RESUMEN
We present an alternative scheme to achieve nonreciprocal unconventional magnon blockade (NUMB) in a hybrid system formed by two microwave cavities and one yttrium iron garnet (YIG) sphere, where the pump and signal cavities interact nonlinearly with each other and the signal cavity is coupled to the YIG sphere. It is found that the nonlinear coupling occurs between the pump cavity and magnon modes due to the dispersive interactions among three bosonic modes. Meanwhile, the Kerr nonlinearity is present in the pump cavity. Based on these nonlinear effects, a nonreciprocal magnon blockade could be achieved with the help of the weak parametric driving of the pump cavity. The present work provides an alternative method to prepare single magnon resource, which may be helpful for quantum information processing.
RESUMEN
Electromagnetically induced phase grating is theoretically investigated in the driven two-level quantum dot exciton system at the presence of the exciton-phonon interactions. Due to the phonon-induced coherent population oscillation, the dispersion and absorption spectra are sharply changed and the phase modulation is enhanced via the high refractive index with nearly-vanishing absorption, which could effectively diffract a weak probe light into the first-order direction with the help of a standing-wave control field. Moreover, the diffraction efficiency of the grating can be easily manipulated by controlling the Huang-Rhys factor representing the exciton-phonon coupling, the intensity and detuning of the control field, and the detuning of the probe field. The scheme we present has potential applications in the photon devices for optical-switching and optical-imaging in the micro-nano solid-state system.
RESUMEN
<p><b>OBJECTIVE</b>To investigate the effect of Shenshao Decoction on the inflammatory status: in the aorta in a rat model of atherosclerosis.</p><p><b>METHODS</b>Forty Sprague-Dawley rats were randomly divided into: five groups, 8 rats in each group: control untreated group, atherosclerosis group, atherosclerosis with Shenshao Decoction (low dose) group, atherosclerosis with Shenshao Decoction (high dose) group, atherosclerosis with simvastatin group. To stimulate atherosclerosis, the rats were fed vitamin D3 and a high-cholesterol diet. Four weeks later, treatments were maintained for eight weeks. Morphology changes were investigated by hematoxylin and eosin staining. Serum levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were obtained by enzymatic assays with use of an automated biochemical analyzer. The expression of malondialdehyde (MDA), glutathione peroxidase (GSH-PX) were detected by enzyme-enzymelinked immunosorbent assay. The expression levels of interleukin (IL)-1β, IL-17A, and IL-23 were detected by linked immunoblotting.</p><p><b>RESULTS</b>Shenshao Decoction treatment decreased TC, TG, LDL-C and MDA and increased: GSH-PX levels (P<0.01). Compared with the control group, IL-1β, IL-17A, and IL-23 were lower in the high and <low dose Shenshao Decoction groups and the simvastatin group (P<0.01).</p><p><b>CONCLUSION</b>Shenshao Decoction: could attenuate the progression of aortal atherosclerotic plaques by inhibiting the inflammatory response in a rat atherosclerotic model.</p>
Asunto(s)
Animales , Masculino , Ratas , Aorta Torácica , Patología , Aterosclerosis , Sangre , Quimioterapia , Patología , Colesterol , Sangre , LDL-Colesterol , Sangre , Modelos Animales de Enfermedad , Medicamentos Herbarios Chinos , Usos Terapéuticos , Glutatión Peroxidasa , Sangre , Inmunohistoquímica , Inflamación , Quimioterapia , Patología , Interleucina-17 , Metabolismo , Interleucina-1beta , Metabolismo , Interleucina-23 , Metabolismo , Malondialdehído , Sangre , Ratas Sprague-Dawley , Triglicéridos , SangreRESUMEN
<p><b>BACKGROUND</b>Y-27632 is a specific inhibitor of Rho-associated coiled kinase (ROCK) and has been shown to promote the survival and induce the differentiation of a variety of cells types. However, the effects of Y-27632 on adult human adipose tissue-derived stem cells (ADSCs) are unclear. This study aimed to investigate the effects of Y-27632 on the neuronal-like differentiation of ADSCs.</p><p><b>METHODS</b>ADSCs were isolated from women undergoing plastic surgery and cultured. ADSCs were treated with different doses of Y-27632 and observed morphological changes under microscope. The expression of nestin, neuron specific enolase (NSE) and microtubule-associated protein-2 (MAP-2) in ADSCs treated with Y-27632 was detected by immunocytochemistry and Western blotting analysis.</p><p><b>RESULTS</b>Y-27632 had the potency to induce neuronal-like differentiation in ADSCs in a dose-dependent manner. Moreover, the differentiation induced by Y-27632 was recovered upon drug withdraw. ADSCs treated with Y-27632 expressed neuronal markers such as NSE, MAP-2 and nestin while untreated ADSCs did not express these markers.</p><p><b>CONCLUSION</b>Selective ROCK inhibitor Y-27632 could potentiate the neuronal-like differentiation of ADSCs, suggesting that Y-27632 could be utilized to induce the differentiation of ADSCs to neurons and facilitate the clinical application of ADSCs in tissue engineering.</p>