1.
Bioorg Med Chem Lett
; 17(17): 4901-5, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17587578
RESUMO
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which exhibit good selectivity against other steroidal nuclear hormone receptors is described.