RESUMO
OBJECTIVES: The purpose of this study was to analyze the relationship between working hours (WHs) and the likelihood of poor self-reported general health (SRGH) in the first data wave from a cohort of immigrant and native workers in Spain. STUDY DESIGN: Cross-sectional analyses from a prospective cohort study. METHODS: Data were drawn from the first wave of the Platform of Longitudinal Studies on Immigrant Families. The selected sample was composed of 217 immigrant workers and 89 native-born workers. We explored differences by immigrant status and family structure, assessing prevalences and Poisson regression models; an additional analysis explored statistically optimized work hour cut points. RESULTS: Highest prevalence of poor SRGH (72.7%) was reported by immigrant, single-parent workers working >40 WH/week. Immigrant single-parent families were more likely to report poor SRGH for three WH categories: ≤20 WH/week (prevalence ratio [PR] = 3.3, 95% confidence interval [CI] 1.6-7.2), >30-≤40 WH/week (PR = 2.8, 95% CI 1.3-6.4), and >40 WH/week (PR = 4.2, 95% CI 1.8-10.1). In two-parent families, immigrants working standard hours (i.e. >30-≤40) and native-born workers in the highest and lowest categories of WHs (i.e. ≤20 and >40) had similar PRs for poor SRGH compared with native-born workers working standard hours. Findings suggested that native-born workers residing in two-parent families were able to work more than 10 h longer per week than immigrant workers before reporting equivalent prevalences of poor SRGH. CONCLUSIONS: Differences in the association of WHs and poor SRGH among immigrants in Spain seem to be explained by family structure, which suggests that the influence of WHs on health differentially affects vulnerable groups, such as immigrant workers residing in single-parent families.
Assuntos
Emigrantes e Imigrantes/estatística & dados numéricos , Emprego/estatística & dados numéricos , Características da Família , Nível de Saúde , Adolescente , Adulto , Idoso , Colômbia/etnologia , Estudos Transversais , Equador/etnologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Espanha , Fatores de Tempo , Adulto JovemRESUMO
BACKGROUND: As the world's population ages, the prevalence of multiple chronic and non-chronic health-related conditions is increasing. Research on multimorbidity, the co-occurrence of two or more health-related conditions, has mainly involved patient and older populations. Its effect in working populations, presumably younger and healthier, is not well known but could conceivably affect sickness absence (SA) and ability to return to work. AIMS: To examine the effect of multimorbidity on the incidence and duration of SA episodes by frequent diagnostic groups. METHODS: A prospective study (in 2006-2008) of workers in Spain. Information on health-related conditions was gathered with a standardized questionnaire and used to construct a sex-specific multidimensional multimorbidity score (MDMS). In order to estimate the effect of MDMS on incidence and duration of SA episodes due to cardiovascular diseases (CVD), musculoskeletal disorders (MSD) and mental health disorders (MHD), we fitted Cox models adjusted by age, occupational social class and number of prior SA episodes for both sexes. RESULTS: The study population was 372370. Men with high MDMS showed a trend towards higher incidence risk for SA due to CVD and MSD [adjusted hazard ratio (aHR) = 2.03; 95% confidence interval (CI) 1.48-2.78 and aHR = 1.20; 95% CI 1.01-1.43, respectively]. Women showed a similar trend for MSD, but MHD had the strongest association (aHR = 4.78; 95% CI 1.97-11.62) for high MDMS. In both sexes, the effect of MDMS was strongest among those without a prior SA. No consistent associations with SA duration were observed. CONCLUSIONS: Multimorbidity increased the risk of incident musculoskeletal, mental and cardiovascular SA episodes but not their duration.
Assuntos
Doenças Cardiovasculares/epidemiologia , Transtornos Mentais/epidemiologia , Doenças Musculoesqueléticas/epidemiologia , Retorno ao Trabalho/estatística & dados numéricos , Licença Médica/estatística & dados numéricos , Absenteísmo , Adulto , Idoso , Comorbidade , Feminino , Cefaleia/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Saúde Ocupacional , Estudos Prospectivos , Fatores de Risco , Espanha/epidemiologiaRESUMO
Objectives Patients with common mental disorders (CMDs) often suffer from comorbidities, which may limit their functioning at work. We assessed the longitudinal impact of multimorbidity, defined as two or more co-occurring chronic health conditions, on work functioning over time among workers who had returned to work after sick leave due to CMDs. Methods Prospective cohort study of 156 workers followed for 1 year after return to work from sick leave due to CMDs. A multimorbidity score was computed by counting severity-weighted chronic health conditions measured at baseline. Work functioning was measured at baseline and at 3, 6 and 12 months follow-up with the Work Role Functioning Questionnaire. Work functioning trajectories, i.e. the course of work functioning after return to work over time, were identified through latent class growth analysis. Results A total of 44 % of workers had multimorbidity. Four work functioning trajectories were identified: one (12 % of the workers) showed increasing work functioning scores during follow-up, whereas the other trajectories showed low, medium and high scores (23, 41 and 25 %, respectively) that remained stable across time points. Although multimorbidity did not predict membership in any trajectory, within the increasing score trajectory levels of work functioning were lower among those with high baseline multimorbidity score (p < 0.001). Conclusions Over time, multimorbidity negatively impacts work functioning after return to work from sick leave due to CMDs.
