Pesquisa | Portal de Pesquisa da BVS

1.

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.

Ramasamy, Saravana K; Kusumbe, Anjali P; Itkin, Tomer; Gur-Cohen, Shiri; Lapidot, Tsvee; Adams, Ralf H.

Annu Rev Cell Dev Biol ; 32: 649-675, 2016 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-27576121

2.

Spatial mapping of human hematopoiesis at single-cell resolution reveals aging-associated topographic remodeling.

Sarachakov, Aleksandr; Varlamova, Arina; Svekolkin, Viktor; Polyakova, Margarita; Valencia, Itzel; Unkenholz, Caitlin; Pannellini, Tania; Galkin, Ilia; Ovcharov, Pavel; Tabakov, Dmitrii; Postovalova, Ekaterina; Shin, Nara; Sethi, Isha; Bagaev, Alexander; Itkin, Tomer; Crane, Genevieve; Kluk, Michael; Geyer, Julia; Inghirami, Giorgio; Patel, Sanjay.

Blood ; 142(26): 2282-2295, 2023 12 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774374

3.

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Ludin, Aya; Itkin, Tomer; Gur-Cohen, Shiri; Mildner, Alexander; Shezen, Elias; Golan, Karin; Kollet, Orit; Kalinkovich, Alexander; Porat, Ziv; D'Uva, Gabriele; Schajnovitz, Amir; Voronov, Elena; Brenner, David A; Apte, Ron N; Jung, Steffen; Lapidot, Tsvee.

Nat Immunol ; 13(11): 1072-82, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-22983360

4.

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

Schajnovitz, Amir; Itkin, Tomer; D'Uva, Gabriele; Kalinkovich, Alexander; Golan, Karin; Ludin, Aya; Cohen, Dror; Shulman, Ziv; Avigdor, Abraham; Nagler, Arnon; Kollet, Orit; Seger, Rony; Lapidot, Tsvee.

Nat Immunol ; 12(5): 391-8, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21441933

5.

Cardiovascular diseases disrupt the bone-marrow niche.

Itkin, Tomer; Rafii, Shahin.

Nature ; 601(7894): 515-517, 2022 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-34949859

6.

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe, Anjali P; Ramasamy, Saravana K; Itkin, Tomer; Mäe, Maarja Andaloussi; Langen, Urs H; Betsholtz, Christer; Lapidot, Tsvee; Adams, Ralf H.

Nature ; 532(7599): 380-4, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27074508

7.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin, Tomer; Gur-Cohen, Shiri; Spencer, Joel A; Schajnovitz, Amir; Ramasamy, Saravana K; Kusumbe, Anjali P; Ledergor, Guy; Jung, Yookyung; Milo, Idan; Poulos, Michael G; Kalinkovich, Alexander; Ludin, Aya; Kollet, Orit; Shakhar, Guy; Butler, Jason M; Rafii, Shahin; Adams, Ralf H; Scadden, David T; Lin, Charles P; Lapidot, Tsvee.

Nature ; 532(7599): 323-8, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27074509

8.

Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe, Anjali P; Ramasamy, Saravana K; Itkin, Tomer; Mäe, Maarja Andaloussi; Langen, Urs H; Betsholtz, Christer; Lapidot, Tsvee; Adams, Ralf H.

Nature ; 539(7628): 314, 2016 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-27626373

9.

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin, Tomer; Gur-Cohen, Shiri; Spencer, Joel A; Schajnovitz, Amir; Ramasamy, Saravana K; Kusumbe, Anjali P; Ledergor, Guy; Jung, Yookyung; Milo, Idan; Poulos, Michael G; Kalinkovich, Alexander; Ludin, Aya; Golan, Karin; Khatib, Eman; Kumari, Anju; Kollet, Orit; Shakhar, Guy; Butler, Jason M; Rafii, Shahin; Adams, Ralf H; Scadden, David T; Lin, Charles P; Lapidot, Tsvee.

Nature ; 538(7624): 274, 2016 Oct 13.

Artigo em Inglês | MEDLINE | ID: mdl-27437586

10.

FGF signaling facilitates postinjury recovery of mouse hematopoietic system.

Zhao, Meng; Ross, Jason T; Itkin, Tomer; Perry, John M; Venkatraman, Aparna; Haug, Jeffrey S; Hembree, Mark J; Deng, Chu-Xia; Lapidot, Tsvee; He, Xi C; Li, Linheng.

Blood ; 120(9): 1831-42, 2012 Aug 30.

Artigo em Inglês | MEDLINE | ID: mdl-22802336

11.

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

Itkin, Tomer; Ludin, Aya; Gradus, Ben; Gur-Cohen, Shiri; Kalinkovich, Alexander; Schajnovitz, Amir; Ovadya, Yossi; Kollet, Orit; Canaani, Jonathan; Shezen, Elias; Coffin, Douglas J; Enikolopov, Grigori N; Berg, Thorsten; Piacibello, Wanda; Hornstein, Eran; Lapidot, Tsvee.

