Influence of Rotational Speed on Isothermal Piston Compression System.

An isothermal piston is a device that can achieve near-isothermal compression by enhancing the heat transfer area with a porous media. However, flow resistance between the porous media and the liquid is introduced, which cannot be neglected at a high operational speed. Thus, the influence of rotational speed on the isothermal piston compression system is analyzed in this study. A flow resistance mathematical model is established based on the face-centered cubic structure hypothesis. The energy conservation rate and efficiency of the isothermal piston are defined. The effect of rotational speed on resistance is discussed, and a comprehensive energy conservation performance assessment of the isothermal piston is analyzed. The results show that the increasing rate of the resistance work increases significantly proportional to the rotational speed, and the proportion of resistance work in the total work increases gradually and sharply. The total work including compression and resistance cannot be larger than the compression work under adiabatic conditions. The maximum rotational speed is 650 rpm.

Characterization of a convection-based support microstructure through a flow resistance parameter.

Modern convection-based supports differ substantially in pore size, porosity, and microstructure topology. Due to such variability, it is challenging to evaluate the contribution of a particular microstructure topology on flow resistance. We demonstrated that the flow resistance parameter ( ϕ $\phi $ ) introduced decades ago can be used as a criterion to evaluate the effect of microstructure topology on a pressure drop when the pore size is used as a characteristic support dimension. Furthermore, the ϕ $\phi $ value of simple cubic packing was calculated over the entire range of open porosity and compared to the ϕ $\phi $ values determined for pressure drop models derived for particular convection-based supports and experimental values of various convection-based supports from the literature. It was shown that different convection-based supports become clustered into distinct groups when plotted according to their ϕ $\phi $ and open porosity values, allowing their discrimination.

The Impact of Wettability on Dynamic Fluid Connectivity and Flow Transport Kinetics in Porous Media.

Usually, models describing flow and transport for sub-surface engineering processes at the Darcy-scale do not take into consideration the effects of pore-scale flow regimes and fluid connectivity on average flow functions. In this article, we investigate the impact of wettability on pore-scale flow regimes. We show that fluid connectivity at the pore scale has a significant impact on average flow kinetics and therefore its contribution should not be ignored. Immiscible two-phase flow simulations were performed in a two-dimensional model of a Berea sandstone rock for wettability conditions ranging from moderately water-wet to strongly oil-wet. The simulation results show that wettability has a strong impact on invading fluid phase connectivity, which subsequently influences flow transport resistance. The effect of invading-phase connectivity and ganglion dynamics (GD) on two-phase displacement kinetics was also investigated. It was found that invading phase connectivity decreases away from the neutrally wet (intermediate wet) state. This study provides evidence that GD accelerate fluid flow transport kinetics during immiscible displacement processes. Lastly, the impact of wettability on fluid displacement efficiency and residual saturations was investigated. Maximum displacement efficiency occurred at the neutrally wet state.

Research on Measurement Principle and Key Measuring Devices of Pressure Change Rate for Electronically Controlled Pneumatic Brake of Commercial Vehicle Based on Poiseuille's Law.

For intelligence brakes in the electronic pneumatic brake system of commercial vehicles, the pressure change rate is used as the key control parameter and evaluation index. This can improve the brake safety, stability, and ride comfort of the vehicle. The real-time detection of the brake pressure change rate for commercial vehicles is the premise for realizing the accurate control of brake pressure change rate. Based on Poiseuille's law, an efficient measurement method of brake pressure change rate is proposed for commercial vehicles, and a new measuring device with an isothermal container and laminar flow resistance tube as the core components is designed. Through thermal insulation performance tests, flow resistance tests and measurement accuracy tests, combined with simulations, the effects of structural parameters and copper wire filling density on the performance of the isothermal container are analyzed, and these key parameters are optimized to improve the thermal insulation performance. A tubular laminar flow resistance tube composed of 304 stainless steel capillaries in parallel is designed. The influence mechanism of core parameters such as the number, radius, and length of laminar flow channels on its performance is studied, and the optimal parameter array is selected to optimize its performance. The experimental platform for measuring brake pressure change rate is constructed. By comparing the measurement curve of brake pressure change rate under simulation and experiment, the correctness and effectiveness of the pressure change rate measurement principle and the key components for electronically controlled pneumatic brakes of commercial vehicles are verified to meet engineering requirements.

