Prophylaxis for preventing venous thromboembolism in knee arthroscopy and soft tissue reconstruction: consensus statements from an international panel of experts.

PURPOSE: There is a lack of consensus regarding need for Venous Thrombo Embolism (VTE) prophylaxis following arthroscopic knee surgery and open soft tissue knee reconstruction. Clear cut guidelines like ones for trauma surgery and arthroplasty do not exist and the published literature is limited to case reports with a few society guidelines. Given this lack of consensus, we conducted a modified Delphi questionnaire of international experts to provide recommendations on this topic. METHODS: The consensus statements were generated using an anonymised 3 round modified Delphi questionnaire, sent to an international panel of 38 knee surgeons, with an 80% agreement being set as the limit for consensus. The responses were analysed using descriptive statistics with measures like mode, median and box plots. Feedback was provided to all panelists based on responses from the previous rounds to help generate the consensus. RESULTS: Six consensus statements were generated after the three rounds of Delphi. Patient factors, prolonged surgery duration and family history of thrombogenic events emerged as the main points to be taken into consideration for prophylaxis. CONCLUSION: It was established through this study, that there exists a select group of patients undergoing arthroscopic surgery that justify the usage of VTE prophylaxis. The expert responses to most of the questions in different scenarios favoured usage of VTE prophylaxis based on patient factors like advanced age, past history of VTE, smoking, oral contraceptive use etc. LEVEL OF EVIDENCE: Level V.

A new method for measurement of the size of subacromial spurs of the shoulder by cassette tilt view.

OBJECTIVE: Subacromial impingement syndrome is one of the most common causes of pain in the shoulder. To this date, there is no specific radiographic view that can be used to evaluate the size of a subacromial spur. This study aims to examine a cassette tilt view can be used to evaluate the size of a subacromial spur. METHODS: A cross-sectional study was conducted between the time period of January 1, 2016, and December 31, 2016. Forty-three consecutive patients that had planned treatment of arthroscopic subacromial decompression (SAD) participated in this study. Rockwood view and cassette tilt view (caudal tilt 30  with beam and cassette) X-rays were done in all these patients. The measurements of the spur sizes were calculated from both views and were compared to the spur sizes measured intraoperatively. RESULT: The size of the spurs from intraoperative measurement was not significantly different from the spur size measured using the cassette tilt view with a mean difference of 0.54 (95% confidence interval (CI): - 0.58, 1.65), but the intraoperative measurement was significantly different from the Rockwood view spur measurement, with a mean difference of 2.84 (95% CI: 1.56, 4.11). Average proportions of the size of the spur from the cassette tilt and Rockwood view compared to that from intraoperative measurements were 1.09 and 1.55, respectively. CONCLUSION: The cassette tilt view is a simple method of measurement of the size of subacromial spurs, with good inter- and intra-observer reliabilities and good validity. This can be useful clinically when setting the patient position and portals to evaluate the size of the spur when planning SAD. LEVEL OF EVIDENCE: This is level III.

Arthroscopic direct meniscal extrusion reduction: surgical tips to reduce persistent meniscal extrusion in meniscal root repair.

Meniscal extrusion (ME) is defined as extension of the meniscal margin by at least 3 mm beyond the tibial margin. The main purpose of meniscal root repair is to restore the anatomy and function of the meniscus. Therefore, the reduction in the ME is one of the important objective outcomes. Nevertheless, the reduced meniscal extrusion was obtained in limited patients after meniscal root repair. This technical note described the arthroscopic direct meniscal extrusion reduction as surgical tips to reduce persistent meniscal extrusion in posterior meniscal root repair.

3D CAD/reverse engineering technique for assessment of Thai morphology: Proximal femur and acetabulum.

