RESUMO
The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
Assuntos
Proteínas de Membrana Transportadoras/metabolismo , Preparações Farmacêuticas/metabolismo , Fatores Etários , Animais , Transporte Biológico , Pesquisa Biomédica/métodos , Criança , Desenvolvimento Infantil , Pré-Escolar , Humanos , Lactente , Recém-Nascido , Preparações Farmacêuticas/administração & dosagem , FarmacocinéticaRESUMO
Tissue samples taken during surgery for therapeutic reasons from patients with acquired valvular heart disease (a.v.h.d.) were examined for collagen ultrastructure evaluation. The case material was obtained from 26 patients, and samples from the following organs were evaluated: palatine tonsils, mitral and aortic valves, heart auricle, skeletal muscle, periodontium and subcutaneous tissue. The examinations revealed the presence of general collagenopathy in a.v.h.d. The authors believe that examinations of the connective tissue ultrastructure may be useful and important in diagnostics and prophylaxis of a.v.h.d.