Decoding the biological information contained in two ancient Slavonic parchment codices: an added historical value.

This study provides an example in the emerging field of biocodicology showing how metagenomics can help answer relevant questions that may contribute to a better understanding of the history of ancient manuscripts. To this end, two Slavonic codices dating from the 11th century were investigated through shotgun metagenomics. Endogenous DNA enabled to infer the animal origin of the skins used in the manufacture of the two codices, while nucleic sequences recovered from viruses were investigated for the first time in this material, opening up new possibilities in the field of biocodicology. In addition, the microbiomes colonizing the surface of the parchments served to determine their conservation status and their latent risk of deterioration. The saline environment provided by the parchments selected halophilic and halotolerant microorganisms, which are known to be responsible for the biodegradation of parchment. Species of Nocardiopsis, Gracilibacillus and Saccharopolyspora, but also members of the Aspergillaceae family were detected in this study, all possessing enzymatic capabilities for the biodeterioration of this material. Finally, a relative abundance of microorganisms originating from the human skin microbiome were identified, most probably related to the intensive manipulation of the manuscripts throughout the centuries, which should be taken with caution as they can be potential pathogens.

Missionaries, measles, and manuscripts: revisiting the Whitman tragedy.

The missionaries Marcus Whitman, a doctor, and Narcissa Whitman, his wife, and twelve other members of the Waiilatpu Mission were murdered in November 1847 by a small contingent of the Cayuse Indians in the Oregon Territory. The murders became known as the "Whitman Massacre." The authors examine the historical record, including archived correspondence held at the Yale University Libraries and elsewhere, for evidence of what motivated the killings and demonstrate that there were two valid perspectives, Cayuse and white. Hence, the event is better termed the "Whitman Tragedy." A crucial component, a highly lethal measles epidemic, has been called the spark that lit the fuse of the tragedy.

Visiting Newton's atelier before the Principia, 1679-1684.

The worksheets that presumably contained Newton's early development of the fundamental concepts in his Principia have been lost. A plausible reconstruction of this development is presented based on Newton's exchange of letters with Robert Hooke in 1679, with Edmund Halley in 1686, and on some clues in the diagram associated with Proposition 1 in Book 1 of the Principia that have been ignored in the past. A graphical construction associated with this proposition leads to a rapidly convergent method to obtain orbits for central forces, which elucidates how Newton may have have been led to formulate some of his most fundamental propositions in the Principia.

Medical and neuropsychiatric phenomena depicted in two Spanish medieval texts of Marian miracles.

In the history of Christianity, veneration of the Virgin Mary reached its greatest intensity in the XIII century. Her perceived impact on daily life was tremendous and not surprisingly this extended to the spheres of disease and healing. The purpose of this study is to compare the medical and neuropsychiatric findings in two XIII century Spanish texts of Marian miracles, both examples of the popular Catholicism (vs. official catholic doctrine). We analyzed the medical and neuropsychiatric events in the Cantigas de Santa Maria (Canticles of St. Mary, CSM), composed at the court of Alfonso X and the Milagros de Nuestra Señora (The Miracles of Our Lady, MNS), written by Gonzalo de Berceo. Among the 25 miracles reported in the MNS, medically relevant facts were addressed in 19 miracles with a total of 23 recorded events (including resurrection or escape from death in five) and demonic possession in three (one with witchcraft/deicide). The most common medical subjects were ergotism, obstetric-gynecological, sudden death, intellectual disability/illiteracy, encephalopathy/alcohol intoxication, suicide (with self-mutilation/castration), infanticide, infections, and absence of body decomposition after death. The 427 canticles in the CSM contain 270 medically relevant facts. Neuropsychiatric conditions were alluded to in 98 songs. Blindness and dystonia/weakness/deformities were the most common phenomena. Illuminations detailed many of the medical facts in the CSM, but not in the MNS. Medically relevant facts were described in both texts, but with more details in the CSM. Neurological conditions were more often described in the CSM, psychiatric conditions in the MNS.

