Biomarkers of orthodontic tooth movement with fixed appliances and vibration appliance therapy: a pilot study.

INTRODUCTION: The aim of this study was to investigate the effect of supplemental vibratory force on biomarkers of bone remodelling during orthodontic tooth movement, the rate of mandibular anterior alignment (RMAA), and compliance with a vibration device. DESIGN, SETTINGS, AND PARTICIPANTS: Forty patients between the ages 15-35 undergoing fixed appliance treatment that presented to a university orthodontic clinic were randomly allocated to supplemental use of an intraoral vibrational device (n = 20, AcceleDent®) or fixed appliance only (n = 20). Salivary multiplex assay was completed to analyse the concentration of selected biomarkers of bone remodelling before treatment (T0) and at three following time points (T1, T2, T3), 4-6 weeks apart. Irregularity of the mandibular anterior teeth and compliance was assessed at the same trial time points. Data were analysed blindly on an intention-to-treat basis with descriptive statistics, Mann-Whitney U-test, Wilcoxon signed-rank test, and linear mixed effects regression modelling. RESULTS: No difference in the changes in salivary biomarkers of bone remodelling and RMAA between groups at any time point over the trial duration was observed. No correlation was found between changes in irregularity and biomarker level from baseline to another time point. Lastly, there was no association between RMAA and compliance with the AcceleDent® device. CONCLUSIONS: Supplemental vibratory force during orthodontic treatment with fixed appliances does not affect biomarkers of bone remodelling or the RMAA. LIMITATIONS: The main limitation of the study was the small sample size and the large variability in the salivary biomarkers. HARMS: No harms were observed during the duration of the trial. PROTOCOL: The protocol was not published prior to trial commencement. REGISTRATION: The study was registered in Clinical Trials.gov (NCT02119455) first posted on April 2014.

Evolución del tratamiento de la discrepancia hueso- diente negativa en Ortodoncia

Se realizó un estudio descriptivo retrospectivo sobre el tratamiento realizado en el Departamento de Ortodoncia de la Clínica Estomatología Provincial de Sancti-Spíritus a pacientes con Discrepancia Hueso-Diente negativa desde 1998 hasta el 2003.Se consultaron 446 Historias Clínicas archivadas en la unidad y de ellas se tomaron 235 historias de pacientes que presentaron este tipo de discrepancia. Se realizó un procesamiento estadístico con los objetivos de determinar el comportamiento de los tratamientos que no incluyen las extracciones y los que sí las incluyen, e identificar los aparatos más usados en ambos tipos de tratamiento. Se obtuvieron como principales resultados, que predominan los tratamientos que no incluyen las extracciones, observándose un aumento progresivo del empleo de los aparatos expansionistas. Es de destacar que la Discrepancia Hueso-Diente negativa predominante en este estudio es la elevada.Se concluyó que en este Departamento existe tendencia a aumentar el número de tratamientos conservadores ante la discrepancia hueso-diente negativa y que existe un aumento progresivo a usar aparatos que ayudan a la expansión, predominando el Hawley, el Lip Bumper, y los Funcionales(AU)