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1.
Nature ; 585(7826): 545-550, 2020 09.
Artículo en Inglés | MEDLINE | ID: mdl-32968258

RESUMEN

To constrain global warming, we must strongly curtail greenhouse gas emissions and capture excess atmospheric carbon dioxide1,2. Regrowing natural forests is a prominent strategy for capturing additional carbon3, but accurate assessments of its potential are limited by uncertainty and variability in carbon accumulation rates2,3. To assess why and where rates differ, here we compile 13,112 georeferenced measurements of carbon accumulation. Climatic factors explain variation in rates better than land-use history, so we combine the field measurements with 66 environmental covariate layers to create a global, one-kilometre-resolution map of potential aboveground carbon accumulation rates for the first 30 years of natural forest regrowth. This map shows over 100-fold variation in rates across the globe, and indicates that default rates from the Intergovernmental Panel on Climate Change (IPCC)4,5 may underestimate aboveground carbon accumulation rates by 32 per cent on average and do not capture eight-fold variation within ecozones. Conversely, we conclude that maximum climate mitigation potential from natural forest regrowth is 11 per cent lower than previously reported3 owing to the use of overly high rates for the location of potential new forest. Although our data compilation includes more studies and sites than previous efforts, our results depend on data availability, which is concentrated in ten countries, and data quality, which varies across studies. However, the plots cover most of the environmental conditions across the areas for which we predicted carbon accumulation rates (except for northern Africa and northeast Asia). We therefore provide a robust and globally consistent tool for assessing natural forest regrowth as a climate mitigation strategy.


Asunto(s)
Secuestro de Carbono , Carbono/metabolismo , Agricultura Forestal/estadística & datos numéricos , Agricultura Forestal/tendencias , Bosques , Mapeo Geográfico , Árboles/crecimiento & desarrollo , Árboles/metabolismo , Conservación de los Recursos Naturales , Recolección de Datos , Restauración y Remediación Ambiental , Calentamiento Global/prevención & control , Internacionalidad , Cinética
2.
Aging Ment Health ; 28(8): 1078-1089, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38850259

RESUMEN

OBJECTIVES: Post-diagnostic support is a significant factor in facilitating personal recovery following a diagnosis of dementia, but access is often inconsistent and insufficient. Recovery Colleges offer peer-led, co-produced courses that can support people to have meaningful lives and have been adapted for use in the context of dementia. A realist review was conducted to understand the application and sustainability of Recovery College dementia courses. METHOD: An iterative, five-step process combined literature published to 2023 with knowledge from stakeholders with lived and professional experience of dementia involved with Recovery College dementia courses (PROSPERO registration CRD42021293687). RESULTS: Thirty-five documents and discussions with 19 stakeholders were used to build the initial programme theory comprising of 24 context-mechanism-outcome configurations. Reoccurring factors included: attending to aspects of co-production and course delivery to ensure they promoted inclusion and were not compromised by organisational pressures; how stigma impacted access to course opportunities; and embedding personal recovery principles throughout course development to be relevant for people living with dementia and those who support them. CONCLUSION: People struggling to reconcile their future alongside dementia need practical and emotional support to access and benefit from Recovery College dementia courses, ways to achieve this will be explored through a realist evaluation.


Asunto(s)
Demencia , Humanos
3.
Neuropsychol Rehabil ; : 1-33, 2024 Apr 12.
Artículo en Inglés | MEDLINE | ID: mdl-38605647

RESUMEN

Unilateral visual neglect is a condition that negatively impacts the lives of many stroke survivors. Studies have investigated different forms of vestibular stimulation as a potential therapy, but evidence is yet to be systematically reviewed. We therefore reviewed the effects of vestibular stimulation on outcomes of neglect and activities of daily living (ADL) for people with visual neglect. We searched relevant databases up until September 2022. Eligible articles included any form of vestibular stimulation, study design, or control condition. Included participants were 18 years or older, presenting with neglect following a haemorrhagic or ischaemic stroke. Relevant outcomes were clinically validated measures of neglect and ADL. Cochrane risk of bias tools were used to assess study quality. Meta-analyses and narrative methods were used to synthesize the data. Our search returned 17 relevant studies comprising 180 participants. Meta-analyses showed no difference between galvanic vestibular stimulation and sham conditions on outcomes, whereas caloric vestibular stimulation led to improvement compared to pre-stimulation scores. Narrative syntheses showed mixed results. Clinical and methodological heterogeneity was found both within and between studies. Overall, results were inconsistent regarding the effects of vestibular stimulation as a treatment for neglect. Further trials are warranted but require more careful methodological planning.

