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1.
Community Dent Health ; 41(1): 70-74, 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38533922

RESUMO

There are important calls for greater inclusion of Indigenous and racialised communities in oral microbiome research. This paper uses the concept of racial capitalism (the extractive continuity of colonialism) to critically examine this inclusion agenda. Racial capitalism explicitly links capitalist exploitations with wider social oppressions e.g., racisms, sexism, ableism. It is not confined to the commercial sector but pervades white institutions, including universities. By using the lens of racial capitalism, we find inclusion agendas allow white institutions to extract social and economic value from relations of race. Racially inclusive research is perceived as a social good, therefore, it attracts funding. Knowledge and treatments developed from research create immense value for universities and pharmaceutical companies with limited benefits for the communities themselves. Moreover, microbiome research tends to drift from conceptualisations that recognise it as something that is shaped by the social, including racisms, to one that is determined genetically and biologically. This location of problems within racialised bodies reinforces racial oppressions and allows companies to further profit from raciality. Inclusion in oral microbiome research must consider ways to mitigate racial capitalism. Researchers can be less extractive by using an anti-racism praxis framework. This includes working with communities to co-design studies, create safer spaces, giving marginalised communities the power to set and frame agendas, sharing research knowledges and treatments through accessible knowledge distributions, open publications, and open health technologies. Most importantly, inclusion agendas must not displace ambitions of the deeper anti-oppression social reforms needed to tackle health inequalities and create meaningful inclusion.


Assuntos
Capitalismo , Racismo , Humanos
2.
Community Dent Health ; 39(2): 143-148, 2022 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-35543461

RESUMO

Students across disciplines in UK universities are demanding decolonisation of their education. These demands aim to resist the white European colonial endeavour that create racist inequalities. To address racial inequalities, the dental discipline has predominantly focused on diversity rather than decolonisation. By using two inter-related referents of decolonisation to dental caries and cosmetic dentistry, this article demonstrates the epistemic violence exerted through the objective hierarchised knowledge practices in dentistry. First, by starting from the position of racisms, empire and slavery, the enduring colonial patterns of power and hierarchies come into view. We see how knowledge production in dentistry has neglected the interconnected histories of colonialism, racial capitalism and patriarchy that continue to shape oral health inequalities and work towards promoting white supremacist beauty ideals. Moreover, the interconnected character of inequalities - race, class and gender - begin to emerge. Second, by proceeding from the place of colonialism, the limits of dental knowledge and the violence embedded in knowledge practices emerge. This highlights the need for new ways of knowing. To decolonise is to confront and weaken the dental discipline's entanglement with the enduring colonial patterns of power and hierarchies that are complicit in maintaining inequalities. Diversity without decolonisation will simply subsume marginalised voices into the existing hierarchised knowledge paradigm and continue to reproduce a hierarchised, unequal world. I argue that if dental schools want to address racial and intersectional inequalities, they need new transformative ways of learning and knowing to equip students to work towards social justice in the outside world.


Assuntos
Cárie Dentária , Racismo , Colonialismo , Currículo , Humanos , Reino Unido
3.
Community Dent Health ; 38(2): 142-149, 2021 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-33769723

RESUMO

This article analyses the underrepresentation of racialised minorities across the three stages of the dental workforce pipeline through the critical lens of power. The reformist view of power was used, which focuses on concealment caused by systemic biases. We observed adequate representation of racialised minorities in the first two stages of the pipeline; entry to dental schools and completion of dental education. However, the categorisation of diverse groups into a single 'BAME' category conceals the underrepresentation of Black people and those who experience intersectional forms of discrimination rooted in race, gender and class. We observed all racialised minorities to be underrepresented in the third stage of the pipeline; career development and progression. The data suggest that institutional processes are more likely to recruit and promote White1 people, and racialised minorities are more likely to be exposed to bullying and inequitable disciplinary processes. Consistently across dental institutions, as the level of seniority increases, the representation of racialised minorities decreases. Thus, senior decision-making and agenda-setting spaces in UK dentistry are overwhelmingly White. Multiple actions are suggested; including collation of comprehensive, inclusive data, widening participation and representation initiatives to help re-distribute the power dynamics towards racialised minorities and ensure equality of representation across the dental pipeline, including in senior spaces. We hope this will work towards putting some of the systemic problems that we see in dentistry; such as differential staff and student experiences, inequitable recruitment, promotions and disciplinary proceedings, and colonial dental curricula and research on the institutional agenda.


