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Bioorg Med Chem Lett
; 22(16): 5222-6, 2012 Aug 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22801646
RESUMEN
The lead optimization of a series of potent azaindole IKK2 inhibitors is described. Optimization of the human whole blood activity and selectivity over IKK1 in parallel led to the discovery of 16, a potent and selective IKK2 inhibitor showing good efficacy in a rat model of neutrophil activation.