RESUMO
Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 µM.
Assuntos
Flammulina , Sesquiterpenos , Humanos , Sesquiterpenos/química , Células HeLaRESUMO
A novel alkaloid caulophyine A (1) was isolated from the roots of Caulophyllum robustum Maxim., along with six known alkaloids 2-7. The structure of 1 was elucidated by extensive NMR and high resolution-time-of-flight (HR-TOF)-MS analyses, it is a rare nitrogen containing polycyclic aromatic hydrocarbon. The in vitro bioassays revealed that 2 presented remarkable cytotoxicity against A549 with an IC50 value of 3.83 µM in comparison with the positive control etoposide (IC50 = 11.63 µM). Compounds 1 and 2 also displayed weak Acetylcholinesterase (AChE) inhibitory activity with IC50 values of 123.03 and 80.74 µM respectively.
Assuntos
Alcaloides , Caulophyllum , Acetilcolinesterase/metabolismo , Alcaloides/química , Caulophyllum/química , Estrutura Molecular , Raízes de Plantas/químicaRESUMO
We identified two new diterpenoidal acrocalyenes A (1) and B (2) through chemical investigation on Acrocalymma sp., a plant-associated fungus from the tender stem isolates of Sinomenium acutum collected from the Qinling Mountains, along with seven already-recognized compounds (3-9). The HR-ESI-TOF-MS and 1D/2D NMR data were utilized for structural elucidation of these compounds, and the single-crystal X-ray diffraction was employed for absolute configuration clarification of the novel acrocalyenes 1 and 2. Bioassays revealed that the cytotoxicities of compounds 2, 4, 6, 7, and 8 against three human carcinoma cells (RKO, HeLa and HCC-1806) were moderate to strong, with IC50 between 6.70-38.82â µM. These isolates were also evaluated for their fungal resistant potentials against Botrytis cinerea, Fusarium culmorum and Fusarium solani, in which 3 displayed significant inhibitory effects on all three phytopathogenic fungi, showing respective MIC of 50, 25 and 25â µM.
Assuntos
Ascomicetos , Carcinoma Hepatocelular , Diterpenos , Neoplasias Hepáticas , Antifúngicos/química , Antifúngicos/farmacologia , Ascomicetos/química , Diterpenos/química , Diterpenos/farmacologia , Humanos , SinomeniumRESUMO
Four new diphenyl ether derivatives, sinopestalotiollides A-D (1-4), one new natural α-pyrone product (11), as well as twelve known compounds (5-1â¯7), were obtained from the ethyl acetate extract of the endophytic fungus Pestalotiopsis palmarum isolated from the leaves of medicinal plant Sinomenium acutum (Thunb.) Rehd et Wils. The structures were elucidated by HR-ESI-MS and NMR spectrometry data. Bioassay experiments revealed that compounds 1-4 and 11 exhibited strong to weak cytotoxicities against three human tumor cell lines Hela, HCT116 and A549.
Assuntos
Antineoplásicos/farmacologia , Éteres Fenílicos/farmacologia , Xylariales/química , Células A549 , Antineoplásicos/química , Antineoplásicos/isolamento & purificação , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Células HCT116 , Células HeLa , Humanos , Estrutura Molecular , Éteres Fenílicos/química , Éteres Fenílicos/isolamento & purificação , Sinomenium/microbiologia , Relação Estrutura-AtividadeRESUMO
Two new species of Nazeris Fauvel collected from Daming Shan, Guangxi Province, are described and illustrated: N. damingshanus Hu & Li, sp. n., N. longilobus Hu & Li, sp. n. An identification key to the Nazeris species from Guangxi is provided.
Assuntos
Besouros/classificação , Distribuição Animal , Estruturas Animais/anatomia & histologia , Animais , China , Besouros/anatomia & histologia , Ecossistema , Feminino , MasculinoRESUMO
A new species of Quwatanabius Smetana, Q. dayaoensis Hu, Li & Zhao sp. n. from Dayao Mountain, Guangxi Province, China, is described and illustrated. An identification key to species of Quwatanabius is provided.
Assuntos
Besouros/classificação , Animais , Biodiversidade , China , Besouros/anatomia & histologia , MasculinoRESUMO
Nine species of Nazeris Fauvel are reported from Xizang, China. Seven of them are described as new: N. mirabilis sp. n., N. dinggyensis sp. n., N. jifuensis sp. n., N. wenxuani sp. n., N. gladius sp. n., N. gyirongensis sp. n. and N. yadongensis sp. n. An identification key to the Nazeris species in Xizang and a map showing their distribution are provided.
