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1.
Nano Lett ; 24(23): 7012-7018, 2024 Jun 12.
Artículo en Inglés | MEDLINE | ID: mdl-38820129

RESUMEN

Light management is critical to maximizing the external quantum efficiency of perovskite light-emitting diodes (PeLEDs), but strategies for enhancing light out-coupling are typically complex and expensive. Here, using a facile solvent treatment strategy, we create a layer of lithium fluoride (LiF) nanoislands that serve as a template to reconstruct the light-extracting interfaces for PeLEDs. The nanoisland interface rearranges the near-field light distribution in order to maximize the efficiency of internal light extraction. With the proper adjustment of the nanoisland size and distribution, we have achieved an optimal balance between charge injection and light out-coupling, resulting in bright, pure-red quasi-two-dimensional PeLEDs with a 21.8% peak external quantum efficiency.

2.
Macromol Rapid Commun ; 44(23): e2300411, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37632834

RESUMEN

High refractive index polymers (HRIPs) are widely used in lenses, waveguide, antireflective layer and encapsulators, especially the advanced fields of augmented/virtual reality (AR / VR) holographic technology and photoresist for chip manufacturing. In order to meet the needs of different applications, the development of HRIPs focuses not only on the increase in refractive index but also on the balance of other properties. Sulfur-containing high refractive index polymers have received extensive attention from researchers due to their excellent properties. In recent years, not only ultrahigh refractive index sulfur-containing polymers have been continuously developed, but also low dispersion, low birefringence, high transparency, good mechanical properties, and machinability have been studied. The design of HRIPs is generally based on formulas and existing experience. In fact, molecular structure and properties are closely related. Mastering the structure-property relationship helps researchers to develop high refractive index polymer materials with balanced properties. This review briefly introduces the preparation methods of sulfur-containing high refractive index polymers, and summarizes the structure-property relationship between the sulfur-containing molecular structure and optical properties, mechanical properties, thermal properties, etc. Finally, the important role of synergistic effect in the synthesis of HRIPs and the prospect of future research on HRIPs are proposed.


Asunto(s)
Polímeros , Refractometría , Estructura Molecular , Polímeros/química , Azufre/química
3.
BMC Psychiatry ; 23(1): 852, 2023 11 17.
Artículo en Inglés | MEDLINE | ID: mdl-37978352

RESUMEN

Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolic changes induced by MA in the brains of mice by exercise intervention. It was found that after 2 weeks of treadmill training, aerobic exercise modulated MA-induced brain metabolic disorders, in which 129 metabolites existed that were significantly differentiated in response to MA induction, and 32 metabolites were significantly affected by exercise. These differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this study is the first to use LC-MS to investigate the effects of aerobic exercise on MA-induced brain metabolic profiling. The findings of this study provide new insights into exercise therapy using MA.


Asunto(s)
Trastornos Relacionados con Anfetaminas , Metanfetamina , Ratones , Animales , Metanfetamina/efectos adversos , Cromatografía Liquida/métodos , Espectrometría de Masas en Tándem , Encéfalo/metabolismo
4.
Ann Surg ; 271(5): 978-983, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-30531532