6.
Med Mycol ; 57(Supplement_1): S30-S40, 2019 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-30690599

RESUMEN

The incidence of reported coccidioidomycosis in the past two decades has increased greatly; monitoring its changing epidemiology is essential for understanding its burden on patients and the healthcare system and for identifying opportunities for prevention and education. We provide an update on recent coccidioidomycosis trends and public health efforts nationally and in Arizona, California, and Washington State. In Arizona, enhanced surveillance shows that coccidioidomycosis continues to be associated with substantial morbidity. California reported its highest yearly number of cases ever in 2016 and has implemented interventions to reduce coccidioidomycosis in the prison population by excluding certain inmates from residing in prisons in high-risk areas. Coccidioidomycosis is emerging in Washington State, where phylogenetic analyses confirm the existence of a unique Coccidioides clade. Additional studies of the molecular epidemiology of Coccidioides will improve understanding its expanding endemic range. Ongoing public health collaborations and future research priorities are focused on characterizing geographic risk, particularly in the context of environmental change; identifying further risk reduction strategies for high-risk groups; and improving reporting of cases to public health agencies.


Asunto(s)
Coccidioides/aislamiento & purificación , Coccidioidomicosis/epidemiología , Coccidioidomicosis/prevención & control , Arizona/epidemiología , California/epidemiología , Coccidioides/genética , Humanos , Incidencia , Filogenia , Prisioneros , Salud Pública , Factores de Riesgo , Estados Unidos/epidemiología , Washingtón/epidemiología
7.
MMWR Morb Mortal Wkly Rep ; 65(7): 178-81, 2016 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-26914322

RESUMEN

Early diagnosis of human immunodeficiency virus (HIV) infection and initiation of antiretroviral treatment (ART) improves health outcomes and prevents HIV transmission. Before 2010, HIV testing was available to inmates in the California state prison system upon request. In 2010, the California Correctional Health Care Services (CCHCS) integrated HIV opt-out screening into the health assessment for inmates entering California state prisons. Under this system, a medical care provider informs the inmate that an HIV test is routinely done, along with screening for sexually transmitted, communicable, and vaccine-preventable diseases, unless the inmate specifically declines the test. During 2012-2013, CCHCS, the California Department of Public Health, and CDC evaluated HIV screening, rates of new diagnoses, linkage to and retention in care, ART response, and post-release linkage to care among California prison inmates. All prison inmates are processed through one of eight specialized reception center facilities, where they undergo a comprehensive evaluation of their medical needs, mental health, and custody requirements for placement in one of 35 state prisons. Among 17,436 inmates who entered a reception center during April-September 2012, 77% were screened for HIV infection; 135 (1%) tested positive, including 10 (0.1%) with newly diagnosed infections. Among the 135 HIV-positive patient-inmates, 134 (99%) were linked to care within 90 days of diagnosis, including 122 (91%) who initiated ART. Among 83 who initiated ART and remained incarcerated through July 2013, 81 (98%) continued ART; 71 (88%) achieved viral suppression (<200 HIV RNA copies/mL). Thirty-nine patient-inmates were released on ART; 12 of 14 who were linked to care within 30 days of release were virally suppressed at that time. Only one of nine persons with a viral load test conducted between 91 days and 1 year post-release had viral suppression. Although high rates of viral suppression were achieved in prison, continuity of care in the community remains a challenge. An infrastructure for post-release linkage to care is needed to help ensure sustained HIV disease control.