Assuntos
Emprego/psicologia , Transtornos Mentais/complicações , Multimorbidade , Retorno ao Trabalho/psicologia , Retorno ao Trabalho/estatística & dados numéricos , Licença Médica , Absenteísmo , Adulto , Estudos de Casos e Controles , Doença Crônica , Feminino , Humanos , Estudos Longitudinais , Masculino , Transtornos Mentais/reabilitação , Pessoa de Meia-Idade , Países Baixos , Serviços de Saúde do Trabalhador , Estudos Prospectivos , Autorrelato , Índice de Gravidade de DoençaRESUMO
BACKGROUND: There is limited evidence of the role of working conditions as prognostic factors for non-work-related sickness absence (i.e. absence due to injuries or diseases of non-occupational origin). AIMS: To analyse the association between working conditions and time to return to work (RTW) in workers with long-term (>15 days) non-work-related sickness absence. METHODS: We followed up a total of 655 workers, who completed a baseline questionnaire including physical and psychosocial work factors, until their non-work-related long-term sickness absence ended. Time to RTW was determined based on the health insurance company register. Cox proportional hazard models were constructed to evaluate the associations between working conditions and time to RTW. RESULTS: A self-perceived high level of physical activity at work and work with back twisted or bent were related to longer duration of sickness absence. We did not find any strong evidence of associations between psychosocial work factors and time to RTW, although higher job insecurity and low reward showed marginal statistical significance. CONCLUSIONS: Hazardous physical working conditions are associated with longer duration of non-work-related sickness absence. Workplace ergonomic interventions could conceivably shorten the length of sickness absence that has not originated at work.
Assuntos
Absenteísmo , Licença Médica/estatística & dados numéricos , Carga de Trabalho/estatística & dados numéricos , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Fatores de Risco , Autorrelato , Espanha , Tolerância ao Trabalho Programado/psicologia , Local de Trabalho/psicologiaRESUMO
INTRODUCTION: Arterial hypertension is the main factor in attributable mortality. It is therefore considered one of the most important public health problems. Health professionals require special training and skills to make a diagnosis. No studies have been found in the literature search that use a validated instrument (questionnaire) to assess health professionals' theoretical and practical knowledge in diagnosing hypertension or measuring blood pressure. AIM: To design and validate an instrument for gauging health professionals' theoretical knowledge in measuring blood pressure for the initial diagnosis of hypertension. METHODOLOGY: Design, development, and validation of a questionnaire in three languages (English, Spanish, and Catalan) to assess knowledge based on the Rasch-item response theory model. RESULTS: A questionnaire in three languages was constructed and validated. It consisted of 23 questions on the theoretical knowledge of the initial diagnosis of hypertension and was called the ARC questionnaire. It met all the Rasch-IRT model criteria: item- and person-fit measurement, unidimensionality, local independence, invariance, targeting, and reliability. CONCLUSIONS: The ARC questionnaire is a validated tool that enables objective and uniform analyses of knowledge in the initial diagnosis of hypertension among medical and nursing professionals, comparing them over time. It allows for established strategies to be developed to enhance this knowledge.
Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Hipertensão , Humanos , Hipertensão/diagnóstico , Idioma , Reprodutibilidade dos Testes , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Physical demands at work remain a leading cause of work-related injuries in industrialized countries. AIMS: To use the 2003 Spanish National Survey of Work Conditions to examine prevalence of work-related musculoskeletal disorders (MSDs) and physical load at work. METHODS: Using a representative sample of 5236 persons from the Spanish workforce, the prevalence of carrying or lifting heavy loads, use of significant force and repetitive movements was examined among those with and without MSDs. RESULTS: Use of significant force and carrying heavy weights decreased inversely in relation to exposure time and was always higher among those with MSD symptoms or work-related injury. For repetitive movements, prevalence increased with longer duration of exposure and was also significantly higher in those with MSD symptoms, except in the shortest duration category. CONCLUSIONS: One-third of workers used significant force during part of their shifts, while 4% were exposed for >50% of their work shift, suggesting that 500 000 workers in Spain are at high risk of musculoskeletal injury. Moreover, repetitive movements involving >50% of the work shift affected 30% of workers. To reduce the high incidence of MSDs and work-related injury in Spain, preventive interventions should be directed at these risk factors.