RESUMEN

OBJECTIVE: Our aims were to describe a new surgical technique for the treatment of type A aortic dissection (TAAD) and to report the operative outcomes of 154 patients. SUMMARY BACKGROUND DATA: Surgical treatment of TAAD is complicated and carries a high mortality risk. To lower this risk, we developed a simplified procedure in which a stent graft was implanted as frozen elephant trunk (FET), and the proximally trimmed vascular graft was sutured from the inside of the aortic arch using the inclusion technique under moderate hypothermic circulatory arrest and antegrade selective cerebral perfusion. METHODS: We conducted a retrospective analysis of 154 cases of TAAD treated with our novel technique (93 men and 61 women, 52.5 ±â€Š11.4 years). Computed tomography angiography was performed before discharge and at 6 months postoperatively. RESULTS: In-hospital mortality rate was 5.19%, with paraplegia occurring in 2 patients (1.3%) and stroke in 6 (3.9%). The rate of closure of the aortic arch false lumen was 77.8%, with a 69.2% rate of descending thoracic aorta thrombosis at discharge. The survival rate was 91.1% at a mean follow-up of 21 ±â€Š10 months, with rates of aortic arch false lumen closure of 92.4% and descending thoracic aorta thrombosis of 74.3% at 6 months postoperatively. CONCLUSIONS: The aortic arch inclusion technique with FET provides a safe alternative for TAAD treatment, with satisfactory operative results. Short-term follow-up results are encouraging, and long-term outcomes need further evaluation.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/cirugía , Implantación de Prótesis Vascular/métodos , Disección Aórtica/diagnóstico por imagen , Disección Aórtica/mortalidad , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/mortalidad , Angiografía por Tomografía Computarizada , Femenino , Mortalidad Hospitalaria , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Stents , Tasa de Supervivencia
5.
Int Heart J ; 61(6): 1229-1235, 2020 Nov 28.
Artículo en Inglés | MEDLINE | ID: mdl-33116020

RESUMEN

Various surgical techniques have been proposed for treating aortic arch aneurysm (AAA); however, the optimal treatment has not been well defined. This study introduces a new aortic arch inclusion technique with frozen elephant trunk (FET) for AAA treatment.A retrospective analysis was performed among 22 patients for AAA surgical treatment between March 2010 and March 2019. Patients were classified into Z1, Z2, and Z3 groups based on the origins of aneurysms. A stent graft with a 10 cm stented graft and 5-9 cm proximal vascular prosthesis was released into the descending thoracic aorta as FET through an incision in the aortic arch. The proximal vascular prosthesis was retracted into the aortic arch, trimmed to expose the orifices of the brachiocephalic vessels, and sutured inside the aortic arch using the inclusion technique. The proximal sealing location of the vascular graft was tailored to cover the origins of aneurysms.There was no 30-day mortality. No patient had postoperative stroke or paraplegia. Complete aneurysm thrombosis was achieved in all patients. One patient died of severe respiratory tract stenosis 3 months postoperatively. All other 21 patients were alive during 53.3 ± 36.5-month follow-up. Computed tomography angiography was obtained in 15 patients during follow-up. Endoleak was observed in one patient, and the other 14 patients were free from aneurysm-related or graft-related complications during follow-up.The aortic arch inclusion technique with FET provides an alternative technique in treating AAA with satisfactory mid-term follow-up results. A larger patient population with long-term follow-up results is warranted.


Asunto(s)
Aorta Torácica/cirugía , Aneurisma de la Aorta Torácica/cirugía , Implantación de Prótesis Vascular/métodos , Prótesis Vascular , Lesión Renal Aguda/epidemiología , Adulto , Anciano , Puente Cardiopulmonar , Angiografía por Tomografía Computarizada , Endofuga/epidemiología , Femenino , Humanos , Imagenología Tridimensional , Tiempo de Internación , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Estudios Retrospectivos
6.
Int Heart J ; 60(5): 1131-1136, 2019 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-31484859