Astronomy and calendar reform at the curia of Pope Clement VI: a new source.

The article introduces a previously unknown fourteenth-century treatise on computus and calendrical astronomy entitled Expositio kalendarii novi, whose author proposed elaborate solutions to the technical flaws inherent in the calendar used by the Roman Church. An analysis of verbal parallels to other contemporary works on the same topic makes it possible to establish that the Expositio was produced in the context of a calendar reform initiative led by Pope Clement VI in 1344/45 and that this anonymous text is probably identical to a 'great and laborious work' on the calendar that the monk Johannes de Termis prepared for the pope around this time. Its author strove to make an original contribution by extracting new astronomical parameters from both ancient and contemporary data, which made him arrive at an estimate of the length of the tropical year that was independent of the then-current Alfonsine Tables. With its suggestion to remove eleven days from the Julian calendar and to correct the calendar through modified leap-year rhythms and periodically adjusted sequences of lunar epacts, the proposal enshrined in the Expositio exhibits some remarkable similarities to the Gregorian reform of the calendar promulgated in 1582. Although its influence on the latter must remain a matter of speculation, the newly discovered text sheds a revealing light on the history of medieval calendar reform debates and on the mathematical sciences practiced at the Avignon court of Clement VI.

Evaluation of a Parchment Document, the 13th Century Incorporation Charter for the City of Krakow, Poland, for Microbial Hazards.

The literature of environmental microbiology broadly discusses issues associated with microbial hazards in archives, but these publications are mainly devoted to paper documents. There are few articles on historical parchment documents, which used to be very important for the development of literature and the art of writing. These studies present a broad spectrum of methods for the assessment of biodeterioration hazards of the parchment document in question. They are based on both conventional microbiological methods and advanced techniques of molecular biology. Here, a qualitative analysis was conducted, based on genetic identification of bacteria and fungi present on the document as well as denaturing gradient gel electrophoresis profiling and examining the destructive potential of isolated microbes. Moreover, the study involved a quantitative and qualitative microbiological assessment of the indoor air in the room where the parchment was kept. The microbes with the highest destructive potential that were isolated from the investigated item were Bacillus cereus and Acinetobacter lwoffii bacteria and Penicillium chrysogenum,Chaetomium globosum, and Trichoderma longibrachiatum fungi. The presence of the B. cereuss train was particularly interesting since, under appropriate conditions, it leads to complete parchment degradation within several days.

Ancient administrative handwritten documents: X-ray analysis and imaging.

Handwritten characters in administrative antique documents from three centuries have been detected using different synchrotron X-ray imaging techniques. Heavy elements in ancient inks, present even for everyday administrative manuscripts as shown by X-ray fluorescence spectra, produce attenuation contrast. In most cases the image quality is good enough for tomography reconstruction in view of future applications to virtual page-by-page `reading'. When attenuation is too low, differential phase contrast imaging can reveal the characters from refractive index effects. The results are potentially important for new information harvesting strategies, for example from the huge Archivio di Stato collection, objective of the Venice Time Machine project.

The remarkable life of Erwin Schrödinger's What Is Life?

In the seven decades since Schrödinger's book was published, it has gone through stages of differing appraisal, starting with guarded approbation in the 1940s. When several luminaries in molecular biology described the work as influencing their careers, the book's renown increased. In What Is Life?, Schrödinger examined genetics from the perspective of a theoretical physicist, and conjured up ideas that dilettantes admired and experts slighted. Schrödinger sowed his most important ideas in terms of metaphors, allowing readers considerable latitude for interpretation. Some found nothing worthwhile in the book, only chemical naivete and ignorance of work that had already been done. Others found deep inspiration and a desire to understand biological reproduction, even if it required new paradigms of physical science. What Is Life?--like the ancient parable of the blind men and an elephant--is an example of the ineffable nature of truth, pitting subjective experience against the totality of the reality. The legacy of What Is Life? may ultimately be respect for different opinions.

