresponding volumes (Vs, Vd) of PA proximal to the band or mPA. RESULT: WSs and WSd correlated well with Vs and Vd, respectively, with the correlation coefficient of 0.91 and 0.62, indicating that the Windkessel in these patients corresponds to mPA. Among five patients whose resistance at the band comprised more than half of the whole PA resistance, the coefficients proved even better. CONCLUSION: Much bigger secondarily developed Windkessel, as placed proximal to the band on top of a substantial resistance at PAB, contributed much to alleviate the stress downstream at the periphery caused by greatly increased systolic stroke volume into mPA in these cardiac defects.
Asunto(s)
Cardiopatías Congénitas/cirugía , Arteria Pulmonar/fisiopatología , Arteria Pulmonar/cirugía , Niño , Preescolar , Femenino , Cardiopatías Congénitas/fisiopatología , Humanos , Lactante , Masculino , Modelos CardiovascularesRESUMEN
BACKGROUND: Large-shunt ventricular septal defect (VSD) infants manifest varied serious symptoms resulting from peripheral arterial constriction to compensate for increased pulmonary blood flow (Qp) and concomitantly decreased systemic blood flow (Qs). The aim of the present paper was therefore to estimate the whole arterial space proximal to arterioles as the systemic Windkessel size (WS) in these infants and compare it with aortic volume (AV) estimated angiographically. METHOD: Subjects were divided into three groups. Group 1a consisted of the so-called balanced-pressure VSD infants; group 1b consisted of those with normal or moderately increased pulmonary artery pressure (PAP) and highly augmented Qp; and group 2 consisted of those with a history of mucocutaneous lymph node syndrome as controls for Qp and pulmonary artery pressure. WS was computed from the Windkessel model, while the AV was calculated from the angiogram. Maximal systolic (WSs), mean (WSm), and minimum diastolic (WSd) WS were defined, computed, and compared. RESULT: All WS were significantly smaller in group 1a; those of group 1b were between group 1a and group 2, with Qs-dependent reduction of WS throughout all these three groups. WSs, WSm, and WSd had negative correlations with right ventricular systolic pressure/left ventricular systolic pressure in group 1a and group 1b. WSm, or the time averaged size, proved to be larger than the corresponding AV in all patients. The ratio of WSm/AV was significantly reduced in group 1a compared to group 1b and group 2, indicating that systemic arterial Windkessel space in severe VSD infants is significantly small, especially so in terms of space distal to aortic valve and proximal to arterioles. CONCLUSION: In severe VSD infants the whole systemic arterial space proximal to arterioles (WS) is reduced in size according to severity.