1.
Angew Chem Int Ed Engl
; 61(28): e202203051, 2022 07 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35593892
RESUMEN
We report the first total syntheses of tricyclic mutanobactinsâ A and B, lipopeptides incorporating a thiazepanone, isolated from Streptococcus mutans, a member of the human oral microbiome. A rapid, solid-phase peptide synthesis (SPPS) based route delivers these natural products from a cascade of cyclization reactions. This versatile process was also employed in a streamlined synthesis of mutanobactinâ D. Additionally, we provide an independent synthesis of a truncated mutanobactinâ A analog, utilizing a novel thiazepanone amino acid building block.