Blood ; 120(9): 1843-55, 2012 Aug 30.

Artigo em Inglês | MEDLINE | ID: mdl-22645180

12.

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.

Golan, Karin; Vagima, Yaron; Ludin, Aya; Itkin, Tomer; Cohen-Gur, Shiri; Kalinkovich, Alexander; Kollet, Orit; Kim, Chihwa; Schajnovitz, Amir; Ovadya, Yossi; Lapid, Kfir; Shivtiel, Shoham; Morris, Andrew J; Ratajczak, Mariusz Z; Lapidot, Tsvee.

Blood ; 119(11): 2478-88, 2012 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-22279055

13.

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Orlovsky, Kira; Kalinkovich, Alexander; Rozovskaia, Tanya; Shezen, Elias; Itkin, Tomer; Alder, Hansjuerg; Ozer, Hatice Gulcin; Carramusa, Letizia; Avigdor, Abraham; Volinia, Stefano; Buchberg, Arthur; Mazo, Alex; Kollet, Orit; Largman, Corey; Croce, Carlo M; Nakamura, Tatsuya; Lapidot, Tsvee; Canaani, Eli.

Proc Natl Acad Sci U S A ; 108(19): 7956-61, 2011 May 10.

Artigo em Inglês | MEDLINE | ID: mdl-21518888

14.

Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.

Itkin, Tomer; Kaufmann, Kerstin B; Gur-Cohen, Shiri; Ludin, Aya; Lapidot, Tsvee.

Curr Opin Hematol ; 20(3): 237-44, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23567340

15.

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.

Keren, Zohar; Naor, Shulamit; Nussbaum, Shahar; Golan, Karin; Itkin, Tomer; Sasaki, Yoshiteru; Schmidt-Supprian, Marc; Lapidot, Tsvee; Melamed, Doron.

Blood ; 117(11): 3104-12, 2011 Mar 17.

Artigo em Inglês | MEDLINE | ID: mdl-21228330

16.

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.

Tesio, Melania; Golan, Karin; Corso, Simona; Giordano, Silvia; Schajnovitz, Amir; Vagima, Yaron; Shivtiel, Shoham; Kalinkovich, Alexander; Caione, Luisa; Gammaitoni, Loretta; Laurenti, Elisa; Buss, Eike C; Shezen, Elias; Itkin, Tomer; Kollet, Orit; Petit, Isabelle; Trumpp, Andreas; Christensen, James; Aglietta, Massimo; Piacibello, Wanda; Lapidot, Tsvee.

Blood ; 117(2): 419-28, 2011 Jan 13.

Artigo em Inglês | MEDLINE | ID: mdl-20585044

17.

Chronic B cell deficiency from birth prevents age-related alterations in the B lineage.

Keren, Zohar; Averbuch, Dana; Shahaf, Gitit; Zisman-Rozen, Simona; Golan, Karin; Itkin, Tomer; Lapidot, Tsvee; Mehr, Ramit; Melamed, Doron.

J Immunol ; 187(5): 2140-7, 2011 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-21810615

18.

A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells.

Tan, Lei; Duan, Xiaohua; Mutyala, Pratyusha; Zhou, Ting; Amin, Sadaf; Zhang, Tuo; Herbst, Brian; Askan, Gokce; Itkin, Tomer; Xiang, Zhaoying; Michelassi, Fabrizio; Lieberman, Michael D; Iacobuzio-Donahue, Christine A; Leach, Steven D; Evans, Todd; Chen, Shuibing.

J Mol Cell Biol ; 15(6)2023 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-37327088

19.

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing.

Itkin, Tomer; Houghton, Sean; Schreiner, Ryan; Lin, Yang; Badwe, Chaitanya R; Voisin, Veronique; Murison, Alex; Seyedhassantehrani, Negar; Kaufmann, Kerstin B; Garcia-Prat, Laura; Booth, Gregory T; Geng, Fuqiang; Liu, Ying; Gomez-Salinero, Jesus M; Shieh, Jae-Hung; Redmond, David; Xiang, Jenny Z; Josefowicz, Steven Z; Trapnell, Cole; Spencer, Joel A; Zangi, Lior; Hadland, Brandon; Dick, John E; Xie, Stephanie Z; Rafii, Shahin.

bioRxiv ; 2023 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-37034724

20.

Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.

Hadland, Brandon; Varnum-Finney, Barbara; Dozono, Stacey; Dignum, Tessa; Nourigat-McKay, Cynthia; Heck, Adam M; Ishida, Takashi; Jackson, Dana L; Itkin, Tomer; Butler, Jason M; Rafii, Shahin; Trapnell, Cole; Bernstein, Irwin D.

Nat Commun ; 13(1): 1584, 2022 03 24.

Artigo em Inglês | MEDLINE | ID: mdl-35332125

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