RESUMO
Hashimoto's encephalopathy (HE) is a rare neuropsychiatric syndrome associated with increased level of antithyroid antibodies. Two types of clinical manifestation can be described: a vasculitic type with stroke like episodes and diffuse progressive type with deterioration of mental function. Neurologic symptoms are present in euthyreosis as well as in thyroid dysfunction. Because of good response to immunosuppressive therapy, the prompt diagnosis and management of HE are crucial. In this study we present the review of current literature and discuss two representative cases.
Assuntos
Gerenciamento Clínico , Encefalite/patologia , Doença de Hashimoto/patologia , Encefalite/diagnóstico , Encefalite/tratamento farmacológico , Encefalite/etiologia , Feminino , Doença de Hashimoto/diagnóstico , Doença de Hashimoto/tratamento farmacológico , Doença de Hashimoto/etiologia , Humanos , Pessoa de Meia-Idade , Guias de Prática Clínica como AssuntoRESUMO
The authors present the problem of the migraine and tension-type headache treatment in the children basing on the questionnaires, carried out among the participants of The Third Polish Days of Children Neurology.
Assuntos
Transtornos de Enxaqueca/tratamento farmacológico , Cefaleia do Tipo Tensional/tratamento farmacológico , Criança , Pré-Escolar , Tratamento Farmacológico/métodos , Humanos , Transtornos de Enxaqueca/diagnóstico , Índice de Gravidade de Doença , Inquéritos e Questionários , Cefaleia do Tipo Tensional/diagnóstico , Fatores de TempoAssuntos
Pressão Sanguínea/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Imidazóis/farmacologia , Animais , Benzofuranos/farmacologia , Feminino , Idazoxano/farmacologia , Receptores de Imidazolinas , Masculino , Fenoxibenzamina/farmacologia , Ratos , Ratos Wistar , Receptores de Droga/agonistas , Relação Estrutura-Atividade , Ioimbina/farmacologiaRESUMO
Phospholipase A(2) (E.C. 3.1.1.4, PLA(2)) plays an essential role in metabolism of membrane phospholipids, it is related to inflammatory reactions, secretion of amyloid precursor protein and activation of NMDA receptor after ischemia. In the present study we investigated PLA(2) activity in platelets from 37 Alzheimer's disease (AD) patients, 32 vascular dementia (VaD) patients and 32 individuals with ischemic stroke as compared to 27 healthy elderly controls. PLA(2) activity was determined using radiometric assay. Mean platelet PLA(2) activity was increased in individuals with Alzheimer's disease (p < 0.001). In VaD group the enzyme activity was between the values in AD and controls, these differences being significant from both groups. In the group of patients with ischemic stroke mean PLA(2) activity was higher either 48 h after the stroke or 7 days later (in both cases p < 0.001). The results may be particularly interesting in light of the fact, that inhibitors of PLA(2) activity are known.
Assuntos
Doença de Alzheimer/enzimologia , Plaquetas/enzimologia , Isquemia Encefálica/enzimologia , Encéfalo/enzimologia , Demência Vascular/enzimologia , Fosfolipases A2 do Grupo II/metabolismo , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/fisiopatologia , Peptídeos beta-Amiloides/biossíntese , Biomarcadores/metabolismo , Encéfalo/fisiopatologia , Isquemia Encefálica/fisiopatologia , Demência Vascular/fisiopatologia , Encefalite/metabolismo , Encefalite/fisiopatologia , Feminino , Humanos , Masculino , Lipídeos de Membrana/metabolismo , Receptores de N-Metil-D-Aspartato/metabolismo , Acidente Vascular Cerebral/enzimologia , Acidente Vascular Cerebral/fisiopatologia , Regulação para Cima/fisiologiaRESUMO
A series of novel N-(4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole derivatives 2a-d, 3a-d and 4a-p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.