[The Codex of the Laboratory of Pharmacognosy of the University of Athens, Part. I]. / Le Codex manuscrit du laboratoire de pharmacognosie de l'Université d'Athènes, I(re) unite.

This work concerns the first part of a manuscript written in the 18th century and stored in the Laboratory of Pharmacognosy of the University of Athens. This part includes an introduction based on the theories of Hippocrates and Galen concerning the four humors: blood, phlegm, yellow bile and black bile, which should be in balance. During the seasons and depending of the age, these humors are converted to each other. Blood increases in the spring and in children, phlegm is growing in winter and in old man, yellow bile in adulthood and black bile in the fall and the third age. The disease is due to the increase or decrease in these fluids. Many formulas with purgative and cholagogue effects are described for each humor. The chapter ends with advice on the necessary diet, hygiene and lifestyle to keep health care.

[A handwritten inscription leading to new information]. / Une inscription manuscrite riche d'enseignements.

Manuscripts written on white pages or margins of ancient books often present some interest for the historian. Here is studied the handwritten inscription on the page facing the frontispiece of the Pharmacopée des dogmatiques by Joseph du Chesne. It referred to the opinion of traditional doctors such as Guy Patin or Jean Riolan about Joseph du Chesne and chemical medicine issued from the theories of Paracelsus. A special interest was given to the pills against plague.

The William Beaumont papers: a life in letters.

The Becker Medical Library holds the correspondence, notebooks and casebooks of William Beaumont, the physician known for his landmark publication on human digestion. Beaumont came to St. Louis, Missouri in 1835. He took part in the creation of the first medical professional society and the first medical school west of the Mississippi. His collection sheds light not only on his research and career, but also on the medical profession in the burgeoning American West.

Wallace, Darwin and Ternate 1858.

Recent debates on the mailing date of Alfred Russel Wallace's 'Ternate essay' to Charles Darwin in the spring of 1858 have ignored certain details that, once taken into account, alter the matter considerably. Here, a closer look is taken at the critical question of whether Wallace's manuscript-accompanying letter represented a reply to the Darwin letter that arrived in Ternate on 9 March; it is concluded that it very probably did not.

Pedagogical progeniture or tactical translation? George Fordyce's additions and modifications to William Cullen's philosophical chemistry--Part II.

This paper compares the affinity theories and the associated affinity diagrams of William Cullen (1710-1790) and George Fordyce (1736-1802), exploring in particular one episode that took place during the brief hiatus between Fordyce's student years at Edinburgh University and the start of his own pedagogical career in London. This investigation complements that contained in Part I of this paper, which compared the chemistry courses given by Cullen and Fordyce, demonstrating that the knowledge originally imparted to Fordyce by Cullen in his Edinburgh lectures was augmented and translated by Fordyce for his own pedagogical purposes. Part II offers greater insight into the flow of knowledge between Fordyce and Cullen. Their correspondence suggests that the relationship between master and student transmuted into something more complicated after Fordyce left Edinburgh, while the model of knowledge transmission between the two can be seen to be more collaborative than might be expected.

The little known Mineral and Chemical History of Iron and A History of Brass by an eighteenth-century technologist, William Lewis (1708-1781).

Sometime during the 1920s, Cardiff Public Libraries (later to become Cardiff Central Library) acquired a six-volume handwritten manuscript collection entitled Mineral & Chemical History of Iron. The author of the manuscripts is named as William Lewis. Now uniformly bound in half-leather and cloth boards, this impressive holding provides, in more than a thousand handwritten pages, an early attempt to produce a full-scale treatise in English on the history of iron.' This note traces the route by which the collection reached Cardiff, and also presents evidence for the existence of a hitherto unknown work on the history of brass by the same author.

Pedagogical progeniture or tactical translation? George Fordyce's additions and modifications to William Cullen's philosophical chemistry--Part I.