RESUMEN

Reinforcing the dissected and fragile aortic root is critical in acute type A aortic dissection (ATAAD) surgery. This study introduces our new aortic root reinforcement technique and reports our early operative results and midterm follow-up results.A retrospective analysis study was performed on 235 patients (aged 53.2 ±15.5 years) who were admitted to our hospital for ATAAD surgery and underwent the procedure with our new technique between October 2011 and June 2016. Two vascular graft rings were placed inside and outside aortic root, followed by a running horizontal mattress suture, placed just above the coronary artery ostiums and aortic valve commissures, with another horizontal suture at distal end of the aortic root stump, to reinforce the inner vascular graft, aortic wall, and outside vascular graft. Then additional 3-5 vertical mattress sutures were placed for further reinforcement within the reconstructed aortic root. Computed tomography angiography was performed at discharge and annually during follow-up.The patients' 30-day mortality was 5.1% (12/235). There was no uncontrollable intraoperative bleeding from the aortic root, and re-exploration for bleeding occurred in 0.79% (2/235). The survival rate was 90.2% during follow-up of 4.2 ± 2.1 years. There were no requests for aortic root reoperations during follow-up. All patients were free from aortic root disruptions, proximal anastomosis complications, and re-dissections of the reconstructed aortic root.Our new aortic root reinforcement technique provides a safe and effective technique for aortic root in ATAAD surgery, by reinforcing friable aortic root tissues and minimizing aortic root complications.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/mortalidad , Disección Aórtica/cirugía , Implantación de Prótesis Vascular/métodos , Mortalidad Hospitalaria/tendencias , Procedimientos Quirúrgicos Vasculares/métodos , Adulto , Anciano , Disección Aórtica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/mortalidad , Puente Cardiopulmonar/métodos , China , Estudios de Cohortes , Terapia Combinada , Angiografía por Tomografía Computarizada/métodos , Femenino , Hospitales Universitarios , Humanos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Retrospectivos , Medición de Riesgo , Tasa de Supervivencia , Técnicas de Sutura , Resistencia a la Tracción , Resultado del Tratamiento
7.
Int Heart J ; 60(4): 845-848, 2019 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-31308322

RESUMEN

The aim of this study was to summarize the clinical experience of postoperative extracorporeal membrane oxygenation (ECMO) support in Stanford type A aortic dissection (STAAD) patients.We retrospectively reviewed 246 consecutive acute STAAD patients undergoing operations at our institution from January 2012 to December 2016. Postoperative ECMO was used in 7 patients. There were 5 males and 2 females with a mean age of 43.1 ± 9.3 years. All 7 patients with acute STAAD underwent ascending aorta replacement and total arch repair with a self-designed stent graft (Micropart Corp, Shanghai, China). Concomitant procedures were aortic root replacement in 1 patient and coronary artery bypass grafting (CABG) in 2 patients. All patients received veno-arterial ECMO through the femoral artery and vein. Five patients were extubated before being removed from ECMO. The mean ECMO supporting time was 244.5 ± 57.8 hours. All 7 patients were successfully weaned from ECMO support, and 6 (85.7%) patients survived to discharge. The average hospital time was 26.3 ± 8.8 days. One patient died of cardiac arrest after being weaned from ECMO. Two patients underwent reoperation for bleeding and 1 patient showed transient delirium. The remaining patients all survived during a median follow-up of 19 months.ECMO provides a good temporary cardiopulmonary support in STAAD patients with refractory cardiogenic shock after surgery for aortic dissection. The early use of ECMO and preventing its complications actively can improve the patient survival rate.


Asunto(s)
Aorta Torácica/cirugía , Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/cirugía , Implantación de Prótesis Vascular/métodos , Oxigenación por Membrana Extracorpórea/métodos , Adulto , Disección Aórtica/diagnóstico , Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/diagnóstico , Angiografía por Tomografía Computarizada , Ecocardiografía , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
8.
Int Heart J ; 59(1): 223-225, 2018 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-29332920

RESUMEN

An aorto-cutaneous fistula is a rare complication that occurs after aortic surgery. Due to its rarity, postoperative complications are not normally highlighted in most standard teaching. We report here a case of aorto-cutaneous fistula after surgical treatment of a Stanford type A aortic dissection (AD) in a 67-year-old Chinese male. The patient presented with severe right heart dysfunction and a mass was found in the upper-middle of his chest, which started bleeding in the next years. On admission, preoperative aortic computed tomography angiography (CTA) showed a huge hematoma located in the anterior superior mediastinum and a shunt between the embedding cavity of the aortic root and right atrium. An emergent procedure was performed. Intraoperatively, we found two leaks approximately 2 mm from the anastomosis of the greater curvature of the ascending aortic graft and stented graft after the hematoma was cleared and we confirmed the shunt had a large amount of blood flow after a right atrium incision. After the surgery, the patient was diagnosed with a cerebral hemorrhage, and his family decided to refuse therapy on the third postoperative day (p.o.d.).