Asunto(s)
Continuidad de la Atención al Paciente/estadística & datos numéricos , Infecciones por VIH/diagnóstico , Infecciones por VIH/tratamiento farmacológico , Tamizaje Masivo/estadística & datos numéricos , Prisioneros , Terapia Antirretroviral Altamente Activa/estadística & datos numéricos , Recuento de Linfocito CD4/estadística & datos numéricos , California , Femenino , Investigación sobre Servicios de Salud , Humanos , Masculino , Prisioneros/estadística & datos numéricos , Prisiones/estadística & datos numéricos , Carga Viral/estadística & datos numéricos
8.
Med Mycol ; 54(3): 318-21, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26705838

RESUMEN

Bipolaris mould surgical site infections (SSIs) are exceedingly rare. We describe 21 cases of Bipolaris SSIs in pediatric and adult cardiothoracic surgery patients at ten hospitals in Texas, Arkansas, and Florida during 2008-2013. Median case-patient age was 55 years (range: 3 days-82 years), and 19 (90%) were male. Ten (48%) had coronary artery bypass or valve surgery, and seven (33%) had heart transplantation. Fifteen (71%) had more than one cardiothoracic procedure (median: 3, range: 1-11). Thirteen (62%) case-patients (all 5 pediatric patients, and 8 (50%) of 16 adult patients) had delayed sternal closure (chest closed >1 day [median = 8 days; range: 2-22] following the initial cardiothoracic procedure). Thirteen (62%) had mediastinitis. Median time from initial surgery to positive Bipolaris culture was 20 days (range: 6-497). Sixteen (76%) case-patients died.


Asunto(s)
Ascomicetos/aislamiento & purificación , Feohifomicosis/patología , Infección de la Herida Quirúrgica/patología , Procedimientos Quirúrgicos Torácicos/efectos adversos , Adolescente , Adulto , Distribución por Edad , Anciano , Arkansas/epidemiología , Niño , Preescolar , Femenino , Florida/epidemiología , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Feohifomicosis/epidemiología , Feohifomicosis/microbiología , Distribución por Sexo , Infección de la Herida Quirúrgica/epidemiología , Infección de la Herida Quirúrgica/microbiología , Análisis de Supervivencia , Texas/epidemiología , Adulto Joven
9.
Emerg Infect Dis ; 21(1): 70-5, 2015 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25533149

RESUMEN

In California, coccidioidomycosis is a disease acquired by inhaling spores of Coccidioides immitis, a fungus found in certain arid regions, including the San Joaquin Valley, California, USA, where 8 state prisons are located. During 2011, we reviewed coccidioidomycosis rates at 2 of the prisons that consistently report >80% of California's inmate cases and determined inmate risk factors for primary, severe (defined as pulmonary coccidioidomycosis requiring >10 hospital days), and disseminated coccidioidomycosis (defined by hospital discharge International Classification of Disease, Ninth Revision code). Inmates of African American ethnicity who were >40 years of age were at significantly higher risk for primary coccidioidomycosis than their white counterparts (odds ratio = 2.0, 95% CI 1.5-2.8). Diabetes was a risk factor for severe pulmonary coccidioidomycosis, and black race a risk factor for disseminated disease. These findings contributed to a court decision mandating exclusion of black inmates and inmates with diabetes from the 2 California prisons with the highest rates of coccidioidomycosis.


Asunto(s)
Coccidioidomicosis/epidemiología , Prisioneros , Adolescente , Adulto , Negro o Afroamericano , Anciano , Anciano de 80 o más Años , California/epidemiología , Hispánicos o Latinos , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto Joven
10.
Glob Chang Biol ; 20(7): 2162-72, 2014 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-24764180

RESUMEN

With the rapidly expanding ecological footprint of agriculture, the design of farmed landscapes will play an increasingly important role for both carbon storage and biodiversity protection. Carbon and biodiversity can be enhanced by integrating natural habitats into agricultural lands, but a key question is whether benefits are maximized by including many small features throughout the landscape ('land-sharing' agriculture) or a few large contiguous blocks alongside intensive farmland ('land-sparing' agriculture). In this study, we are the first to integrate carbon storage alongside multi-taxa biodiversity assessments to compare land-sparing and land-sharing frameworks. We do so by sampling carbon stocks and biodiversity (birds and dung beetles) in landscapes containing agriculture and forest within the Colombian Chocó-Andes, a zone of high global conservation priority. We show that woodland fragments embedded within a matrix of cattle pasture hold less carbon per unit area than contiguous primary or advanced secondary forests (>15 years). Farmland sites also support less diverse bird and dung beetle communities than contiguous forests, even when farmland retains high levels of woodland habitat cover. Landscape simulations based on these data suggest that land-sparing strategies would be more beneficial for both carbon storage and biodiversity than land-sharing strategies across a range of production levels. Biodiversity benefits of land-sparing are predicted to be similar whether spared lands protect primary or advanced secondary forests, owing to the close similarity of bird and dung beetle communities between the two forest classes. Land-sparing schemes that encourage the protection and regeneration of natural forest blocks thus provide a synergy between carbon and biodiversity conservation, and represent a promising strategy for reducing the negative impacts of agriculture on tropical ecosystems. However, further studies examining a wider range of ecosystem services will be necessary to fully understand the links between land-allocation strategies and long-term ecosystem service provision.


