[Effectiveness of a new Soviet drug Benzonal, inductor of microsomal enzymes of the liver, in the complex treatment of hemolytic disease of newborn]. / Effektivnost' primeneniia novogo otechestvennogo induktora mikro- somal'nykh fermentov pecheni benzonala v kompleksnoi terapii hemoliticheskoi bolezni novorozhdennykh.

The effects of benzonal on the course of neonatal hemolytic disease due to the Rhesus factor-conflict was studied in comparison with that of phenobarbital. Dynamic follow-up of infants in the early neonatal period showed benzonal to produce a more pronounced hypobilirubinemic effect which was manifested as a prompter disappearance of skin jaundice and lower percentages of complications. By depressing the activity of organospecific enzymes and lowering the serum biliary acid levels, benzonal promotes normalization of the metabolic shifts present in neonatal hemolytic disease. The findings make it possible to recommend the new inductor of microsomal liver enzymes benzonal as part of the combined therapy of neonatal hemolytic disease.

[Clinico-pathogenetic aspects of infectious toxicosis in infants caused by acute pneumonia]. / Kliniko-patogeneticheskie aspekty infektsionnogo toksikoza u detei rannego vozrasta, vyzvannogo ostrymi pnevmoniiami.

Altogether 101 children under one year of age with infectious toxicosis due to acute pneumonia were examined for the clinical, roentgenomorphological and biochemical aspects of the given condition. The clinical aspects were delineated on the basis of the universal status covered by the formalized case report. The biochemical processes were analyzed according to the content of peroxidation products of membrane lipids, the concentration of hydrogen peroxide, phospholipase activity, antioxidant and antiperoxide defence of the blood as well as according to the physical constants of red blood cell membranes. A direct relationship was discovered between the clinical picture (the degree of toxicosis) and membranopathological processes. The data obtained make it possible to conceive the model of infectious toxicosis as a membranopathological one, induced by the syndrome of the deficiency of antioxidant and antiperoxide enzymes.