PURPOSE: To assess morphological parameters of proximal femur and acetabulum in Thai population with three-dimensional measurement technique, and to analysis of collateral side symmetric, gender difference, and correlation between morphometric parameters. METHODS: Investigation was performed in 240 femurs. All three-dimensional femur models were acquitted from 64-slice spiral CT scanner. Morphometric parameters under consideration included acetabular diameter, femoral head diameter, shaft isthmus location, intramedullary canal diameter, diaphyseal diameter, femoral head height, femoral neck isthmus, femoral neck length, neck shaft angle, bow angle, and anteversion angle. All parameters were measured based on functions and least-square regression function in CAD software. Obtained measured data were then used for analysis of collateral side symmetric, gender difference, correlation between morphometric parameters, and compared with other populations. RESULTS: Female had a smaller dimension compared with male in most of the parameters. No significant difference was observed between left and right femurs. High correlation pairs of morphometric parameters included femoral head diameter-acetabular diameter, femoral head diameter-neck isthmus diameter, femoral head diameter-diaphyseal diameter at shaft isthmus level, acetabular diameter-neck isthmus diameter, neck isthmus diameter-diaphyseal diameter at shaft isthmus level, and acetabular diameter-diaphyseal diameter at shaft isthmus level. Some morphometric parameters of Thai are smaller than other Caucasian, and some Asian nation, i.e. femoral head diameter, femoral neck length, and femoral head height. CONCLUSIONS: This study provides essential morphometric data for various orthopedic implant designs relating to proximal femur region.

The Effect of Radiographic Beam Angle on Acromiohumeral Interval: 3D-CT Analytic Study.

BACKGROUND: An acromiohumeral interval (AHI) narrower than 7 mm measured on AP shoulder radiographs has been considered pathology and strongly indicative for rotator cuff tears. No study to date has investigated the effect ofradiographic beam position on acromiohumeral interval (AHI) measurement. OBJECTIVE: To study the AHI measurement on conventional radiographs compared with 3D computed tomography (3D-CT) scans and the effectiveness of tilted CT images in physician-performed AHI measurement. MATERIAL AND METHOD: Twenty-eight patients were measured the AHI on conventional radiographs. The same measurement was performed on 3D-CT image tilted in coronal plane--15 degree, 0 degree (Baseline), +15-degree, +30-degree and +45- degree views. For baseline 3D-CT scan, the image position was set as 30 degrees medial and 10-degree downward tilts. RESULTS: The mean AHI on conventional radiographs (8.8 ± 2.4.mm) is significantly more than the AHI on 3D-CT image (7.10 ± 1.5 mm, p = 0.002). The AHI on conventional radiographs and baseline 3D-CT image showed significant moderate to high correlation (r = 0.647, p < 0.001). The upward 3D-CT angle affected the AHI significantly (p = 0.002). CONCLUSION: The AHI measurement on conventional radiographs is significantly higher than 3D-CTscan, with moderate to high correlation. The different position ofthe CT image tilts affected the AHI measurements.

Validity and Reliability of Thai Version of the Foot and Ankle Ability Measure (FAAM) Subjective Form.

BACKGROUND: Self-administered questionnaires have become an important aspect for clinical outcome assessment of foot and ankle-related problems. The Foot and Ankle Ability Measure (FAAM) subjective form is a region-specific questionnaire that is widely used and has sufficient validity and reliability from previous studies. OBJECTIVE: Translate the original English version of FAAM into a Thai version and evaluate the validity and reliability of Thai FAAM in patients with foot and ankle-related problems. MATERIAL AND METHOD: The FAAM subjective form was translated into Thai using forward-backward translation protocol. Afterward, reliability and validity were tested. Following responses from 60 consecutive patients on two questionnaires, the Thai FAAM subjective form and the short form (SF)-36, were used. The validity was tested by correlating the scores from both questionnaires. The reliability was adopted by measuring the test-retest reliability and internal consistency. RESULTS: Thai FAAM score including activity of daily life (ADL) and Sport subscale demonstrated the sufficient correlations with physical functioning (PF) and physical composite score (PCS) domains of the SF-36 (statistically significant with p < 0.001 level and ≥ 0.5 values). The result of reliability revealed highly intra-class correlation coefficient as 0.8 and 0.77, respectively from test-retest study. The internal consistency was strong (Cronbach alpha = 0.94 and 0.88, respectively). CONCLUSION: The Thai version of FAAM subjective form retained the characteristics of the original version and has proved a reliable evaluation instrument for patients with foot and ankle-related problems.

The Anterior Cruciate Ligament Reconstruction with the Peroneus Longus Tendon: A Biomechanical and Clinical Evaluation of the Donor Ankle Morbidity.