Assuntos
População Negra , Grupos Minoritários , Humanos , Reino Unido , População Branca , Recursos Humanos
4.
J Pediatr Hematol Oncol ; 42(6): 381-385, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32011565

RESUMO

As beta-thalassemia major patients need regular blood transfusions due to the severe hemoglobin deficiency, the occurrence of related bone defects with simultaneous fluctuations in the biochemical and hematologic parameters is seen. The hospital-based cross-sectional observational study was done to determine and correlate the bone mineral density (BMD) with biochemical parameters and hematologic parameters in 50 regularly transfused beta-thalassemia major patients of older than 6 years of age. Descriptive statistics were analyzed with SPSS version 20.0 software. A P<0.05 was considered as statistically significant. The prevalence of suboptimal BMD at lumbar spine was 86% and at femur neck was 74%. A statistically significant correlation of BMD was found with mean pretransfusion hemoglobin values, serum calcium levels, and serum vitamin D levels (P<0.05). It was concluded that continuous monitoring of the BMD, biochemical, and hematologic parameters in regularly transfused beta-thalassemia major patients may help assess the ongoing deficiencies; helping to maintain timely and regular blood transfusions with supplementation of calcium, vitamin D to ensure good bone health.


Assuntos
Transfusão de Sangue/métodos , Densidade Óssea , Osteoporose/epidemiologia , Talassemia beta/terapia , Criança , Estudos Transversais , Feminino , Seguimentos , Humanos , Índia/epidemiologia , Masculino , Prevalência , Prognóstico
5.
Breast Cancer Res Treat ; 173(3): 597-602, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30390216

RESUMO

PURPOSE: Prior research demonstrates racial disparities in breast cancer treatment. Disparities are commonly attributed to more advanced stage at presentation or aggressive tumor biology. We seek to evaluate if racial disparities persist in the treatment of stage 1 breast cancer patients who by definition are not delayed in presentation. METHODS: We selected stage 1 breast cases in the National Cancer Data Base. Patients were divided into two cohorts based on race and included White and Black patients. We also performed a subgroup analysis of patients with private insurance for comparison to determine if private insurance diminished the racial disparities noted. We analyzed differences in time to treatments by race. RESULTS: Our analysis included 546,351 patients of which 494,784 (90.6%) were White non-Hispanic and 51,567 (9.4%) were Black non-Hispanic. Black women had significantly longer times to first treatment (35.5 days vs 28.1 days), surgery (36.6 days vs 28.8 days), chemotherapy (88.1 days vs 75.4 days), radiation (131.3 days vs 99.1 days), and endocrine therapy (152.1 days vs 126.5 days) than White women. When patients with private insurance were analyzed the difference in time to surgery decreased by 1.2 days but racial differences remained statistically significant. CONCLUSIONS: Despite selecting for early-stage breast cancer, racial disparities between White and Black women in time to all forms of breast cancer treatment persist. These disparities while likely not oncologically significant do suggest institutional barriers for obtaining care faced by women of color which may not be addressed with improving access to mammography alone.


Assuntos
Neoplasias da Mama/epidemiologia , Disparidades em Assistência à Saúde , Adulto , Idoso , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/terapia , Terapia Combinada , Gerenciamento Clínico , Detecção Precoce de Câncer , Etnicidade , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Cobertura do Seguro , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Fatores Raciais , Tempo para o Tratamento
6.
J Surg Res ; 238: 35-40, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30735964

RESUMO

BACKGROUND: Previous studies using the NSQIP database to study hepatectomies lacked hepatic specific variables and outcomes. We used the targeted NSQIP hepatectomy database to examine the nationwide trend and the safety profile of synchronous liver and colorectal resection compared with hepatectomy alone for colorectal liver metastasis. METHODS: The targeted NSQIP hepatectomy database from 2014 was used to study patients who underwent hepatectomy for diagnosis of adenocarcinoma of the colon and rectum. RESULTS: Of the 3064 hepatic resections in the database, 1138 cases were performed for colorectal metastasis. Of these, 1040 were liver-alone surgery and 98 were synchronous liver and colorectal resection. Most (58.7%) patients received neoadjuvant therapy. The rate of neoadjuvant therapy, intraoperative ablation, biliary reconstruction, and the use of minimally invasive technique were similar between the two groups. The overall 30-d mortality in this cohort was low (1.1%). While the mortality rate in the synchronous group was similar to liver-only group (3.1% versus 0.9%, P = 0.077). The rate of liver failure (3.3% versus 4.1%, P = 0.722) and biliary leak (5.3% versus 9.6%, P = 0.084) were similar between the two groups. However, the rate of major complications was higher on multivariable analyses (25.5% versus 12.1%, OR 2.5, 95% CI 1.5-4.1, P < 0.001) for the synchronous group. CONCLUSIONS: Hepatic resection for colorectal metastasis in the modern era has low short-term mortality. While synchronous resection was associated with a higher incidence of major complications, liver-specific complications did not increase with synchronous resection.