Assuntos
Acidentes de Trabalho/estatística & dados numéricos , Inquéritos Epidemiológicos , Doenças Musculoesqueléticas/epidemiologia , Doenças Profissionais/epidemiologia , Local de Trabalho/estatística & dados numéricos , Adolescente , Adulto , Transtornos Traumáticos Cumulativos/epidemiologia , Feminino , Humanos , Remoção/efeitos adversos , Masculino , Pessoa de Meia-Idade , Doenças Musculoesqueléticas/etiologia , Sistema Musculoesquelético/lesões , Doenças Profissionais/etiologia , Postura/fisiologia , Prevalência , Fatores de Risco , Espanha/epidemiologia , Carga de Trabalho , Adulto JovemRESUMO
OBJECTIVES: To identify occupational exposure risk factors associated with the development of new-onset asthma in nurses. METHODS: A cross-sectional survey was administered to a sample of licensed Texas nurses (response rate 70%) and compared to three other healthcare professional groups. Nursing professionals were defined based on self-reported longest held job. Outcome variables were physician-diagnosed new-onset asthma after entry into the healthcare profession and symptoms associated with bronchial hyper-responsiveness (BHR). Occupational exposures were ascertained through a job-exposure matrix, grouped into four categories: cleaning-related tasks, use of powdered latex gloves, administration of aerosolised medications, and tasks involving adhesive compounds, glues and/or solvents. RESULTS: After adjustment for age, sex, ethnicity, atopy, smoking, body mass index and seniority, reported asthma was significantly greater among nursing professionals involved in medical instrument cleaning (OR = 1.67, 95% CI 1.06 to 2.62) and exposure to general cleaning products and disinfectants (OR = 1.72, 95% CI 1.00 to 2.94). Use of powdered latex gloves during 1992-2000 was associated with 1.6 times (95% CI 1.01 to 2.50) the odds of reported asthma. In univariate analysis, exposure to adhesives, glues and/or solvents was associated with a twofold increase in the odds of reported asthma, but not after adjustment for covariates. Similarly, the odds of BHR-related symptoms were significantly greater among nursing professionals exposed to general cleaning products and disinfectants (OR = 1.57, 95% CI 1.11 to 2.21) and adhesives, glues and/or solvents used in patient care (OR = 1.51, 95% CI 1.08 to 2.12). CONCLUSION: Among nursing professionals, workplace exposures to cleaning products and disinfectants increase the risk of new-onset asthma.
Assuntos
Asma/epidemiologia , Hiper-Reatividade Brônquica/epidemiologia , Recursos Humanos de Enfermagem , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Adesivos/efeitos adversos , Adulto , Estudos Transversais , Detergentes/efeitos adversos , Desinfetantes/efeitos adversos , Feminino , Luvas Protetoras/efeitos adversos , Pessoal de Saúde , Humanos , Látex/efeitos adversos , Masculino , Pessoa de Meia-Idade , Papel do Profissional de Enfermagem , Obesidade/epidemiologia , Terapia Ocupacional , Médicos , Terapia Respiratória , Fatores de Risco , Fumar/epidemiologia , Solventes/efeitos adversos , Texas/epidemiologia , Local de TrabalhoRESUMO
Introduction: Arterial hypertension is the main factor in attributable mortality. It is therefore considered one of the most important public health problems. Health professionals require special training and skills to make a diagnosis. No studies have been found in the literature search that use a validated instrument (questionnaire) to assess health professionals theoretical and practical knowledge in diagnosing hypertension or measuring blood pressure. Aim: To design and validate an instrument for gauging health professionals theoretical knowledge in measuring blood pressure for the initial diagnosis of hypertension. Methodology: Design, development, and validation of a questionnaire in three languages (English, Spanish, and Catalan) to assess knowledge based on the Rasch-item response theory model. Results: A questionnaire in three languages was constructed and validated. It consisted of 23 questions on the theoretical knowledge of the initial diagnosis of hypertension and was called the ARC questionnaire. It met all the Rasch-IRT model criteria: item- and person-fit measurement, unidimensionality, local independence, invariance, targeting, and reliability. Conclusions: The ARC questionnaire is a validated tool that enables objective and uniform analyses of knowledge in the initial diagnosis of hypertension among medical and nursing professionals, comparing them over time. It allows for established strategies to be developed to enhance this knowledge.(AU)
