Asunto(s)
Antidepresivos/uso terapéutico , Ciclohexanoles/uso terapéutico , Trastorno Depresivo Mayor/sangre , Trastorno Depresivo Mayor/tratamiento farmacológico , Mianserina/análogos & derivados , Adulto , Anciano , Análisis de Varianza , Femenino , Humanos , Masculino , Mianserina/uso terapéutico , Persona de Mediana Edad , Mirtazapina , Recuento de Plaquetas , Escalas de Valoración Psiquiátrica , Clorhidrato de VenlafaxinaAsunto(s)
Antidepresivos de Segunda Generación/uso terapéutico , Antidepresivos Tricíclicos/uso terapéutico , Ciclohexanoles/uso terapéutico , Trastorno Depresivo Mayor/sangre , Trastorno Depresivo Mayor/tratamiento farmacológico , Mianserina/análogos & derivados , Proteínas Plasmáticas de Unión al Retinol/metabolismo , Adulto , Anciano , Antidepresivos de Segunda Generación/efectos adversos , Antidepresivos Tricíclicos/efectos adversos , Estudios Transversales , Ciclohexanoles/efectos adversos , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/psicología , Femenino , Humanos , Masculino , Mianserina/efectos adversos , Mianserina/uso terapéutico , Persona de Mediana Edad , Mirtazapina , Clorhidrato de VenlafaxinaRESUMEN
INTRODUCTION: The present study was designed to test the hypothesis that total and free insulin-like growth factor-I (IGF-I) serum concentrations in depressed patients are related to hypothalamus-pituitary-adrenal (HPA) system activity and show a longitudinal decline in patients responding to treatment as well as to declining HPA system activity. METHODS: We measured total and free IGF-I as well as IGF-binding protein-3 in 77 depressed patients after wash-out of pre-medication and again after 28 or 35 days of treatment with paroxetine or amitriptyline. RESULTS: Total but not free IGF-I serum concentrations are related to saliva cortisol concentrations in drug-free depressed patients. In responders to both amitriptyline and paroxetine, total IGF-I serum concentrations declined during treatment. DISCUSSION: Our findings show IGF-I to be related to HPA system activity and to decline in responders to treatment while serum concentrations of the biologically active free IGF-I are neither related to HPA system activity nor do they change during the course of treatment. Our data do not support the hypothesis that free IGF-I may play a major role in physical disturbances in depressed patients.