RESUMEN
The aim of this study was the investigation of effects of the metenolone enanthate (ME) that is used among athletes as doping and muscle amplifier, on hearts of male and female rats that are in puberty using morphometrical methods. A total of 36 rats which were divided into three separate groups (Experiment, ME; vehicle, PO; control, C) each consisting of 6 male and 6 female rats were used. 0.5 mg/kg metenolone enanthate was applied intraperitoneally into experiment subjects 5 times a week over a period of 4 weeks. At the end of experiment, rats were euthanized and their hearts were cut at the level of musculus papillaris after the fixation in formalin. Hearts were taken out and embedded in paraffin wax. Photos were taken at cut surfaces, and thickness, diameters and surface area levels were measured. Left ventriculus mass (LVM) and left ventriculus mass index (LVMI) were calculated. In the study LVM (p<0.005) and LVMI (p<0.05) were found to be significantly higher in the ME group in females whereas left ventricular lumen diameter (LVLD) were found to be significantly lower (p<0.05). Thus left ventricular hypertrophy development was observed. LVM and LVMI were found to be similar in ME and C groups among male rats and the highest level of these data were found in the group. LVM and LVMI were higher among females (p<0.006). In conclusion, it has been shown that the adverse effects of ME on heart were developing starting from puberty and resulting with the enlargement of the heart and left ventricular hypertrophy and especially among females this condition was more evident. It has also been discussed that the continuous use of drugs may further enhance this condition.
Asunto(s)
Envejecimiento/efectos de los fármacos , Anabolizantes/toxicidad , Corazón/efectos de los fármacos , Hipertrofia Ventricular Izquierda/inducido químicamente , Metenolona/análogos & derivados , Caracteres Sexuales , Envejecimiento/patología , Animales , Peso Corporal/efectos de los fármacos , Femenino , Corazón/crecimiento & desarrollo , Hipertrofia Ventricular Izquierda/patología , Masculino , Metenolona/toxicidad , Tamaño de los Órganos/efectos de los fármacos , Ratas , Ratas Sprague-DawleyRESUMEN
Many athletes use drugs, especially anabolic androgenic steroids (AAS), but there are few reports on the endocrinological and pathological changes in AAS abusers. In this study we reported the results of endocrinological examinations in rats administered AAS and also physical changes. We separated 37 male Wistar rats (7 weeks old) into 3 groups: Group A was medicated with nandrolone decanoate, metenolone acetate, and dromostanolone; Group B with nandrolone decanoate and saline; and Group C was given only saline. They were given subcutaneous injections of the medications or the control vehicle once a week for 6 weeks. Medications were stopped for 4 weeks, and then resumed for another 6 weeks. After that, rats were sacrificed. Serum testosterone level in Group A was significantly higher than that in Group C. Serum dihydrotestosterone in Group A was significantly higher than that in both Groups B and C. Serum estradiol-17beta levels in Groups A and B were significantly higher than that in Group C. In pathological evaluation, heart, testis, and adrenal gland were severely damaged. These findings indicate that there is a high degree of risk related to the use of AAS.
Asunto(s)
Anabolizantes/farmacología , Andrógenos/farmacología , Metenolona/análogos & derivados , Nandrolona/análogos & derivados , Glándulas Suprarrenales/patología , Anabolizantes/toxicidad , Andrógenos/toxicidad , Androstanoles/farmacología , Androstanoles/toxicidad , Animales , Conducta Animal/efectos de los fármacos , Dihidrotestosterona/sangre , Estradiol/sangre , Masculino , Metenolona/farmacología , Metenolona/toxicidad , Miocardio/patología , Nandrolona/farmacología , Nandrolona/toxicidad , Nandrolona Decanoato , Ratas , Ratas Wistar , Testículo/patología , Testosterona/sangreRESUMEN
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