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1.
Phys Rev Lett ; 112(9): 091302, 2014 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-24655238

RESUMO

The CERN Axion Solar Telescope has finished its search for solar axions with (3)He buffer gas, covering the search range 0.64 eV ≲ ma ≲ 1.17 eV. This closes the gap to the cosmological hot dark matter limit and actually overlaps with it. From the absence of excess x rays when the magnet was pointing to the Sun we set a typical upper limit on the axion-photon coupling of gaγ ≲ 3.3 × 10(-10) GeV(-1) at 95% C.L., with the exact value depending on the pressure setting. Future direct solar axion searches will focus on increasing the sensitivity to smaller values of gaγ, for example by the currently discussed next generation helioscope International AXion Observatory.

2.
Eur Rev Med Pharmacol Sci ; 26(15): 5562-5567, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35993653

RESUMO

OBJECTIVE: In the emergency context of COVID-19 pandemic and lockdown, mindfulness relaxation techniques can provide a safe and effective strategy to obtain in a reasonably short time some degree of relief from suffering and to guarantee a greater confidence with emotional reactions in the general population. SUBJECTS AND METHODS: The Mindfulness-Based Stress Reduction program for coping with COVID-19 emergency was designed as an 8-week program during the early phase of lockdown consisting in practice meditation exercises at least once a day guided and structured by certified instructors entered on a free online platform. At the end of the program all participants completed a survey. RESULTS: A total of 108 surveys were completed (67.6% male; 32.4% female). Despite the difficult moment of lockdown and the fear linked to the pandemic, 61.9% of interviewed subjects declared a state of general well-being from fair to good linked to the practice of mindfulness. Female subjects (p=0.001), married subjects (p=0.05) and people taking pharmacologic therapy demonstrated (p=0.009) significant improvement in daily management of emotions and practical requests during the early phase of the COVID-19 outbreak. CONCLUSIONS: Mindfulness meditation may be effective in helping people to regulate emotions and to support their mental health during this period of worry and uncertainty.


Assuntos
COVID-19 , Meditação , Atenção Plena , Controle de Doenças Transmissíveis , Feminino , Humanos , Masculino , Meditação/métodos , Atenção Plena/métodos , Pandemias
3.
Phys Rev Lett ; 107(26): 261302, 2011 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-22243149

RESUMO

The CERN Axion Solar Telescope (CAST) has extended its search for solar axions by using (3)He as a buffer gas. At T=1.8 K this allows for larger pressure settings and hence sensitivity to higher axion masses than our previous measurements with (4)He. With about 1 h of data taking at each of 252 different pressure settings we have scanned the axion mass range 0.39 eV≲m(a)≲0.64 eV. From the absence of excess x rays when the magnet was pointing to the Sun we set a typical upper limit on the axion-photon coupling of g(aγ)≲2.3×10(-10) GeV(-1) at 95% C.L., the exact value depending on the pressure setting. Kim-Shifman-Vainshtein-Zakharov axions are excluded at the upper end of our mass range, the first time ever for any solar axion search. In the future we will extend our search to m(a)≲1.15 eV, comfortably overlapping with cosmological hot dark matter bounds.

4.
J Dermatol Sci ; 2018 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-29731194

RESUMO

BACKGROUND: Lipoxin A4 (LXA4) is a metabolic product of arachidonic acid. Despite potent anti-inflammatory and pro-resolution activities, it remains to be determined if LXA4 has effect on ultraviolet (UV) radiation-induced skin inflammation. OBJECTIVE: To investigate the effects of systemic administration with LXA4 on UV radiation-induced inflammation and oxidative damage in the skin of mice. METHODS: Varied parameters of inflammation and oxidative stress in the skin of mice were evaluated after UV radiation (4.14 J/cm2). RESULTS: Pretreatment with LXA4 significantly inhibited UV radiation-induced skin edema and myeloperoxidase activity. LXA4 efficacy was enhanced by increasing the time of pre-treatment to up to 72 h. LXA4 reduced UV radiation-induced skin edema, neutrophil recruitment (myeloperoxidase activity and LysM-eGFP+ cells), MMP-9 activity, deposition of collagen fibers, epidermal thickness, sunburn cell counts, and production of pro-inflammatory cytokines (TNF-α, IL-1ß, IL-6 and IL-33). Depending on the time point, LXA4 increased the levels of anti-inflammatory cytokines (TGF-ß and IL-10). LXA4 significantly attenuated UV radiation-induced oxidative damage returning the oxidative status to baseline levels in parameters such as ferric reducing ability, scavenging of free radicals, GSH levels, catalase activity and superoxide anion production. LXA4 also reduced UV radiation-induced gp91phox [nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) subunit] mRNA expression and enhanced nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target enzyme nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase (Nqo1) mRNA expression. CONCLUSION: LXA4 inhibited UV radiation-induced skin inflammation by diminishing pro-inflammatory cytokine production and oxidative stress as well as inducing anti-inflammatory cytokines and Nrf2.