Assuntos
Neoplasias Colorretais/terapia , Hepatectomia/tendências , Neoplasias Hepáticas/terapia , Procedimentos Cirúrgicos Minimamente Invasivos/tendências , Complicações Pós-Operatórias/epidemiologia , Idoso , Colectomia/efeitos adversos , Colectomia/métodos , Colectomia/tendências , Colo/cirurgia , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Feminino , Hepatectomia/efeitos adversos , Hepatectomia/métodos , Mortalidade Hospitalar , Humanos , Incidência , Fígado/cirurgia , Neoplasias Hepáticas/mortalidade , Neoplasias Hepáticas/secundário , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Terapia Neoadjuvante/estatística & dados numéricos , Complicações Pós-Operatórias/etiologia , Protectomia/efeitos adversos , Protectomia/métodos , Protectomia/tendências , Estudos Retrospectivos , Análise de Sobrevida
7.
Community Dent Health ; 36(1): 5-8, 2019 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-30211484

RESUMO

The Health and Social Care Act 2012 created a new commissioning framework for the provision of health, social care and public health in England (UK Government, 2012). NHS England became the sole commissioner for all NHS dental services, including primary, secondary and unscheduled dental care. Local authorities became responsible for public health, epidemiological surveys, improving the oral health of their communities and for commissioning oral health improvement services including water fluoridation (NHS Bodies and Local Authorities (Partnership Arrangements, Care Trusts, Public Health and Local Healthwatch) Regulations (SI 2012/3094)). At the time this needs assessment was conducted, NHS South Yorkshire and Bassetlaw Area Team commissioned all the NHS dental services in the local authority areas of Barnsley, Doncaster, Rotherham, Sheffield and Bassetlaw. The dental Local Professional Network provided clinical and public health input to the commissioning process through its annual work plan. However, there was no up to date information on local oral health needs and how these needs were being met by NHS dental services, hence it was difficult to determine what were the local commissioning priorities.


Assuntos
Atenção à Saúde , Avaliação das Necessidades , Saúde Bucal , Inglaterra , Humanos , Saúde Pública
8.
Herz ; 43(2): 146-155, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28235980

RESUMO

BACKGROUND: Galectin-3 has been reported as a mediator of heart failure (HF) development and progression. Most studies, however, have been conducted on patients with chronic HF rather than acute HF (AHF). The aim of this study was to confirm galectin-3 as a prognostic marker in subjects with AHF and to investigate its possible relationship with left ventricular (LV) remodeling. METHODS: A total of 69 patients hospitalized with a primary diagnosis of AHF were followed up for 18 months. Galectin-3 and echocardiographic parameters were measured at baseline and after 6 months. Survival analysis and exploratory analysis of LV remodeling were performed. RESULTS: Patients with high baseline galectin-3 values (>16.5 ng/ml) had a significantly worse survival profile over the 18-month follow-up (log-rank test, p = 0.017), with Cox proportional hazards modeling showing a crude hazard ratio (HR) of 4.66 (95% CI = 1.16-18.67; likelihood-ratio test, p = 0.037) for all-cause mortality. Changes in galectin-3 levels (1 SD increase over 6 months) proved to be a significant explanatory factor for HF hospital re-admission in the short term when compared with quasi-stationary galectin-3 levels: worse Kaplan-Meier survival curves (log-rank test, p = 0.001) and a crude HR of 4.44 (95% CI = 1.76-11.18; likelihood-ratio test, p = 0.004). A significant association was found between the pathological evolution of relative wall thickness, LV end-diastolic diameter, LV end-diastolic volume, and increasing levels of galectin-3 in the short term (Cochran-Mantel-Haenszel test, p < 0.01). CONCLUSION: Galectin-3 can predict long-term mortality in patients with AHF. The results of our study suggest a possible relation between left ventricular remodeling and increasing galectin-3 levels.


Assuntos
Biomarcadores/sangue , Galectina 3/sangue , Insuficiência Cardíaca/sangue , Remodelação Ventricular/fisiologia , Doença Aguda , Idoso , Ecocardiografia , Feminino , Seguimentos , Insuficiência Cardíaca/mortalidade , Ventrículos do Coração/fisiopatologia , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Readmissão do Paciente , Prognóstico
9.
Ann Vasc Surg ; 38: 158-163, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27666802