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/cirugía , Implantación de Prótesis Vascular/efectos adversos , Fístula Cutánea/etiología , Complicaciones Posoperatorias , Stents/efectos adversos , Fístula Vascular/etiología , Anciano , Disección Aórtica/diagnóstico , Aneurisma de la Aorta Torácica/diagnóstico , Angiografía por Tomografía Computarizada , Fístula Cutánea/diagnóstico , Fístula Cutánea/cirugía , Ecocardiografía Doppler en Color , Humanos , Masculino , Reoperación , Fístula Vascular/diagnóstico , Fístula Vascular/cirugía , Procedimientos Quirúrgicos Vasculares/métodos
9.
Int Heart J ; 59(2): 448-450, 2018 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-29503402

RESUMEN

Acute aortic dissection occurring during pregnancy poses great danger to both the mother and fetus. Cesareans are usually performed before or after the aortic repair depending on the conditions of the mother and fetus. Here we report our experience in treating a 32-week pregnant woman with a type B aortic dissection, whose baby had died before admission. A cesarean section was initially arranged after emergency aortic repair. However, the patient started to deliver the fetus vaginally after the aortic surgery and the stillborn baby was delivered vaginally. This case report provides new insight into the method of delivery in a pregnant woman with an aortic dissection.


Asunto(s)
Disección Aórtica/cirugía , Complicaciones Cardiovasculares del Embarazo/cirugía , Mortinato , Disección Aórtica/complicaciones , Disección Aórtica/diagnóstico , Femenino , Humanos , Embarazo , Complicaciones Cardiovasculares del Embarazo/diagnóstico , Complicaciones Cardiovasculares del Embarazo/etiología
10.
Zhongguo Dang Dai Er Ke Za Zhi ; 19(12): 1301-1305, 2017 Dec.
Artículo en Zh | MEDLINE | ID: mdl-29237534

RESUMEN

Nasal intermittent positive pressure ventilation (NIPPV) can augment nasal continuous positive airway pressure (nCPAP) by delivering intermittent positive pressure ventilation in a noninvasive way and can provide a new option for neonatal noninvasive respiratory support. NIPPV has an advantage over nCPAP in primary and post-extubation respiratory support. Moreover, it can reduce severe apnea of prematurity. Synchronized NIPPV has promising application prospects. This review article summarizes the advances in the application of NIPPV in neonatal respiratory support to promote the understanding and standardization of this technique.


Asunto(s)
Ventilación con Presión Positiva Intermitente , Extubación Traqueal , Humanos , Recién Nacido , Ventilación con Presión Positiva Intermitente/efectos adversos , Ventilación con Presión Positiva Intermitente/instrumentación , Ventilación con Presión Positiva Intermitente/métodos , Pronóstico
11.
Biochemistry ; 54(45): 6806-14, 2015 Nov 17.
Artículo en Inglés | MEDLINE | ID: mdl-26507929

RESUMEN

Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Pioglitazone, the widely used thiazolidinedione, is shown to be efficient in the prevention of cardiovascular complications of T2DM. In this study, we report that pioglitazone inhibits CXCR7 expression and thus blocks chemotaxis in differentiated macrophage without perturbing cell viability or macrophage differentiation. In addition, pioglitazone-mediated CXCR7 suppression and chemotaxis inhibition occur via activating peroxisome proliferator-activated receptor γ (PPARγ) but not PPARα in differentiated macrophage. More importantly, pioglitazone therapy-induced PPARγ activation suppresses CXCR7 expression in human carotid atherosclerotic lesions. Collectively, our data demonstrate that pioglitazone suppresses CXCR7 expression to inhibit human macrophage chemotaxis through PPARγ.