Introducción: La hipertensión arterial es el principal factor de mortalidad atribuible. Es por eso que se considera uno de los problemas de salud pública más importantes. Los profesionales de la salud necesitan una formación y unas habilidades especiales para realizar un diagnóstico. En la literatura actual no se han encontrado estudios que utilicen un instrumento validado (cuestionario) para evaluar los conocimientos teóricos y prácticos de los profesionales de la salud en el diagnóstico de la hipertensión o medición de la tensión arterial. Objetivo: Diseñar y validar un instrumento para medir los conocimientos teóricos de los profesionales de la salud en la medida de la tensión arterial para el diagnóstico inicial de la hipertensión. Metodología: Diseño, desarrollo y validación de un cuestionario en tres idiomas (inglés, español y catalán) para evaluar los conocimientos basados en el modelo de Rasch (teoría de la respuesta al ítem). Resultados: Se construyó y validó un cuestionario en tres idiomas. Constaba de 23 preguntas sobre los conocimientos teóricos en el diagnóstico inicial de hipertensión que se denominó cuestionario ARC. Cumplió con todos los criterios del modelo Rasch-IRT: medición de ajuste (fit) al ítem y a la persona, unidimensionalidad, independencia local, invarianza, targeting y fiabilidad. Conclusiones: El cuestionario ARC es una herramienta validada que permite realizar análisis objetivos y uniformes de los conocimientos en el diagnóstico inicial de la hipertensión entre profesionales de medicina y de enfermería, comparándolos en el tiempo. Permite desarrollar estrategias establecidas para potenciar este conocimiento.(AU)
Assuntos
Humanos , Pessoal de Saúde , Atenção Primária à Saúde , Hipertensão , Conhecimento , Estudos de Validação como Assunto , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: To determine whether observed higher risks of occupational injury among temporary workers are due to exposure to hazardous working conditions and/or to lack of job experience level. METHODS: Data systematically recorded for 2000 and 2001 by the Spanish Ministry of Labour and Social Affairs on fatal and non-fatal traumatic occupational injuries were examined by type of employment and type of accident, while adjusting for gender, age, occupation, and length of employment in the company. In the study period there were 1500 fatal and 1 806 532 non-fatal traumatic occupational injuries that occurred at the workplace. Incidence rates and rate ratios (RR) were estimated using Poisson regression models. RESULTS: Temporary workers showed a rate ratio of 2.94 for non-fatal occupational injuries (95% CI 2.40 to 3.61) and 2.54 for fatal occupational injuries (95% CI 1.88 to 3.42). When these associations were adjusted by gender, age, occupation, and especially length of employment, they loose statistic significance: 1.05 (95% CI 0.97 to 1.12) for non-fatal and 1.07 (95% CI 0.91 to 1.26) for fatal. CONCLUSIONS: Lower job experience and knowledge of workplace hazards, measured by length of employment, is a possible mechanism to explain the consistent association between temporary workers and occupational injury. The role of working conditions associated with temporary jobs should be assessed more specifically.
Assuntos
Acidentes de Trabalho/estatística & dados numéricos , Emprego/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Acidentes de Trabalho/mortalidade , Adulto , Distribuição por Idade , Idoso , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Fatores de Risco , Distribuição por Sexo , Espanha/epidemiologia , Fatores de Tempo , Ferimentos e Lesões/mortalidadeRESUMO
BACKGROUND: Previous studies have described increased occurrence of asthma among healthcare workers, but to our knowledge there are no validated survey questionnaires with which to study this occupational group. AIMS: To develop, validate, and refine a new survey instrument on asthma for use in epidemiological studies of healthcare workers. METHODS: An initial draft questionnaire, designed by a multidisciplinary team, used previously validated questions where possible; the occupational exposure section was developed by updating health services specific chemical lists through hospital walk-through surveys and review of material safety data sheets. A cross-sectional validation study was conducted in 118 non-smoking subjects, who also underwent bronchial challenge testing, an interview with an industrial hygienist, and measurement of specific IgE antibodies to common aeroallergens. RESULTS: The final version consisted of 43 main questions in four sections. Time to completion of the questionnaire ranged from 13 to 25 minutes. Test-retest reliability of asthma and allergy items ranged from 75% to 94%, and internal consistency for these items was excellent (Cronbach's alpha > or = 0.86). Against methacholine challenge, an eight item combination of asthma related symptoms had a sensitivity of 71% and specificity of 70%; against a physician diagnosis of asthma, this same combination showed a sensitivity of 79% and specificity of 98%. Agreement between self-reported exposures and industrial hygienist review was similar to previous studies and only moderate, indicating the need to incorporate more reliable methods of exposure assessment. Against the aerollergen panel, the best combinations of sensitivity and specificity were obtained for a history of allergies to dust, dust mite, and animals. CONCLUSIONS: Initial evaluation of this new questionnaire indicates good validity and reliability, and further field testing and cross-validation in a larger healthcare worker population is in progress. The need for development of more reliable occupational exposure assessment methods that go beyond self-report is underscored.
