Assuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/virologia , Microscopia Eletrônica de Transmissão/métodos , Placenta/virologia , Pneumonia Viral/virologia , Complicações Infecciosas na Gravidez/virologia , Adulto , COVID-19 , Infecções por Coronavirus/transmissão , Feminino , Humanos , Pandemias , Pneumonia Viral/transmissão , Gravidez , SARS-CoV-2Assuntos
COVID-19 , Complicações Infecciosas na Gravidez , SARS-CoV-2 , Feminino , Humanos , Microscopia Eletrônica , Pandemias , Placenta , GravidezRESUMO
The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population. Additionally, the fertility preservation methods for pre- and postpubertal females differ, with only experimental methods available for prepubertal females. We will review the risk of chemotherapy and radiation on female fertility, the approach to fertility preservation in the pediatric and adolescent female population, methods of fertility preservation for both pre- and postpubertal females, barriers to fertility preservation, cost, and psychological and ethical considerations.