Asunto(s)
Quimiotaxis/efectos de los fármacos , Macrófagos/efectos de los fármacos , PPAR gamma/agonistas , Receptores CXCR/antagonistas & inhibidores , Tiazolidinedionas/farmacología , Benzamidas/farmacología , Enfermedades de las Arterias Carótidas/complicaciones , Enfermedades de las Arterias Carótidas/tratamiento farmacológico , Enfermedades de las Arterias Carótidas/metabolismo , Enfermedades de las Arterias Carótidas/cirugía , Diferenciación Celular/efectos de los fármacos , Células Cultivadas , Terapia Combinada , Depresión Química , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Regulación hacia Abajo , Endarterectomía Carotidea , Regulación de la Expresión Génica/efectos de los fármacos , Humanos , PPAR alfa/efectos de los fármacos , PPAR alfa/genética , PPAR gamma/antagonistas & inhibidores , PPAR gamma/genética , PPAR gamma/fisiología , Pioglitazona , Piridinas/farmacología , Interferencia de ARN , ARN Interferente Pequeño/farmacología , Receptores CXCR/biosíntesis , Receptores CXCR/genética , Rosiglitazona
12.
Environ Sci Technol ; 48(7): 3847-55, 2014 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-24628413

RESUMEN

E-waste that contains polychlorinated biphenyls (PCBs) is moved across national boundaries, often from industrialized countries in the northern hemisphere, where the items were formerly used, to subtropical and tropical regions in southeastern Asia and Africa. As a result, there is a high likelihood that PCBs will be released into the environment from a primary source due to the elevated temperatures encountered in these low-latitude regions. In the present study, PCBs and enantiomer fractions (EFs) of chiral PCBs (PCB 84, 95, 132, 136, 149, and 183) were analyzed in air, eucalyptus leaves, pine needles, and soil at an e-waste site and a rural site in southern China. The concentrations of PCBs at the e-waste site ranged from 7825 to 76330 pg/m(3), 27.5 to 1993 ng/g, and 24.2 to 12045 ng/g in the air (gas plus particle), plant leaves, and soils, respectively. The atmospheric PCB composition profiles in the present study indicated relatively high abundances of penta- and hexa-PCBs, which were different from those previously observed in the air across China. The Clausius-Clapeyron regression analysis indicated that evaporation from local contaminated surfaces constitutes a primary emission source of PCBs in the air at the e-waste site. The chiral signatures of PCBs in the air at the e-waste site were essentially racemic (mean EFs = (0.484 ± 0.022)-(0.499 ± 0.004) in the gaseous phase) except for PCB 84 (0.420 ± 0.050), indicating that racemic sources dominate the PCB emission in the air. PCB chiral signatures in the soils ((0.422 ± 0.038)-(0.515 ± 0.016)) were similar to those in the air except for PCB 95. However, the chiral PCBs in the plants (especially the eucalyptus leaves) had significantly nonracemic residues ((0.368 ± 0.075)-(0.561 ± 0.045)) compared to those in the air and soil. This finding suggests that enantioselective biotransformation of these atropisomeric PCBs was very likely to occur in the plant leaves, possibly due to metabolism by cytochrome P-450 enzymes in leaves. To our knowledge, this is the first report on the enantioselective metabolism of chiral PCBs in plants under field conditions.


Asunto(s)
Aire/análisis , Residuos Electrónicos , Monitoreo del Ambiente , Plantas/química , Bifenilos Policlorados/análisis , Bifenilos Policlorados/química , Suelo/química , Biotransformación , China , Contaminantes Ambientales/análisis , Contaminantes Ambientales/química , Humanos , Hojas de la Planta/química , Estereoisomerismo
13.
Environ Res ; 135: 190-5, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25282276

RESUMEN

Halogenated flame retardants (HFRs) are a class of ubiquitous pollutants in the environment and attract increasing attention. In the present study, HFR concentrations were measured in indoor and outdoor dust in an important industrial city (Dongguan) in southern China, in which their presence and associated human exposure are unknown. The HFRs were dominated by polybrominated diphenyl ethers (PBDEs) and decabromodiphenyl ethane (DBDPE), with mean concentrations of 2365 and 2441 ng/g in the indoor dust, respectively, which were 2-3 order of magnitude higher the concentrations of other HFRs. However elevated tri- to hepta-BDE concentrations (869 ng/g) were found in Houjie Town, a furniture manufacturing center. The mean indoor/outdoor (I/O) ratios of HFR concentrations in the dust were all larger than one (1.55-16.4), suggesting the importance of indoors sources for HFRs in indoor dust in this industrial city. Principal component analysis (PCA) showed that the correlations among the HFRs in the indoor dust probably revealed differences in their commercial applications, while most HFRs in the outdoor dust have similar sources except for phased-out BDE47 and 99. The compositions of lower brominated PBDEs varied among the towns, probably due to their different sources or influence of photo-degradation. Nevertheless, the similar composition of highly brominated congeners indicated little photo-degradation encountered in the ambient environment. The non-cancer risk associated with indoor dust ingestion is low for the general population in Dongguan, but some children in the furniture manufacturing center have significantly high risk of exposure to banned PBDEs.