Asunto(s)
Biodiversidad , Aves/fisiología , Secuestro de Carbono , Escarabajos/fisiología , Conservación de los Recursos Naturales/métodos , Agricultura , Animales , Bosques , Modelos Teóricos , Clima Tropical
11.
Sci Data ; 11(1): 287, 2024 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-38467652

RESUMEN

The forest area of China is the fifth largest of any country, and unlike in many other countries, in recent decades its area has been increasing. However, there are substantial differences in estimates of the amount of carbon this forest contains, ranging from 3.92 to 17.02 Pg C for circa 2007. This makes it unclear how the changes in China's forest area contribute to the global carbon cycle. We generate a circa 2007 aboveground biomass (AGB) map at a resolution of 50 m using optical, radar and LiDAR satellite data. Our estimates of total carbon stored in the forest in China was 9.52 Pg C, with an average forest AGB of 104 Mg ha-1. Compared with three existing AGB maps, our AGB map showed better correlation with a distributed set of forest inventory plots. In addition, our high resolution AGB map provided more details on spatial distribution of forest AGB, and is likely to help understand the carbon storage changes in China's forest.


Asunto(s)
Biomasa , Monitoreo del Ambiente , Bosques , Carbono , China , Árboles
12.
Philos Trans R Soc Lond B Biol Sci ; 378(1867): 20210090, 2023 01 02.
Artículo en Inglés | MEDLINE | ID: mdl-36373930

RESUMEN

Current policy is driving renewed impetus to restore forests to return ecological function, protect species, sequester carbon and secure livelihoods. Here we assess the contribution of tree planting to ecosystem restoration in tropical and sub-tropical Asia; we synthesize evidence on mortality and growth of planted trees at 176 sites and assess structural and biodiversity recovery of co-located actively restored and naturally regenerating forest plots. Mean mortality of planted trees was 18% 1 year after planting, increasing to 44% after 5 years. Mortality varied strongly by site and was typically ca 20% higher in open areas than degraded forest, with height at planting positively affecting survival. Size-standardized growth rates were negatively related to species-level wood density in degraded forest and plantations enrichment settings. Based on community-level data from 11 landscapes, active restoration resulted in faster accumulation of tree basal area and structural properties were closer to old-growth reference sites, relative to natural regeneration, but tree species richness did not differ. High variability in outcomes across sites indicates that planting for restoration is potentially rewarding but risky and context-dependent. Restoration projects must prepare for and manage commonly occurring challenges and align with efforts to protect and reconnect remaining forest areas. The abstract of this article is available in Bahasa Indonesia in the electronic supplementary material. This article is part of the theme issue 'Understanding forest landscape restoration: reinforcing scientific foundations for the UN Decade on Ecosystem Restoration'.


Asunto(s)
Ecosistema , Clima Tropical , Biodiversidad , Plantas , Asia
13.
Clin Infect Dis ; 55(1): 61-6, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22423132

