RESUMO
In the present paper, we report the case of a patient with long-standing Crohn s disease and multiple complications that, after receiving treatment with infliximab, was diagnosed with an adenocarcinoma of the rectum and anus that required radical surgery, later presenting multiple metastases. In the discussion, characteristics and major risk factors for colorectal cancer in patients with inflammatory bowel disease will be largely reviewed, and current studies will be analyzed in connection with the appearance of neoplasms in patients being treated with biologics.
Assuntos
Adenocarcinoma/induzido quimicamente , Anticorpos Monoclonais/efeitos adversos , Neoplasias do Ânus/induzido quimicamente , Doença de Crohn/tratamento farmacológico , Neoplasias Retais/induzido quimicamente , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Anticorpos Monoclonais/uso terapêutico , Humanos , Infliximab , Masculino , Pessoa de Meia-IdadeRESUMO
Presentamos el caso de un paciente con enfermedad de Crohnde larga evolución y con múltiples complicaciones de su enfermedadque, tras recibir tratamiento con infliximab, es diagnosticadode un adenocarcinoma de recto y ano que precisa cirugía radical,presentando posteriormente metástasis múltiples. Se repasarándurante la discusión las características y los factores de riesgo másimportantes del cáncer colorrectal en pacientes con enfermedadinflamatoria intestinal, y se analizarán los trabajos existentes hastala fecha en relación con la aparición de neoplasias en pacientestratados con fármacos biológicos(AU)
In the present paper, we report the case of a patient with longstandingCrohns disease and multiple complications that, after receivingtreatment with infliximab, was diagnosed with an adenocarcinomaof the rectum and anus that required radical surgery,later presenting multiple metastases. In the discussion, characteristicsand major risk factors for colorectal cancer in patients withinflammatory bowel disease will be largely reviewed, and currentstudies will be analyzed in connection with the appearance of neoplasmsin patients being treated with biologics(AU)