Assuntos
Asma/diagnóstico , Pessoal de Saúde , Doenças Profissionais/diagnóstico , Exposição Ocupacional/efeitos adversos , Inquéritos e Questionários/normas , Adulto , Estudos Transversais , Feminino , Substâncias Perigosas/efeitos adversos , Humanos , Masculino , Sensibilidade e EspecificidadeRESUMO
The frequency of loss of heterozygosity (LOH) around MMAC/PTEN and DMBT1 loci and survival analyses based on the LOH status were assessed in 110 patients with different histological groups of gliomas. Twenty-six of the patients had anaplastic oligodendrogliomas, 31 had anaplastic astrocytomas, and 53 had glioblastomas multiforme (GM). At the DMBT1 locus, LOH was observed very frequently in all three histological groups, with no significant difference in the frequency of LOH among the three histological groups. At the MMAC/PTEN locus, patients with GM exhibited a significantly increased frequency of LOH (72%) compared with patients with anaplastic astrocytomas (29%) or anaplastic oligodendrogliomas (31%) (P < 0.0001). Kaplan-Meier survival plots showed that patients with LOH at the MMAC/PTEN locus had a significantly worse prognosis than did patients without LOH at the MMAC/PTEN locus [hazard ratio (LOH versus non-LOH), 2.65; 95% confidence interval (CI), 1.69-4.46; P < 0.0001]. Cox proportional hazards regression analysis, adjusted for age at surgery and histological grades (GM and non-GM), showed that LOH at the MMAC/PTEN locus was a significant predictor of shorter survival [hazard ratio (LOH versus non-LOH), 2.01; 95% CI, 1.1-3.5; P = 0.018). Our analysis failed to indicate a similar association between the frequency of LOH at the DMBT1 locus and patient survival [hazard ratio (LOH versus non-LOH), 2; 95% CI, 0.37-3.13; P = 0.2]. These results suggest that the DMBT1 gene may be involved early in the oncogenesis of gliomas, whereas alterations in the MMAC/PTEN gene may be a late event in the oncogenesis related to progression of gliomas and provide a significant prognostic marker for patient survival.
Assuntos
Aglutininas , Mapeamento Cromossômico , Genes Supressores de Tumor , Glioma/genética , Perda de Heterozigosidade , Monoéster Fosfórico Hidrolases/genética , Receptores de Superfície Celular/genética , Proteínas Supressoras de Tumor , Proteínas de Ligação ao Cálcio , Proteínas de Ligação a DNA , Glioma/mortalidade , Humanos , PTEN Fosfo-Hidrolase , Prognóstico , Taxa de SobrevidaRESUMO
AIMS: To explore the relation between occupational and organisational factors and work related injuries (WRI) among public hospital employees in Costa Rica. METHODS: A cross-sectional survey was conducted among a stratified random sample of 1000 employees from 10 of the 29 public hospitals in Costa Rica. A previously validated, self-administered questionnaire which included occupational and organisational factors and sociodemographic variables was used. From the final eligible sample (n = 859), a total of 842 (response rate 98%) questionnaires were returned; 475 workers were analysed after excluding not-at-risk workers and incomplete questionnaires. WRI were computed for the past six months. RESULTS: Workers exposed to chemicals (RR = 1.36) and physical hazards (RR = 1.26) had higher WRI rate ratios than non-exposed workers. Employees reporting job tasks that interfered with safety practices (RR = 1.46), and a lack of safety training (RR = 1.41) had higher WRI rate ratios than their counterparts. Low levels of safety climate (RR = 1.51) and safety practices (RR = 1.27) were individually associated with an increased risk of WRI. Also, when evaluated jointly, low levels of both safety climate and safety practices showed the highest association with WRI (RR = 1.92). CONCLUSIONS: When evaluated independently, most of the occupational exposures and organisational factors investigated were significantly correlated with an increased injury risk. As expected, some of these associations disappeared when evaluated jointly. Exposure to chemical and physical hazards, lack of safety training, and low levels of safety climate and safety practices remained significant risk factors for WRI. These results will be important to consider in developing future prevention interventions in this setting.