RESUMEN

BACKGROUND: Fifty-four outbreaks of domestically acquired typhoid fever were reported between 1960 and 1999. In 2010, the Southern Nevada Health District detected an outbreak of typhoid fever among persons who had not recently travelled abroad. METHODS: We conducted a case-control study to examine the relationship between illness and exposures. A case was defined as illness with the outbreak strain of Salmonella serotype Typhi, as determined by pulsed-field gel electrophoresis (PFGE), with onset during 2010. Controls were matched by neighborhood, age, and sex. Bivariate and multivariate statistical analyses were completed using logistic regression. Traceback investigation was completed. RESULTS: We identified 12 cases in 3 states with onset from 15 April 2010 to 4 September 2010. The median age of case patients was 18 years (range, 4-48 years), 8 (67%) were female, and 11 (92%) were Hispanic. Nine (82%) were hospitalized; none died. Consumption of frozen mamey pulp in a fruit shake was reported by 6 of 8 case patients (75%) and none of the 33 controls (matched odds ratio, 33.9; 95% confidence interval, 4.9). Traceback investigations implicated 2 brands of frozen mamey pulp from a single manufacturer in Guatemala, which was also implicated in a 1998-1999 outbreak of typhoid fever in Florida. CONCLUSIONS: Reporting of individual cases of typhoid fever and subtyping of isolates by PFGE resulted in rapid detection of an outbreak associated with a ready-to-eat frozen food imported from a typhoid-endemic region. Improvements in food manufacturing practices and monitoring will prevent additional outbreaks.


Asunto(s)
Frutas/microbiología , Mammea/inmunología , Salmonella typhi/aislamiento & purificación , Fiebre Tifoidea/epidemiología , Adolescente , Adulto , Bebidas/microbiología , California/epidemiología , Estudios de Casos y Controles , Niño , Preescolar , Trazado de Contacto , Brotes de Enfermedades , Femenino , Microbiología de Alimentos , Guatemala , Hispánicos o Latinos , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Nevada/epidemiología , Oregon/epidemiología , Factores de Riesgo , Salmonella typhi/clasificación , Salmonella typhi/genética , Encuestas y Cuestionarios , Fiebre Tifoidea/etnología , Fiebre Tifoidea/microbiología
14.
Carbon Balance Manag ; 15(1): 15, 2020 Jul 29.
Artículo en Inglés | MEDLINE | ID: mdl-32729000

RESUMEN

BACKGROUND: Reliable information about the spatial distribution of aboveground biomass (AGB) in tropical forests is fundamental for climate change mitigation and for maintaining carbon stocks. Recent AGB maps at continental and national scales have shown large uncertainties, particularly in tropical areas with high AGB values. Errors in AGB maps are linked to the quality of plot data used to calibrate remote sensing products, and the ability of radar data to map high AGB forest. Here we suggest an approach to improve the accuracy of AGB maps and test this approach with a case study of the tropical forests of the Yucatan peninsula, where the accuracy of AGB mapping is lower than other forest types in Mexico. To reduce the errors in field data, National Forest Inventory (NFI) plots were corrected to consider small trees. Temporal differences between NFI plots and imagery acquisition were addressed by considering biomass changes over time. To overcome issues related to saturation of radar backscatter, we incorporate radar texture metrics and climate data to improve the accuracy of AGB maps. Finally, we increased the number of sampling plots using biomass estimates derived from LiDAR data to assess if increasing sample size could improve the accuracy of AGB estimates. RESULTS: Correcting NFI plot data for both small trees and temporal differences between field and remotely sensed measurements reduced the relative error of biomass estimates by 12.2%. Using a machine learning algorithm, Random Forest, with corrected field plot data, backscatter and surface texture from the L-band synthetic aperture radar (PALSAR) installed on the on the Advanced Land Observing Satellite-1 (ALOS), and climatic water deficit data improved the accuracy of the maps obtained in this study as compared to previous studies (R2 = 0.44 vs R2 = 0.32). However, using sample plots derived from LiDAR data to increase sample size did not improve accuracy of AGB maps (R2 = 0.26). CONCLUSIONS: This study reveals that the suggested approach has the potential to improve AGB maps of tropical dry forests and shows predictors of AGB that should be considered in future studies. Our results highlight the importance of using ecological knowledge to correct errors associated with both the plot-level biomass estimates and the mismatch between field and remotely sensed data.