RESUMO

BACKGROUND: Interventional strategies for massive and submassive pulmonary embolism (smPE) have historically included either systematic intravenous thrombolytic alteplase or surgical embolectomy, both of which are associated with significant morbidity and mortality. However, with the advent of endovascular techniques, recent studies have suggested that an endovascular approach to the treatment of acute smPE may be both safe and effective with excellent outcomes. The purpose of this study was to evaluate the outcomes of patients who have undergone catheter-directed thrombolysis (CDT) for smPE at our institution in an effort to determine the safety of the procedure. METHODS: A retrospective review was conducted from December 2012 to June 2015 to identify patients whom underwent CDT in the treatment of a smPE at our institution. Primary measure was safety of the procedure. Outcome variables were classified as serious or minor adverse events. Serious events included death, stroke, myocardial infarction, and bleeding complications requiring surgical intervention or transfusion. Minor events included groin hematoma, development of arteriovenous fistula, and bleeding requiring interruption or cessation of CDT. In addition, a secondary measure included effectiveness of CDT based on preinterventional and postinterventional clinical examination and radiographic findings. RESULTS: A total of 27 patients undergoing CDT for smPE at our institution were evaluated. The standard procedure included access via bilateral femoral veins and placement of bilateral EKOS catheters for ultrasound-assisted thrombolysis (USAT), with Activase (alteplase) at 1 mg per hour in each catheter for a total of 12 hr. There were no serious adverse events and only 4 patients (14.8%) had minor events, of which only 1 patient required premature termination of therapy due to bleeding resulting in a 3.7% clinically relevant bleeding rate. In addition, a reduction in a right-to-left ventricular end-diastolic diameter ratio (RV/LV ratio) on follow-up imaging was observed in each of the 18 patients where preinterventional and postinterventional imaging was available. Likewise, via chart review, all patients reported significant cessation of shortness-of-breath and resolution of chest pain with associated decrease in supplemental oxygen requirement. CONCLUSIONS: Current evidence, the majority of which has been industry funded, suggests that CDT should be considered as the first-line therapy for smPE. Our experience, in this single-institution retrospective review, demonstrates that CDT with USAT in the treatment of smPE is safe, while providing immediate resolution of both RV strain and clinical symptoms such as shortness-of-breath and chest pain. We hope that these data will allow other institutions to consider CDT as a plausible option in the treatment of smPE.


Assuntos
Cateterismo de Swan-Ganz , Procedimentos Endovasculares , Fibrinolíticos/administração & dosagem , Embolia Pulmonar/tratamento farmacológico , Terapia Trombolítica , Ativador de Plasminogênio Tecidual/administração & dosagem , Adulto , Idoso , Cateterismo de Swan-Ganz/efeitos adversos , Cateterismo de Swan-Ganz/instrumentação , Procedimentos Endovasculares/efeitos adversos , Procedimentos Endovasculares/instrumentação , Feminino , Fibrinolíticos/efeitos adversos , Humanos , Infusões Intra-Arteriais , Masculino , Pessoa de Meia-Idade , Ohio , Embolia Pulmonar/diagnóstico por imagem , Estudos Retrospectivos , Terapia Trombolítica/efeitos adversos , Terapia Trombolítica/instrumentação , Fatores de Tempo , Ativador de Plasminogênio Tecidual/efeitos adversos , Resultado do Tratamento , Dispositivos de Acesso Vascular
10.
J Arthroplasty ; 32(5): 1478-1482, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28159420

RESUMO

BACKGROUND: Aspirin at 325 mg twice daily is now included as a nationally approved venous thromboembolism (VTE) prophylaxis protocol for low-risk total knee arthroplasty (TKA) patients. The purpose of this study is to examine whether there is a difference in deep vein thrombosis (DVT) occurrence after a limited tourniquet TKA using aspirin-based prophylaxis with or without extended use of mechanical compression device (MCD) therapy. METHODS: One hundred limited tourniquet TKA patients, whose DVT risk was managed with aspirin 325 mg twice daily for 3 weeks, were randomized to either using an MCD during hospitalization only or extended use at home up to 6 weeks postoperatively. Lower extremity duplex venous ultrasonography (LEDVU) was completed on the second postoperative day, 14 days postoperatively, and at 3 months postoperatively to confirm the absence of DVT after treatment. RESULTS: The DVT rate for the postdischarge MCD therapy group was 0% and 23.1% for the inpatient MCD group (P < .001). All DVTs resolved by 3 months postoperatively. Patient satisfaction was 9.56 (±0.82) for postdischarge MCD patients vs 8.50 (±1.46) for inpatient MCD patients (P < .001). CONCLUSION: Limited tourniquet TKA patients who were mobilized early, managed with aspirin for 3 weeks postoperatively, and on MCD therapy for up to 6 weeks postoperatively experienced superior DVT prophylaxis than patients receiving MCD therapy only as an inpatient (P < .05). The 0% incidence of nonsymptomatic DVTs prevented by aspirin and extended-use MCD further validates this type of prophylaxis in low DVT risk TKA patients.


