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1.

Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Kwon, Ilmin; Kato, Masato; Xiang, Siheng; Wu, Leeju; Theodoropoulos, Pano; Mirzaei, Hamid; Han, Tina; Xie, Shanhai; Corden, Jeffry L; McKnight, Steven L.

Cell ; 155(5): 1049-1060, 2013 Nov 21.

Artículo en Inglés | MEDLINE | ID: mdl-24267890

2.

Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

Han, Tina W; Kato, Masato; Xie, Shanhai; Wu, Leeju C; Mirzaei, Hamid; Pei, Jimin; Chen, Min; Xie, Yang; Allen, Jeffrey; Xiao, Guanghua; McKnight, Steven L.

Cell ; 149(4): 768-79, 2012 May 11.

Artículo en Inglés | MEDLINE | ID: mdl-22579282

3.

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato, Masato; Han, Tina W; Xie, Shanhai; Shi, Kevin; Du, Xinlin; Wu, Leeju C; Mirzaei, Hamid; Goldsmith, Elizabeth J; Longgood, Jamie; Pei, Jimin; Grishin, Nick V; Frantz, Douglas E; Schneider, Jay W; Chen, She; Li, Lin; Sawaya, Michael R; Eisenberg, David; Tycko, Robert; McKnight, Steven L.

Cell ; 149(4): 753-67, 2012 May 11.

Artículo en Inglés | MEDLINE | ID: mdl-22579281

4.

Discovery of a proneurogenic, neuroprotective chemical.

Pieper, Andrew A; Xie, Shanhai; Capota, Emanuela; Estill, Sandi Jo; Zhong, Jeannie; Long, Jeffrey M; Becker, Ginger L; Huntington, Paula; Goldman, Shauna E; Shen, Ching-Han; Capota, Maria; Britt, Jeremiah K; Kotti, Tiina; Ure, Kerstin; Brat, Daniel J; Williams, Noelle S; MacMillan, Karen S; Naidoo, Jacinth; Melito, Lisa; Hsieh, Jenny; De Brabander, Jef; Ready, Joseph M; McKnight, Steven L.

Cell ; 142(1): 39-51, 2010 Jul 09.

Artículo en Inglés | MEDLINE | ID: mdl-20603013

5.

Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension.

Macias, David; Moore, Stephen; Crosby, Alexi; Southwood, Mark; Du, Xinlin; Tan, Huiling; Xie, Shanhai; Vassallo, Arlette; Wood, Alexander J T; Wallace, Eli M; Cowburn, Andrew S.

Eur Respir J ; 57(3)2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-32972983

6.

Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.

Tao, Ye; Budhipramono, Albert; Huang, Ji; Fang, Min; Xie, Shanhai; Kim, Jiwoong; Khivansara, Vishal; Dominski, Zbigniew; Tong, Liang; De Brabander, Jef K; Nijhawan, Deepak.

Cell Chem Biol ; 31(1): 139-149.e14, 2024 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-37967558

7.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Nguyen, Thu P; Fang, Min; Kim, Jiwoong; Wang, Baiyun; Lin, Elisa; Khivansara, Vishal; Barrows, Neha; Rivera-Cancel, Giomar; Goralski, Maria; Cervantes, Christopher L; Xie, Shanhai; Peterson, Johann M; Povedano, Juan Manuel; Antczak, Monika I; Posner, Bruce A; McFadden, David G; Ready, Joseph M; De Brabander, Jef K; Nijhawan, Deepak.

bioRxiv ; 2023 Feb 21.

Artículo en Inglés | MEDLINE | ID: mdl-36865268

8.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Nguyen, Thu P; Fang, Min; Kim, Jiwoong; Wang, Baiyun; Lin, Elisa; Khivansara, Vishal; Barrows, Neha; Rivera-Cancel, Giomar; Goralski, Maria; Cervantes, Christopher L; Xie, Shanhai; Peterson, Johann M; Povedano, Juan Manuel; Antczak, Monika I; Posner, Bruce A; Harvey, Colin J B; Naughton, Brian T; McFadden, David G; Ready, Joseph M; De Brabander, Jef K; Nijhawan, Deepak.