15.
Science ; 369(6505): 838-841, 2020 08 14.
Artículo en Inglés | MEDLINE | ID: mdl-32792397

RESUMEN

More than half of all tropical forests are degraded by human impacts, leaving them threatened with conversion to agricultural plantations and risking substantial biodiversity and carbon losses. Restoration could accelerate recovery of aboveground carbon density (ACD), but adoption of restoration is constrained by cost and uncertainties over effectiveness. We report a long-term comparison of ACD recovery rates between naturally regenerating and actively restored logged tropical forests. Restoration enhanced decadal ACD recovery by more than 50%, from 2.9 to 4.4 megagrams per hectare per year. This magnitude of response, coupled with modal values of restoration costs globally, would require higher carbon prices to justify investment in restoration. However, carbon prices required to fulfill the 2016 Paris climate agreement [$40 to $80 (USD) per tonne carbon dioxide equivalent] would provide an economic justification for tropical forest restoration.


Asunto(s)
Restauración y Remediación Ambiental , Bosques , Clima Tropical , Agricultura , Biodiversidad , Dióxido de Carbono/metabolismo , Humanos
16.
Clin Infect Dis ; 48(12): 1669-73, 2009 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-19435438

RESUMEN

BACKGROUND: California has an ongoing epidemic of wound botulism (WB) among injection drug users (IDUs). We retrospectively studied a cohort of patients with WB and determined the sensitivity of the mouse bioassay-the gold standard laboratory test for confirmation of botulism-in verifying WB. METHODS: We defined a clinical case of WB as an acute, bilateral, descending, flaccid paralysis starting with 1 cranial nerve palsies in an IDU with no other explainable diagnosis. We calculated the sensitivity of the mouse bioassay as the proportion of clinical WB cases that had positive serum toxin test results by mouse bioassay. We compared serum toxin-positive with serum toxin-negative patients. RESULTS: Of 73 patients with WB, 50 tested serum toxin positive, yielding a sensitivity of 68%. Serum toxin-positive patients did not differ significantly from serum toxin-negative patients with respect to demographic characteristics or injection drug use practices or in days from patient symptom onset to collection of specimens for testing. Patients did not differ significantly by clinical characteristics, except that serum toxin-positive patients were more likely than serum toxin-negative patients to have required mechanical ventilation during their hospital courses (74% vs. 43%; P = .01). CONCLUSIONS: In this study, the mouse bioassay failed to detect botulinum toxin in the serum samples of nearly one-third of IDUs with characteristic WB. Such patients should be considered to have probable WB. Physicians should be aware of the test's limitations and base their final diagnosis of suspected WB on clinical criteria when the mouse bioassay produces negative results.


Asunto(s)
Bioensayo/métodos , Botulismo/diagnóstico , Infección de Heridas/microbiología , Adulto , Animales , Botulismo/epidemiología , California/epidemiología , Femenino , Humanos , Masculino , Ratones , Persona de Mediana Edad , Estudios Retrospectivos , Sensibilidad y Especificidad , Abuso de Sustancias por Vía Intravenosa/complicaciones , Infección de Heridas/epidemiología , Adulto Joven
17.
Public Health Rep ; 134(1_suppl): 71S-79S, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31059418

RESUMEN

OBJECTIVES: In California, about 80% of tuberculosis disease is caused by untreated latent tuberculosis infection (LTBI), and the rate of LTBI is higher among incarcerated persons (16%) than among nonincarcerated persons (6%). We compared 2 regimens to treat LTBI in an adult prison population in California: 9 months of twice-weekly isoniazid (9H; previous standard of care) and 12 once-weekly doses of isoniazid and rifapentine (3HP; introduced in 2011). METHODS: We evaluated the rates of completion and discontinuation caused by hepatotoxicity among randomly selected patients with LTBI prescribed the 9H regimen in 2011 and among patients with LTBI prescribed the 3HP regimen who entered California prisons during September 2013-March 2014. We compared the cost per fully treated patient for the 2 regimens. RESULTS: Of 92 patients treated with the 9H regimen, the treatment completion rate was 42% and discontinuation due to hepatotoxicity was 14%. Of 122 patients who accepted the 3HP regimen, the completion rate was 90% and discontinuation due to hepatotoxicity was 2%. The cost per fully treated patient for the 9H regimen was $981 and for 3HP was $652. CONCLUSIONS: In an incarcerated population, the 3HP regimen had a higher completion rate, lower hepatotoxicity, and lower cost per fully treated patient than the 9H regimen. If coupled with a high treatment initiation rate, the high rate of LTBI treatment completion with 3HP may contribute to reducing tuberculosis morbidity in California.