Assuntos
Doenças Profissionais/epidemiologia , Recursos Humanos em Hospital/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adulto , Costa Rica/epidemiologia , Estudos Transversais , Equipamentos e Provisões Hospitalares/efeitos adversos , Feminino , Substâncias Perigosas/efeitos adversos , Hospitais Públicos/organização & administração , Humanos , Masculino , Doenças Profissionais/etiologia , Exposição Ocupacional/efeitos adversos , Recursos Humanos em Hospital/educação , Vigilância da População/métodos , Prevalência , Relações Profissional-Paciente , Fatores de Risco , Segurança/normas , Ferimentos e Lesões/etiologiaRESUMO
The associations between lung cancer risk, mutagen sensitivity (a marker of cancer susceptibility), and a putative lung carcinogen, wood dust, were assessed in a hospital-based case-control study. There were 113 African -American and 67 Mexican-American cases with newly diagnosed, previously untreated lung cancer and 270 controls, frequency-matched on age, ethnicity, and sex. Mutagen sensitivity ( 1 chromatid break/cell after short-term bleomycin treatment) was associated with statistically significant elevated risk for lung cancer [odds ration (OR) = 4.3; 95% confidence intervals (CI) = 2.3-7.9]. Wood dust exposure was also a significant predictor of risk (overall OR = 3.5; CI = 1.4-8.6) after controlling for smoking and mutagen sensitivity. When stratified by ethnicity, wood dust exposure was s significant risk factor for African-Americans (OR = 5.5; CI = 1.6-18.9) but not for Mexican-Americans (OR = 2.0; CI = 0.5-8.1). The ORs were 3.8 and 4.8 for non-small cell lung cancer in Mexican-Americans (CI = 1.2-18.5). Stratified analysis suggested evidence of strong interactions between wood dust exposure and both mutagen sensitivity and smoking in lung cancer risk.
Assuntos
População Negra , Poeira/efeitos adversos , Neoplasias Pulmonares/epidemiologia , Americanos Mexicanos , Exposição Ocupacional/efeitos adversos , Madeira , Adulto , Distribuição por Idade , Idoso , População Negra/genética , Estudos de Casos e Controles , Intervalos de Confiança , Feminino , Agricultura Florestal , Humanos , Incidência , Neoplasias Pulmonares/etiologia , Neoplasias Pulmonares/genética , Masculino , Americanos Mexicanos/genética , Americanos Mexicanos/estatística & dados numéricos , Pessoa de Meia-Idade , Testes de Mutagenicidade , Razão de Chances , Medição de Risco , Distribuição por Sexo , Fumar , Texas/epidemiologiaRESUMO
In a previous study of lung cancer, we showed that bleomycin, a radiomimetic agent, induced breaks preferentially on chromosomes 4 and 5. The molecular cytogenetic study reported here, using chromosome painting and G banding, was designed to assess whether the chromatid breaks induced by bleomycin could survive as chromosome-type aberrations after treated lymphocyte populations were allowed to recover in a drug-free medium for one or two cell generations and whether the survival rates of lesions on chromosomes 4 and 5 differed in cases with lung cancer and controls. The findings from 16 cases and 14 controls showed that in samples allowed to recover for 48 h, most aberrations were of the chromosome type. The proportion of chromosome 5 abnormalities surviving as chromosome-type aberrations was significantly higher in the cells of lung cancer cases (13.4%) than in controls (4.6%; P < 0.0001). However, no significant differences in survival of chromosome 4 abnormalities were detected between cases and controls. The proportions of chromosome 5q13-q22 abnormalities were 5.3% in the cases and 0.6% in the controls (P < 0.0001). 5q13-q22 regions encompassed 38.4% of all abnormalities on chromosome 5 in the cases but only 14.5% in the controls. Therefore, the survival rate of chromosome 5 lesions (especially those at 5q13-q22) in lymphocytes might be used as a biomarker to identify populations at high risk for lung cancer.