BACKGROUND: The purpose of this study was to report on ankle and foot functions via the holistic evaluations using clinical examination, functional scores assessment and isokinetic tests after harvesting autogenous peroneus longus tendons for anterior cruciate ligament (ACL) reconstruction focusing on the donor site morbidity with a minimum 1-year follow-up period. MATERIAL AND METHOD: The study included 24 patients who underwent ACL reconstruction using peroneus longus autograft and endobutton fixation. Results of ACL reconstruction were assessed via physical examination. Donor site morbidity of the foot and ankle after tendon-harvesting was assessed using American Orthopedic Foot-and-Ankle Society (AOFAS) for ankle-hindfoot score and Visual Analogue Score-Foot Ankle (VAS-FA). Isokinetic testing for the ankle was performed in 10 voluntary patients after surgery. RESULTS: Mean follow-up time was 12.8 months. Regarding the latest follow-up, anterior drawer tests of ankle showed normal findings in 83.3%, and 1+ anterior laxity in 16.7% of all patients. Mean pre- and postoperative AOFAS scores were 100.0 ± 0.0 and 96.0 ± 9.6, respectively at 6-month follow-up (p = 0.06). Mean pre- and postoperative VAS-FA scores were 99.7 ± 1.1 and 95.4 ± 12.0, respectively at - 13-month follow-up (p = 0.09). At 7-month follow-up by isokinetic testing, peak torques of eversion and inversion were significantly lower on the harvested ankle compared with the contralateral ankle at both velocities (60 degrees/second and 120 degrees/second, p < 0.05). CONCLUSION: Based on overall findings in the present study, the authors could not recommend the peroneus longus tendon as the first option of donor graft for ACL reconstruction due to the several morbidities particularly in the first 12 months after the operation. However, the peroneus longus tendon may be the option after other graft harvestings for the ligament reconstruction, which needs several tendon grafts in a patient with multi-directional instability of the knee due to some specific situation such as a traumatic knee dislocation.

Vascular Injuries in Multiligament Knee Injuries (MLKIs).

Purpose: Vascular injuries are rarely associated with severe knee injuries; nonetheless, it is imperative to efficiently detect this condition and plan for either immediate or definitive treatment at later stages. The diagnosis and management of multiligament knee injuries still present unresolved issues, particularly in the early detection of vascular issues and the sequential stabilisation of ligaments. High-energy trauma is a frequently encountered cause, however, even low-energy trauma in those who are morbidly obese might pose a significant risk. Advancements in detection and management methods have greatly decreased the occurrence of vascular complications and amputation rates over time. MLKIs after transient knee dislocations are frequently misdiagnosed for vascular injuries, underscoring the necessity for improved diagnostic techniques to avoid avoidable amputations. Methods: This article is a new conceptual review of vascular injuries associated with MLKIs. It provides a full overview of these conditions and includes a review of the most recent literature. We have included pertinent citations from the literature, together with suggestions derived from the latest studies. This review article had additional evaluation by proficient specialists with commendable outcomes and more than a decade of expertise in surgical techniques. Results: This article offers a detailed overview of orthopaedic management, including new definitions and summaries of the causes, evaluation of patients, clinical assessment, identification of vascular injuries, and initial management in patients with vascular impairment following major limb and joint injuries (MLKIs). Conclusion: MLKIs (patients with lower limb ischaemia) who have vascular damage necessitate meticulous physical assessment and sophisticated treatments in order to decrease amputation rates. Prompt identification and timely treatment of vascular lesions, namely in the popliteal artery, can substantially reduce the occurrence of amputations. Emerging research suggests that there is a heightened risk in low-energy situations, particularly amongst individuals who are extremely obese. Progress in vascular intervention has led to a reduction in amputation rates, whilst the implementation of new guidelines has enhanced identification. Thorough patient assessment is essential, utilising physical examinations and imaging techniques such as Computed tomography angiography, magnetic resonance angiography (CTA or MRA) to guide treatment decisions. MRA, in particular, is capable of identifying both vascular and knee structural damage. Level of Evidence: Level IV, Literature reviews.

Multipurpose external fixation for unstable comminuted intraarticular fracture of distal radius.