Asunto(s)
Antituberculosos/economía , Antituberculosos/uso terapéutico , Isoniazida/economía , Tuberculosis Latente/tratamiento farmacológico , Tuberculosis Latente/economía , Prisioneros/estadística & datos numéricos , Rifampin/análogos & derivados , Adulto , California , Femenino , Humanos , Isoniazida/uso terapéutico , Masculino , Rifampin/economía , Rifampin/uso terapéutico , Factores de Tiempo
19.
N Engl J Med ; 353(9): 890-7, 2005 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-16135833

RESUMEN

BACKGROUND: In November 2003, a large hepatitis A outbreak was identified among patrons of a single Pennsylvania restaurant. We investigated the cause of the outbreak and factors that contributed to its unprecedented size. METHODS: Demographic and clinical outcome data were collected from patients with laboratory confirmation of hepatitis A, and restaurant workers were tested for hepatitis A. A case-control study was conducted among patrons who dined at the restaurant between October 3 and October 6, 2003. Sequence analysis was performed on a 315-nucleotide region of viral RNA extracted from serum specimens. RESULTS: Of 601 patients identified, 3 died; at least 124 were hospitalized. Of 425 patients who recalled a single dining date at the restaurant, 356 (84 percent) had dined there between October 3 and October 6. Among 240 patients in the case-control study, 218 had eaten mild salsa (91 percent), as compared with 45 of 130 controls (35 percent) (odds ratio, 19.6; 95 percent confidence interval, 11.0 to 34.9) for whom data were available. A total of 98 percent of patients and 58 percent of controls reported having eaten a menu item containing green onions (odds ratio, 33.3; 95 percent confidence interval, 12.8 to 86.2). All restaurant workers were tested, but none were identified who could have been the source of the outbreak. Sequences of hepatitis A virus from all 170 patients who were tested were identical. Mild salsa, which contained green onions grown in Mexico, was prepared in large batches at the restaurant and provided to all patrons. CONCLUSIONS: Green onions that were apparently contaminated before arrival at the restaurant caused this unusually large foodborne outbreak of hepatitis A. The inclusion of contaminated green onions in large batches that were served to all customers contributed to the size of the outbreak.


Asunto(s)
Brotes de Enfermedades , Hepatitis A/epidemiología , Cebollas/envenenamiento , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Manipulación de Alimentos , Microbiología de Alimentos , Enfermedades Transmitidas por los Alimentos/epidemiología , Enfermedades Transmitidas por los Alimentos/virología , Hepatitis A/etiología , Hepatitis A/mortalidad , Virus de la Hepatitis A/genética , Virus de la Hepatitis A/aislamiento & purificación , Humanos , Lactante , Masculino , México , Persona de Mediana Edad , Cebollas/virología , Pennsylvania/epidemiología , ARN Viral/análisis , Restaurantes
20.
J Correct Health Care ; 24(4): 342-351, 2018 10.
Artículo en Inglés | MEDLINE | ID: mdl-30099936

RESUMEN

Two California state prisons (A and B) have very high rates of coccidioidomycosis (Valley Fever). The prison health care service sought to improve their prevention strategy by risk stratification with a newly available spherulin-based Coccidioides delayed-type hypersensitivity test. Of the 36,789 voluntarily screened inmates, 4.7% experienced adverse reactions. A positive test (8.6% of those tested) was independently associated with (1) incarceration at prisons A and B, (2) admission to prison from a Coccidioides-endemic county, (3) length of stay at prisons A and B, and (4) increasing age. These findings suggest that the test is safe and performing well at risk stratification; the prison system now restricts inmates with negative tests from prisons A and B. This novel use of the test might benefit other coccidioidomycosis prevention programs.


Asunto(s)
Coccidioidomicosis/diagnóstico , Coccidioidomicosis/epidemiología , Prisiones/organización & administración , Pruebas Cutáneas/efectos adversos , Pruebas Cutáneas/métodos , Adolescente , Adulto , Negro o Afroamericano , Anciano , California/epidemiología , Coccidioidomicosis/etnología , Hispánicos o Latinos , Hospitalización , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto Joven
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