Detalhe da pesquisa
1.
Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model.
Respir Res
; 24(1): 289, 2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37978368
2.
Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice.
FASEB J
; 35(1): e21198, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33225469
3.
Identification of selective homeodomain interacting protein kinase 2 inhibitors, a potential treatment for renal fibrosis.
Bioorg Chem
; 126: 105866, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636124
4.
Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, structure-activity relationship studies, and regulation of the AMPK/70S6K pathway.
Arch Pharm (Weinheim)
; 355(7): e2100465, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35415908
5.
Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.
Biochem Biophys Res Commun
; 534: 694-701, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33220928
6.
Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKÉ1ß1γ1 activators.
Arch Pharm (Weinheim)
; 354(7): e2000458, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33683726
7.
Fluorofenidone protects against acute kidney injury.
FASEB J
; 33(12): 14325-14336, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31661638
8.
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Bioorg Med Chem
; 28(9): 115404, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32216987
9.
Targeted degradation of CD147 proteins in melanoma.
Bioorg Chem
; 105: 104453, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197849
10.
9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non-small-cell lung cancer.
J Cell Physiol
; 234(11): 20728-20741, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31004362
11.
Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors.
Bioorg Med Chem
; 27(9): 1871-1881, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926312
12.
Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives.
Bioorg Med Chem
; 27(6): 944-954, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30777660
13.
The Protective Effect of Fluorofenidone against Cyclosporine A-Induced Nephrotoxicity.
Kidney Blood Press Res
; 44(4): 656-668, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31387101
14.
Synthesis and structure-activity relationships of pyrazolo-[3,4-b]pyridine derivatives as adenosine 5'-monophosphate-activated protein kinase activators.
Arch Pharm (Weinheim)
; 352(8): e1900066, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31373047
15.
Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.
Bioorg Med Chem Lett
; 28(2): 222-229, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29248299
16.
Fluorofenidone attenuates interleukin-1ß production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction.
Nephrology (Carlton)
; 23(6): 573-584, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28437591
17.
Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1ß/IL-1R1/MyD88/NF-κB pathway.
J Cell Mol Med
; 20(11): 2064-2077, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27306439
18.
[Research progress of NADPH oxidases and their inhibitors].
Yao Xue Xue Bao
; 51(4): 499-506, 2016 04.
Artigo
em Zh
| MEDLINE | ID: mdl-29859517
19.
[Progress in the study of new cancer target Cdk5 and its inhibitors].
Yao Xue Xue Bao
; 51(2): 226-33, 2016 02.
Artigo
em Zh
| MEDLINE | ID: mdl-29856575
20.
Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation.
Mol Cell Biochem
; 407(1-2): 77-87, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26033204