Effect of cytosol viscosity on the flow behavior of red blood cell suspensions in microvessels.

OBJECTIVE: The flow behavior of blood is strongly affected by red blood cell (RBC) properties, such as the viscosity ratio C between cytosol and suspending medium, which can significantly be altered in several pathologies (e.g. sickle-cell disease, malaria). The main objective of this study is to understand the effect of C on macroscopic blood flow properties such as flow resistance in microvessels, and to link it to the deformation and dynamics of single RBCs. METHODS: We employ mesoscopic hydrodynamic simulations to investigate flow properties of RBC suspensions with different cytosol viscosities for various flow conditions in cylindrical microchannels. RESULTS: Starting from a dispersed cell configuration which approximates RBC dispersion at vessel bifurcations in the microvasculature, we find that the flow convergence and development of RBC-free layer (RBC-FL) depend only weakly on C, and require a convergence length in the range of 25D-50D, where D is channel diameter. In vessels with D≤20µm , the final resistance of developed flow is nearly the same for C = 5 and C = 1, while for D=40µm , the flow resistance for C = 5 is about 10% larger than for C = 1. The similarities and differences in flow resistance can be explained by viscosity-dependent RBC-FL thicknesses, which are associated with the viscosity-dependent dynamics of single RBCs. CONCLUSIONS: The weak effect on the flow resistance and RBC-FL explains why RBCs can contain a high concentration of hemoglobin for efficient oxygen delivery, without a pronounced increase in the flow resistance. Furthermore, our results suggest that significant alterations in microvascular flow in various pathologies are likely not due to mere changes in cytosolic viscosity.

On deriving Murray's law from constrained minimization of flow resistance.

Murray's law, which states that the cube of the radius of a parent vessel equals the sum of the cubes of the radii of the daughter vessels, was originally derived by minimizing the cost of operation of blood flow in a single cylindrical tube. An alternative widely cited derivation by Sherman is based upon the optimization problem of minimizing the total flow resistance subject to a material constraint, and that study claimed that "Conservation of the sum of the cubes of the radii is the condition for minimal resistance whether the parent vessel divides symmetrically or asymmetrically, and whether it divides into two, three, four, or, presumably, any number of daughter vessels." In this paper we show that Sherman's analysis is flawed, since with N daughter vessels there are 2N-N-1 sets of vessel radii which satisfy Murray's law but which do not yield minimal total flow resistance. Moreover, we show that when there are N daughter vessels, each with the same radius, the minimal total flow resistance is an increasing function of N for N⩾1. Since N=1 corresponds to the degenerate case of no branching at all, our result implies that bifurcation (N=2) achieves the minimal total flow resistance. Our analysis thus offers an explanation for the preponderance of bifurcations (as opposed to trifurcations or higher level branchings) in many biological systems.

Magnetohydrodynamic Moving Liquid Plug Within a Microchannel: Analytical Solutions.

The wide applications of plug flows in microscale in science and engineering help them attract a great deal recent interest. An analytical study is undertaken here to study the impacts of a transversely applied external uniform magnetic field affecting the motion of liquid in the plug in terms of hydrodynamic mixing properties. The well-known symmetric vortex structure occurring in a long plug with moderate aspect ratio is observed to be preserved, while the recirculation phenomenon is highly affected by the action of the magnetic field. The decelerating feature of Lorentz force on the liquid motion is illuminated by reducing the strength of the recirculating vortex moving towards the upper and lower walls. The effects of magnetic field on the flow resistance of the liquid plug as well as on the plug circulation rate and on the axial flux are also clarified. The liquid plug considered here is shown to be fully consistent with the continuous liquid flow in a channel whose exact solution is further extracted.