Assuntos
Artroplastia do Joelho/efeitos adversos , Artroplastia do Joelho/métodos , Aspirina/uso terapêutico , Dispositivos de Compressão Pneumática Intermitente , Tromboembolia Venosa/prevenção & controle , Trombose Venosa/prevenção & controle , Idoso , Aspirina/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Estudos Prospectivos , Resultado do Tratamento , Ultrassonografia Doppler , Tromboembolia Venosa/etiologia , Trombose Venosa/etiologia , Cicatrização
11.
Community Dent Health ; 33(3): 218-224, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28509518

RESUMO

INTRODUCTION: The popularity of cosmetic surgery has seen a rapid increase recently, with the trend mirrored in dentistry. The Department of Health expressed concerns about the potential for biological and psychosocial harm of these cosmetic procedures. Furthermore, the dental public health implications (DPH) of the growing uptake of cosmetic dental procedures have not been explored. OBJECTIVES: Conduct a scoping review to explore the DPH implications of cosmetic dentistry and identify gaps for future research. METHODS: A fivestage scoping review was conducted of studies identified using the search terms cosmetic AND dentistry. Data from the studies meeting the inclusion criteria were extracted, collated and summarised into themes. RESULTS: Fifty-seven papers met the inclusion criteria (11 cross-sectional studies, 10 literature reviews and 36 opinion pieces). The DPH implications were summarised into five emergent themes: dento-legal and ethical, marketing, psychosocial, biological and workforce. These themes revealed patients' increased expectations, expanding commercialisation of the profession, psychological risks to vulnerable patients, the iatrogenic consequences of invasive cosmetic dental procedures and workforce implications of the current trends. CONCLUSIONS: The scoping review found that existing literature on cosmetic dentistry is predominately anecdotal - professional opinions and discussions. Despite this, our findings demonstrated workforce training and governance implications due to increased demand for cosmetic dentistry. Further empirical research is needed to understand the DPH implications of the increasing demand and uptake of cosmetic dental procedures to guide evidence-based policy to safeguard patients and improve the quality of dental services.


Assuntos
Estética Dentária , Saúde Pública , Indústria da Beleza , Ética Odontológica , Humanos , Marketing de Serviços de Saúde
12.
Nat Genet ; 16(3): 311-5, 1997 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9207801

RESUMO

Ulnar-mammary syndrome is a rare pleiotropic disorder affecting limb, apocrine gland, tooth and genital development. We demonstrate that mutations in human TBX3, a member of the T-box gene family, cause ulnar-mammary syndrome in two families. Each mutation (a single nucleotide deletion and a splice-site mutation) is predicted to cause haploinsufficiency of TBX3, implying that critical levels of this transcription factor are required for morphogenesis of several organs. Limb abnormalities of ulnar-mammary syndrome involve posterior elements. Mutations in TBX5, a related and linked gene, cause anterior limb abnormalities in Holt-Oram syndrome. We suggest that during the evolution of TBX3 and TBX5 from a common ancestral gene, each has acquired specific yet complementary roles in patterning the mammalian upper limb.


Assuntos
Anormalidades Múltiplas/genética , Glândulas Apócrinas/anormalidades , Braço/anormalidades , Genitália/anormalidades , Mutação , Proteínas com Domínio T , Fatores de Transcrição/genética , Sequência de Aminoácidos , Sequência de Bases , Mama/anormalidades , Cromossomos Humanos Par 12 , Análise Mutacional de DNA , Feminino , Regulação da Expressão Gênica no Desenvolvimento , Humanos , Íntrons/genética , Masculino , Dados de Sequência Molecular , Alinhamento de Sequência , Síndrome , Fatores de Transcrição/química
13.
Osteoporos Int ; 23(7): 1987-98, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21947033

RESUMO

SUMMARY: We measured bone properties by phalangeal quantitative ultrasound in 1,719 pediatric patients with bone disorders, classifying them according to fracture status. Quantitative ultrasound discriminated fractured and nonfractured pediatric patients and enabled us to stratify fractured patients into classes according to the severity of the causative trauma (spontaneous, minimal trauma, appropriate trauma fractures). INTRODUCTION: The correlation between quantitative bone measurements and fractures is poorly established in pediatric patients with bone disorders. We correlated phalangeal quantitative ultrasound (QUS) and fracture history in children and adolescents with bone disorders and evaluated the ability of QUS to recognize fractured patients. METHODS: Amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT) were measured in 1,719 pediatric patients with bone disorders and related to fracture history. The patients were classified as (1) spontaneously (77), (2) minimal trauma (101), or (3) appropriate trauma fractured (206), and (4) nonfractured (1,335). The likelihood of fracture according to QUS was calculated as odds ratio per SD decrease (OR/SD), and the effectiveness in discriminating fractured patients was evaluated by receiver operating characteristic (ROC) analysis. The influence of age, sex, puberty, height, and BMI was explored by respective adjustments and multiple logistic regression. RESULTS: Fractured patients showed significantly reduced AD-SoS and BTT standard deviation score (-0.32 ± 1.54 and -0.78 ± 1.49) compared to nonfractured subjects (0.43 ± 1.63 and -0.11 ± 1.34). QUS measurements paralleled the causative trauma severity, ranging from the lowest values in spontaneously fractured patients to normal values in appropriate trauma fractured subjects. The OR/SD were increasingly higher in appropriate trauma fractured, minimal trauma fractured, and spontaneously fractured patients. At ROC analysis, both parameters proved to have significant discrimination power in recognizing spontaneously and minimal trauma-fractured patients. CONCLUSIONS: QUS identifies fractured pediatric patients with bone disorders, reflecting the severity of the causative trauma with a high discrimination power for fragility fractures.