This article contributes to a growing body of research on the dissemination, dispersion or diffusion of scientific knowledge via pedagogical networks. By examining students' handwritten lecture notes, I compare the eighteenth-century chemistry lectures given by William Cullen (1710-1790) at Glasgow and Edinburgh Universities with those of his one-time student George Fordyce (1736-1802), in London, at first privately and then as part of the medical education of physicians at St. Thomas's Hospital. Part I examines the broad structure of Cullen's and Fordyce's courses, comparing both course content and pedagogical approaches to ask how far knowledge flowed directly 'downstream,' and the extent to which it was transformed, translated or transmuted in the process of transmission. Part II (forthcoming) will approach the affinity theories of Cullen and Fordyce in greater depth, revealing the dynamics of knowledge transfer. The results shed light on the transmission of knowledge and skills between master and student, and reflect on whether Fordyce can be better described as Cullen's pedagogical progeny, or less straightforwardly as a tactical translator.

Mercury and sulphur among the High Medieval alchemists: from Razi and Avicenna to Albertus Magnus and pseudo-Roger Bacon.

This essay challenges the often expressed view that the principles of metals, namely mercury and sulphur, were generally viewed by alchemists as being of a 'metaphysical' character that made them inaccessible to the tools and operations of the laboratory. By examining a number of Arabo-Latin and Latin alchemical texts in circulation before the end of the thirteenth century, the author presents evidence that most alchemists of the period considered mercury and sulphur to be materials subject to techniques of purification in the same way that naturally occurring salts and minerals could be freed of their impurities or dross. The article also points to the immense influence of Avicenna and Albertus Magnus in formulating the theory that mercury and sulphur were compounds of different materials, containing both fixed and unfixed components. Finally, the author briefly examines the relationship between this materialist approach to the principles and the chymical atomism of early modern authors who were deeply aware of medieval alchemical literature.

Fragments of Alchemy from a Cairene Synagogue: Context, Codicology, and Contents of the Alchemical Corpus of the Cairo Genizah.

This article presents the results of a survey and a first assessment of the corpus of alchemical manuscripts retrieved from the Cairo Genizah, a storage room mainly intended for sacred writings that is attached to the Ben Ezra synagogue of Old Cairo. The alchemical manuscripts are described in their codicological and palaeographic features; their content is analysed in the context of the medieval production of alchemical texts in the surrounding Islamic world. The alchemical corpus of the Genizah represents a unique and widely unstudied source for our understanding of the relationship between Jews and alchemy in the medieval Mediterranean World.

Quantifying degradation of collagen in ancient manuscripts: the case of the Dead Sea Temple Scroll.

Since their discovery in the late 1940s, the Dead Sea Scrolls, some 900 ancient Jewish texts, have never stopped attracting the attention of scholars and the broad public alike, because they were created towards the end of the Second Temple period and the "time of Christ". Most of the work on them has been dedicated to the information contained in the scrolls' text, leaving physical aspects of the writing materials unexamined. They are, however, crucial for both historical insight and preservation of the scrolls. Although scientific analysis requires handling, it is essential to establish the state of degradation of these valued documents. Polarized Raman Spectroscopy (PRS) is a powerful tool for obtaining information on both the composition and the level of disorder of molecular units. In this study, we developed a non-invasive and non-destructive methodology that allows a quantification of the disorder (that can be related to the degradation) of protein molecular units in collagen fibers. Not restricted to collagen, this method can be applied also to other protein-based fibrous materials such as ancient silk, wool or hair. We used PRS to quantify the degradation of the collagen fibers in a number of fragments of the Temple Scroll (11Q19a). We found that collagen fibers degrade heterogeneously, with the ones on the surface more degraded than those in the core.

[Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne]. / Das Wissen der deutschen Neurologen über die Migräne um 1890. Paul Julius Möbius und seine Monographie Die Migräne 1894.

Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.