Fritz Rohrer (1888-1926), a pioneer in pulmonary mechanics whose work was inexplicably ignored for about 30 years.

Fritz Rohrer (1888-1926) has a special place in the history of respiratory physiology for two reasons. The first is that he laid the foundations of modern pulmonary mechanics in the early 1900s. For example, his seminal paper on pulmonary dynamics, that is, the pressure-flow relationships in the airways, was published in 1915 in one of the top journals in the field. It included extensive measurements of airway dimensions in postmortem human lungs and a sophisticated analysis of the modes of airflow. This was closely followed by a very original analysis of lung statics, which included studies of airway pressures at normal, maximal, and minimal lung volumes in relaxed normal volunteers, and was published in 1916. Remarkably, both papers were essentially ignored at the time. Fortunately, in 1925 he was able to summarize his major findings in a chapter in an important handbook of physiology. However, he tragically died from pulmonary tuberculosis in the following year at the early age of 37. The second reason for his importance in the history of pulmonary mechanics is that inexplicably his very innovative research was essentially ignored for about 30 years. It was not until the 1940s that his work was rediscovered, although not in time to save investigators from duplicating his very original studies. Possible reasons why his work was ignored for so long are discussed. Even today it is not easy to recover some important features of his career, and some aspects of his very original research are still almost unknown.

Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?

Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGR fetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies ( P < 0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation, which occurs in adults. During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance ( P < 0.05). fHbF sequestered NO in acute and chronic exposure models ( P < 0.001), and fHbF-primed placental endothelial cells developed a proinflammatory phenotype, demonstrated by activation of NF-κB pathway, generation of IL-1α and TNF-α (both P < 0.05), uncontrolled angiogenesis, and disruption of endothelial cell flow alignment. Elevated fHbF contributes to increased fetoplacental vascular resistance and impaired endothelial protection. This unrecognized mechanism for fetal compromise offers a novel insight into FGR as well as a potential explanation for associated poor fetal outcomes such as fetal demise and stillbirth.-Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P., Brownbill, P. Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?

The Detection of Water Flow in Rectangular Microchannels by Terahertz Time Domain Spectroscopy.

Flow characteristics of water were tested in a rectangular microchannel for Reynolds number (Re) between 0 and 446 by terahertz time domain spectroscopy (THz-TDS). Output THz peak trough intensities and the calculated absorbances of the flow were analyzed theoretically. The results show a rapid change for Re < 250 and a slow change as Re increases, which is caused by the early transition from laminar to transition flow beginning nearly at Re = 250. Then this finding is confirmed in the plot of the flow resistant. Our results demonstrate that the THz-TDS could be a valuable tool to monitor and character the flow performance in microscale structures.

Aerodynamic Parameters in Byzantine Chant Voices: Comparisons Across Pitch and Loudness.

