[Effect of a Single Dose of Tranexamic Acid Administered during Anterior Cruciate Ligament Reconstruction Using Hamstrings: a Randomized Clinical Study]. / Efekt jednorázového podání kyseliny tranexamové pri rekonstrukci predního zkrízeného vazu hamstringy: randomizovaná klinická studie.

PURPOSE OF THE STUDY Anterior cruciate ligament reconstruction is one of the most common reconstruction surgeries. The unintended consequences of the surgery are hemarthrosis, blood loss, knee swelling and postoperative pain. The purpose of the study was to evaluate the effect of a single dose of intravenous tranexamic acid (TXA) on the postoperative parameters and functional status of the knee joint 3 months after surgery. MATERIAL AND METHODS It is a prospective randomised clinical study. An intravenous injection of TXA equivalent to 15 mg/kg in 100 ml of saline solution was administered to the test group during the surgery (20 minutes before the end of the surgery). The control group was administered 100 ml of saline solution without TXA. In both groups, the following parameters were evaluated preoperatively and postoperatively (on Day 1 and Day 10 and at 1 month and 3 months): thigh circumference at 1 cm above the patella, Coupens and Yates (CY) score for swelling, and pain score (VAS). At 24 hours after the surgery, the blood loss (secretion into the drain) and decrease in hemoglobin (Hb) and hematocrit (HCT) levels compared to the preoperative levels were assessed. The functional status of the knee joint was assessed based on the Lysholm knee scoring scale and the IKDC subjective knee evaluation form preoperatively, or at 1 and 3 months postoperatively. RESULTS In the test group, a significantly lower blood loss was detected 24 hours after the surgery. The mean difference of 128 ml compared to the control group was both statistically and practically significant (p < 0.001, d =1.42). The test group showed a lower decrease in Hb and HCT levels postoperatively compared to the control group, although with no statistical significance. On the first postoperative day, slightly better results of the thigh circumference at 1 cm above the patella and of the CY score were observed in the test group. However, during the follow-up check performed postoperatively on Day 10, the differences in the thigh circumference at 1 cm above the patella, CY score and pain VAS score were negligible. The differences in the functional status of the knee joint between the two groups ascertained during the check performed 1 month and 3 months after the surgery were insignificant. DISCUSSION Our study, just like other studies, confirms a significant effect of a single dose of intravenous TXA on the volume of blood loss and early postoperative swelling, which are the parameters affecting the early postoperative course. Even though the intervention does not affect the subsequent result of surgery, it can undoubtedly be of benefit perioperatively. There is a fairly limited number of randomised clinical studies on this topic in literature, with most of them published in the last 7 years. Further research should, among other things, optimise the protocol and identify a suitable candidate for TXA administration in patients undergoing an ACL reconstruction. CONCLUSIONS Our study confirmed the positive effect of a single dose of intravenous TXA during the reconstruction of anterior cruciate ligament using hamstrings on early postoperative blood loss and early postoperative swelling, which can have a positive effect on wound healing and prevent postoperative complications. Therefore, in agreement with available literature, we recom mend administering a single dose of intravenous TXA in ACL reconstruction, unless there is a contraindication to this therapy. Key words: anterior cruciate ligament reconstruction, hamstrings tranexamic acid, single intravenous administration, clinical evaluation.

[Influence of Anterior Cruciate Ligament Reconstruction on Gait Kinematics]. / Vliv rekonstrukce predního zkrízeného vazu na kinematiku chuze.

INTRODUCTION The anterior cruciate ligament (ACL) reconstruction is a tried and tested method in treating knee joint instability which brings valuable results in an acceptable time frame. In the long-term follow-up, however, a higher risk of knee osteoarthritis development is described. One of the possible reasons is considered to be the abnormal kinematics of the operated knee. The purpose of our study was to determine the degree to which the ACL reconstruction helps restore the correct gait cycle compared to the healthy limb. MATERIAL AND METHODS The study included patients after the ACL reconstruction performed in the period from 1 January 2016 to 31 March 2018. With the use of strict criteria, 11 patients were selected for kinematic analysis, who underwent examinations in a gait laboratory and were also evaluated using the Tegner and Lysholm rating systems and the IKDC (International Knee Documentation Committee) knee score, namely preoperatively and at 6 and 12 months postoperatively. The kinematic assessment of gait was carried out using the Vicon MX system with the placement of reflexive markers in line with the Plug-In Gait model. RESULTS The clinical outcomes (namely the score according to Tegner, Lysholm as well as the IKDC) during the first year postoperatively showed a major improvement in knee function and the achievement of the pre-injury activity level. The kinematic analysis revealed lower knee extension at the stance phase and lower overall range of motion of the limb with the injured ACL compared to the healthy limb. The follow-up evaluation at 6 and 12 months postoperatively showed a persisting between-limbs difference in knee extension, whereas the range of motion gradually improved during the year. CONCLUSIONS Although our study confirmed that the ACL reconstruction is an efficient method to treat knee joint instability, it also indicated that even at one year after the ACL reconstruction, the kinematics of the operated knee was not fully restored to the level of the heathy knee. The persisting limb-difference in gait kinematics could contribute to the gradual development of degenerative changes in the operated knee joint. Key words: anterior cruciate ligament deficiency, anterior cruciate ligament reconstruction, knee kinematics during gait, knee osteoarthritis.

[Short-Term Outcomes of Endoscopic Treatment of Inferior Calcar Calcanei in Patients with Plantar Fasciitis]. / Krátkodobé výsledky endoskopické ablace patní ostruhy u pacientu s plantární fasciitidou.

PURPOSE OF THE STUDY The prospective study evaluates the short-term outcomes of endoscopic treatment of calcar calcanei in patients who underwent unsuccessfully more than 6 months of conservative therapy. MATERIAL AND METHODS Our study included 34 patients with refractory plantar fasciitis, in whom endoscopic treatment of inferior calcar calcanei with partial plantar fasciotomy was performed in the period from 01. 01. 2009 to 31. 07. 2015. The assessed parameters were the following: level of function, pain relief and patient satisfaction on the FAAM (Foot and Ankle Ability Measure) score and VAS (Visual Analog Scale) score with the minimum follow-up of 1 year. RESULTS A marked increase in the FAAM score from 39.2 preoperatively to 94.0 one year after the surgery and also a major pain relief on the VAS score from the initial 8 to the median 0 were observed. In total, 79.4% of patients were symptom-free one year after the surgery. The recurrence of calcar calcanei or ossification was seen on the radiograph taken one year after the surgery in 8 patients (23.5 %). DISCUSSION In our opinion, the most important outcome of our study is the considerable reduction in pain postoperatively (the median VAS score declined from 8 to 0 one year after the surgery) and concurrently a notable increase in the FAAM score (from 39.2 preoperatively to 94.0 one year after the surgery). Similar results of endoscopic partial fasciotomy were achieved also by some other authors. Therefore, this method can be considered validated. It has also been proven that the correlation between the calcar calcanei recurrence, or a higher BMI and recurrence of symptoms postoperatively is insignificant. CONCLUSIONS The endoscopic treatment of inferior calcar calcanei and plantar fasciotomy with denervation of fascial attachment is a fast, minimally invasive and safe method which brings very satisfactory results in the treatment of refractory plantar fasciitis. It is evidenced by subjective patient satisfaction, great function improvement, considerable pain relief after the surgery together with a minimum incidence of complications. Kew words:hindfoot, plantar heel pain, plantar fasciitis, arthroscopic treatment, short-term results.