Assuntos
Besouros , Animais , China , Distribuição AnimalRESUMO
Seven species of Nazeris Fauvel, 1873 are reported for Guizhou, China. All of them are described as new: N. ingentis Lin, Yu Hu, sp. n., N. resimus Lin, Yu Hu, sp. n., N. leigongensis Lin, Yu Hu, sp. n., N. yujiei Lin, Yu Hu, sp. n., N. muricatus Lin, Yu Hu, sp. n., N. excertus Lin, Yu Hu, sp. n. and N. serratus Lin, Yu Hu, sp. n.
Assuntos
Besouros , Animais , ChinaRESUMO
Fourteen species of Nazeris Fauvel, 1873 are reported for the Nanling Mountain Range, China. Four of them are described as new: N.xingmini Lin & Hu, sp. nov. (Guangdong, Jiangxi), N.huaiweni Lin & Hu, sp. nov. (Guangdong), N.meihuaae Lin & Hu, sp. nov. (Guangdong, Jiangxi) and N.lichongi Lin & Hu, sp. nov. (Hunan). An identification key to the Nazeris species reported for the Nanling Mountains, and a map showing their distribution are provided.
RESUMO
Two species of Anchocerus Fauvel are reported from China, one of them described as new: A. wenxuani Lin Hu, sp. n. (Guangxi). Anchocerus giganteus Hu, Li Zhao, 2010 is newly recorded from Shanghai, Jiangxi, Guangxi and Guangdong. A map showing the distribution of all Chinese species is provided.
Assuntos
Besouros , Animais , ChinaRESUMO
Three new species of Nazeris Fauvel, 1873 from the Dayao Mountains, Guangxi, China, are described and illustrated: N. shengtangus Ma, Miao Hu, sp. n., N. songi Ma, Miao Hu, sp. n., and N. curvilaminatus Ma, Miao Hu, sp. n. An identification key to the Nazeris species in Guangxi, and a map showing their distribution are provided.
Assuntos
Besouros , Distribuição Animal , Animais , ChinaRESUMO
A new species of Nazeris Fauvel, 1873 from Anhui, China, is described and illustrated: N. yaoluopingus, sp. n. Additional records of N. cultellatus Assing, 2013, an identification key to the Nazeris species in Anhui and a map showing their distribution are provided.
Assuntos
Besouros , Distribuição Animal , Animais , ChinaRESUMO
Six species of Nazeris Fauvel are reported for Guangxi, China. Five of them are described as new: N. maoershanus Hu Qiao, sp. n., N. rugosus Hu Qiao, sp. n., N. yuyimingi Hu Qiao, sp. n., N. biacuminatus Hu Qiao, sp. n., and N. yanzhuqii Hu Qiao, sp. n. Additional records of N. latilobatus Assing, 2016 and an identification key to the Nazeris species in Guangxi are provided.
Assuntos
Besouros , Animais , ChinaRESUMO
A new species of Nazeris Fauvel, 1873 from Xizang, China, is described and illustrated: N. zhifeii Hu Pan, sp. n. A key to Nazeris species in Xizang and a map showing their distribution are given.
Assuntos
Besouros , Distribuição Animal , Animais , ChinaRESUMO
Four species of Nazeris Fauvel are reported from Guangdong and Hunan, China, with three of them described as new: N. rubidus Hu, Luo Li, sp. n., N. nanlingensis Hu, Luo Li, sp. n., and N. gaoleii Hu, Luo Li, sp. n. Nazeris inaequalis Assing, 2014 is newly recorded from Guangdong Province.
Assuntos
Besouros , Animais , ChinaRESUMO
Six species of the genus Nazeris Fauvel, 1873 are recorded in the Luoxiao Mountain Range, China. Two of them are described: N. yipingae sp. n. and N. jiaweii sp. n. Nazeris xiaobini Hu Li, 2015 and N. rufus Hu Li, 2015 are newly recorded from Hubei Province. An identification key to the Nazeris species in this area and a map showing their distribution are given.
Assuntos
Besouros , Distribuição Animal , Animais , ChinaRESUMO
The paederine genus Nazeris Fauvel, 1873 previously included 241 described species and seven subspecies (Assing, 2016). As many as 49 species have been recorded from the Himalaya (Assing, 2014). In China, Yunnan has the greatest diversity of Nazeris (45 species). Xizang is the second largest province of China, and adjacent to Yunnan and the Himalaya. But only two Nazeris species have been described from this area: N. motuensis Hu, Li & Zhao, 2008 and N. tangi Hu, Li & Zhao, 2008. Both of them were found in eastern Xizang. Three additional species in the insect collection of the Shanghai Normal University are described in this paper.