COLOCdb: a comprehensive resource for multi-model colocalization of complex traits.

Large-scale genome-wide association studies (GWAS) have provided profound insights into complex traits and diseases. Yet, deciphering the fine-scale molecular mechanisms of how genetic variants manifest to cause the phenotypes remains a daunting task. Here, we present COLOCdb (https://ngdc.cncb.ac.cn/colocdb), a comprehensive genetic colocalization database by integrating more than 3000 GWAS summary statistics and 13 types of xQTL to date. By employing two representative approaches for the colocalization analysis, COLOCdb deposits results from three key components: (i) GWAS-xQTL, pair-wise colocalization between GWAS loci and different types of xQTL, (ii) GWAS-GWAS, pair-wise colocalization between the trait-associated genetic loci from GWASs and (iii) xQTL-xQTL, pair-wise colocalization between the genetic loci associated with molecular phenotypes in xQTLs. These results together represent the most comprehensive colocalization analysis, which also greatly expands the list of shared variants with genetic pleiotropy. We expect that COLOCdb can serve as a unique and useful resource in advancing the discovery of new biological mechanisms and benefit future functional studies.

Corrigendum to "Support Vector Machine Weather Prediction Technology Based on the Improved Quantum Optimization Algorithm".

[This corrects the article DOI: 10.1155/2021/6653659.].

Support Vector Machine Weather Prediction Technology Based on the Improved Quantum Optimization Algorithm.

Emotion recognition is a research hotspot in the field of artificial intelligence. If the human-computer interaction system can sense human emotion and express emotion, it will make the interaction between the robot and human more natural. In this paper, a multimodal emotion recognition model based on many-objective optimization algorithm is proposed for the first time. The model integrates voice information and facial information and can simultaneously optimize the accuracy and uniformity of recognition. This paper compares the emotion recognition algorithm based on many-objective algorithm optimization with the single-modal emotion recognition model proposed in this paper and the ISMS_ALA model proposed by recent related research. The experimental results show that compared with the single-mode emotion recognition, the proposed model has a great improvement in each evaluation index. At the same time, the accuracy of emotion recognition is 2.88% higher than that of the ISMS_ALA model. The experimental results show that the many-objective optimization algorithm can effectively improve the performance of the multimodal emotion recognition model.