5.
Hum Gene Ther ; 10(7): 1219-28, 1999 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-10340553

RESUMO

A cDNA sequence encoding a soluble form of the human low-density lipoprotein receptor (LDL-R) was produced by RT-PCR amplification. This form of the receptor contains the N-terminal cysteine-rich domain, the EGF homology domain, and the serine/threonine-rich domain, but lacks the membrane anchor as well as the cytoplasmic domain. By the same technical approach a cDNA sequence encoding rabbit transferrin was generated. In-frame fusion of the two cDNAs produced a sequence encoding a chimeric protein potentially capable of binding LDL on the N-terminal side and the transferrin receptor on the C-terminal side. It was expected that LDL bound to the chimeric protein could be internalized, targeted to an acidic compartment, and processed through the pathway of the transferrin receptor. Cells transfected with the LDL-R/transferrin cDNA translate, glycosylate, and secrete the corresponding protein in the culture medium. The secreted protein binds LDL in a ligand-blotting experiment. Finally, the chimeric protein mediates the binding and internalization of LDL in mutant cells lacking the LDL receptor. In fact, Watanabe rabbit fibroblasts, incubated with the chimeric protein show a fourfold increase in LDL binding, a fivefold increase in LDL internalization, and a sixfold increase in LDL degradation, with respect to unincubated fibroblasts.


Assuntos
Hiperlipoproteinemia Tipo II/terapia , Receptores de LDL/genética , Proteínas Recombinantes de Fusão/genética , Transferrina/genética , Animais , Células COS , DNA Complementar , Fibroblastos/metabolismo , Imunofluorescência , Humanos , Lipoproteínas LDL/metabolismo , Plasmídeos/genética , Testes de Precipitina , Coelhos , Receptores de LDL/metabolismo , Proteínas Recombinantes de Fusão/metabolismo , Transfecção , Transferrina/metabolismo
6.
J Neurol Sci ; 168(1): 32-6, 1999 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-10500271

RESUMO

A high frequency of anti-thyroid antibodies has been demonstrated in multiple sclerosis (MS), but there is a lack of data on the possible association of thyroid autoimmunity with disease activity. To assess whether anti-thyroid antibodies are synthesized early in MS or are induced over the course of the disease and whether or not they are correlated with clinical findings, we assayed serum anti-peroxidase and anti-thyroglobulin antibodies in 129 relapsing-remitting MS patients at the time of diagnosis and prior to any immunosuppressive or immunomodulatory treatment. Anti-peroxidase antibodies were detected in 28/129 (21.7%) MS patients, compared to 12/130 (9.2%) neurological controls (P=0.006) and 8/152 (5.3%) normal healthy subjects (P<0.0001). High titres of anti-thyroglobulin antibodies were detected in 11/129 (8.5%) MS patients compared to 6/130 (4.6%) patients with other neurological diseases (P=0.22) and 5/152 (3.3%) normal healthy subjects (P=0.07). Anti-peroxidase antibodies were associated with initial relapse in 14 of 28 (50%) of the patients compared to 18/101 (18%) without antibodies (P=0.001). Similarly, anti-thyroglobulin antibodies were associated with first relapse in 8/11 (73%) of the patients compared to 11/118 (9.3%) of those without (P<0.0001). However, there was no correlation between anti-thyroid antibody titres and disease duration or CSF IgG index values. By contrast, a significant inverse correlation was found between anti-thyroglobulin antibody titres and EDSS score (r(s)=-0. 75; P=0.008). Our findings demonstrate that anti-peroxidase and anti-thyroglobulin antibodies are synthesized early in relapsing-remitting MS and are associated with early clinical disease activity. Furthermore, high titres of anti-thyroglobulin antibodies are associated with low disability scores, suggesting a possible protective role of these antibodies that deserves further investigation.