Assuntos
Antibióticos Antineoplásicos/farmacologia , Bleomicina/farmacologia , Aberrações Cromossômicas , Cromossomos Humanos Par 4/efeitos dos fármacos , Cromossomos Humanos Par 5/efeitos dos fármacos , Neoplasias Pulmonares/sangue , Antibióticos Antineoplásicos/administração & dosagem , Bleomicina/administração & dosagem , Células Cultivadas , Marcadores Genéticos , Humanos , Neoplasias Pulmonares/genética , Linfócitos , Valores de Referência , Sensibilidade e EspecificidadeRESUMO
OBJECTIVE: To assess the impact of a needleless intravenous (i.v.) connection system on the rate of reported intravenous-connection-related (IVCR) percutaneous injuries, and to assess user satisfaction, frequency of use, and barriers to use. DESIGN: A pre-post intervention design, with injury incidence rates being compared 3 years before and 1 year after hospital wide device implementation; and a cross-sectional descriptive user satisfaction survey. SETTING: Two tertiary-care teaching hospitals, one general and one pediatric, located in a large metropolitan medical center. OUTCOME VARIABLE: All IVCR percutaneous injuries reported to the employee health services at both hospitals during the years from 1989 to 1991 and 1993. STUDY POPULATION: Survey participants were selected randomly from licensed nursing employees at both hospitals. INTERVENTION: i.v. connection system consisting of blunt plastic cannulas and compressed latex injection sites. RESULTS: After device implementation, the IVCR injury rate was reduced 62.4% (rate ratio [RR], 0.38; 95% confidence interval [CI95], 0.27-0.53) at the general hospital and 70.2% (RR, 0.30; CI95, 0.17-0.53) at the pediatric hospital. After adjusting for the reduction in injury rate due to factors other than device implementation, the IVCR injury rate was reduced 54.5% (adjusted RR, 0.46; CI95, 0.32-0.65) at the general hospital and 57.2% (adjusted RR, 0.43; CI95, 0.24-0.78) at the pediatric hospital. Approximately 94% of survey respondents (n = 478, response rate = 51%) were satisfied with the device and recommended continued use. However, needles still were being used for activities that could have been performed with the needleless system because of compatibility, accessibility, and other technical problems related to the device. CONCLUSIONS: The device was effective in reducing the rate of reported IVCR percutaneous injuries and users were satisfied with the device, but barriers to universal use were identified.
Assuntos
Infusões Intravenosas/instrumentação , Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle , Recursos Humanos em Hospital/psicologia , Estudos Transversais , Hospitais Gerais , Hospitais Pediátricos , Humanos , Incidência , Satisfação no Emprego , Ferimentos Penetrantes Produzidos por Agulha/classificação , Ferimentos Penetrantes Produzidos por Agulha/epidemiologia , TexasRESUMO
OBJECTIVE: To assess and characterize self-reported levels of compliance with universal precautions among hospital-based health care workers and to determine correlates of compliance. DESIGN: Confidential questionnaire survey of 1716 hospital-based health care workers. PARTICIPANTS: Participants were recruited from three geographically distinct hospitals. A stratified convenience sample of physicians, nurses, technicians, and phlebotomists working in emergency, surgery, critical care, and laboratory departments was selected from employment lists to receive the survey instrument. All participants had direct contact with either patients or patient specimens. RESULTS: For this study, overall compliance was defined as "always" or "often" adhering to the desired protective behavior. Eleven different items composed the overall compliance scale. Compliance rates varied among the 11 items, from extremely high for certain activities (e.g., glove use, 97%; disposal of sharps, 95%) to low for others (e.g., wearing protective outer clothing, 62%; wearing eye protection, 63%). Compliance was strongly correlated with several key factors: (1) perceived organizational commitment to safety, (2) perceived conflict of interest between workers' need to protect themselves and their need to provide medical care to patients; (3) risk-taking personality; (4) perception of risk; (5) knowledge regarding routes of HIV transmission; and (6) training in universal precautions. Compliance rates were associated with some demographic characteristics: female workers had higher overall compliance scores than did male workers (25% of female and 19% of male respondents circled "always" or "often" on each of the 11 items, p < 0.05); and overall compliance scores were highest for nurses, intermediate for technicians, and lowest for physicians. Overall compliance scores were higher for the mid-Atlantic respondents (28%) than for those from the Southwest (20%) or Midwest (20%, p = 0.001). CONCLUSIONS: This study supports earlier findings regarding several compliance correlates (perception of risk, knowledge of universal precautions), but it also identifies important new variables, such as the organizational safety climate and perceived conflict of interest. Several modifiable variables were identified, and intervention programs that address as many of these factors as possible will probably succeed in facilitating employee compliance.