Cell Chem Biol ; 30(11): 1453-1467.e8, 2023 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-37607550

9.

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.

Xu, Rui; Wang, Keshi; Rizzi, James P; Huang, Heli; Grina, Jonas A; Schlachter, Stephen T; Wang, Bin; Wehn, Paul M; Yang, Hanbiao; Dixon, Darryl D; Czerwinski, Robert M; Du, Xinlin; Ged, Emily L; Han, Guangzhou; Tan, Huiling; Wong, Tai; Xie, Shanhai; Josey, John A; Wallace, Eli M.

J Med Chem ; 62(15): 6876-6893, 2019 08 08.

Artículo en Inglés | MEDLINE | ID: mdl-31282155

10.

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

Wehn, Paul M; Rizzi, James P; Dixon, Darryl D; Grina, Jonas A; Schlachter, Stephen T; Wang, Bin; Xu, Rui; Yang, Hanbiao; Du, Xinlin; Han, Guangzhou; Wang, Keshi; Cao, Zhaodan; Cheng, Tzuling; Czerwinski, Robert M; Goggin, Barry S; Huang, Heli; Halfmann, Megan M; Maddie, Melissa A; Morton, Emily L; Olive, Sarah R; Tan, Huiling; Xie, Shanhai; Wong, Tai; Josey, John A; Wallace, Eli M.

J Med Chem ; 61(21): 9691-9721, 2018 11 08.

Artículo en Inglés | MEDLINE | ID: mdl-30289716

11.

Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia.

Lin, Hui; Monaco, Giuseppe; Sun, Tong; Ling, Xiaoyang; Stephens, Clifton; Xie, Shanhai; Belmont, John; Arlinghaus, Ralph.

Oncogene ; 24(20): 3246-56, 2005 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-15735695

12.

Inhibition of the Bcr-Abl oncoprotein by Bcr requires phosphoserine 354.

Hawk, Natalyn; Sun, Tong; Xie, Shanhai; Wang, Yan; Wu, Yun; Liu, Jiaxin; Arlinghaus, Ralph B.

Cancer Res ; 62(2): 386-90, 2002 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-11809685

13.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

Wallace, Eli M; Rizzi, James P; Han, Guangzhou; Wehn, Paul M; Cao, Zhaodan; Du, Xinlin; Cheng, Tzuling; Czerwinski, Robert M; Dixon, Darryl D; Goggin, Barry S; Grina, Jonas A; Halfmann, Megan M; Maddie, Melissa A; Olive, Sarah R; Schlachter, Stephen T; Tan, Huiling; Wang, Bin; Wang, Keshi; Xie, Shanhai; Xu, Rui; Yang, Hanbiao; Josey, John A.

Cancer Res ; 76(18): 5491-500, 2016 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-27635045

14.

Jak2 is involved in c-Myc induction by Bcr-Abl.

Xie, Shanhai; Lin, Hui; Sun, Tong; Arlinghaus, Ralph B.

Oncogene ; 21(47): 7137-46, 2002 Oct 17.

Artículo en Inglés | MEDLINE | ID: mdl-12370803

15.

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

Lee, Jaeick; Xu, Yingda; Chen, Yue; Sprung, Robert; Kim, Sung Chan; Xie, Shanhai; Zhao, Yingming.

Mol Cell Proteomics ; 6(4): 669-76, 2007 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-17208939

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Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Discovery of a proneurogenic, neuroprotective chemical.

Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension.

Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia.

Inhibition of the Bcr-Abl oncoprotein by Bcr requires phosphoserine 354.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

Jak2 is involved in c-Myc induction by Bcr-Abl.

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.