Asunto(s)
Contaminación del Aire Interior/análisis , Contaminación del Aire/análisis , Ciudades , Polvo/análisis , Exposición a Riesgos Ambientales/análisis , Retardadores de Llama/análisis , Hidrocarburos Bromados/análisis , Factores de Edad , China , Cromatografía de Gases y Espectrometría de Masas , Humanos , Diseño Interior y Mobiliario , Industria Manufacturera/estadística & datos numéricos , Fotólisis , Análisis de Componente Principal , Medición de Riesgo
14.
Biomed Chromatogr ; 28(12): 1789-94, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24802257

RESUMEN

Vaccarin, a flavonoid glycoside, is considered one of the major active constituents of Vaccaria segetalis. A simple and specific liquid chromatography-tandem mass spectrometric method was developed and validated for quantifying vaccarin in rat plasma following intravenous dosing. Plasma samples were precipitated with methanol and separated on a Venusil-C18 analytical column (2.1 × 50 mm, 5 µm particles) with gradient elution consisting of methanol and 0.1% (v/v) formic acid as the mobile phase. The detection was performed on an Agilent Triple Quad LC/MS with electrospray ionization inlet in the positive multiple reaction monitoring mode. Good linearity was achieved over the concentration range of 12.5-25,000 ng/mL (r(2) > 0.99). Intra- and inter-day precisions were <9.1%, and accuracy ranged from -2.8 to 8.7%. The lower limit of quantification for vaccarin was 12.5 ng/mL, and the analyte was stable under various storage conditions. This validated method was successfully applied to the preliminary pharmacokinetic studies of vaccarin following intravenous administrations of 1.21, 2.41, and 4.82 mg/kg vaccarin in rats.


Asunto(s)
Flavonoides/sangre , Flavonoides/farmacocinética , Glicósidos/sangre , Glicósidos/farmacocinética , Animales , Cromatografía Liquida/métodos , Estabilidad de Medicamentos , Flavonoides/química , Glicósidos/química , Modelos Lineales , Masculino , Ratas , Ratas Sprague-Dawley , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Espectrometría de Masas en Tándem/métodos
15.
J Colloid Interface Sci ; 672: 477-485, 2024 Jun 06.
Artículo en Inglés | MEDLINE | ID: mdl-38852350

RESUMEN

Hydrophilic coating can prevent surface from fogging but its application is limited by low mechanical performance. In this study, a hydrophilic coating was prepared by crosslinking the Si-doped carbonized polymer dot (Si-CPD) with 3-glycidyloxypropyltrimethoxysilane (GPTMS) and ethylene oxide (EO). The hydrophilic coating can be used as robust hydrophilic anti-fogging coating. The Si-CPD derived from ethylene diamine tetraacetic acid (EDTA) and aminopropyl oligosiloxanes (APOS) was successfully prepared via one-step hydrothermal method. Then, a resin solution was prepared by mixing Si-CPD, GPTMS and EO. Epoxy group of GPTMS and EO can react with amino group of Si-CPD. Finally, a composite coating with antifogging function can be obtained by simple heating curing. Due to the introduction of hydroxyl which derived from EO, the coating shows excellent antifogging performance. Meanwhile, the presence of inorganic component endows the coating with outstanding mechanical performance. The coating has great potential in related applications, such as optical lenses, mirrors and other transparency substrates.