Assuntos
Comportamento Cooperativo , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Recursos Humanos em Hospital , Precauções Universais , Patógenos Transmitidos pelo Sangue , Distribuição de Qui-Quadrado , Feminino , Infecções por HIV/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Modelos Logísticos , Masculino , Mid-Atlantic Region , Meio-Oeste dos Estados Unidos , Motivação , Razão de Chances , Cultura Organizacional , Assunção de Riscos , Fatores Socioeconômicos , Sudoeste dos Estados UnidosRESUMO
This study characterized and assessed self-reported levels of compliance with universal precautions (UP) among hospital-based physicians, and determined significant factors associated with both compliance and noncompliance. The physicians (n = 322) were a subgroup of a larger study population of hospital-based health care workers recruited from three geographically distinct locations (n = 1746), and were surveyed using a detailed confidential questionnaire that assessed personal, work-related, and organizational factors. Compliance with UP was measured through 11 items that examined how often physicians followed specific recommended work practices. Compliance was found to vary among the 11 items: they were high for certain activities (eg, glove use, 94%; disposal of sharps, 92%) and low for others (eg, wearing protective clothing, 55%; not recapping needles, 56%). Compliance with all items was low (31% to 38%). Stepwise logistic regression revealed that noncompliant physicians were likely to be age 37 or older, to report high work stress, and to perceive a conflict of interest between providing patient care and protecting themselves. Compliant physicians were more likely to be knowledgeable and to have been trained in universal precautions, to perceive protective measures as being effective, and to perceive an organizational commitment to safety.
Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Corpo Clínico Hospitalar , Exposição Ocupacional/prevenção & controle , Precauções Universais , Adulto , Patógenos Transmitidos pelo Sangue , Intervalos de Confiança , Estudos Transversais , Feminino , Infecções por HIV/prevenção & controle , Humanos , Modelos Logísticos , Masculino , Razão de Chances , Risco , Inquéritos e Questionários , Estados UnidosRESUMO
Integrated job analysis is a form of job evaluation that considers cognitive, physical, and environmental factors related to occupational performance, assessment, and rehabilitation. First, the analysis describes cognitive factors that determine worker interactions with data, people, and things and educational and training requirements. A task description is provided and tools used are identified, along with job physical requirements, environmental conditions, and personal protective equipment needs. Supplementary information is elicited to describe the environment, task requirements, workstations, and work areas. Based on this information, preliminary recommendations are made for abating occupational hazards, and accommodations for alternatively-challenged individuals are identified. The value of this approach is in the detailed documentation of all occupational components regarding a specific job classification, which can then guide the development of meaningful preplacement and periodic medical examinations, physical agility tests, training criteria, rehabilitation, and return-to-work regimens.
Assuntos
Documentação , Ergonomia/métodos , Descrição de Cargo , Saúde Ocupacional , Trabalho/classificação , Avaliação de Desempenho Profissional , Readaptação ao Emprego , Controle de Formulários e Registros , Humanos , Capacitação em Serviço , Exame Físico , Aptidão Física , Competência Profissional , Análise e Desempenho de Tarefas , Trabalho/fisiologia , Trabalho/normasRESUMO
In response to growing concern for occupational health and safety in the public hospital system in Costa Rica, a cross-sectional survey of 1,000 hospital-based health care workers was conducted in 1997 to collect baseline data that are being used to develop worker training programs in occupational health in Costa Rica. The objectives of this survey were to: 1) describe the safety climate within the national hospital system, 2) identify factors associated with safety, and 3) evaluate the relationship between safety climate and workplace injuries and safety practices of employees. The safety climate was found to be very poor. The two most significant predictors of safety climate were training and administrative support for safety. Safety climate was a statistically significant predictor of workplace injuries and safety practices, respectively, and there was an underreporting rate of 71% of workplace injuries. These findings underscore the need for improvement of the safety climate in the public hospital system in Costa Rica.
Assuntos
Pessoal de Saúde , Hospitais Públicos , Doenças Profissionais/epidemiologia , Saúde Ocupacional , Ferimentos e Lesões/epidemiologia , Adulto , Costa Rica , Estudos Transversais , Educação , Feminino , Humanos , Recém-Nascido , Capacitação em Serviço , Masculino , Doenças Profissionais/prevenção & controle , Ocupações , Análise de Regressão , Inquéritos e Questionários , Ferimentos e Lesões/prevenção & controleRESUMO
The Fogarty-supported International Training Program of the Southwest Center for Occupational and Environmental Health (SWCOEH) at the University of Texas School of Public Health was initiated in 1995, with its activities focused primarily on Latin America. As this program has matured, its participants have been concerned about including elements that increase the likelihood that its trainees and projects will have a sustainable impact on occupational and environmental health in collaborating countries. The Center recently reviewed the experiences of various international organizations and national development agencies with established track records involving donor-supported projects. The authors summarize factors associated with project sustainability and describe how some of them are being incorporated into the SWCOEH program. Particular mention is made of the importance of supporting an infrastructure for broad information dissemination in the language of the intended audience. An example of a project to support a peer-reviewed Spanish-language journal devoted to occupational and environmental health, Salud de los Trabajadores, is presented.