RESUMO
The time course of salmonellosis and some immunity indices (composition of serum immunoglobulins A, M and G, phagocytosis and activity of bactericidal substances of peripheral blood neutrophils) were studied in 80 infants. According to the applied therapy the infants were divided into 2 groups. 40 infants of group 1 were subjected to the routine therapy with gentamicin and tobramycin and 40 patients of group 2 were additionally treated with an immunostimulant (humisol). In the patients of group 2 treated with the antibiotics and humisol the disease time course was more favourable, the time required for the treatment was shorter and the hemograms and immunity indices earlier came to the normal.
Assuntos
Substâncias Húmicas , Infecções por Salmonella/tratamento farmacológico , Salmonella enteritidis , Salmonella typhimurium , Doença Aguda , Adjuvantes Imunológicos/uso terapêutico , Aminoglicosídeos , Antibacterianos/uso terapêutico , Complexo Antígeno-Anticorpo/sangue , Complexo Antígeno-Anticorpo/efeitos dos fármacos , Anti-Hipertensivos/uso terapêutico , Avaliação de Medicamentos , Quimioterapia Combinada , Humanos , Imunoglobulinas/sangue , Imunoglobulinas/efeitos dos fármacos , Síndromes de Imunodeficiência/tratamento farmacológico , Síndromes de Imunodeficiência/etiologia , Síndromes de Imunodeficiência/imunologia , Lactente , Indução de Remissão , Infecções por Salmonella/complicações , Infecções por Salmonella/imunologiaRESUMO
The efficacy of antibiotic therapy of salmonellosis was studied and functional activity of peripheral blood leukocytes from electron microscopic data was estimated in 200 infants. It was shown that the use of antibiotics in combination with immunostimulants such as leukocyte mass, lysozyme and prodigiozan in complex therapy of salmonellosis in infants had a favourable effect on both the time course of the clinical signs and the functional state of the neutrophil leukocytes. The duration of the treatment decreased by 6.14 +/- 0.34 days and repeated isolation of the pathogen from the host appeared to be less frequent.