[The reproductive function of male rats in the late periods after x-ray irradiation]. / Reproduktivnaia funktsiia samtsov krys v otdalennye sroki posle rentgenovskogo oblucheniia.

Reproductive function in male rats was studied in 1, 3 and 6 months after X-ray irradiation of doses of 2 and 3 Gy. It has been established that long-term effects of irradiation at a dose of 3 Gy are manifested through decrease in spermatozoa content in the epididymis and reduction of nucleic acid and protein content in the testes. Fertility of male rats under study significantly lowered shortly after irradiation and full recovery of fecundating ability was observed 6 months later. The effect of irradiation with a dose of 2 Gy was less pronounced.

[Characteristics of the long-term effects of niphtholide on the functional state of the testes in animals]. / Osobennosti prodolzhitel'nogo vozdeistviia niftolidom na funktsional'noe sostoianie semennikov zhivotnykh.

Long-term application of non-steroid antiandrogen niphtholid (10 or 25 mg/kg daily for 8-9 months) exerts a stimulating effect on the functional state of testicles. This effect is more pronounced in rats, than in dogs and guinea pigs. In all these animals the drug antiandrogenic effect caused a decrease of the prostatic mass, while in rats--an increase of the adenohypophysis mass. The peculiarities of the niphtholid effect in various animals should be taken into account when evaluating and interpreting investigation results.

[Recovery of various parameters of the functional state of the reproductive system in thymectomized rats as affected by thymic membrane factor]. / Vosstanovlenie nekotorykh pokazatelei funktsional'nogo sostoianiia reproduktivnoi sistemy u timéktomirovannykh krys pod vliianiem membrannogo faktora timusa.

Ten-month-old male rats thymectomized in early post-puberty were ascertained to have lower plasma luteinizing and testicular hormones and higher testicular steroid dehydrogenase activity. Following 24 hours of administration of a thymocyte membrane structural agent, pituitary gonadotropic and gonadal androgenic functions became normal. There was no agreement between the hormonal parameters and the levels of nucleic acids in the testes and prostate.

[The functional activity of the hypothalamo-hypophyseal-gonadal system in male rats in the late periods after x-ray irradiation]. / Funktsional'naia aktivnost' gipotalamo-gipofizarno-gonadnoi sistemy u samtsov krys v otdalennye sroki posle rentgenovskogo oblucheniia.

The hypothalamo-hypophysis-gonad system was studied in male rats 1, 3 and 6 months after external irradiation with doses of 2 and 3 Gy. Irradiation with a dose of 3 Gy was shown to cause a decrease in the level of LH and testosterone in blood plasma, impairment of steroidogenesis in the testes and diminution of their mass. All this was most pronounced 6 months after X irradiation. The morphofunctional status of prostate, inhibited by X radiation, was restored by that time.

[Effect of 131I incorporation on the status of the reproductive system in male rats and the dose-dependent effect]. / Vliianie inkorporatsii 131I na sostoianie reproduktivnoi sistemy samtsov krys dozozavisimogo éffekta.

Radioactive 131I was injected in single doses 9.25, 37, and 92.5 kBq to prepubertal (30-day-old) male rats. Iodine incorporation in doses 37 and 92.5 kBq resulted in some functional changes in the reproductive system of mature rats: blood testosterone level increased, its hypothalamic aromatization intensified, and biologically active LH level in the blood dropped. Incorporation of 9.25 kBq of 131I had no effect on male reproductive system. A possibility of direct injury to rat testicles by 131I incorporation is suggested.