BACKGROUND: Most of the Intraarticular distal radius fractures are complex and unstable. They are caused by high-energy injuries. The optimal and appropriate treatment remains a topic of controversy. Many different methods of treatment have been advocated such as closed reduction maintained by cast, K-wire fixation with cast, and opened reduction with internal fixation with plate and screws or external fixation with or without K-wire augmentation. OBJECTIVE: To study the efficacy of the TU Model External Fixator for the treatment of unstable intraarticular fracture of distal radius. This was assessed by radiographic anatomical alignment and clinical functional outcome. MATERIAL AND METHOD: Between January 2009 and March 2011, 147 cases of displaced unstable intra articular fracture of distal radius were treated at Thammasat University Hospital. Among these, 35 cases were treated by closed reduction and fixed by TU Model External Fixator Their anatomical alignment (Jupitor and Knirk grading) and clinical outcome (Modified Green and O'Brien score) were assessed with at least 18 months of follow-up. The inclusion criteria are age more than 18 year and AO Type A2 to Type C3 unstable comminuted intraarticular fracture. The patients were excluded if they were Type II Gustillo open fracture, cannot follow the treatment protocol for at least two months, and the cases with volar marginal intraarticular fracture (AO type B or volar Barton pattern), or were younger than 18 year RESULTS: The anatomical outcome were good to excellent in 28 of 30 cases = 93%. The clinical outcome was excellent in 21 cases. The functional result (Green & O'Brien) were good to excellent in 28 of 31 cases = 90%. CONCLUSION: The study shows the functional and/or anatomical outcome for the treatment of the unstable intraarticular fracture of distal radius by the TU Model external fixator It demonstrated equally the efficacy of this device when compared to the previous studies by the other researchers. Therefore, the TU Model external fixator could be a new device for the treatment of unstable comminuted fracture of the distal radius.

Bi-Cortical transhumeral drilling for biceps tenodesis - Is it safe?

Background: Biceps tenodesis is an effective procedure performed to treat shoulder pain originating from the long head biceps tendon. In arthroscopic biceps tenodesis unicortical drilling of the humerus is more commonly practiced as it is considered safe to the vital structures lying posterior to the proximal humerus. Many surgeons are wary of the bi-cortical approach as it poses a risk to these vital structures. The aim of this study was to establish whether bi-cortical drilling in proximal humerus is safe or not. Our second purpose was to find a safe zone (if any) for bi-cortical drilling if bi-cortical drilling is safe. Methods: This study is a descriptive study conducted on cadaveric shoulders. Bilateral shoulders and arms of ten fresh-frozen cadavers (mean age 77.7 y) were dissected. Four landmarks in the dissected humerus were identified. They were superior margin of the bicipital groove, center of the bicipital groove, upper and lower border of pectoralis major insertion. Bi-cortical trans-humeral pinning was done in the humerus at all these points so that the pin exited through the posterior cortex of the humerus. The shortest distance between the pin and the nearest vital structure namely axillary nerve, radial nerve, articular surface of the humeral head, and cephalic vein was calculated from each fixed landmark. Results: We established that bi-cortical drilling in proximal humerus was safe. The safe zone established for bi-cortical biceps tenodesis is at the middle of bicipital groove, which is 18.00 ± 4.02 mm inferior to the groove's upper border. The boundaries of the safe zone lie 9.39 mm superiorly and 9.40 mm inferiorly to the middle of the bicipital groove. Conclusion: The center of the established safe zone for bi-cortical trans-humeral pinning was 18 mm inferior to the bicipital groove's upper border.

Risk Factors for Rotator Cuff Repair Failure and Reliability of the Rotator Cuff Healing Index (RoHI) in Thai Patients: Comparison of the RoHI With a Modified Scoring System.