OBJECTIVE: This study was designed to assess the impact of phonation frequency and loudness increase on aerodynamic parameters of the singing voice in Byzantine chant (BC). DESIGN: Aerodynamic measurements in BC were obtained and statistically analyzed. METHOD: Fifteen experienced BC chanters, all baritones, performed the ascending notes G2, C3, E3, G3, C4, E4, and G4, at normal and high levels of loudness within a mask, while repeating strings of /pi/ syllables. The parameters of airflow (FR), subglottal pressure (Psub), and sound pressure level (SPL) were directly measured, and from them, the glottal flow resistance (Rg) and vocal efficiency (VE) were calculated. All the parameters' values were statistically analyzed. RESULTS: Statistically significant differences for FR, Psub, and SPL parameters in BC between the two loudness levels, at constant pitch, and for Psub, SPL, Rg, and VE among different pitches, at constant loudness levels were detected. When loudness increases, a) only the mean values of FR, Psub, and SPL, within C3-C4, increase, whereas those of Rg and VE do not show any change, and b) at G2, only the mean Psub increases, while in the upper range E4-G4, both mean SPL and mean VE decrease. When pitch is raised, a) for each level of loudness, within G2-E4 pitch range, the means of Psub, SPL, Rg, and VE increase while this is not the case for FR, and b) in the highest range (E4-G4), average SPL and VE drop while Rg and Psub remain stable. Our findings suggest that: a) most participants increase Psub and SPL without modification of Rg when loudness increases, and b) most participants increase both SPL and Psub while changing Rg with pitch rise. Idiosyncratic differences among the participants were detected in Rg and Psub, because of pitch rise, and, also, in Rg and VE due to loudness increase. CONCLUSIONS: The results from this study reveal that, within the C3-C4 pitch range: a) there is independent control between the loudness and glottal adduction, and b) Psub is the main tool for increasing both the loudness and SPL. For some exceptions among the participants, either the Rg alteration or other modifications of the vocal system are, possibly, the cause of the loudness increase. The increased mean values of SPL, Rg, and Psub with pitch rise, for most participants, suggest that both glottal adduction and Psub increase together with the SPL and pitch increase. The VE increase within G2-E4 pitches reaches a maximum value at E4. Some exceptions among the participants exist that suggest the possible use of different phonatory strategies when changing either the pitch or the vocal loudness.

Nasal turbinate lymphatic obstruction: a proposed new paradigm in the etiology of essential hypertension.

Hypertension affects an estimated 1.3 billion people worldwide and is considered the number one contributor to mortality via stroke, heart failure, renal failure, and dementia. Although the physiologic mechanisms leading to the development of essential hypertension are poorly understood, the regulation of cerebral perfusion has been proposed as a primary cause. This article proposes a novel etiology for essential hypertension. Our hypothesis developed from a review of nuclear medicine scans, where the authors observed a significantly abnormal increase in nasal turbinate vasodilation in hypertensive patients using quantitative region of interest analysis. The authors propose that nasal turbinate vasodilation and resultant blood pooling obstruct the flow of cerebrospinal fluid passing through nasal turbinate lymphatics, thereby increasing intracranial pressure. The authors discuss the glymphatic/lymphatic clearance system which is impaired with age, and at which time hypertension also develops. The increased intracranial pressure leads to compensatory hypertension via Cushing's mechanism, i.e., the selfish brain hypothesis. The nasal turbinate vasodilation, due to increased parasympathetic activity, occurs simultaneously along with the well-established increased sympathetic activity of the cardiovascular system. The increased parasympathetic activity is likely due to an autonomic imbalance secondary to the increase in worldwide consumption of processed food. This hypothesis explains the rapid worldwide rise in essential hypertension in the last 50 years and offers a novel mechanism and a new paradigm for the etiology of essential hypertension. This new paradigm offers compelling evidence for the modulation of parasympathetic nervous system activity as a novel treatment strategy, specifically targeting nasal turbinate regulation, to treat diseases such as hypertension, idiopathic intracranial hypertension, and degenerative brain diseases. The proposed mechanism of essential hypertension presented in this paper is a working hypothesis and confirmatory studies will be needed.

Non-invasive fractional flow reserve derived from reduced-order coronary model and machine learning prediction of stenosis flow resistance.

