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1.

ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis.

Cheng, Paul; Wirka, Robert C; Shoa Clarke, Lee; Zhao, Quanyi; Kundu, Ramendra; Nguyen, Trieu; Nair, Surag; Sharma, Disha; Kim, Hyun-Jung; Shi, Huitong; Assimes, Themistocles; Brian Kim, Juyong; Kundaje, Anshul; Quertermous, Thomas.

Circulation ; 145(6): 469-485, 2022 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-34990206

2.

Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm.

Pedroza, Albert J; Dalal, Alex R; Shad, Rohan; Yokoyama, Nobu; Nakamura, Ken; Cheng, Paul; Wirka, Robert C; Mitchel, Olivia; Baiocchi, Michael; Hiesinger, William; Quertermous, Thomas; Fischbein, Michael P.

Arterioscler Thromb Vasc Biol ; 42(9): 1154-1168, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35861960

3.

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.

Nurnberg, Sylvia T; Guerraty, Marie A; Wirka, Robert C; Rao, H Shanker; Pjanic, Milos; Norton, Scott; Serrano, Felipe; Perisic, Ljubica; Elwyn, Susannah; Pluta, John; Zhao, Wei; Testa, Stephanie; Park, YoSon; Nguyen, Trieu; Ko, Yi-An; Wang, Ting; Hedin, Ulf; Sinha, Sanjay; Barash, Yoseph; Brown, Christopher D; Quertermous, Thomas; Rader, Daniel J.

PLoS Genet ; 16(1): e1008538, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31917787

4.

Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.

Nagao, Manabu; Lyu, Qing; Zhao, Quanyi; Wirka, Robert C; Bagga, Joetsaroop; Nguyen, Trieu; Cheng, Paul; Kim, Juyong Brian; Pjanic, Milos; Miano, Joseph M; Quertermous, Thomas.

Circ Res ; 126(4): 517-529, 2020 02 14.

Artículo en Inglés | MEDLINE | ID: mdl-31815603

5.

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.

Rykaczewska, Urszula; Suur, Bianca E; Röhl, Samuel; Razuvaev, Anton; Lengquist, Mariette; Sabater-Lleal, Maria; van der Laan, Sander W; Miller, Clint L; Wirka, Robert C; Kronqvist, Malin; Gonzalez Diez, Maria; Vesterlund, Mattias; Gillgren, Peter; Odeberg, Jacob; Lindeman, Jan H; Veglia, Fabrizio; Humphries, Steve E; de Faire, Ulf; Baldassarre, Damiano; Tremoli, Elena; Lehtiö, Janne; Hansson, Göran K; Paulsson-Berne, Gabrielle; Pasterkamp, Gerard; Quertermous, Thomas; Hamsten, Anders; Eriksson, Per; Hedin, Ulf; Matic, Ljubica.

Circ Res ; 126(5): 571-585, 2020 02 28.

Artículo en Inglés | MEDLINE | ID: mdl-31893970

6.

The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles.

Xu, Bing; Fu, Ying; Liu, Yan; Agvanian, Sosse; Wirka, Robert C; Baum, Rachel; Zhou, Kang; Shaw, Robin M; Hong, TingTing.

PLoS Biol ; 15(8): e2002354, 2017 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-28806752

7.

Advances in Transcriptomics: Investigating Cardiovascular Disease at Unprecedented Resolution.

Wirka, Robert C; Pjanic, Milos; Quertermous, Thomas.

Circ Res ; 122(9): 1200-1220, 2018 04 27.

Artículo en Inglés | MEDLINE | ID: mdl-29700068

8.

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.

Paik, David T; Tian, Lei; Lee, Jaecheol; Sayed, Nazish; Chen, Ian Y; Rhee, Siyeon; Rhee, June-Wha; Kim, Youngkyun; Wirka, Robert C; Buikema, Jan W; Wu, Sean M; Red-Horse, Kristy; Quertermous, Thomas; Wu, Joseph C.

Circ Res ; 123(4): 443-450, 2018 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-29986945

9.

Blood pressure lowering in the prevention of type 2 diabetes.

Cavender, Matthew A; Wirka, Robert C.

Lancet ; 398(10313): 1778-1779, 2021 11 13.

Artículo en Inglés | MEDLINE | ID: mdl-34774133

10.

Low prevalence of connexin-40 gene variants in atrial tissues and blood from atrial fibrillation subjects.

Tchou, Gregory D; Wirka, Robert C; Van Wagoner, David R; Barnard, John; Chung, Mina K; Smith, Jonathan D.

BMC Med Genet ; 13: 102, 2012 Nov 07.

Artículo en Inglés | MEDLINE | ID: mdl-23134779

11.

Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque.

Cheng, Paul; Wirka, Robert C; Kim, Juyong Brian; Kim, Hyun-Jung; Nguyen, Trieu; Kundu, Ramendra; Zhao, Quanyi; Sharma, Disha; Pedroza, Albert; Nagao, Manabu; Iyer, Dharini; Fischbein, Michael P; Quertermous, Thomas.

Nat Cardiovasc Res ; 1(4): 322-333, 2022 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-36246779

12.

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Gallina, Alessandro L; Rykaczewska, Urszula; Wirka, Robert C; Caravaca, April S; Shavva, Vladimir S; Youness, Mohamad; Karadimou, Glykeria; Lengquist, Mariette; Razuvaev, Anton; Paulsson-Berne, Gabrielle; Quertermous, Thomas; Gisterå, Anton; Malin, Stephen G; Tarnawski, Laura; Matic, Ljubica; Olofsson, Peder S.

Front Cardiovasc Med ; 8: 655869, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33959644

13.

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.

Wirka, Robert C; Wagh, Dhananjay; Paik, David T; Pjanic, Milos; Nguyen, Trieu; Miller, Clint L; Kundu, Ramen; Nagao, Manabu; Coller, John; Koyano, Tiffany K; Fong, Robyn; Woo, Y Joseph; Liu, Boxiang; Montgomery, Stephen B; Wu, Joseph C; Zhu, Kuixi; Chang, Rui; Alamprese, Melissa; Tallquist, Michelle D; Kim, Juyong B; Quertermous, Thomas.

Nat Med ; 25(8): 1280-1289, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31359001

14.

Circulating peptide prevents preeclampsia.

Wirka, Robert C; Quertermous, Thomas.

Science ; 357(6352): 643-644, 2017 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-28818928

15.

A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation.

Wirka, Robert C; Gore, Shamone; Van Wagoner, David R; Arking, Dan E; Lubitz, Steven A; Lunetta, Kathryn L; Benjamin, Emelia J; Alonso, Alvaro; Ellinor, Patrick T; Barnard, John; Chung, Mina K; Smith, Jonathan D.

Circ Arrhythm Electrophysiol ; 4(1): 87-93, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-21076161

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