16.
J Hazard Mater ; 468: 133699, 2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38368680

RESUMEN

Chlorine has been proven to promote the volatilization of heavy metals during sludge combustion. This work compared the migration of heavy metals with NaCl addition under different combustion modes at 900 â„ƒ. The combustion modes have less effect on the mineral phase of residues, but the volatilization and toxicity reduction of heavy metals were more pronounced under isothermal combustion. The mineral evolution, release of Cl, and migration of metals were dynamically tracked by the continuous sampling at different combustion time under isothermal combustion. It was found that the volatile matter and fixed carbon burned almost simultaneously, and the addition of NaCl promoted them. As combustion proceeded, the minerals gradually crystallized and the heavy metals were volatilized due to the direct and indirect chlorination. Meanwhile, the chlorination and volatilization of Zn was less than that of Pb due to its effective solidification by minerals. The combination of the adsorption by exposed char and solidification by sludge minerals influenced the dynamic leaching behavior of metals. These results will help understand the interactions between heavy metals, inorganic Cl, and Fe-Si-Al minerals during combustion, which will further help optimize the combustion strategy for both stabilization or enrichment of heavy metals when inorganic chlorine exists.

17.
Am Surg ; : 31348241257464, 2024 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-38835213

RESUMEN

BACKGROUND: This study aimed to evaluate the effectiveness and safety of 2D laparoscopy vs 3D laparoscopy for the treatment of colorectal cancer. METHODS: A literature search was conducted through PubMed, Web of Science, and Embase from their inception to January 2024. Studies investigating different outcomes of colorectal surgery were included. Results are presented as odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs). The protocol for this review has been registered on PROSPERO (CRD42024504902). RESULTS: A total of 10 publications were retrieved in this article. The 3D group is associated with a significant improvement in intraoperative blood loss (MD = -8.04, 95% CI = -14.18 to -1.89, P = 0.01, I2 = 55%), operative time (MD = -17.33, 95% CI = -29.15 to -5.51, P = 0.004, I2 = 90%), and postoperative hospital stay (MD = -0.23, 95% CI = -0.43 to -0.04, P = 0.02, I2 = 48%) compared to that of patients treated in the 2D group, particularly for rectal cancer patients above three results (MD = -10.36, 95% CI = -15.00 to -5.73, P < 0.001, I2 = 0%), (MD = -18.85, 95% CI = -34.88 to -2.82, P = 0.02, I2 = 57%), and (MD = -0.93, 95% CI = -1.53 to -0.34, P = 0.002, I2 = 0%), respectively. There was no significant statistical difference in the time of pass flatus (MD = -0.14, 95% CI = -0.49 to 0.21, P = 0.44, I2 = 79%) and the number of dissected lymph nodes (MD = 0.36, 95% CI = -0.49 to 1.21, P = 0.41, I2 = 45%), but the 3D group had an earlier postoperative pass flatus for rectal cancer patients (MD = -0.46, 95% CI = -0.66 to -0.27, P<0.001, I2 = 0%) and the more number of dissected lymph nodes for colon cancer patients (MD = 1.54, 95% CI = 0.05 to 3.03, P = 0.04, I2 = 69%) than the 2D group. There was no significant difference in postoperative overall complication (OR = 0.94, 95% CI = 0.67 to 1.31, P = 0.71, I2 = 0%) and anastomotic leakage (OR = 0.93, 95% CI = 0.48 to 1.80, P = 0.83, I2 = 0%) in the two groups, regardless of rectal cancer and colon surgery patients. CONCLUSION: This meta-analysis demonstrates that 3D laparoscopy could reduce the amount of blood loss, accelerate postoperative pass flatus, and shorten the operation time and postoperative hospital stay over 2D for radical rectal cancer surgery, without obvious advantage for radical colon cancer surgery. Moreover, 3D laparoscopy increases the number of dissected lymph nodes for radical colon cancer surgery but may not be observed in rectal cancer surgery.