Background: The success rate of surgical treatment for rotator cuff (RC) tear ranges from 16% to 94%. The Rotator Cuff Healing Index (RoHI) is a system for predicting failure after RC repair and is based on a combined score of factors, including age, anteroposterior (AP) tear size, tendon retraction, fatty infiltration of the infraspinatus muscle, bone mineral density (BMD), and level of work activity. Purpose: To determine the factors leading to RC repair failure in a Thai population, to test the reliability of the RoHI in this population, and to compare the RoHI with a modified RoHI (m-RoHI) based on the factors for repair failure as determined. Study Design: Case-control study; Level of evidence, 3. Methods: This study included 133 Thai patients who underwent arthroscopic RC repair between February 2012 and February 2021. Postoperative magnetic resonance imaging was performed at 6 to 24 months to evaluate RC healing. Variables that might affect failure rates were evaluated, including demographic characteristics, AP tear size and retraction, radiographic measurements, and magnetic resonance imaging findings. The m-RoHI was created using factors that significantly predicted repair failure on multivariate analysis. The area under the receiver operating characteristic curve was calculated to determine the reliability of the RoHI and to compare the reliability of the RoHI and m-RoHI to predict failure rates. Results: Multivariate logistic regression analysis revealed that body mass index ≥23 (adjusted odds ratio [OR], 9.02; P = .034), high work activity (adjusted OR, 19.53; P = .008), AP tear size ≥2.5 cm (adjusted OR, 19.04; P = .001), and a retraction size of 2 to <3 cm (adjusted OR, 20.36; P = .013) were the independent factors that predicted repair failure in our population. BMD was not independently predictive of repair failure. We used these 4 significant independent factors to generate the m-RoHI. The area under the curve of the final adjusted m-RoHI was slightly improved as compared with the original RoHI, but this difference was not significant (0.827 [95% CI, 0.741-0.913] vs 0.780 [95% CI, 0.686-0.875], respectively; P = .447). Conclusion: The m-RoHI had a similar predictive value for repair failure to the original RoHI in our study population, but it did not require obtaining BMD. The m-RoHI may be useful in populations where BMD is not routinely obtained.

Medium to long-term outcomes of medial patellofemoral ligament reconstruction using the superficial quadriceps versus a hamstring autograft in patellar instability patients.

Medial patellofemoral ligament (MPFL) reconstruction is a standard procedure in patellar dislocation patients. Superficial quadriceps autografts (QA) and hamstring autografts (HA) are popular graft choices in MPFL reconstruction with the lack of directly compared clinical studies between both methods. A total of 43 patellar instability patients, who underwent QA and HA for patellar stabilization at a specified center between 2012 and 2021, were retrospectively reviewed. 21 QA and 22 HA patients were 52.4% of males and 47.6% females with a median age of 25 years (range 12-58) in the QA group, while 63.6% were females with a median age of 21 years (range 14-58) in the HA group. The mean follow-up period was 46.9 months (range 24-77) in QA and 61 months (range 24-100) in the HA group. At the final follow-up, no complications were observed with either technique. No patients presented with recurrent dislocations after surgery. There was no statistically significant difference in postoperative mean Kujala scores (QA = 94.9+/- 4.1 and HA = 94.2+/- 8.0, p = 0.73) or the mean Lysholm scores (QA = 94.1+/- 5.0 and HA = 93.2+/- 7.0, p = 0.61).

Intercruciate trans-septal arthroscopic approach to the posterior compartment of the knee joint.

Approach to the posterior compartment of the knee joint and working within it has been made assessable since the trans-septal approach was established. Herein, the authors describe a simple intercruciate trans-septal approach to the posterior compartment of the knee joint. This technique allows a direct visualization to the posterior septum (septum), creating a safer trans-septal portal and easier separation of the septum. The authors have used this approach in conditions such as the posterior cruciate ligament (PCL) reconstruction, PCL avulsion repairs, popliteus tendon reconstruction, posterior compartment synovectomy, hardware removal, loose bodies removal, meniscus ramp lesion repair, and others. No complications such as femoral condyle damage, meniscus damage, or neurovascular bundle injuries has occurred with this approach.

Efficacy of high-volume vs very low volume corticosteroid subacromial injection in subacromial impingement syndrome: a randomized controlled trial.

Subacromial corticosteroid injections (SCI) treat shoulder pain from subacromial impingement syndrome (SIS). However, a high-volume corticosteroid injection (HVCI) increases the incidence of local and general complications from lidocaine. This study aimed to compare the results of functional and clinical outcomes between the very low-volume corticosteroid injection (VLVCI) and HVCI including to WORC (Western Ontario Rotator Cuff Index), VAS (Visual Analog Scale), DASH (The disabilities of the arm, shoulder, and hand) and ROM (Range of Motion). A total of 64 patients presenting with SIS were evaluated in two SCI volume in a randomization-controlled trial study. The VAS for pain pre-injection and post-injection at 15 min, was from 5.34 ± 2.44 at before injection to 2.44 ± 1.58 at post injection 15 min in the HVCI group (P < 0.001) and from 5.19 ± 2.33 to 2.84 ± 1.49 in VLVCI group (P < 0.001). Not significant differences at mean difference VAS post-injection 15 min VAS (P = 0.324) and Percentage difference VAS pre-injection and post-injection (P = 0.24). All follow-up timing, there were no significant differences in WORC, DASH and ROM between two groups (P > 0.05). The results revealed the VLVCI is non-inferior to HVCI both of functional outcomes and VAS.

