1.
Medicina (B Aires)
; 56(1): 51-4, 1996.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-8734932
RESUMO
Previous studies from our laboratory have demonstrated that human melanoma cell lines and tumors expressed high levels of the extracellular protein SPARC. In order to demonstrate its role in human melanoma progression, IIB-MEL-LES human melanoma cells were transfected with SPARC full length c-DNA in the antisense orientation. In vivo studies demonstrated that all the control mice injected with parental cells developed tumors, while none of the mice injected with cells obtained from three different clones with diminished levels of SPARC expression, developed tumors. These studies suggest that SPARC may play a key role in human melanoma progression.
Assuntos
Melanoma/patologia , Osteonectina/fisiologia , Animais , Northern Blotting , Western Blotting , Células Clonais , DNA Antissenso/genética , Humanos , Masculino , Melanoma/metabolismo , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Osteonectina/metabolismo , Fatores de Tempo , Células Tumorais Cultivadas
2.
Bol Oficina Sanit Panam
; 62(5): 383-6, 1967 May.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-4227692
3.
Bol Oficina Sanit Panam
; 77(3): 231-46, 1974 Sep.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-4278768
4.
Bol Oficina Sanit Panam
; 62(5): 406-17, 1967 May.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-4227694
5.
Boletín de la Oficina Sanitaria Panamericana (OSP)
; 77(3),sept. 1974
Artigo
| PAHOIRIS
| ID: phr-10752
6.
Boletín de la Oficina Sanitaria Panamericana (OSP)
; 77(3): 231-46, sept. 1974.
Artigo
em Espanhol
| PAHO
| ID: pah-39576
7.
Não convencional
em Espanhol
| PAHO
| ID: pah-1644