18.
Biomater Sci ; 12(9): 2229-2243, 2024 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-38497247

RESUMEN

Nanozymes, a distinctive class of nanomaterials endowed with enzyme-like activity and kinetics akin to enzyme-catalysed reactions, present several advantages over natural enzymes, including cost-effectiveness, heightened stability, and adjustable activity. However, the conventional trial-and-error methodology for developing novel nanozymes encounters growing challenges as research progresses. The advent of artificial intelligence (AI), particularly machine learning (ML), has ushered in innovative design approaches for researchers in this domain. This review delves into the burgeoning role of ML in nanozyme research, elucidating the advancements achieved through ML applications. The review explores successful instances of ML in nanozyme design and implementation, providing a comprehensive overview of the evolving landscape. A roadmap for ML-assisted nanozyme research is outlined, offering a universal guideline for research in this field. In the end, the review concludes with an analysis of challenges encountered and anticipates future directions for ML in nanozyme research. The synthesis of knowledge in this review aims to foster a cross-disciplinary study, propelling the revolutionary field forward.


Asunto(s)
Aprendizaje Automático , Nanoestructuras , Nanoestructuras/química , Enzimas/química , Enzimas/metabolismo , Humanos
19.
Asian J Surg ; 47(1): 112-117, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-37331857

RESUMEN

OBJECTIVE: Unilateral laminotomy for bilateral decompression (ULBD) has been adopted widely to treat lumbar spinal stenosis (LSS). The objective of the study is to investigate clinical and radiological outcomes of the biportal endoscopic ULBD (BE-ULBD) and uniportal endoscopic ULBD (UE-ULBD). METHODS: We collected retrospectively 65 patients' data who met the inclusion criteria (July 2019-June 2021). 33 patients underwent BE-ULBD surgery, and 32 patients underwent the UE-ULBD surgery, and were followed up for at least 1 year. The following preoperative and postoperative outcomes were compared between groups: the visual analog scale (VAS) for pain, the Oswestry disability index (ODI) for nerve function, and modified Macnab criteria for satisfaction, the cross-sectional area of the dural sac (DSCSA), the mean angle of facetectomy. RESULTS: Age, BMI, gender, levels of involvement and duration of symptoms were not significantly different at baseline in this study. Clinical data showed that postoperative ODI, VAS scores and Modified Macnab Criteria were not statistically different between the two groups. The BE-ULBD group had a shorter operation time than the UE-ULBD group (P < 0.001). Patients in the BE-ULBD group had a larger postoperative expansion of DSCSA expansion postoperatively (85.58 ± 3.16 mm2 VS 71.43 ± 3.35 mm2, P < 0.001) and a larger contralateral facetectomy angle (63.95 ± 3.34° vs 57.80 ± 3.43°, P < 0.001) compared with patients in the UE-ULBD group. There were no statistical differences in the incidence of postoperative complications between the two groups. CONCLUSION: Both the BE-ULBD and the UE-ULBD yielded clinical improvement in terms of pain and stenosis symptoms. The BE-ULBD technique has the advantages of the shorter operation time, larger DSCSA expansion and larger contralateral facetectomy angle.


Asunto(s)
Laminectomía , Estenosis Espinal , Humanos , Laminectomía/métodos , Descompresión Quirúrgica/métodos , Estenosis Espinal/diagnóstico por imagen , Estenosis Espinal/cirugía , Estudios Retrospectivos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Resultado del Tratamiento , Dolor
20.
Waste Manag ; 186: 46-54, 2024 Jun 08.
Artículo en Inglés | MEDLINE | ID: mdl-38852376

RESUMEN

Medical waste incineration ash (MWIA) has significant concentrations of heavy metals, dioxins, and chlorine that, if handled incorrectly, might cause permanent damage to the environment and humans. The low content of calcium (Ca), silicon (Si), and aluminum (Al) is a brand-new challenge for the melting technique of MWIA. This work added coal fly ash (CFA) to explore the effect of melting on the detoxication treatment of MWIA. It was found that the produced vitrification product has a high vitreous content (98.61%) and a low potential ecological risk, with an initial ash solidification rate of 67.38%. By quantitatively assessing the morphological distribution features of heavy metals in ashes before melting and molten products, the stabilization and solidification rules of heavy metals during the melting process were investigated. This work ascertained the feasibility of co-vitrification of MWIA and CFA. In addition, the high-temperature melting and vitrification accelerated the detoxification of MWIA and the solidification of heavy metals.

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