[Evaluation of liposomal forms of rifampicin and prodigiozan in the treatment of experimental chronic tonsillitis]. / Otsenka liposomal'nykh form rifampitsina i prodigiozana pri lechenii éksperimental'nogo khronicheskogo tonzillita.

Therapeutic effect of liposomal dosages of rifampicin and prodigiozan was studied on rabbits with simulated chronic tonsillitis in comparison to that of commercial ones of the drugs. The treatment schemes included daily intra-tonsillar++ injections of the dosage forms for 5 days. A high efficacy of their liposomal dosage forms in treatment of experimental chronic tonsillitis was confirmed microbiologically and immunologically. Approval of the liposomal dosage forms used in the therapy of patients with chronic tonsillitis requires clinical trials.

[The role of immunopathological factors in severe forms of insulin-dependent diabetes mellitus]. / Rol' immunopatologicheskikh faktorov pri tiazhelykh formakh insulinozavisimogo sakharnogo diabeta.

Immunogrammes of 31 patients with grave forms of insulindependent diabetes mellitus were reviewed. The illness has been characterized as a systemic immunopathologic process combining autoimmune and infectious-and-allergic components realized by organ and tissue abnormalities; it evolves against the manifest background of allergy of both delayed anl immediate types, impairement of the humoral and cell-mediated immunity function, pathogenetic activity of endogenous proteases, the complement system components and interferon.

[The cause-effect interdependence in the pathogenesis of chronic tonsillitis as an infectious allergic process]. / K voprosu o prichinno-sledstvennykh vzaimosviaziakh v patogenese khronicheskogo tonzillita kak infektsionno-allergicheskogo protsessa.

Clinical and immunological examinations of 360 patients with chronic tonsillitis and 286 patients suffering from systemic complications of chronic tonsillitis at various post-tonsillectomy stages demonstrated that the major immunopathological factor in the case of chronic compensated tonsillitis was microbial allergy and in the case of chronic decompensated tonsillitis, autoimmune disorders. The high titer of autoantibodies to tonsillar antigen that persisted at various post-tonsillectomy stages made it necessary to use systemic immune correction as part of therapy of chronic tonsillitis.

[Effect of some drugs on the intensity of lipid peroxidation in surrounding tissues in the local treatment of suppuration]. / Vliianie nekotorykh preparatov na intensivnost perekisnogo okisleniia lipidov v perifokalnykh tkaniakh pri mestnom lechenii gnoinogo ochaga.

The effect of some drugs in their local use for treatment of purulent wounds on the intensity of peroxide oxidation of lipids in the perifocal tissues of an experimental suppurative focus was studied. The increased antioxidant and antiinflammatory effect in use of lyposomal form of gentamycin with the ectericide-modified membranes versus ectericide solution as well as more pronounced antioxidant and antiinflammatory effect of ferecterisole vs. cimesole was revealed. The results obtained indicate that the use of ferecterisole and lyposomal forms of some antibiotics for local treatment of purulent wounds has good prospects.

[Mechanism of action of ectericide on opportunistic microbes]. / K mekhanizmu deistviia ékteritsida na uslovno-patogennye mikroby.

Ectericide is a product of cod-liver oil oxidation (lower fatty acids, organic peroxides and aldehydes). Its antibacterial activity is based on the capacity for partial disintegration and extraction of the structural lipopolysaccharide of the microbial cell without any significant effect on the quantitative content of the structural proteins and nucleotides.

[Ectericide as a dispersion medium for the preparation of prospective clinical liposomal drug forms]. / Ekteritsid kak dispersionnaia sreda dlia polucheniia klinicheski perspektivnykh liposomal'nykh lekarstvennykh form.

The possibility of using ectericide, having antibacterial, detergent, antioxidative, and reparative effects, as a dispersion medium for liposome production has been studied. Its application allows for elaboration of a simplified liposome production technique simultaneously imparting them stability against oxidation, heating, and pH changes. A technology to produce multivesicular liposomes with ectericide++, containing rifampicin in the membranous envelope and gentamicin in the inner volume, has been developed. Liposomal antibiotics proved to be effective in clinical trials.