Assuntos
Doenças Ósseas/diagnóstico por imagem , Falanges dos Dedos da Mão/diagnóstico por imagem , Fraturas Ósseas/diagnóstico por imagem , Adolescente , Antropometria/métodos , Densidade Óssea/fisiologia , Doenças Ósseas/complicações , Doenças Ósseas/fisiopatologia , Criança , Pré-Escolar , Feminino , Falanges dos Dedos da Mão/fisiopatologia , Fraturas Ósseas/etiologia , Fraturas Ósseas/fisiopatologia , Fraturas Espontâneas/diagnóstico por imagem , Fraturas Espontâneas/etiologia , Fraturas Espontâneas/fisiopatologia , Humanos , Masculino , Ultrassonografia , Adulto Jovem
14.
J Endocrinol Invest ; 33(6 Suppl): 39-43, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21057185

RESUMO

Short stature homeobox-containing (SHOX) gene deficiency is acknowledged under the term "dyschondrosteosis", which is included in the family of congenital osteodystrophies. Under current regulations, the cost of the genetic testing and treatment with GH in children with short stature, and SHOX gene deficiency may be reimbursed. Prescription of costs exemption is subject to the identification of the regional centers qualified to diagnose congenital osteodystrophies (RNG060). The centers qualified to diagnose and treat "dyschondrosteosis" have been identified in only a few regions, whereas in other regions centers for the diagnosis and treatment of congenital osteodystrophies have been identified, and in still others, no specific centers have been identified yet. Treatment with GH as indicated by European Medicines Agency (EMEA) for people with short stature and evidence of SHOX gene deficiency is governed by Agenzia Italiana del Farmaco (AIFA) note number 39. The latest version does not provide for the medication to be directly reimbursed by the National Health Service, although it may be prescribed for patients with well-defined auxological characteristics, subject to the prior authorization of the regional commission qualified to monitor the use of the GH. Therefore, a diagnostic/ therapeutic course for patients with short stature with SHOX gene mutation has been proposed. The healthcare course relating to such patients has not been thoroughly defined in terms of implementation and is affected by regional organizational approaches. Implementing specific healthcare courses for such patients may provide a model for treating other patients with short stature and rare diseases with GH.


Assuntos
Deficiências Nutricionais/diagnóstico , Deficiências Nutricionais/tratamento farmacológico , Hormônio do Crescimento/uso terapêutico , Proteínas de Homeodomínio/genética , Mutação/genética , Saúde Pública , Doenças Raras/diagnóstico , Doenças Raras/tratamento farmacológico , Criança , Pré-Escolar , Deficiências Nutricionais/genética , Feminino , Testes Genéticos/economia , Hormônio do Crescimento/economia , Custos de Cuidados de Saúde , Humanos , Itália , Masculino , Doenças Raras/genética , Proteína de Homoeobox de Baixa Estatura
15.
J Am Soc Nephrol ; 19(8): 1509-19, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18448587

RESUMO

An apparent conflict exists between observational studies that suggest that vitamin D receptor (VDR) activators provide a survival advantage for patients with ESRD and other studies that suggest that they cause vascular calcification. In an effort to explain this discrepancy, we studied the effects of the VDR activators calcitriol and paricalcitol on aortic calcification in a mouse model of chronic kidney disease (CKD)-stimulated atherosclerotic cardiovascular mineralization. At dosages sufficient to correct secondary hyperparathyroidism, calcitriol and paricalcitol were protective against aortic calcification, but higher dosages stimulated aortic calcification. At protective dosages, the VDR activators reduced osteoblastic gene expression in the aorta, which is normally increased in CKD, perhaps explaining this inhibition of aortic calcification. Interpreting the results obtained using this model, however, is complicated by the adynamic bone disorder; both calcitriol and paricalcitol stimulated osteoblast surfaces and rates of bone formation. Therefore, the skeletal actions of the VDR activators may have contributed to their protection against aortic calcification. We conclude that low, clinically relevant dosages of calcitriol and paricalcitol may protect against CKD-stimulated vascular calcification.