BACKGROUND AND OBJECTIVE: Recently, computational fluid dynamics enables the non-invasive calculation of fractional flow reserve (FFR) based on 3D coronary model, but it is time-consuming. Currently, machine learning technique has emerged as an efficient and reliable approach for prediction, which allows saving a lot of analysis time. This study aimed at developing a simplified FFR prediction model for rapid and accurate assessment of functional significance of stenosis. METHODS: A reduced-order lumped parameter model (LPM) of coronary system and cardiovascular system was constructed for rapidly simulating coronary flow, in which a machine learning model was embedded for accurately predicting stenosis flow resistance at a given flow from anatomical features of stenosis. Importantly, the LPM was personalized in both structures and parameters according to coronary geometries from computed tomography angiography and physiological measurements such as blood pressure and cardiac output for personalized simulations of coronary pressure and flow. Coronary lesions with invasive FFR ≤ 0.80 were defined as hemodynamically significant. RESULTS: A total of 91 patients (93 lesions) who underwent invasive FFR were involved in FFR derived from machine learning (FFRML) calculation. Of the 93 lesions, 27 lesions (29.0%) showed lesion-specific ischemia. The average time of FFRML simulation was about 10 min. On a per-vessel basis, the FFRML and FFR were significantly correlated (r = 0.86, p < 0.001). The diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value were 91.4%, 92.6%, 90.9%, 80.6% and 96.8%, respectively. The area under the receiver-operating characteristic curve of FFRML was 0.984. CONCLUSION: In this selected cohort of patients, the FFRML improves the computational efficiency and ensures the accuracy. The favorable performance of FFRML approach greatly facilitates its potential application in detecting hemodynamically significant coronary stenosis in future routine clinical practice.

A computational study of the hemodynamic impact of open- versus closed-cell stent design in carotid artery stenting.

The aim of this study is to analyze the shape and flow changes of a patient-specific carotid artery after carotid artery stenting (CAS) performed using an open-cell (stent-O) or a closed-cell (stent-C) stent design. First, a stent reconstructed from micro-computed tomography (microCT) is virtually implanted in a left carotid artery reconstructed from CT angiography. Second, an objective analysis of the stent-to-vessel apposition is used to quantify the lumen cross-sectional area and the incomplete stent apposition (ISA). Third, the carotid artery lumen is virtually perfused in order to quantify its resistance to flow and its exposure to atherogenic or thrombogenic hemodynamic conditions. After CAS, the minimum cross-sectional area of the internal carotid artery (ICA) (external carotid artery [ECA]) changes by +54% (-12%) with stent-O and +78% (-17%) with stent-C; the resistance to flow of the ICA (ECA) changes by -21% (+13%) with stent-O and -26% (+18%) with stent-C. Both stent designs suffer from ISA but the malapposed stent area is larger with stent-O than stent-C (29.5 vs. 14.8 mm(2) ). The untreated vessel is not exposed to atherogenic flow conditions whereas an area of 67.6 mm(2) (104.9) occurs with stent-O (stent-C). The area of the stent surface exposed to thrombogenic risk is 5.42 mm(2) (7.7) with stent-O (stent-C). The computer simulations of stenting in a patient's carotid artery reveal a trade-off between cross-sectional size and flow resistance of the ICA (enlarged and circularized) and the ECA (narrowed and ovalized). Such a trade-off, together with malapposition, atherogenic risk, and thrombogenic risk is stent-design dependent.

Allometric equations for estimating peak uprooting force of riparian vegetation.

Uprooting caused by flood events is a significant disturbance factor that affects the establishment, growth, and mortality of riparian vegetation. If the hydraulic drag force acting on riparian plants exceeds the peak uprooting force originate from their below-ground portion, it may result in the uprooting of these plants. Despite previous studies have documented and investigated the uprooting processes and factors influencing the peak uprooting force of plants, most of these studies have focused on how the root morphological traits of tree and shrub seedlings affect peak uprooting force or mainly collected data in indoor experiments, which may limit the extrapolation of the results to natural environments. To address these limitations, we assume that the peak uprooting force can be estimated by the morphological traits of the above-ground portion of the vegetation. In this study, we conducted in-situ vertical uprooting tests on three locally dominant species: Conyza canadensis, Daucus carota, and Leonurus sibiricus, in a typical riverine environment. The three species were found to have the highest abundance based on the outcomes of the quadrat method. We measured the peak uprooting force, plant height, stem basal diameter, shoot and root wet biomass, and shoot and root dry biomass of each plant and compared them between species. Furthermore, we quantified the influence of morphology on peak uprooting force. Our results showed significant differences in morphological traits and peak uprooting force among the three species. We found a significant positive correlation between peak uprooting force and the morphological traits of the three species. The peak uprooting force increases with plant size following a power law function which is analogous to allometric equations. The allometric equation provided a convenient and non-destructive method to estimate the peak uprooting force based on the above-ground morphological traits of the plants, which may help to overcome the limitations of measuring root morphological traits.