Reliability of Upright Chest Radiography as a Diagnostic Screening Tool for Acromioclavicular Joint Dislocations.

Background: The standard radiographic view for diagnosing acromioclavicular joint (ACJ) dislocations is the Zanca view of both shoulders to assess superior displacement of the distal clavicle by measuring the coracoclavicular distance (CCD) and comparing it with the uninjured shoulder; however, there is no consensus on a gold standard for diagnostic measures to classify acute ACJ injuries. Purpose: To compare the CCD from an upright chest radiograph with a standard Zanca view of both shoulders in patients with an ACJ dislocation. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: We reviewed the records of 70 patients with an ACJ dislocation between 2010 and 2021 who had both an upright chest radiograph and a Zanca view. An ACJ dislocation was classified as low grade (Rockwood types 1-3) or high grade (Rockwood type 5). The CCD was measured on the upright chest radiograph and the Zanca view by 2 independent reviewers, and the percentage of the CCD difference compared with the unaffected side (ΔCCD) was calculated and compared between the upright chest radiograph and the Zanca view. Interrater and intrarater reliability were determined using the intraclass correlation coefficient. Results: Included were 70 patients (55 male and 15 female; mean age, 46 years). There were 29 patients (41.43%) with a low-grade injury and 41 patients (58.57%) with a high-grade injury. In the overall analysis, the ΔCCD on the upright chest radiograph and Zanca view was significantly different (130.25% ± 88.42% vs 152.69% ± 106.56%, respectively; mean difference, 22.44% [95% CI, 2.40% to 42.48%]; P = .029). The subgroup analysis revealed that the ΔCCD on the upright chest radiograph and Zanca view was significantly different for patients with a low-grade injury (60.71% ± 25.79% vs 91.46% ± 68.54%, respectively; mean difference, 30.76% [95% CI, 7.18% to 54.33%]; P = .012) but not different for patients with a high-grade injury (179.45% ± 83.87% vs 196.00% ± 107.97%, respectively; mean difference, 16.56% [95% CI, -14.06% to 47.18%]; P = .281). The intraclass correlation coefficients for the ΔCCD measurements indicated good to excellent interrater and intrarater reliability. Conclusion: The study findings indicated that upright chest radiography can be used as a diagnostic screening tool for high-grade ACJ dislocations, but not for low-grade ACJ injuries, compared with the Zanca view.

Blended Suture-bridge Technique for Arthroscopic Rotator Cuff Repair.

Techniques in rotator cuff repair are constantly evolving, with the main goal of a biologic, stable, and tension-free construct. Significant controversy exists between various methods, and there is no gold standard surgical protocol. We demonstrate an alternative arthroscopic rotator cuff repair technique with 2 key components. First, we performed a transosseous equivalent, suture bridge technique with a combination of triple-loaded medial anchors and knotless lateral anchors. Second, we incorporated 2-strand and 3-strand suture shuttling through the torn rotator cuff and selective medial knot-tying. A total of 6 passes through the tendon are made, comprising 1-2-3-3-2-1 strands each pass. This minimizes the number of passes through the tendon and the overall number of medial knots. Our technique retains the known biomechanical advantages akin to a double-row repair, including less gap formation and wider footprint coverage. In addition, using fewer medial knots with efficient suture passing may result to decreased cuff strangulation and favorable biologic environment for tendon healing. We theorize that this technique may yield lower retear rates while maintaining immediate stability, translating to improved clinical results.

The pathology of oxidative stress-induced autophagy in a chronic rotator cuff enthesis tear.