Assuntos
Conservadores da Densidade Óssea/administração & dosagem , Calcinose/prevenção & controle , Calcitriol/administração & dosagem , Ergocalciferóis/administração & dosagem , Falência Renal Crônica/tratamento farmacológico , Animais , Aorta/metabolismo , Doenças da Aorta/etiologia , Doenças da Aorta/prevenção & controle , Doenças Ósseas Endócrinas/etiologia , Doenças Ósseas Endócrinas/patologia , Doenças Ósseas Endócrinas/prevenção & controle , Calcinose/etiologia , Cálcio/sangue , Gorduras na Dieta/efeitos adversos , Feminino , Fêmur/efeitos dos fármacos , Fêmur/patologia , Expressão Gênica/efeitos dos fármacos , Falência Renal Crônica/sangue , Falência Renal Crônica/complicações , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Osteoblastos/efeitos dos fármacos , Fósforo/sangue , Receptores de Calcitriol/agonistas
16.
J Am Soc Nephrol ; 19(6): 1092-105, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18417722

RESUMO

Hyperphosphatemia and vascular calcification have emerged as cardiovascular risk factors among those with chronic kidney disease. This study examined the mechanism by which phosphorous stimulates vascular calcification, as well as how controlling hyperphosphatemia affects established calcification. In primary cultures of vascular smooth muscle cells derived from atherosclerotic human aortas, activation of osteoblastic events, including increased expression of bone morphogenetic protein 2 (BMP-2) and the transcription factor RUNX2, which normally play roles in skeletal morphogenesis, was observed. These changes, however, did not lead to matrix mineralization until the phosphorus concentration of the media was increased; phosphorus stimulated expression of osterix, a second critical osteoblast transcription factor. Knockdown of osterix with small interference RNA (siRNA) or antagonism of BMP-2 with noggin prevented matrix mineralization in vitro. Similarly, vascular BMP-2 and RUNX2 were upregulated in atherosclerotic mice, but significant mineralization occurred only after the induction of renal dysfunction, which led to hyperphosphatemia and increased aortic expression of osterix. Administration of oral phosphate binders or intraperitoneal BMP-7 decreased expression of osterix and aortic mineralization. It is concluded that, in chronic kidney disease, hyperphosphatemia stimulates an osteoblastic transcriptional program in the vasculature, which is mediated by osterix activation in cells of the vascular tunica media and neointima.


Assuntos
Doenças Cardiovasculares/etiologia , Nefropatias/complicações , Fósforo/fisiologia , Animais , Calcinose/complicações , Calcinose/etiologia , Células Cultivadas , Doença Crônica , Humanos , Camundongos , Fatores de Risco , Doenças Vasculares/complicações , Doenças Vasculares/etiologia
17.
Am J Surg ; 216(5): 923-925, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29580557

RESUMO

INTRODUCTION: This study evaluated the effect of resident involvement on patient outcomes following major ventral hernia repair (VHR). METHODS: National Surgical Quality Improvement Program database was queried to identify patients with major VHR between 2007 and 2010. Patient outcomes were compared based on presence or absence of resident in the operating room. RESULTS: Residents participated in 57% of the 27,773 identified cases. There was no significant difference in return to operating room or 30-day mortality. A higher incidence of superficial surgical site infection (SSI) (4.9% vs 3.9%, P = 0.013) and longer operative time (129.2 vs 99.1 min, P < 0.001) were observed with resident involvement in open inpatient cases. We found no evidence of a "July effect" on outcomes. CONCLUSION: Resident involvement in VHR has little impact on morbidity, and patients can be reassured that resident participation in their care is safe.


Assuntos
Educação de Pós-Graduação em Medicina/normas , Hérnia Ventral/cirurgia , Herniorrafia/educação , Internato e Residência/métodos , Laparoscopia/educação , Vigilância da População/métodos , Melhoria de Qualidade , Bases de Dados Factuais , Seguimentos , Herniorrafia/métodos , Humanos , Laparoscopia/métodos , Morbidade/tendências , Duração da Cirurgia , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Taxa de Sobrevida/tendências , Estados Unidos/epidemiologia
18.
Am Surg ; 84(9): 1429-1432, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-30268170