Derivation of new resistance principle on flow-induced morphological response of flexible vegetation.

Water flow under vegetated environments is a noteworthy research topic in environmental hydraulics and restoration ecology, and this research is particularly important for maintaining water transport and streambed stability in water ecosystems. The calculation of the resistance coefficient in vegetated water flow is the core of this research. But there are still problems such as complex expressions and low simulation accuracy in this research field. To solve this scientific problem, this research, based on the theoretical study of environmental hydraulics and genetic algorithm, selected three basic parameters of vegetation submergence, resistance length and curvature degree, and successfully constructed the formula for calculating the resistance coefficient for flexible vegetated flow by using a wide range of data sets. New quantitative relationship between the drag coefficient and the relative roughness of flexible vegetation was established in this study. The formula of drag coefficients for flexible vegetation conditions has a more concise form and can be successfully applied to both flexible and rigid vegetation. As flexible vegetation is deformed under the action of water flow, and the quantitative expressions of Vogel number and relative roughness are given quantitatively through the analysis of its physical properties. Overall, this study improves the basic theoretical study of vegetated flow in environmental fluid dynamics and provides scientific theoretical support for vegetation restoration.

Properties of Self-Compacting Concrete Produced with Optimized Volumes of Calcined Clay and Rice Husk Ash-Emphasis on Rheology, Flowability Retention and Durability.

The durability of concrete requires a dense microstructure which can be achieved by using self-compacting concrete (SCC). Both calcined clay (CC) and rice husk ash (RHA) are promising supplementary cementitious materials (SCMs) that can partially replace cement, but their use in SCC is critical due to their higher water demand (WD) and specific surface area (SSA) compared to cement. The effect of partial substitution of cement at 20 vol-% with binary and ternary blends of CC and RHA on flowability retention and durability of SCC was investigated. The empirical method of SCC design was adopted considering the physical properties of both CC and RHA. The deformability of the SCC was evaluated using the slump flow and J-ring tests. The T500 time and the V-funnel test were used to assess the viscosity of the SCC. The flowability retention was monitored by the plunger method, and flow resistance was determined based on the rheological measurements of SCC. The evolution of the hydrate phases of the binder in SCC was determined by thermogravimetric analysis, while the durability was evaluated by a rapid chloride migration test. Cement partial replacement with 20 vol-% CC has no significant effect on fresh SCC, flowability retention, compressive strength and durability properties. On the other hand, 20 vol-% RHA requires a higher dosage of SP to achieve self-compactability and increase the viscosity of SCC. Its flowability retention is only up to 30 min after mixing and exhibited higher flow resistance. It consumes more calcium hydroxide (CH) and improves the compressive strength and chloride resistance of SCC. The ternary blending with CC and RHA yielded better fresh SCC properties compared to the binary blend with RHA, while an improved chloride penetration resistance could be achieved compared to the binary CC blend.

The Role of the Vocal Tract's Acousto-Mechanical Resonance on the Mechanism of Bubble Release From Tubes Used in SOVTE.