Partial-thickness rotator cuff tears (PTRCTs) are often found in daily orthopedic practice, with most of the tears occurring in middle-aged patients. An anaerobic process and imbalanced oxygenation have been observed in PTRCTs, resulting in oxidative stress. Studies have shown the roles of oxidative stress in autophagy and the potential of unregulated mechanisms causing disturbance in soft tissue healing. This article aims to review literature works and summarize the potential pathology of oxidative stress and unregulated autophagy in the rotator cuff enthesis correlated with chronicity. We collected and reviewed the literature using appropriate keywords, in addition to the manually retrieved literature. Autophagy is a normal mechanism of tissue repair or conversion to energy needed for the repair of rotator cuff tears. However, excessive mechanisms will degenerate the tendon, resulting in an abnormal state. Chronic overloading of the enthesis in PTRCTs and the hypovascular nature of the proximal tendon insertion will lead to hypoxia. The hypoxia state results in oxidative stress. An autophagy mechanism is induced in hypoxia via hypoxia-inducible factors (HIFs) 1/Bcl-2 adenovirus E1B 19-kDa interacting protein (BNIP) 3, releasing beclin-1, which results in autophagy induction. Reactive oxygen species (ROS) accumulation would induce autophagy as the regulator of cell oxidation. Oxidative stress will also remove the mammalian target of rapamycin (mTOR) from the induction complex, causing phosphorylation and initiating autophagy. Hypoxia and endoplasmic reticulum (ER) stress would initiate unfolded protein response (UPR) through protein kinase RNA-like ER kinase (PERK) and activate transcription factor 4, which induces autophagy. Oxidative stress occurring in the hypovascularized chronic rotator cuff tear due to hypoxia and ROS accumulation would result in unregulated autophagy directly or autophagy mediated by HIF-1, mTOR, and UPR. These mechanisms would disrupt enthesis healing.

Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study.

Chronic osteomyelitis is still a serious health problem that causes disabling conditions and has an impact on the quality of life. The objective of this study was to determine the clinical efficacy and safety of localized antibiotics delivery via impregnated microporous nanohydroxyapatite (nHA-ATB) beads for chronic osteomyelitis treatment. A total of 62 patients were enrolled in this study. After radical surgical debridement, the bone defect was filled with three types of antibiotics (vancomycin or gentamicin or fosfomycin) impregnated HA beads. The follow-up period was 48 weeks. It was found that the success rate was approximately 98% with a re-infection in only one patient. Quality of life of all patients after treatment improved significantly over time. Systemic exposure to vancomycin and gentamicin after beads implantation was limited and high local antibiotics concentrations were found in wound drainage fluid at 24, 48 and 72 h. Blood biochemistry measurements did not show any nephrotoxic or hepatotoxic effects. 20 adverse events were reported, but 90% of the events were resolved without having to remove the beads and the patients recovered. Satisfactory outcomes were observed in terms of success rate, quality of life and adverse effect. nHA-ATB beads impregnated by vancomycin or gentamicin or fosfomycin could potentially be employed as an alternative product of choice for localized antibiotics delivery in chronic osteomyelitis treatment.

Elastofibroma: a rare case report and review of the literature.

Elastofibroma is an uncommon fibroelastic tumor-like lesion which usually presents in a characteristic area between the lower portion of the scapula and the chest wall, lying deep to the latissimus dorsi and rhomboid major muscles. It appears almost exclusively in elderly individuals and is associated with history of repetitive tissue injuries. It has pathognomonic histopathologic findings. Although the lesion has previously been defined as a reactive process, its true etiology remains unknown. Based on clinical manifestations and correlation with imaging studies, a presumptive diagnosis of elastofibroma can be made in order to avoid an unnecessary surgery. Here we report a case of elastofibroma in a typical location and present a review of the literature behind its pathogenesis.

Posterior Root Medial Meniscus Tear With Medial Opening Wedge High Tibial Osteotomy: A Step-By-Step Systematic Arthroscopic Repair Technique.

Medial meniscus root repair is often combined with correction of knee varus alignment by performing an opening wedge high tibial osteotomy (HTO) in patients with varus knee malalignment, particularly in those with suspected long-term medial meniscus root tear (MRT). Before planning a corrective alignment treatment, radiographic imaging of the knee alignment is recommended to assess a medial joint space and the tibiofemoral axis. Because HTO can reduce pressure on the repair site, new alignment may promote healing in the attachment of the MR repair. When HTO is used with meniscus root repair (MRR), the tunnel convergence remains a major concern. We describe an arthroscopic technique for treating chronic MRT with knee malalignment using the technique of arthroscopic posterior MRR with HTO. This approach was used to enhance anatomic healing of the meniscus root, decrease the load to the medial knee compartment to achieve MRR, and stop progressive osteoarthritis of the medial knee compartment.