Assuntos
Autoanticorpos/sangue , Esclerose Múltipla/imunologia , Tireoglobulina/imunologia , Glândula Tireoide/imunologia , Adolescente , Adulto , Autoanticorpos/líquido cefalorraquidiano , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/sangue , Esclerose Múltipla/líquido cefalorraquidiano , Doenças do Sistema Nervoso/sangue , Doenças do Sistema Nervoso/líquido cefalorraquidiano , Doenças do Sistema Nervoso/imunologia , Recidiva , Testes de Função Tireóidea
7.
Cutis ; 47(2): 119-22, 1991 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-2001632

RESUMO

In 1988, 633 patients attending our Allergology Center underwent patch testing with the standard series recommended by the Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali. Of these, 576 patients completed the test correctly and their results were evaluated statistically. Nickel, cobalt, and potassium dichromate were the three most common sensitizers; concomitant positive reactions were present at significant levels. The authors discuss environmental and occupational exposure to contact allergens and correlate the major sites of dermatitis with the sensitivity to each metal in patients of both sexes.


Assuntos
Cobalto/efeitos adversos , Dermatite de Contato/etiologia , Níquel/efeitos adversos , Testes do Emplastro , Dicromato de Potássio/efeitos adversos , Dermatite de Contato/diagnóstico , Feminino , Humanos , Masculino
8.
Cutis ; 42(5): 459-62, 1988 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3143520

RESUMO

A 52-year-old woman who had had ulcerative colitis for more than ten years experienced a third relapse of pyoderma gangrenosum of her lower extremities. She was treated with topical disodium cromoglycate. The dosage of salicylazosulfapyridine and steroids she was taking, and by which the ulcerative colitis, but not the pyoderma gangrenosum could be controlled, was not increased. Because pyoderma gangrenosum is often very difficult to treat and may require an aggressive approach using drugs that can cause serious side effects, we believe that a topical therapy is worth trying.


Assuntos
Cromolina Sódica/administração & dosagem , Úlcera da Perna/tratamento farmacológico , Pioderma/tratamento farmacológico , Administração Tópica , Colite Ulcerativa/complicações , Cromolina Sódica/uso terapêutico , Feminino , Humanos , Úlcera da Perna/complicações , Pessoa de Meia-Idade , Pioderma/complicações , Recidiva
9.
G Ital Dermatol Venereol ; 125(11): 497-500, 1990 Nov.
Artigo em Italiano | MEDLINE | ID: mdl-1965181

RESUMO

Seventy-five patients with anogenital warts were biopsied in the Center for Sexually Transmitted Disease of Galliera Hospital (Genoa). Bioptic specimens were processed for histologic examination, immunohistochemistry using polyclonal antibodies against HPV capsid common antigens and in situ hybridization using HPV 6/11, 16/18, 31/35/51 DNA probes. The aim of the study was to detect patients positive for HPV 16/18, 31/35/51 DNA probes. These HPV types have a higher oncogenic potential and patients with lesions harbouring them are considered to be at risk for progression to malignancy. These patients should be followed up carefully and periodically for early detection of new lesions and neoplastic transformation.


Assuntos
Neoplasias do Ânus/diagnóstico , Condiloma Acuminado/diagnóstico , Neoplasias Penianas/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Neoplasias Vulvares/diagnóstico , Antígenos Virais/análise , Capsídeo/imunologia , Sondas de DNA de HPV , Feminino , Humanos , Imuno-Histoquímica , Masculino , Papillomaviridae/imunologia
10.
G Ital Dermatol Venereol ; 125(6): 247-9, 1990 Jun.
Artigo em Italiano | MEDLINE | ID: mdl-2279749

RESUMO

In January 1989, the Center for Sexually Transmitted Diseases (STD) of Galliera Hospital-Genoa was equipped with a network of 5 Personal Computers connected by a Token Ring to another Personal Computer which is the "server" unit. The Authors report their experiences in the use of the computer system and examine the advantages of networking in the management of a Center for Sexually Transmitted Disease.


Assuntos
Hospitais Especializados , Microcomputadores , Infecções Sexualmente Transmissíveis , Itália
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