AND OBJECTIVES: Semi-occluded vocal tract exercises involving a tube with a distal end immersed in water have been used as a voice rehabilitation technique for nearly 60 years. Advantages of this technique include a constant flow resistance, which is mainly dependent on the tube's immersion depth, and an oscillatory component of the back pressure due to bubble release, which is assumed to provide relief of muscle hypertension around the laryngeal and pharyngeal regions. The goal of this study is twofold. First, to shed more light on the contribution of geometrical parameters, such as tube inner diameter and inclination, on the amplitude of the back pressure oscillation and on the bubble release frequency (BRF). The second goal aims to understand the role of vocal tract compliance on the mechanism of bubble release. We hypothesize that the low-frequency acousto-mechanical resonance of a real compliant vocal tract becomes strongly coupled with the mechanism of bubble release, thereby augmenting the back pressure oscillation and dictating the BRF. METHODS: The BRF and the back pressure are assessed experimentally as a function of flow rate for tubes with a non-compliant upstream condition, considering different diameters and inclinations. These results are compared with theoretical predictions and the experimental data obtained with six adult subjects, from which the vocal tract acousto-mechanical resonance frequencies are also assessed. RESULTS: The results obtained with tubes involving a non-compliant upstream condition agreed well with the theoretical results and did not indicate a significant influence of the inclination nor the inner diameter on the BRF and on the oscillatory component of the back pressure. Despite the good agreement with the theory, the results obtained from the tube with a non-compliant upstream termination diverged significantly from those obtained with human subjects. In the latter case, the back pressure fluctuation was considerably higher and the BRF measured for each subject coincided with the frequency associated their respective vocal tract acousto-mechanical resonance. CONCLUSIONS: Results indicate that the BRF is essentially driven by the acousto-mechanical resonance of the vocal tract. Furthermore, the substantial increase on the amplitude of the oscillatory component of the back pressure suggests a strong feedback loop between the source of pressure (bubble release mechanism) and the resonator (vocal tract). The high-pressure fluctuations within the oral cavity implies that subjects need a considerable extra effort to adjust their vocal tract in order to achieve an adequate impedance match between vocal folds and vocal tractsd to produce voice.

Experimental study on flow resistance characteristics of the uniform steam injection outflow control device.

Introduction: Multi-point steam injection technology is a new completion method for heavy oil horizontal wells to solve the uneven distribution of the intake profile in the horizontal section. It is equipped with the flow control device to achieve the effect of balanced steam injection. Methods: The steady-state experiment method was adopted; Considering the variable mass complex flow of the steam-liquid two-phase flow in the downhole flow device, the pressure loss of downhole tools through uniform steam injection with different steam-liquid compositions was tested, the influencing factors of the pressure drop were analyzed, and a more reliable pressure drop calculation method was established. Results: The overflow pressure drop can be adjusted by changing the aperture, steam dryness, and fluid flow of the downhole outflow control device (OCD). Discussion: By comparing the experimental and theoretical results, the calculation method of the overflow resistance of single-phase and steam-liquid two-phase fluids in OCD is given, and the error is within the usable range.

Comparative evaluation of straight and curved extension dialysis catheters for continuous renal replacement therapy in dogs with acute kidney injury.

Background: A patent dual-lumen dialysis catheter is one of the basic requirements for efficient extracorporeal (EC) therapy. Aims: The objective of this study was to measure the resistance to blood flow offered by straight and curved-extension dual-lumen dialysis catheters used for continuous renal replacement therapy (CRRT). Methods: Twenty dogs suffering from acute kidney injury (AKI) were subjected to CRRT. The dogs were allocated randomly to Group-I (curved extension catheter, n=12) or Group II (straight extension catheter, n=8), based on the type of dual-lumen catheter used in CRRT. The catheter outflow and inflow pressures were recorded at blood pump speeds of 50 ml/min and 99-100 ml/min. Data were tested for normality, and differences in mean inflow and outflow catheter resistances were evaluated for statistical significance using independent samples t-tests. Results: Straight extension catheters offered lower inflow resistance than curved extension catheters at both 50 ml/min (41.50 ± 5.84 mm Hg vs. 63.75 ± 6.88 mm Hg, P=0.03) and 99-100 ml/min (63.00 ± 8.11 mm Hg vs. 86.92 ± 7.02 mm Hg, P=0.04) blood flow rates. Straight extension catheters also offered lower outflow resistance than curved catheters at 99-100 ml/min blood flow rate (-94.12 ± 7.91 mm Hg vs. -128.25 ± 7.56 mm Hg, P=0.01; the negative signs only indicate the direction of blood flow). Conclusion: These findings suggest that straight-extension dual-lumen dialysis catheters perform better than the curved model in extracorporeal renal replacement therapy by considering their lower resistance to blood flow.