RESUMO

The objective of this study was to determine whether implementing an outpatient infusion pathway (OIP) resulted in a decreased 30-day readmission rate after laparoscopic Roux-en-Y gastric bypass (LRYGB). Data were retrospectively gathered on all patients who underwent LRYGB at our institution between April 1, 2015, and March 31, 2016, after instituting an OIP (postinfusion group). Thirty-day readmission rate, length of stay, and 30-day mortality rate were compared with patients who underwent LRYGB between January 1, 2014, and December 31, 2014, before implementing the OIP (preinfusion group). Patients not able to take 40 ounces of fluid orally at discharge after surgery were enrolled in the OIP. One OIP session would include an antiemetic, 1 liter bolus of 0.9 per cent saline, and intravenous multivitamin, thiamine, and folic acid. A total of 174 patients were included for analysis. Seventy-nine patients were in the preinfusion group and 95 patients in the postinfusion group. Of the 95 patients in the postinfusion group, 18 patients (18.9%) met inclusion criteria for the OIP. There was a 45 per cent decrease in 30-day readmission rate after the institution of the OIP for patients who underwent LRYGB, however this was not statistically significant (11.39% vs 6.31%; OR 1.907; 95% confidence interval: 0.648-5.613, P = 0.235). There was no difference in postoperative length of hospital stay (1.65 vs 1.41 days, P = 0.114) or mortality (0.7% vs 0%, P = 0.454), in the pre- and postinfusion groups, respectively. Implementation of an OIP decreased 30-day readmission rate after LRYGB by 45 per cent; however, this was not statistically significant.


Assuntos
Procedimentos Clínicos , Derivação Gástrica , Terapia por Infusões no Domicílio , Laparoscopia , Obesidade Mórbida/cirurgia , Readmissão do Paciente , Adulto , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Nutrição Parenteral , Estudos Retrospectivos , Fatores de Tempo
19.
J Surg Educ ; 74(6): e138-e146, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28988955

RESUMO

PURPOSE: The quality of working life of US surgical residents has not been studied, and given the complexity of interaction between work and personal life there is a need to assess this interaction. We utilized a validated Work Related Quality of Life (WRQoL) questionnaire to evaluate the perceived work-related quality of life of general surgery residents, using a large, nationally representative sample in the United States. METHODS: Between January 2016 and March 2016, all US general surgery residents enrolled in an ACGME general surgery training program were invited to participate. The WRQoL scale measures perceived quality of life covering six domains: General Well-Being (GWB), Home-Work Interface (HWI), Job and Career Satisfaction (JCS), Control at Work (CAW), Working Conditions (WCS) and Stress at Work (SAW). RESULTS: After excluding for missing data, the final analysis included 738 residents. The average age was 30 (±3) years, of whom 287 (38.9%) were female, 272 (36.9%) were from a community hospital, and 477 (64.6%) were juniors (postgraduate year ≤ 3). Demographically, the respondents matched expected percentages. When male and female residents were compared, males had statistically better HWI (p<0.001), better GWB (p = 0.03), more CAW (p = 0.0003) and WCS (p = 0.001). Junior residents had a lower JCS (p = 0.002) and CAW (p = 0.04) compared to seniors. There were no differences between university and community residents in any of the domains of WRQoL. Although residents were more stressed than other professions but the overall WRQoL was comparable. CONCLUSIONS: The nature of surgical residency and a surgical career may in fact be more "stressful" than other professions, yet may not translate into a worsened Quality of Life. Our findings suggest further study is needed to elucidate why female residents have or experience a lower perceived WRQoL than their male colleagues.


Assuntos
Cirurgia Geral/educação , Internato e Residência/organização & administração , Qualidade de Vida , Estresse Psicológico/epidemiologia , Carga de Trabalho , Adulto , Esgotamento Profissional , Educação de Pós-Graduação em Medicina/organização & administração , Feminino , Humanos , Satisfação no Emprego , Masculino , Avaliação de Programas e Projetos de Saúde , Medição de Risco , Inquéritos e Questionários , Estados Unidos , Tolerância ao Trabalho Programado
20.
Am Surg ; 83(1): 3-7, 2017 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-28234104

RESUMO

Literature on postoperative urinary retention (POUR) after colorectal resections is limited. The aim of our study was to evaluate the incidence of and risk factors for POUR after elective colorectal resections in men ≥55 years without genitourinary issues. A retrospective review of elective colorectal resections (June 1, 2014 to June 1, 2015) in men ≥55 years without genitourinary conditions was performed at our institution. Patient demographics, American Society of Anesthesiologist score, body mass index (BMI), surgical history, type of disease, extent of resection, surgical approach, operating room (OR) time, volume of OR fluids administered, and intra- and postoperative urine output were included for analysis. Seventy patients were identified. Nine (12.9%) experienced POUR. Patients with POUR experienced longer OR time (324 vs 239 minutes; P = 0.048) and had a lower median BMI (23.8 vs 28 kg/m2; P = 0.038). There were no significant differences in regards to age, comorbidities, diagnosis, type of resection, surgical approach, intravenous fluids administered operatively, or postoperative urine output. The incidence of POUR in male patients at least 55 years of age after elective colorectal resection in our institution was 12.9 per cent. Longer operative time and lower BMI were associated with a higher incidence of POUR.


Assuntos
Índice de Massa Corporal , Colo/cirurgia , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Duração da Cirurgia , Complicações Pós-Operatórias/epidemiologia , Reto/cirurgia , Retenção Urinária/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Fatores de Risco , Retenção Urinária/etiologia , Micção
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